ライフサイエンスコーパス: hypodermal

1 cyte, we found that exopher removal requires hypodermal actin and Arp2/3, and the hypodermal plasma m

2 tein products of all three genes localize to hypodermal adherens junctions in embryos.

3 sisted for weeks after infection, regulating hypodermal adipocyte expansion and production of the adi

4 rmal and dermal thickness and an increase in hypodermal adipose tissue.

5 1, ablation of which abrogated HDMs from the hypodermal adventitia.

6 through the formation of epidermal, dermal, hypodermal and adnexal regulatory units.

7 ion and quantification method for infectious hypodermal and hematopoietic necrosis virus (IHHNV), a s

8 g, we found that PEB-1 was detectable in all hypodermal and hindgut cells underlying the cuticle.

9 berrant expression of SKN-1 causes a loss of hypodermal and neuronal tissue and an excess of pharynge

10 Dysregulation of let-7 results in irregular hypodermal and vulval development.

11 nt ages but generally had reduced dermal and hypodermal areas compared with age-matched controls.

12 osed skin histology revealed highly inflamed hypodermal areas with infiltrated immune cells at 6 and

13 cones extend fingers dorsally between these hypodermal attachment structures.

14 duced in size by different proportions, with hypodermal blast cell size most closely proportional to

15 the inappropriate deaths of many of the Pn.p hypodermal blast cells and prevent the surviving Pn.p ce

16 patterns were observed, either intestinal or hypodermal, but no gross RNAi phenotypes were found poss

17 al ovule development in maize, only a single hypodermal cell develops into an archesporial cell and t

18 shown that ELT-3 is not essential for either hypodermal cell differentiation or the viability of the

19 of ELT-1 in a redundant pathway controlling hypodermal cell differentiation.

20 In a normal anther a hypodermal cell divides periclinally with the inner cell

21 ot suppress defects in two different ventral hypodermal cell fate decisions in hermaphrodites and mal

22 In angiosperm ovules and anthers, the hypodermal cell layer provides the progenitors of meiocy

23 atory element which is sufficient to specify hypodermal cell reporter gene expression.

24 er transcription factor that is required for hypodermal cell terminal differentiation and proper vulv

25 he heterochronic gene lin-29, which triggers hypodermal cell terminal differentiation during the fina

26 which formed regularly spaced stripes on the hypodermal cell.

27 and is essential for the production of most hypodermal cells (22).

28 The gene is expressed in hypodermal cells 4 hours before ecdysis during all larva

29 Abnormal organization of hypodermal cells and expression of a hypodermal marker i

30 he mutants had abnormal-shaped epidermal and hypodermal cells and showed an unusual arrangement of sm

31 ect the failure of mac1 gene function in the hypodermal cells and their cellular progeny.

32 in transgene is expressed in lateral rows of hypodermal cells and these cells fail to properly change

33 in the adult stage with strong expression in hypodermal cells and weaker expression in gut cells.

34 nt bundles at the adherens junctions between hypodermal cells and, thereby, transmit the force of bun

35 Mesodermal, endodermal, and hypodermal cells appear to be completely absent in most

36 endently of immediately adjacent neighboring hypodermal cells because dorsal intercalation is not blo

37 how that lin-26 is expressed not only in all hypodermal cells but also in all glial-like cells.

38 pecify and/or maintain the fates not only of hypodermal cells but also of all other non-neuronal ecto

39 This pathway is activated in hypodermal cells by the LET-23 epidermal growth factor r

40 In mac1 mutant ovules several hypodermal cells develop into archesporial cells, and th

41 ecifically in the nuclei of a variety of non-hypodermal cells during development.

42 elt-3 is expressed in all of the major hypodermal cells except the lateral seam cells, and expr

43 The external hypodermal cells fail to spread over and enclose the emb

44 plays an important role in the switch of the hypodermal cells from the vegetative pathway to the meio

45 plays an important role in the switch of the hypodermal cells from the vegetative to the meiotic (spo

46 les, LECT-2 decorates neuronal processes and hypodermal cells in a pattern similar to the cell adhesi

47 is the interactions of body wall muscle and hypodermal cells in Caenorhabditis elegans.

