ライフサイエンスコーパス: hyphal

1 gainst M. chitwoodi by nematode trapping via hyphal adhesion to the cuticle layer, penetration of the

2 This hyphal advantage arises because transporting nutrients v

3 d fusion of recipient and donor protoplasts, hyphal anastomosis, and single-conidium isolation.

4 differential localization of slr1Delta/Delta hyphal and yeast morphologies within the kidney.

5 with a retention efficiency depending on the hyphal and, to a lesser extent, the phage surface proper

6 of concentrated endocytosis just behind the hyphal apex (the "endocytic collar"); and small, rapidly

7 ed dwelling times for MTs after reaching the hyphal apex.

8 nspicuous appearance at the MT ends near the hyphal apex.

9 protein localizes at the polarisome and the hyphal apical dome (HAD) where it acts as a GTPase-activ

10 of specific mRNAs play an important role in hyphal apical growth.

11 n oogonium shape, size, spine morphology and hyphal attachment between the Permian forms from the Pri

12 ays that correlated with impaired in insecta hyphal body formation and altered host immune prophenol

13 trunk and in some cases, a few initial thick hyphal branches.

14 Sch9) was defective in aerial hyphal growth, hyphal branching and conidial germination.

15 ation of parasitic plant seeds, they enhance hyphal branching of arbuscular mycorrhizal fungi of the

16 idue S584 was necessary for Sec2p to support hyphal, but not yeast growth.

17 14 retention on phagosomes was prolonged for hyphal cargo and was directly proportional to hyphal len

18 formation of septa that divide a filamentous hyphal cell into tens of prespore compartments.

19 was indistinguishable, even though yeast and hyphal cell lengths differ by two- to fivefold, demonstr

20 In the elongated hyphal cell of the fungus Ustilago maydis, Higuchi et al

21 -inflammatory secreted protease, Sap6, and a hyphal cell surface adhesin, Hyr1.

22 ure of beta-glucan and chitin content on the hyphal cell surface, but diminished TNF production by bo

23 cture, we extracted glucans from C. albicans hyphal cell walls.

24 Intriguingly, hyphal cells display a slr1-6SA-GFP focus at the tip nea

25 The hyphal cells of filamentous fungi concentrate both exocy

26 tosis are strictly segregated at the ends of hyphal cells of filamentous fungi, with a collar of endo

27 Here, we show that hyphal cells of the fungal pathogen Sclerotinia scleroti

28 Rim101, and genes characteristic of invasive hyphal cells.

29 geneity supporting division of labor between hyphal cells.

30 ut are intermittently present throughout all hyphal cells; the region of concentrated endocytosis jus

31 can interconnect plant root systems through hyphal common mycorrhizal networks, which may influence

32 tive dynamics of gene expression with single hyphal compartment resolution in response to carbon sour

33 Septation in Fgcdc14 was reduced and hyphal compartments contained multiple nuclei, indicatin

34 een trafficking long distances in nearly all hyphal compartments.

35 chitin, and beta-glucan are not the relevant hyphal components; instead, the recently identified fung

36 ability to adopt a non-branching vegetative hyphal conformation and rapidly transverse solid surface

37 were readily cotransmitted horizontally via hyphal contact to different vegetative compatibility gro

38 gorous ability to proliferate and spread via hyphal contact.

39 sensing molecule that prevents the yeast to hyphal conversion.

40 logy characterized by poor hyphal extension, hyphal curvature and limited formation of conidia.

41 equire Fn and ERK but not ROS, and result in hyphal destruction.

42 Recent studies suggest that hyphal development in C. albicans requires two temporall

43 Hyphal development requires two temporally linked change

44 aling system with similarity to processes of hyphal development that are linked with virulence in rel

45 rg1 recruits Hda1 to promoters for sustained hyphal development, and BRG1 expression is a readout of

46 HIR operates as a crucial modulator of hyphal development, since genetic ablation of the HIR co

47 To better understand hyphal development, we examined the role of GlcNAc metab

48 e expression of NRG1, the major repressor of hyphal development.

49 to inflammatory foci, leading to widespread hyphal dissemination to lung blood vessels.

