ライフサイエンスコーパス: hypochlorous acid

1 l react with approximately 3.5 to 4.0 mol of hypochlorous acid.

2 hen subsequently to the bactericidal oxidant hypochlorous acid.

3 e repair of periplasmic proteins oxidized by hypochlorous acid.

4 s, including the highly microbicidal species hypochlorous acid.

5 peroxidase that catalyzes the production of hypochlorous acid.

6 ut were inactive against the related oxidant hypochlorous acid.

7 potentially mutagenic pathway by generating hypochlorous acid.

8 ing with an antibody to proteins modified by hypochlorous acid, a characteristic product of the enzym

9 Human neutrophils synthesize hypochlorous acid, a nonradical oxidant, as one of the a

10 dent oxidation of chloride anion to generate hypochlorous acid, a potent antimicrobial agent.

11 s hydrogen peroxide and chloride to generate hypochlorous acid, a potent bactericidal oxidant in vitr

12 defense systems is their ability to generate hypochlorous acid, a potent microbicide, by reacting oxi

13 2020 hydrochloric acid, chlorine nitrate and hypochlorous acid abundances are in good agreement with

14 The reactive chlorinating species, hypochlorous acid and chlorine gas, both attacked the vi

15 de, chlorine nitrate, chlorine monoxide, and hypochlorous acid and decreases in ozone, nitrogen dioxi

16 c cleavage of free available chlorine (i.e., hypochlorous acid and hypochlorite) to generate hydroxyl

17 MPO generates the oxidants hypochlorous acid and nitrogen dioxide, which can lead t

18 n chloride and hydrogen peroxide to generate hypochlorous acid and other reactive compounds that have

19 eclines markedly because of its oxidation by hypochlorous acid and subsequent degradation.

20 hT), which results from the reaction between hypochlorous acid and taurine, is a powerful and less di

21 DPPH, superoxide and hydroxyl radicals, and hypochlorous acid), and inhibitory activity against chol

22 Hydrogen peroxide (H2O2), hypochlorous acid, and azurophilic granule proteins had

23 richia coli cells against hydrogen peroxide, hypochlorous acid, and chloramines.

24 t in the rheumatoid joint (hydroxyl radical, hypochlorous acid, and peroxynitrite) were used for modi

25 active species hydrogen peroxide (H(2)O(2)), hypochlorous acid, and singlet oxygen are generated.

26 actions between primary aliphatic amines and hypochlorous acid (aqueous Cl2).

27 Reactive chlorine species (RCS) such as hypochlorous acid are powerful antimicrobial oxidants.

28 ed myeloperoxidase, inhibiting production of hypochlorous acid by 50% at 25 nm.

29 uncontrolled the extracellular generation of hypochlorous acid by MPO can cause bystander tissue dama

30 ng chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the g

31 from mast cells and the oxidation of HDL by hypochlorous acid can impair the function of phospholipi

32 s (ROS; peroxyl radical, superoxide radical, hypochlorous acid), cytotoxicity assay (MTT) and quantif

33 oA1(WT) conditioned media in the presence of hypochlorous acid emulating conditions of oxidative stre

34 icate that electrolysis reactions generating hypochlorous acid from chloride are likely a main contri

35 ns is myeloperoxidase (MPO), which generates hypochlorous acid from Cl(-) and hydrogen peroxide.

36 ghly damaging species, hydroxyl radicals and hypochlorous acid, from hydrogen peroxide contributed to

37 or constituent of iron corrosion scales) and hypochlorous acid (HClO, the main reactive chlorine spec

38 Hypochlorous acid (HOCl + Br- -> kHOClHOBr + Cl-) and mo

39 vely modified by peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl) and by activated monocytes and

40 nvironments leads to the emission of gaseous hypochlorous acid (HOCl) and chlorine (Cl(2)), both of w

41 of highly oxidative gaseous species, such as hypochlorous acid (HOCl) and chlorine (Cl(2)).

