ライフサイエンスコーパス: hyperresponsive

1 lation of 11% oxygen, and were classified as hyperresponsive.

2 leted and (2) Noe mice in which NK cells are hyperresponsive.

3 to even a small extent (25% increase) become hyperresponsive.

4 not exacerbate the developmental defects and hyperresponsive activity of A20-deficient B cells.

5 anded population of apoptosis-resistant, TLR-hyperresponsive alveolar macrophages that enhance airway

6 cted pronounced limbic volume reductions and hyperresponsive amygdala during emotional arousal, with

7 patitis, the monocytes of cHCV patients were hyperresponsive and failed to show homo- or heterotolera

8 l T and B cells, LAX(-/-) T and B cells were hyperresponsive and had enhanced calcium flux, protein t

9 ar dorsal horn multireceptive neurons became hyperresponsive and when behavioral nociceptive threshol

10 ar dorsal horn multireceptive neurons became hyperresponsive and when behavioral nociceptive threshol

11 with two possible regimes-hyporesponsive and hyperresponsive-and the transition between the two corre

12 f SLE is T cell dysfunction characterized by hyperresponsive antigen receptor signaling.

13 icient B cells, the E613R mutation generates hyperresponsive B cells.

14 h supraphysiologic CD45 expression exhibited hyperresponsive BCR signaling, they did so by opposite r

15 reased Btk association with the membrane and hyperresponsive BCR signaling.

16 Compared with adults, youth have hyperresponsive beta-cells and their decline in beta-cel

17 These correspond with hyperresponsive calcium and pERK responses to TCR stimul

18 with fatal autoimmune-like disease caused by hyperresponsive CD4(+) T cells.

19 of a susceptible microenvironment can drive hyperresponsive CD45 E613R B cells to break tolerance.

20 B cells in the double mutant mice phenocopy hyperresponsive CD45 E613R B cells, whereas peripheral T

21 CTLA-4 knockout T cells are hyperresponsive compared with wild-type T cells in B7-fr

22 d increased adhesion on type I collagen, and hyperresponsive CRP and CLEC-2-induced alpha and dense g

23 This became apparent from the hyperresponsive degranulation of lyn-/- bone marrow-deri

24 as Jurkat T cells suppressed for IQGAP1 were hyperresponsive, displaying increased IL-2 and IFN-gamma

25 esponse to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a

26 In the stress-hyperresponsive Fischer strain, P1-14 pups were isolated

27 gnificantly reduced SHP-1 activity, are also hyperresponsive following integrin engagement.

28 ucocorticoids, and women tend to have a more hyperresponsive HPA axis than men.

29 Itpkb(-/-) thymocytes are pre-TCR hyperresponsive, hyperactivate Akt, downstream mTOR and

30 A hyperresponsive immune system is suggested by the follic

31 yl-lactosamine and led to hypersensitive and hyperresponsive immunocytes.

32 ence indicating this system is overactive or hyperresponsive in depression and with genetic evidence

33 atory environment because the thymocytes are hyperresponsive in preinflammatory-stage Tgfb1(-/-) mice

34 ARAP3-deficient neutrophils are hyperresponsive in several adhesion-dependent situations

35 d that B cells lacking c-ets-1 are generally hyperresponsive in terms of Ab secretion and form large

36 The mutant B cells were not hyperresponsive in terms of proliferation and antibody p

37 Cells expressing active RhoA were thus hyperresponsive in the context of TCR-induced proliferat

38 avenously activates T cells, rendering cells hyperresponsive in vitro for at least two days after inj

39 mice that expressed CD1d only on thymocytes, hyperresponsive iNKT cells in the periphery expressed si

40 stricted expression of CD1d gives rise to Ag hyperresponsive iNKT cells.

41 sion developed a comparable population of Ag hyperresponsive iNKT cells.

42 intrauterine insulin secretion, followed by hyperresponsive insulin secretion once the adrenergic st

43 nd whether the pathogenesis of IA involves a hyperresponsive mast cell compartment.