50 atin-remodeling does not disrupt C. albicans hyphal elongation and virulence during invasive infectio

51 genetic screen for mutants that can sustain hyphal elongation in rich media, we found hog1, ssk2, an

52 Virulence and hyphal elongation in vivo are attenuated only when the p

53 CO2, but neither condition alone, maintains hyphal elongation, even in mutants lacking the nutrient-

54 phosphatases to activate BRG1 expression for hyphal elongation.

55 sition and size of the nuclei occur prior to hyphal entry into the cortical cells and do not require

56 necessary to enable hyphopodium formation or hyphal entry into the root but is essential to support a

57 mination in macrophages and also resulted in hyphal escape.

58 tributions to MT dynamics and unidirectional hyphal expansion in filamentous fungi.

59 Ascomycetes and EM fungi with short-contact hyphal exploration types.

60 of normal Golgi organization stops polarized hyphal extension and triggers de-polarization of the hyp

61 sents an adaptation that is as important for hyphal extension as is the presence of a Spitzenkorper.

62 Fungal growth rate (hyphal extension rate) was the strongest single predicto

63 n the natural environment indicated that the hyphal extension rates of P. roseus isolates and the act

64 an abnormal morphology characterized by poor hyphal extension, hyphal curvature and limited formation

65 During hyphal extension, the growing tip may be separated from

66 ed by Cdk1, which is necessary for efficient hyphal extension.

67 class V myosin (myoE) is required for proper hyphal extension; deletion of myoE resulted in hyperbran

68 ducted to determine the direct impact of AMF hyphal exudates on growth of the PSB.

69 In the fungal Ascomycota, CM is based on hyphal filaments and arose in the Pezizomycotina.

70 lbicans grows both as single yeast cells and hyphal filaments in the planktonic mode of growth.

71 s of a single-copy gene isolated from single hyphal filaments revealed nuclear heterogeneity both amo

72 al transition from yeast to pseudohyphal and hyphal filaments, which is required for virulence.

73 strategies to disseminate compared with long hyphal filaments.

74 Although mechanisms that regulate hyphal forces on the substrate during expansion have bee

75 udy sheds light on the ambiguous role of the hyphal form during vaginal human commensalism.

76 switching from the yeast to the filamentous hyphal form following phagocytosis by macrophages, facil

77 icans cells more efficiently in their mature hyphal form than in their yeast form.

78 uncommon to rare, to occur exclusively in a hyphal form, and to be parasitic on the dominant fungal

79 he phagosome in the presence of the invasive hyphal form, which favors fungal survival and escape.

80 es the number of fungal cells present in the hyphal form.

81 ce of SR-like RNA-binding protein Slr1 slows hyphal formation and decreases virulence in a systemic c

82 The impact of SLR1 deletion on hyphal formation and function thus may be partially due

83 Hyphal formation is a type of polarized growth, and memb

84 Hyphal formation is controlled by a multilayer regulator

85 eus For C. dubliniensis-mediated protection, hyphal formation was not required, with protection confe

86 biofilm formation through the inhibition of hyphal formation, a critical virulence trait.

87 ts in a delay in alkalinization, a defect in hyphal formation, and a reduction in the amount of ammon

88 enes required for suppression of C. albicans hyphal formation.

89 f fungus in FFPE tissues, demonstrating both hyphal forms and granular fungal antigens, and PCR ident

90 ible morphological changes between yeast and hyphal forms in response to environmental cues.

91 effectively discriminates between yeast and hyphal forms of C. albicans.

92 ind the transition from unicellular fungi to hyphal forms of growth, we develop a comparative model o

93 reater binding by Dectin-1 in both yeast and hyphal forms.

94 stopathological presentations included short hyphal fragments in tissues (n=23/129, 18%).

95 Restoration of growth in hyphal fragments of both wild-type and ftsZ mutant hypha

96 cluding immune defense, neuronal connection, hyphal fusion, and sexual reproduction.

97 Conidial melanin and hydrophobin as well as hyphal galactosaminogalactan represent important pathoge

98 rity-complex dynamics was investigated using hyphal galvanotropic and thigmotropic responses as repor

99 a and dfg16Delta mutants to form hyphae, but hyphal gene expression was partially defective.

100 ng the complex transcriptional regulation of hyphal gene expression.

101 between alkalinization and GlcNAc to induce hyphal genes involves the Rim101 pH-sensing pathway; Glc

102 Ac could induce the triple mutant to express hyphal genes when the medium was buffered to a higher pH

103 to form hyphae without obvious induction of hyphal genes.