42 gh protein degradation by neutrophil-derived hypochlorous acid (HOCl) and eosinophil-derived hypobrom

43 t of fibrin polymerization after exposure to hypochlorous acid (HOCl) and increased methionine oxidat

44 Furthermore, oxidation of WWOM by hypochlorous acid (HOCl) and molecular ozone also result

45 e the biologic effects of exposure of IgG to hypochlorous acid (HOCl) and peroxynitrite (ONOO).

46 trated selective turn-on fluorescence toward hypochlorous acid (HOCl) and successfully visualized end

47 specific end product of the reaction between hypochlorous acid (HOCl) and tyrosine residues of protei

48 roxide (O2(.-)), hydroxyl radicals (.OH) and hypochlorous acid (HOCl) assays, and their potential as

49 rate to form the highly microbicidal species hypochlorous acid (HOCl) at neutral pH.

50 d cyt c was reacted with an excess amount of hypochlorous acid (HOCl) at pH 7.4, the peroxidase activ

51 operoxidase generates significant amounts of hypochlorous acid (HOCl) at sites of inflammation to inf

52 uction of potent halogenating agents such as hypochlorous acid (HOCl) by the myeloperoxidase-hydrogen

53 ted whether the potent antibacterial oxidant hypochlorous acid (HOCl) contributes to killing of Mycob

54 Solutions of hypochlorous acid (HOCl) decay over time.

55 xidation product of nitric oxide (.NO), with hypochlorous acid (HOCl) forms reactive intermediate spe

56 It has been reported that topical hypochlorous acid (HOCl) formulations lead to relief of

57 Hypochlorous acid (HOCl) from activated neutrophils at s

58 microbial role, hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) function as inflammatory mediat

59 However, hypochlorous acid (HOCl) generated by the myeloperoxidas

60 A major new finding is that hypochlorous acid (HOCl) in its neutral form is especial

61 Production of hypochlorous acid (HOCl) in neutrophils, a critical oxid

62 02 and chloride, and was mimicked by reagent hypochlorous acid (HOCl) in the absence of enzyme, sugge

63 r the generation of the potent antimicrobial hypochlorous acid (HOCl) in the phagosomal space.

64 recently showed that the neutrophil oxidant hypochlorous acid (HOCl) inhibits VWF proteolysis by ADA

65 Hypochlorous acid (HOCl) is an important component of th

66 Hypochlorous acid (HOCl) is by far the most abundant age

67 Hypochlorous acid (HOCl) is considered a temporary reser

68 It is commonly assumed that hypochlorous acid (HOCl) is the chlorinating agent respo

69 The myeloperoxidase-derived oxidant hypochlorous acid (HOCl) is thought to contribute to end

70 scrimination between changes in H(2)O(2) and hypochlorous acid (HOCl) levels in live RAW264.7 macroph

71 es that generate the reactive oxygen species hypochlorous acid (HOCl) or hydrogen peroxide (H(2)O(2))

72 CuO was effective to catalyze hypochlorous acid (HOCl) or hypobromous acid (HOBr) deca

73 by reaction with the inflammatory mediators hypochlorous acid (HOCl) or myeloperoxidase.

74 One potential pathway involves hypochlorous acid (HOCl) produced by myeloperoxidase (MP

75 Hypochlorous acid (HOCl) produced via the enzyme myelope

76 nanomolar-potency reversible inhibitors and hypochlorous acid (HOCl) scavengers.

77 etric method was developed and validated for hypochlorous acid (HOCl) scavenging activity estimation

78 generates controlled, low concentrations of hypochlorous acid (HOCl) suitable for killing biofilm co

79 MPO produces hypochlorous acid (HOCl) that oxidizes the genomic DNA i

80 obe (Hypo-SiF) designed for the detection of hypochlorous acid (HOCl) using a silicon analogue of flu

81 idase required H2O2 and Cl-, suggesting that hypochlorous acid (HOCl) was an intermediate in the reac

82 were each fully destroyed by only 100 ppm of hypochlorous acid (HOCl) within 30 s, which was the shor

83 gosomes where it catalyzes the production of hypochlorous acid (HOCl), a potent chlorinating oxidant.