48 eir direction of migration; posterior dorsal hypodermal cells in die-1(w34) mutants appear to extend

49 The most posterior hypodermal cells in the tail define a specialized, sexua

50 aphrodites at the L2 stage there are 11 Pn.p hypodermal cells in the ventral midline arrayed along th

51 o drive expression of a seam marker in other hypodermal cells in wild-type animals, and in anterior h

52 est a model in which postembryonic growth of hypodermal cells is regulated by TGFbeta-related signali

53 The cpz-1 gene is expressed in various hypodermal cells of all developmental stages and is spec

54 Dorsal hypodermal cells of die-1(w34) homozygous embryos initia

55 ed exclusively in the intestine, seam cells, hypodermal cells of the main body syncytium, and the exc

56 utation alters the developmental fate of the hypodermal cells of the maize anther.

57 cZ) is widely expressed in the intestine and hypodermal cells of transgenic worms, while the fusion p

58 e progenitors for either half of the lateral hypodermal cells or the posterior half of the dorsal hyp

59 is and intestine, and expression of OSR-1 in hypodermal cells rescues the osr-1(rm1) phenotypes.

60 finger transcription factor, is required for hypodermal cells to acquire their proper fates.

61 insight into how NHR-23 acts in the seam and hypodermal cells to coordinate aECM regeneration during

62 ositional cues from muscle are transduced to hypodermal cells to direct sensory dendrite outgrowth.

63 Ce-Duox1 is expressed in hypodermal cells underlying the cuticle of larval animal

64 DRAG-1 expression in the hypodermal cells was required for the branching of the a

65 ed in late embryos and L2d predauers, in the hypodermal cells which synthesize the cuticle.

66 First, LIN-29 accumulates in many non-hypodermal cells with known roles in vulva formation or

67 ls (including various muscle, intestinal and hypodermal cells) in high-resolution images of adult C.e

68 elongate properly, abnormal contacts between hypodermal cells, and failure of the pharynx to attach t

69 EGL-15 indicate that EGL-15 is expressed in hypodermal cells, and hypodermal promoters can drive ful

70 These cells, the hypodermal cells, either directly or indirectly form the

71 les in the intercalation of posterior dorsal hypodermal cells, in muscle cell positioning and in inte

72 eporter, which is localized to boundaries of hypodermal cells, shows that hypodermis is disorganized

73 neurons, the posterior intestine cells, tail hypodermal cells, the T cells and specific T-cell descen

74 d the dense body to the hemidesmosome on the hypodermal cells, which in turn instructed the SAX-7 str

75 solateral protrusions in distinct subsets of hypodermal cells.

76 ed could be due to improper specification of hypodermal cells.

77 r these genes in the function of the lateral hypodermal cells.

78 Weak expression is also detected in hypodermal cells.

79 threads formed, they aborted in epidermal or hypodermal cells.

80 in approximately 85 muscle, epithelial, and hypodermal cells.

81 nction of a wide range of nerve, muscle, and hypodermal cells.

82 MS lineage, a lineage that does not generate hypodermal cells.

83 nic genes in some, but not all, of these non-hypodermal cells.

84 gests that nhr-23 acts primarily in seam and hypodermal cells.

85 drive reporter gene expression in posterior hypodermal cells.

86 ed EFF-1 alters the normal pattern of fusing hypodermal cells.

87 s been shown to pattern posterior muscle and hypodermal cells.

88 This enhancer drives GFP expression in hypodermal cells.

89 s, forming two longitudinal ribbons over the hypodermal cells.

90 SAX-7/L1CAM, a hypodermal component of this complex, shows a male-speci

91 ormed disorganized elastic fibers throughout hypodermal connective tissue as they aged.

92 The increased elastic fibers in Tsk hypodermal connective tissue was associated with increas

93 nesis associated with increased fibulin-2 in hypodermal connective tissues and decreased fibulin-5 at

94 y altering matrix protein composition in Tsk hypodermal connective tissues.

95 esting this gene is required for maintaining hypodermal-cuticle attachment as the animal grows in siz

96 the head cells and spermatheca is constant, hypodermal daf-9::GFP expression is modulated by multipl

97 secreting daughter cells but is repressed in hypodermal daughter cells.