104 linked glucans and C. albicans yeast glucan, hyphal glucan has a unique cyclical or "closed chain" st

105 Hyphal glucan induced robust immune responses in human p

106 lso demonstrated the capacity of C. albicans hyphal glucan, but not yeast glucan, to induce IL-1beta

107 ll GTPase, Cdc42, is essential for polarized hyphal growth and Ca(2+) influx is required for the trop

108 Deletion of AfSUN1 negatively affected hyphal growth and conidiation.

109 cleavage site led to more rapid induction of hyphal growth and delayed hypha-to-yeast transitions.

110 Specific cyclophilin mutants showed impaired hyphal growth and differential effects on conidiation an

111 beta chain (GM-CSFRbeta) developed invasive hyphal growth and exhibited impaired survival after pulm

112 protein DivIVA is a critical determinant of hyphal growth and localizes in foci at hyphal tips and s

113 tes produced by Aspergillus during invasive, hyphal growth and may prove diagnostically useful.

114 r hyphae, localize to the nucleus and affect hyphal growth and morphology.

115 stage, possibly as a result of adaptation to hyphal growth and multinuclearity.

116 n APSES transcription factor (STU1) prevents hyphal growth at RT, validating that the Msb2 regulon co

117 r results suggest that HHK3 regulates fungal hyphal growth by affecting vesicle trafficking.

118 In filamentous fungi, hyphal growth depends on the continuous delivery of vesi

119 Moreover, C. albicans hyphal growth factor HWP1 as well as ALS1 and ALS3, whic

120 Invasive hyphal growth following rice cell ingress is thus depend

121 y to switch between yeast, pseudohyphal, and hyphal growth forms (polymorphism) is one of the most in

122 o the morphological transition from yeast to hyphal growth forms is critical for its pathogenesis.

123 al pathogen Candida albicans from budding to hyphal growth has been implicated in its ability to caus

124 l actin patch dynamics between the yeast and hyphal growth in Candida albicans.

125 nal Spitzenkorper and maintenance of regular hyphal growth in Neurospora crassa.

126 d host cuticles like wild type, but invasive hyphal growth in rice cells was restricted and elicited

127 ry vesicle trafficking, fludioxonil inhibits hyphal growth in the opportunistic fungal pathogen Candi

128 red ability to inhibit Aspergillus fumigatus hyphal growth in vitro and in infected corneas in a muri

129 ound that calcium chelation severely impedes hyphal growth indicating a critical requirement for this

130 Alternatively, maintenance of hyphal growth may increase the farnesol response thresho

131 glucan which led to damage and inhibition of hyphal growth of Aspergillus in vitro and in vivo.

132 Hyphal growth of filamentous fungi requires microtubule-

133 sed species reduced Artemia survivorship and hyphal growth of Fusarium during the immature and mature

134 enetic screen to identify genes required for hyphal growth of H. capsulatum at RT and find that disru

135 However, virus infection suppressed hyphal growth of most germinating conidia of B. cinerea

136 of two vertebrate-dispersed species reduced hyphal growth of Phoma.

137 Toxicity was measured as reduced hyphal growth of two fungal pathogens, Phoma sp. and Fus

138 ophils to interfere with Aspergillus species hyphal growth was impaired after HSCT.

139 l keratitis; however, the ability to inhibit hyphal growth was restored in S100A9(-/-) mice by inject

140 leaf sheath surfaces, but Deltandk1 invasive hyphal growth was restricted and redox homeostasis was p

141 ther at room temperature (RT; which promotes hyphal growth) or at 37 degrees C (which promotes yeast-

142 served roles in regulating stress responses, hyphal growth, and possibly secondary metabolism.