84 se uses hydrogen peroxide (H2O2) to generate hypochlorous acid (HOCl), a potent cytotoxic oxidant.

85 interaction of TIMPs with MMPs might involve hypochlorous acid (HOCl), a potent oxidant produced by t

86 or controlling enzyme activity might involve hypochlorous acid (HOCl), a potent oxidant produced by t

87 e is the only human enzyme known to generate hypochlorous acid (HOCl), a potent oxidizing agent, at p

88 Hypochlorous acid (HOCl), a powerful antimicrobial oxida

89 roxide (H(2)O(2)), myeloperoxidase generates hypochlorous acid (HOCl), a powerful oxidant.

90 We previously showed that hypochlorous acid (HOCl), a specific product of myeloper

91 Hypochlorous acid (HOCl), a strong oxidant emitted durin

92 we developed NR-HOCl-TFMU, which responds to hypochlorous acid (HOCl), an analyte detected in acute m

93 a combination of molecular chlorine (Cl(2)), hypochlorous acid (HOCl), and hypochlorite (OCl(-))) are

94 as a specific product when HE was exposed to hypochlorous acid (HOCl), chloramines, MPO/H2O2/chloride

95 Bleach generates toxic species including hypochlorous acid (HOCl), chlorine (Cl(2)), and chlorami

96 Hypochlorous acid (HOCl), chlorine (Cl(2)), and nitryl c

97 e protein that converts hydrogen peroxide to hypochlorous acid (HOCl), compared with sensitive AML ce

98 ygen species within the phagosome, including hypochlorous acid (HOCl), formed by the oxidation of chl

99 n of alpha-amino acids to aldehydes requires hypochlorous acid (HOCl), formed from H2O2 and chloride

100 In the current studies, we show that hypochlorous acid (HOCl), generated by the myeloperoxida

101 Hypochlorous acid (HOCl), generated from H2O2 and Cl- by

102 olonization on mucosal barrier epithelia are hypochlorous acid (HOCl), hypobromous acid (HOBr) and hy

103 trite, can be oxidized by monochloramine and hypochlorous acid (HOCl), potentially leading to rapid m

104 We exposed ADAMTS13 to hypochlorous acid (HOCl), produced by a myeloperoxidase-

105 Hypochlorous acid (HOCl), the active component of househ

106 Hypochlorous acid (HOCl), the active ingredient in house

107 Hypochlorous acid (HOCl), the active ingredient of house

108 The reaction is mediated by hypochlorous acid (HOCl), the major oxidant generated by

109 Hypochlorous acid (HOCl), the major oxidant generated by

110 Furthermore, hypochlorous acid (HOCl), the major strong oxidant gener

111 lic compounds when water is disinfected with hypochlorous acid (HOCl), there is still considerable un

112 s investigated in wild-type BALB/c mice with hypochlorous acid (HOCl)-induced SSc by ELISA and Wester

113 Hypochlorous acid (HOCL)-modified LDL, a specific biomar

114 -) to generate the chlorinating intermediate hypochlorous acid (HOCl).

115 t nanoprobe for the ratiometric detection of hypochlorous acid (HOCl).

116 d in BALB/c mice by daily s.c. injections of hypochlorous acid (HOCl).

117 system that produces the potent microbicide hypochlorous acid (HOCl).

118 chloride to the potent bactericidal oxidant hypochlorous acid (HOCl).

119 g superoxide radical, hydrogen peroxide, and hypochlorous acid (HOCl).

120 rophils produce high local concentrations of hypochlorous acid (HOCl).