44 There was no evidence of a hyperresponsive mast cell phenotype in patients with IA.

45 elease or glutamate receptor binding yielded hyperresponsive mast cells with a genomic state similar

46 Pep-deficient mice on the B6 background have hyperresponsive memory T cells, autoimmunity does not de

47 enia, and accumulation of a rapidly cycling, hyperresponsive memory-like CD8+CD44+ IL-7R- T cells whi

48 Wistar-Kyoto (WKY) rats exhibit hyperresponsive neuroendocrine and behavioral responses

49 beta1 is a novel marker of tissue homing and hyperresponsive neutrophil subtypes in sepsis, and block

50 ically results in hyporesponsive rather than hyperresponsive NK cells.

51 eprogramming causes these cells to be either hyperresponsive or hyporesponsive, resulting in a change

52 by either I/R or LPS and exhibited endotoxin hyperresponsive patterns (GCN5, CBP and p300).

53 Despite evidence of hyperresponsive peripheral and central nervous system (C

54 ls derived from Cyld knockout mice display a hyperresponsive phenotype and mediate the spontaneous de

55 Previous studies linked the hyperresponsive phenotype in part to increased Fyn kinas

56 ast, the P. aeruginosa pilA mutant induced a hyperresponsive phenotype in TLR2KO mice.

57 TNF-alpha in suspension, indicating that the hyperresponsive phenotype of the pir-b-/- cells during a

58 The hyperresponsive phenotype of TLR2KO mice exposed to the

59 Loss of Lyn resulted in a hyperresponsive phenotype on engagement of surface integ

60 o P-12LO-/- platelet-rich plasma rescues the hyperresponsive phenotype resulting in a diminished ADP-

61 three remaining RI strains exhibited a novel hyperresponsive phenotype significantly different from t

62 ly dependent on HY5 activity for their light-hyperresponsive phenotypes.

63 m patients with mild asthma characterized by hyperresponsive production of mediators implicated in ne

64 ng between various TLRs and NOD2 resulted in hyperresponsive, proinflammatory macrophages, thus provi

65 -) T cells, would exhibit an Ag-independent, hyperresponsive proliferation phenotype.

66 cells capable of suppressing AHR in the OVA-hyperresponsive recipients, but the process of sensitiza

67 ted in enhanced transcription, manifested by hyperresponsive recruitment of RNA polymerase II (Pol II

68 the Tnf-alpha gene, all exhibiting endotoxin hyperresponsive recruitment patterns similar to Pol II.

69 CD11c(+) B cells demonstrate IFN- hyperresponsive signaling compared with other B cell sub

70 or SOCS1 and -3 in the seemingly paradoxical hyperresponsive state in cells deficient in IL-18Ralpha,

71 The hyperresponsive state that results leads to greatly magn

72 ives the paradoxical result of B cells being hyperresponsive, suggesting an inhibitory role for this

73 itory wedge motif in CD45 (E613R) results in hyperresponsive thymocytes and B cells on the C57BL/6 ba

74 d C9orf72(-/-) myeloid cells are selectively hyperresponsive to activators of the stimulator of inter

75 B cells in Helios transgenic mice were also hyperresponsive to Ag stimulation.

76 Rasa3 mutant platelets were hyperresponsive to agonist stimulation, both in vitro an

77 ntal defects, T cells from these animals are hyperresponsive to anti-CD3 Ab stimulation.

78 er mononuclear cells from BTLA(-/-) mice are hyperresponsive to anti-CD3, Con A, and alpha-galactosyl

79 is not only aberrantly autoreactive but also hyperresponsive to antigen stimulation.

80 h these features, PEP-R619W lymphocytes were hyperresponsive to antigen-receptor engagement with a di

81 Cbl-b deficiency thus renders T cells hyperresponsive to antigenic stimulation and predisposes

82 e tolerance, and its absence renders B cells hyperresponsive to autoantigen.