143 rease soil available P, the PSB enhanced AMF hyphal growth, and PSB activity was also stimulated by t

144 constitutive high levels, to drive complete hyphal growth, but does not cause a reduction in UME6 tr

145 RP27 or TrpC promoter resulted in defects in hyphal growth, conidiation, appressorium penetration and

146 ts were examined for effects on conidiation, hyphal growth, cyclosporine and stress resistance, and i

147 emperature, morphogenesis to enable invasive hyphal growth, drug tolerance and resistance, cell wall

148 mutant (DeltaFgSch9) was defective in aerial hyphal growth, hyphal branching and conidial germination

149 ch is known to be particularly important for hyphal growth, represents an effective target for hyphae

150 S1 deletion mutants are severely impaired in hyphal growth, sexual reproduction, melanin pigmentation

151 nscription factor (TF), CrzA, is integral to hyphal growth, stress response and virulence of the path

152 epl1 was predominantly expressed during hyphal growth, whereas epl2 was mainly expressed during

153 dida albicans can transition from budding to hyphal growth, which promotes biofilm formation and inva

154 A pathway, influences primary metabolism and hyphal growth, while represses sexual development in A.

155 a role in glucose uptake and the recovery of hyphal growth.

156 to neutralize the phagolysosome and initiate hyphal growth.

157 n Candida albicans to switch from budding to hyphal growth.

158 aA genes confer FK506 resistance and restore hyphal growth.

159 mation, and the induction and maintenance of hyphal growth.

160 ught about by the highly polarized nature of hyphal growth.

161 ggested that cAMP signaling is essential for hyphal growth.

162 other downstream morphogenetic factors from hyphal growth.

163 inhibited rust spore germination and reduced hyphal growth.

164 uired to maintain cellular health needed for hyphal growth.

165 t of a transcriptional circuitry controlling hyphal growth.

166 ll as other physiological adaptation such as hyphal growth.

167 in morphogenesis, making it unclear whether hyphal inducers must stimulate cAMP, or if normal basal

168 Hyphal initiation also requires inoculation of a small a

169 Hyphal initiation and maintenance depend on host environ

170 Here, we show that farnesol inhibits hyphal initiation mainly through blocking the protein de

171 Hyphal initiation requires a rapid but temporary disappe

172 Therefore, hyphal initiation requires both the cAMP-PKA pathway-dep

173 Hyphal initiation requires the activation of the cAMP-PK

174 transiently activated on inoculation during hyphal initiation, and overexpression of SOK1 overcomes

175 play altered transcriptional amplitudes upon hyphal initiation, suggesting that Hir1 affects transcri

176 gesting that Hir1 impacts the early phase of hyphal initiation.

177 vercomes the farnesol-mediated inhibition of hyphal initiation.

178 Neither pathway alone is sufficient for hyphal initiation.

179 Phage-hyphal interaction energies were approximated by the ext

180 celia provide significant surfaces for phage-hyphal interactions.

181 is specifically recruited to the macrophage-hyphal interface but not the macrophage-spore interface

182 oribund animals revealed massive C. albicans hyphal invasion coupled with S. aureus deep tissue infil

183 l candidiasis specifically, characterized by hyphal invasion of oral mucosal tissue, is the most comm

184 tifying fungal pressures on substrate during hyphal invasions under normal and pathophysiological gro

185 Using C. albicans yeast and hyphal kinesin-5 (Kip1p) heterozygotes (KIP1/kip1), we f

186 gnificantly inhibit yeast dispersal from the hyphal layers of biofilms.

187 penic lung correlated with fungal burden and hyphal length but not induction of GT biosynthetic genes

188 Relative hyphal length is dependent upon soil temperature and moi

189 Hyphal length was high, but stable during winter in mois

190 iferation, AM colonization and extramatrical hyphal length) across 14 coexisting AM subtropical tree

191 luenced the biomass of Collembola and fungal hyphal length, (13) C enrichment and the net transfer of

192 productivity and ECM root tips but decreased hyphal length, whereas interspecific richness had no eff

193 yphal cargo and was directly proportional to hyphal length.

194 auses increased chitin content and increased hyphal length.

195 imes proliferating to form short, branching, hyphal-like elements.

196 cortical patches and cables that extend into hyphal-like structures.

197 Hyphal maintenance in vitro requires chromatin remodelin

198 Hyphal maintenance requires active sensing of the surrou

199 transcription factor Ume6, which facilitates hyphal maintenance, rescues filamentation defects of hir

200 hips among farnesol, germ tube formation and hyphal maintenance.

201 grown with an organic source of P, with the hyphal matrix serving to localize the resultant uranium

202 oryzae in vitro, using multiple methods (ie, hyphal metabolic and fluorescent vital dye reduction ass

203 These results demonstrate that hyphal morphogenesis and gene expression can be regulate

204 oformans requires the PUF protein, Pum1, for hyphal morphogenesis during sexual development.

