ライフサイエンスコーパス: hypha

1 ring spore germination and along the growing hypha.

2 ated with an alteration in morphology of the hypha.

3 prevents the transportation of Pb (II) into hypha.

4 extension where it attaches to the parental hypha.

5 e plasma membrane at the extreme apex of the hypha.

6 ne occupied the apical 0.5 microm of growing hypha.

7 ain distributed throughout the cell body and hypha.

8 ntly in two regions on opposing sides of the hypha.

9 dergo morphological transition from yeast to hypha.

10 esignated CIH1 (Colletotrichum Intracellular Hypha 1).

11 -dependent protrusion of a rigid penetration hypha(3).

12 ed using a tetracycline-off system to assess hypha and biofilm formation in IFEs.

13 lopment at different biological levels - the hypha and its content, hyphal networks and AM fungal spo

14 ermling has its nuclei distributed along the hypha and the septum formed near the spore body.

15 hfully duplicated the elongation of the main hypha and the two apical branches.

16 FP patches were highly mobile throughout the hypha and were concentrated near hyphal apices.

17 munopathology require hypha formation, other hypha-associated factors, or genetic interaction with EF

18 ression and is dispensable for expression of hypha-associated genes in vitro and in vivo.

19 In an effort to disentangle hypha-associated virulence factor regulation from morpho

20 ions of fungal-grain contacts revealed (i) a hypha-biofilm-basaltic glass interface coinciding with t

21 and mobilization of Mg, Fe, Al, and K at the hypha-biotite interface.

22 rack formation, which are abundant below the hypha-biotite interface.

23 The oogonia are attached to a parental hypha by a short truncated stalk with a single septum.

24 fungi-biotite sections along three distinct hypha colonizing the [001] basal plane of biotite, revea

25 drogenase release) compared to that with the hypha-competent control.

26 In the hypha, cytoplasm flows directionally from cell to cell t

27 However the nonvirulent, hypha-defective cla4 mutant line was considerably more r

28 intravaginal challenge of C57BL/6 mice with hypha-defective strains attained high levels of mucosal

29 The conidiation and aerial hypha defects of the Deltagna-3 strain are similar to th

30 Hypha-deficient mutant C. albicans caused no or low mort

31 ans or with an isogenic, Deltaefg1/Deltaefg1 hypha-deficient mutant.

32 at calcineurin is not required for the yeast-hypha dimorphic transition, host cell adherence, or host

33 oxidase, which is necessary for penetration hypha elongation.

34 of GTP-locked Cdc42 reversed the polarity of hypha emergence from cathodal to anodal, an effect augme

35 he discovery that the cell wall of a growing hypha expands orthogonally has major repercussions on tw

36 otein response (UPR), which in turn inhibits hypha formation and pathogenicity in vitro.

37 ectively, showing clearly that cAMP promotes hypha formation in C. albicans.

38 the premature conidiation defect, but aerial hypha formation is still reduced.

39 n cultures containing farnesol or dodecanol, hypha formation was restored upon addition of dibutyryl-

40 Candida albicans hypha formation which has been stimulated via the Ras1-c

41 s of SAPs to vaginal immunopathology require hypha formation, other hypha-associated factors, or gene

42 eletion of both copies of this gene prevents hypha formation.

43 cAMP-repressed genes and cells repressed for hypha formation.

44 Hypha-forming Candida also induced the nuclear disappear

45 ontinued to grow unperturbed, but a daughter hypha gradually branched into the opening and formed its

46 Sb5 exudates also stimulated infection hypha growth and upregulated effector gene expression.

47 H. capsulatum grows as a multicellular hypha in the soil that switches to a pathogenic yeast fo

48 fies additional potential targets to control hypha-induced inflammation.

49 t strains developed germ tubes under several hypha-inducing conditions, they were unable to maintain

50 intain the hyphal growth mode in a synthetic hypha-inducing liquid medium and were deficient in the e

51 perature and low-oxygen environment found in hypha-laden infected tissue may underlie this poor recov

52 coinfection with C. albicans yeast-locked or hypha-locked mutants showed similar mortality, dissemina

53 By contrast, if a hypha made contact with an obstacle at near-orthogonal i

54 We found that, if a hypha made contact with obstacles at acute angles, the S

55 udy, we show that Rad6p also regulates yeast-hypha morphogenesis in the human pathogen Candida albica

56 nticipated, inhibitory role for the yeast-to-hypha morphogenesis program on commensalism.

57 virulence-related functions, including yeast-hypha morphogenesis.

58 ogenetic signalling pathway to repress yeast-hypha morphogenesis.

59 nicity and the ability to undergo a yeast-to-hypha morphological switch in vitro.

60 with a significant reduction of the yeast-to-hypha morphological transition.

61 Sinusoidal hypha morphology was altered in the mid1Delta, chs3Delta

62 y, tip-associated actin polarization in each hypha occurs before the events of the G(1)/S transition

63 dination ensures the loading in the invading hypha of the correct genetic information to proceed with

64 Hypha orientation is an essential aspect of polarised gr

65 ol-rich apical microdomains, are involved in hypha orientation.