83 of the WAS gene results in B cells that are hyperresponsive to B cell receptor and Toll-like recepto

84 verexpressing wild-type Btk were selectively hyperresponsive to BCR stimulation and showed enhanced C

85 Also, HBI1-overexpressing plants are hyperresponsive to BR and more resistant to the BR biosy

86 Seedlings with reduced BAS1 expression are hyperresponsive to brassinosteroids in a light-dependent

87 Bronchi from COX-1(-/-) mice were hyperresponsive to bronchoconstrictors.

88 AMP1/YP mice compared with control mice were hyperresponsive to CCL5 in chemotaxis.

89 Arabidopsis Isd1 mutants are hyperresponsive to cell death initiators and fail to lim

90 tic progenitor cells from SHIP(-/-) mice are hyperresponsive to certain hematopoietic growth factors,

91 rophils and DCs from pir-b-/- mice were also hyperresponsive to chemokine stimulation.

92 Nonetheless, these cells are hyperresponsive to cytokines and have characteristics of

93 lated conditions, these brain regions may be hyperresponsive to disease-specific emotional and affere

94 Antigen-challenged guinea pigs were hyperresponsive to electrical stimulation of the vagus n

95 ins-l flies are also hyperactive and hyperresponsive to environmental perturbations.

96 Accordingly, TCF1-deficient mice are hyperresponsive to experimental autoimmune encephalomyel

97 (BMMCs) from Lyn-deficient (Lyn-/-) mice are hyperresponsive to FcepsilonRI cross-linking with multiv

98 ped neutrophilia, and bone marrow cells were hyperresponsive to G-CSF stimulation.

99 PSGL-1(null) CD8(+) T cells were found to be hyperresponsive to homeostatic cytokines IL-2, IL-4, and

100 The mice are very hyperactive and hyperresponsive to human contact and other sensory stimu

101 lung, liver, and spleen iNKT cells that are hyperresponsive to hypoxia/reoxygenation.

102 sion rendered STAT3-deficient CD8(+) T cells hyperresponsive to IL-12, suggesting that the STAT3-SOCS

103 s expressed the high-affinity IL-2R and were hyperresponsive to IL-2.

104 indicates that p47(phox-/-) macrophages are hyperresponsive to IL-4 and show higher Stat6 phosphoryl

105 alternative activation and, furthermore, are hyperresponsive to IL-4 stimulation.

106 TSK/+ fibroblasts appeared to be hyperresponsive to IL-4, displaying increased synthesis

107 ve GFP(hi) CD4 T cells from SKGNur mice were hyperresponsive to IL-6 receptor signaling.

108 TFF2-/- cells were hyperresponsive to interleukin 1 beta stimulation but sh

109 hat is not secreted, thereby rendering cells hyperresponsive to interleukin-1beta stimulation.

110 entation groups designated shl for seedlings hyperresponsive to light.

111 teoclast progenitors from Nf1(+/-) mice were hyperresponsive to limiting concentrations of M-CSF and

112 MKP-1-/- mice are hyperresponsive to low-dose LPS-induced toxicity and exh

113 Furthermore, cells from Lcn2KO mice were hyperresponsive to LPS ex vivo, exhibiting elevated cyto

114 Moreover, LAB(-/-) mice were hyperresponsive to LPS-induced septic shock.

115 Naive ADAP-deficient CD8 T cells are hyperresponsive to lymphopenia in vivo and exhibit enhan

116 ks a regulator of G protein signaling and is hyperresponsive to mating pheromone.

117 A20-deficient B cells are hyperresponsive to multiple stimuli and display exaggera

118 or that OCL precursors in these lesions are hyperresponsive to osteoclastogenic factors (or both).

119 Furthermore, SA-deficient rice is hyperresponsive to oxidative damage caused by paraquat t

120 disease (XLP), who lack functional SAP, were hyperresponsive to PD-1 signaling, confirming its inhibi

121 ISCLS-derived ECs were functionally hyperresponsive to permeability-inducing factors like VE

122 at the absence of 4-1BB can make CD4 T cells hyperresponsive to protein Ag in vivo, suggesting a new

123 ursors derived from CYLD-deficient mice were hyperresponsive to RANKL-induced differentiation and pro