205 ysis revealed that the inhibition of Candida hyphal morphogenesis is mediated via RadD and Flo9 prote

206 Previous studies suggested that hyphal morphogenesis is stimulated by transcriptional in

207 F. nucleatum ATCC 23726 inhibits growth and hyphal morphogenesis of C. albicans SN152 in a contact-d

208 e F. nucleatum-induced inhibition of Candida hyphal morphogenesis promotes C. albicans survival and n

209 everal compounds that specifically inhibited hyphal morphogenesis were identified.

210 ynthesis and Ras signaling (which determines hyphal morphogenesis).

211 ans was due to the inhibition of C. albicans hyphal morphogenesis, a developmental program crucial to

212 nce, including cell wall synthesis, invasive hyphal morphogenesis, and nutrient uptake.

213 role in osmoadaptation, HHK3 is involved in hyphal morphogenesis, conidiation, virulence, and cellul

214 azole sensitivity via CaERG11 expression or hyphal morphogenesis, respectively.

215 ven neutralization of the phagosome promotes hyphal morphogenesis, sufficient for induction of caspas

216 SOD5 was predominantly induced during hyphal morphogenesis, together with a fungal burst in re

217 To identify compounds able to inhibit hyphal morphogenesis, we screened libraries of existing

218 C. albicans with ergosterol biosynthesis and hyphal morphogenesis.

219 tions of the vesicle supply center model for hyphal morphogenesis.

220 nce of the Nrg1 transcriptional repressor of hyphal morphogenesis.

221 oles while CaGPI2 controls Ras signaling and hyphal morphogenesis.

222 ly implicated in regulation of adherence and hyphal morphogenesis.

223 ar pH, both in vitro and in vivo and induces hyphal morphogenesis.

224 ion of adenylyl cyclase to form cAMP induces hyphal morphogenesis.

225 ultured human epithelial cells, the yeast-to-hyphal morphological transition, induction of the hyphal

226 y of C. albicans to switch between yeast and hyphal morphologies is considered its central virulence

227 factors NRG1 and UME6, to maintain yeast and hyphal morphologies, respectively, confirmed the importa

228 bicans reversibly switches between yeast and hyphal morphologies, with hyphae being associated with v

229 is, cell death, sterigmatocystin production, hyphal morphology and size, and mitochondrial superoxide

230 ding those regulating penicillin production, hyphal morphology, and conidial formation.

231 These new roles include regulation of hyphal morphology, asexual development, as well as amino

232 llioides (Deltaubl1) influenced conidiation, hyphal morphology, pigmentation and amylolysis.

233 ngle mutant strain did not affect colony and hyphal morphology.

234 ion of blocking the transition from yeast to hyphal morphotype, it has an immunomodulatory role on hu

235 e daily change in hyphal production, but not hyphal mortality.

236 ction thus may be partially due to a role in hyphal mRNA transport.

237 able: we observed inhibition of the RFS soil hyphal network and significant reductions in M. racemosu

238 multigenomic lifestyles, the adaptation of a hyphal network for mixing nuclear material provides a pr

239 ots can shuttle a key nutrient through their hyphal network in response to resource inequality.

240 ss fibers (used as a model to mimic a fungal hyphal network) resulted in (i) increased bacterial surf

241 ws of nuclei at all length scales within the hyphal network.

242 explanation for the origins of multicellular hyphal organisms, and explains why fungi, rather than un

243 immobile, hard-to-digest, and nutrient poor, hyphal osmotrophs outcompete motile or autolytic unicell

244 associated closely with fine roots, showing hyphal penetration into the roots, which in some cases w

245 s across an interfacial zone consisting of a hyphal plasma membrane, a specialized interfacial matrix

246 myoE resulted in hyperbranching and loss of hyphal polarity.

247 Hyphal polarized growth is supported by tip-directed tra

248 espiration is related to the daily change in hyphal production, but not hyphal mortality.

249 Hyphal proliferation inside of the nematode coelom was o

250 riptional profile of the C. albicans reverse hyphal-pseudohyphal-yeast transition and demonstrate tha

251 With autumn monsoons, rapid hyphal re-growth occurred following each event.

252 ndent signals contribute to the induction of hyphal responses.