121 gocytes, such as peroxynitrite (ONOO(-)) and hypochlorous acid (HOCl).

122 rophages, uses hydrogen peroxide to generate hypochlorous acid (HOCl).

123 idase that produces the pro-oxidant species, hypochlorous acid (HOCl).

124 (ONOO(-)) and myeloperoxidase (MPO) mediated hypochlorous acid (HOCl/OCl(-)) production.

125 1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and prot

126 tive at micromolar concentrations to bleach (hypochlorous acid, HOCl), a potent antimicrobial produce

127 n of potent antimicrobial oxidants including hypochlorous acid, human myeloperoxidase (MPO) plays a c

128 uding H2O2, hydroxyl radical, peroxynitrite, hypochlorous acid, hypobromous acid, and hypothiocyanous

129 II, we reacted hydrogen peroxide (H(2)O(2)), hypochlorous acid/hypochlorite (HOCl/OCl(-)), and single

130 scission is a strong function of exposure to hypochlorous acid, (iii) the ratio between amide links b

131 radical, reactive nitrogen intermediates and hypochlorous acid in LDL oxidation and lesion formation

132 osyl radical, reactive nitrogen species, and hypochlorous acid in LDL oxidation in the human artery w

133 ially produced from plasmalogen treated with hypochlorous acid in the presence of NaBr.

134 incubation with tert-butyl hydroperoxide and hypochlorous acid in vitro, we identified additional cov

135 trols for all the tested methods, except for hypochlorous acid, in which lemon juice displayed higher

136 robes for monitoring myeloperoxidase-derived hypochlorous acid, including boronate-, aminophenyl- and

137 ophan residues within model peptides via two hypochlorous acid-independent pathways.

138 sence of chlorotyrosine in the cell lysates, hypochlorous acid is hypothesized to be the chemical age

139 Hypochlorous acid is only generated by the phagocytic en

140 ith the resultant radical and, after loss of hypochlorous acid, leads to the observed product.

141 MPO-specific biomarkers 3-chlorotyrosine and hypochlorous acid-modified proteins increase in the brai

142 iments, where the oxidation was induced with hypochlorous acid or by exposure to activated neutrophil

143 Exposure to either hypochlorous acid or tetranitromethane (pH 6) inhibited

144 We find that treatment with hypochlorous acid preferentially oxidizes specific methi

145 xidation of low-density lipoprotein (LDL) by hypochlorous acid produces a modified form (HOCl-LDL) ca

146 oxidase regulation, magnitude of oxidant and hypochlorous acid production, and their repertoire of se

147 an improper fusion of granules, reducing the hypochlorous acid production.

148 nd peroxyl radical scavenging capacity, with hypochlorous acid scavenging activity.

149 d by five common virucidal agents (heat, UV, hypochlorous acid, singlet oxygen, and chlorine dioxide)

150 Hypochlorous acid stimulated apoptosis in both HL-60 and

151 ide ion and little affected by scavengers of hypochlorous acid, suggesting that the reactive agent is

152 myeloperoxidase-containing leukocyte-derived hypochlorous acid targeting the vinyl ether bond of plas

153 acid that interacts with the potent oxidant hypochlorous acid to form the less toxic and more stable

154 zed the sites of chlorination at tyrosine in hypochlorous acid-treated hemoglobin by an accurate mass

155 chieve inactivation: UV, singlet oxygen, and hypochlorous acid treatments generally render the genome

156 ively produced toxicity in bacteria, whereas hypochlorous acid was nonselectively toxic to both bacte

157 Hypochlorous acid was the apparent oxidizing intermediat

158 idase converting H(2)O(2) to highly reactive hypochlorous acid, we hypothesized that gene variants co

159 otonated conjugates (i.e., neutral water and hypochlorous acid), which are much weaker but more predo

160 ile present at alkaline pH and electrophilic hypochlorous acid, which decreases in abundance above it