124 P392L)-transduced osteoclast precursors were hyperresponsive to receptor activator of NF-kappaB ligan

125 with a disrupted CD22 gene were found to be hyperresponsive to receptor signaling: Heightened calciu

126 CD4(+)CD8(+) and CD4(+)CD8(-) thymocytes are hyperresponsive to receptor-mediated and receptor-indepe

127 time that: i) mouse and human MAIT cells are hyperresponsive to SAgs, typified by staphylococcal ente

128 y to InsP3, which subsequently makes neurons hyperresponsive to stimulation and presumably more prone

129 LAX-deficient mast cells were hyperresponsive to stimulation via the Fc epsilonRI, as

130 cyte development, it caused mast cells to be hyperresponsive to stimulation via the FcepsilonRI, evid

131 CAM-1/Lyn double-deficient mice were equally hyperresponsive to stimulation with a GPVI-specific agon

132 ells from lupus-prone mice are intrinsically hyperresponsive to stimulation with antigen, particularl

133 cells from the affected family members were hyperresponsive to stimulation.

134 normal baseline locomotor activity, but are hyperresponsive to stimuli including social partners, ci

135 of STING, and PTEN-null TNBC cell lines were hyperresponsive to STING agonists.

136 thus intrinsically primes T cells to become hyperresponsive to T cell receptor signaling-induced ER

137 CD4 T cells from ACS patients were also hyperresponsive to T cell receptor-mediated stimulation

138 The PTEN-deficient cells were also hyperresponsive to T-cell receptor (TCR) stimulation, as

139 Indeed, SAP-deficient T cells were hyperresponsive to T-cell receptor stimulation, which re

140 ligation of CD28; scurfy cells, however, are hyperresponsive to TCR ligation and exhibit a decreased

141 e we show that DGKzeta-deficient T cells are hyperresponsive to TCR stimulation both ex vivo and in v

142 G2A-deficient T cells are hyperresponsive to TCR stimulation, exhibiting enhanced

143 cells from mice lacking Sts-1 and Sts-2 are hyperresponsive to TCR stimulation.

144 In other experiments, D3R-/- mice were hyperresponsive to the administration of amylin and lept

145 is demonstrated that GP V -/- platelets were hyperresponsive to thrombin, resulting in increased fibr

146 studies identified that c-Cbl(-/-) HSCs are hyperresponsive to thrombopoietin (TPO) and display elev

147 BCAP-deficient macrophages and mice are hyperresponsive to TLR agonists and have reduced PI3K ac

148 istically, LRP5/6-deficient macrophages were hyperresponsive to TLR ligands and produced higher level

149 egulators of immune activation and thus were hyperresponsive to TLR ligands, producing abnormally hig

150 on by small interference RNAs rendered cells hyperresponsive to TNF-alpha stimulation.

151 stituted with mutated p50 precursor p105 are hyperresponsive to TNFalpha stimulation relative to wild

152 Lyn-deficient DCs were hyperactivated and hyperresponsive to Toll-like receptor agonists and IL-1b

153 ver, infection of Ubp43(-/-) mice, which are hyperresponsive to type I IFNs, did not exhibit enhanced

154 ith posttraumatic stress disorder (PTSD) are hyperresponsive to unexpected or potentially threatening

155 Antigen-challenged animals were hyperresponsive to vagal stimulation, but those that rec

156 ECs infected by pathogenic hantaviruses are hyperresponsive to vascular endothelial growth factor (V

157 Mature coronary collateral arteries are hyperresponsive to vasopressin; in contrast, contractile

158 fect rendered human retinal endothelial cell hyperresponsive to VEGF and was not observed in retinal

159 ive-like CD56(dim)CD16(+) NK cells and to be hyperresponsive toward target cells.

160 HO-2 deficiency caused hyperresponsive TRAM-dependent TLR4 signaling and hypers

161 Cbl-b double knock-out (dKO) T cells became hyperresponsive upon anti-CD3 stimulation, even though t

162 ath, even though the mice still maintained a hyperresponsive Vdr-deficient immune system.

163 nals) and mice overexpressing CD19 (that are hyperresponsive) were crossed with CD21- and C3-deficien