253 Our data show initial hyphal retention of phages of up to ~4 x 10(7) plaque-fo

254 S. reilianum localized to the extracellular hyphal space.

255 This action of Cdk1 depends on the hyphal-specific cyclin Hgc1, the homologue of G1 cyclins

256 Notably, the Msb2 regulon shows conserved hyphal-specific expression in other dimorphic fungi, sug

257 l morphological transition, induction of the hyphal-specific HWP1 promoter, biofilm formation on sili

258 n involves not only down-regulation of known hyphal-specific, genes but also differential expression

259 We further show that the hyphal stage, when present in Letharia, is in close cont

260 erest, spindle organization in the yeast and hyphal states was indistinguishable, even though yeast a

261 gene cluster containing genes that alter the hyphal surface and perturb interhyphal interactions to d

262 s and showed defects in colony pigmentation, hyphal surface hydrophobicity, cell wall integrity, auto

263 ranium and phosphorus-containing minerals on hyphal surfaces, and these were identified by X-ray powd

264 ries of existing drugs for inhibition of the hyphal switch under stringent conditions.

265 development of fungal fruiting bodies from a hyphal thallus represents a transition from simple to co

266 ngi), which are concentrated just behind the hyphal tip but are intermittently present throughout all

267 compartments are spatially segregated within hyphal tip cells in a manner that depends upon the integ

268 Hyphal tip cells of the fungus Aspergillus nidulans are

269 Among them, FgMsb3 is found to regulate hyphal tip expansion and to be required for pathogenicit

270 The presence of slr1-6SA-GFP hyphal tip foci is reduced in the absence of the mRNA-tr

271 amples of this polarised growth form include hyphal tip growth in actinobacteria and filamentous fung

272 es (MTs) serve as a rate-limiting factor for hyphal tip growth in the filamentous fungus Aspergillus

273 p of early endosomes that move away from the hyphal tip in the mutant, the average speed of movement

274 diated early endosome movement away from the hyphal tip occurs at a significantly reduced frequency.

275 lization patterns of exocyst subunits at the hyphal tip suggest the dynamic formation of two assembli

276 korper, a vesicle distribution center at the hyphal tip, but display more rapid cytoskeleton-based tr

277 ormal accumulation of early endosomes at the hyphal tip, where microtubule plus ends are located.

278 s required for directional tip growth at the hyphal tip.

279 xtension and triggers de-polarization of the hyphal tip.

280 rus infection by cycloheximide treatment and hyphal tipping.

281 Lcc1) is highly expressed in the specialized hyphal tips (gongylidia) that the ants preferentially ea

282 to root tips (rhizosphere), soil adjacent to hyphal tips (hyphosphere), and bulk soil.

283 idiation, melanin and chitin accumulation in hyphal tips and lesion expansion on wounded hosts, but s

284 e GEMs display especially low diffusivity at hyphal tips and near some nuclei, showing that the physi

285 nt of hyphal growth and localizes in foci at hyphal tips and sites of future branch development.

286 eltatrx2 mutant rarely formed appressoria on hyphal tips and were defective in invasive growth after

287 ents indicated likely elevated Glc levels in hyphal tips during infection.

288 nes adjacent to the PAM around the arbuscule hyphal tips where it interacts with Vapyrin, a plant-spe

289 s1 mutants are able to form appressoria from hyphal tips, but these are unable to re-polarize, and ri

290 In actively growing hyphal tips, FgPal1-GFP mainly localized to the subapica

291 Overexpression of clsA resulted in weakened hyphal tips, misshaped aerial hyphae and anucleate spore

292 n with fungal-derived superoxide produced at hyphal tips.

293 l as supporting polarized growth at existing hyphal tips.

294 growth defects and often displayed abnormal hyphal tips.

295 methylprednisolone acetate results in robust hyphal tissue invasion and a significant reduction in im

296 ations for initiation and maintenance of the hyphal transcriptional program.

297 like those of diploids, including the yeast-hyphal transition, chlamydospore formation and a white-o

298 to drive the C. albicans yeast-pseudohyphal-hyphal transition.

299 albicans to PMMA is morphology dependent, as hyphal tubes had increased adhesion compared with yeast

300 he existence of a root/mycorrhizal exudation-hyphal uptake pathway was supported.