66 describe the molecular machinery regulating hypha orientation.

67 Finally, a hypha passing a lateral opening in constraining channels

68 Growth studies demonstrate among- and within-hypha phenotypic variation for growth in response to gal

69 in the process was demonstrated using a non-hypha-producing and a noninvasive hypha-producing mutant

70 sing a non-hypha-producing and a noninvasive hypha-producing mutant strains of C. albicans.

71 ot contingent upon the presence of the Als3p hypha-specific adhesion.

72 , by the cyclin-dependent kinase Cdc28-Hgc1 (hypha-specific G(1) cyclin) downregulates Ace2 target ge

73 ce in vitro requires chromatin remodeling of hypha-specific gene promoters, although disrupting chrom

74 HWP1, a hypha-specific gene, was identified in a genetic screen

75 CaTup1-regulated genes, which includes known hypha-specific genes and other virulence factors.

76 terestingly, upstream sequences of all known hypha-specific genes are found to contain potential bind

77 However, many hypha-specific genes do not have potential Cph2 binding

78 dium and were deficient in the expression of hypha-specific genes in this medium.

79 to exclusion of Nrg1 binding to promoters of hypha-specific genes or reduced NRG1 expression.

80 filamentous and invasive growth, derepresses hypha-specific genes, increases sensitivity to some stre

81 Ume6, the transcriptional activator of hypha-specific genes, is stabilized via regulation by Of

82 control the transcription of a common set of hypha-specific genes, many of which encode known virulen

83 n hyphal development and in the induction of hypha-specific genes.

84 ism and virulence in which selection against hypha-specific markers limits the disease-causing potent

85 shape, but by activating the expression of a hypha-specific pro-inflammatory secreted protease, Sap6,

86 sphorylation site of Efg1 displays a loss of hypha-specific repression of these genes and impaired ce

87 A hypha-specific surface protein, Hwp1, with similarities

88 These results highlight the yeast-to-hypha switch and the associated morphogenetic response a

89 Many regulators of the yeast-to-hypha switch have emerged from intensive investigations

90 ta cph1Delta/Delta) controlling the yeast-to-hypha switch revealed a crucial role for morphogenetic s

91 ginine activated an Efg1p-dependent yeast-to-hypha switch, enabling wild-type C. albicans and KWN8 to

92 Specific cell wall features such as hypha tails and smaller glycan components modulate a wid

93 ytic patches, 1-2 mum behind the apex of the hypha, that moves forward as the tip grows.

94 Following a period of maturation, a hypha then emerges at the plant interface and penetrates

95 VezA-GFP signals are enriched at the hypha tip in an actin-dependent manner but are not obvio

96 igations of this morphogenetic step, but the hypha-to-yeast switch remains poorly understood.

97 , a novel putative regulator involved in the hypha-to-yeast switch was identified, the C. albicans pe

98 rapid induction of hyphal growth and delayed hypha-to-yeast transitions.

99 l emphasis on the regulation of the yeast-to-hypha transition and different modes of sexual reproduct

100 ndergoes two developmental programs, the bud-hypha transition and high-frequency phenotypic switching

101 nvolve differential gene expression, the bud-hypha transition and high-frequency phenotypic switching

102 has been implicated in controlling the yeast-hypha transition and pathogenesis of Candida albicans.

103 ) and synthetic PGE(2) enhanced the yeast-to-hypha transition in C. albicans.

104 2) has been demonstrated to regulate the bud-hypha transition in C. albicans[14, 15], expression of v

105 These studies demonstrate that the bud-hypha transition is accompanied by the de novo synthesis

106 hogen Candida albicans to undergo a yeast-to-hypha transition is believed to be a key virulence facto

107 study was to determine whether the yeast-to-hypha transition is required for the hallmark inflammato

108 ence factors coregulated during the yeast-to-hypha transition is unknown.

109 on of cell morphogenesis during the yeast-to-hypha transition of C. albicans, we mutated CaCLN1.

110 monstrating that it undergoes either the bud-hypha transition or high-frequency phenotypic switching,

111 the promoters of genes regulated by the bud-hypha transition, high frequency switching and cues from

112 During the yeast-to-hypha transition, the cell evolves from a bipolar to a u

113 ce in the host is the morphogenetic yeast-to-hypha transition.

114 le signaling pathways to control the yeast-->hypha transition.

115 CaRAD6 mRNA levels decrease during the yeast-hypha transition.

116 f 10 mM cAMP and dibutyryl cAMP promoted bud-hypha transitions and filamentous growth in the cap1/cap

117 lating genes that control cAMP levels to bud-hypha transitions has not been reported.

118 relationship between cAMP signaling and bud-hypha transitions in C. albicans, we identified, cloned,

119 cyclic AMP (cAMP) increases in promoting bud-hypha transitions, but genetic evidence relating genes t

120 d cAMP signaling pathway is required for bud-hypha transitions, filamentous growth, and the pathogene

121 that FlbB localizes to both the apex of the hypha, where it interacts with and is anchored by FlbE,

122 mbly of an IF cytoskeleton provides each new hypha with an additional stress-bearing structure at its