98 oral discoordination between the accelerated hypodermal development and normally timed somatic gonada

99 lin-28, a central heterochronic regulator of hypodermal development, causes reduced fertility associa

100 ression pattern suggests a role for ELT-3 in hypodermal development, no functional studies have yet b

101 ct downstream of lin-28 in the regulation of hypodermal developmental timing also act downstream of l

102 ryonic blastomeres, to activate a program of hypodermal differentiation even in blastomeres that are

103 opment and disrupts embryonic proliferation, hypodermal enclosure, and elongation.

104 Defects in late gastrulation, ventral hypodermal enclosure, and formation of the rectum result

105 em rescues a daf-5 mutant, whereas muscle or hypodermal expression does not.

106 ssue-specific promoter studies indicate that hypodermal expression of ptc-3 is required for normal de

107 ent protein gene (gfp) and demonstrated that hypodermal expression of the fusion gene is adult-specif

108 Importantly, we find that hypodermal expression, but not somatic gonadal expressio

109 etrated 1.3 mm and did not travel beyond the hypodermal fat layer.

110 , a GATA transcription factor that specifies hypodermal fate in the embryo, as a regulator of sperm-s

111 way is not activated adopts a differentiated hypodermal fate.

112 pmental program, while its repression in the hypodermal-fated cells requires a transcriptional regula

113 cells in wild-type animals, and in anterior hypodermal-fated daughters in a Wnt pathway-sensitized b

114 -1 structure from mutant Tsk fibrillin cause hypodermal fibrosis and associated changes in dermal gen

115 between the muscle contractile apparatus and hypodermal fibrous organelles.

116 t the conclusion that mup-4 is essential for hypodermal function and that this function is necessary

117 ealed a previously unknown role for mab-9 in hypodermal function and we suggest that MAB-9 is require

118 We showed that ELT-3 can activate hypodermal gene expression in the absence of ELT-1 and t

119 T-1 and that, conversely, ELT-1 can activate hypodermal gene expression in the absence of ELT-3.

120 ithin the mantle, instead of the specialised hypodermal glands in the second antennular segment as re

121 In C. elegans, assembly of hypodermal hemidesmosome-like structures called fibrous

122 MUA-3 localizes to the hypodermal hemidesmosomes and to other sites of mechanic

123 e presumptive mua-6 null allele localizes to hypodermal hemidesmosomes.

124 Dermal and hypodermal hemorrhage is detected in mutant embryos at l

125 izations reveal that mutants have defects in hypodermal integrity and morphology.

126 ith vesicular contents gradually degraded by hypodermal lysosomes.

127 ctive tissues and decreased fibulin-5 at the hypodermal M-CT interface suggest that these proteins me

128 phages in tissue remodeling, we examined the hypodermal macrophages (HDMs) and their impact on host s

129 tion of hypodermal cells and expression of a hypodermal marker in hbl-1(RNAi) animals suggests that m

130 Loss of lep-5 delays hypodermal maturation and male tail tip morphogenesis (T

131 utants, cell migrations are defective during hypodermal morphogenesis, QL neuroblast migration, and t

132 mup-4 is essential in embryonic epithelial (hypodermal) morphogenesis and maintenance of muscle posi

133 ayer found normally at the interface between hypodermal muscle and connective tissue was absent from

134 ion, and, at high levels, completely blocked hypodermal muscle contraction.

135 The lack of elastic fibers at the hypodermal muscle-connective tissue (M-CT) interface was

136 DIE-1 is present in the nuclei of hypodermal, muscle, gut, and pharyngeal cells; its distr

137 thelial pustules resulting in ulceration and hypodermal necrosis.

138 limit the establishment of infection in the hypodermal niche.

139 ntrast and fluorescence imaging of embryonic hypodermal nuclear migration events were used to charact

140 LIN-29 accumulates in all hypodermal nuclei during the L4 stage.

141 enesis of the Caenorhabditis elegans embryo, hypodermal (or epidermal) cells migrate to enclose the e

142 with an essential role of mag-1 in embryonic hypodermal organization and elongation.

143 e results in a severe defect in migration of hypodermal P cells to a ventral position.

144 C. elegans hypodermal P-cell larval nuclei traverse a narrow space

145 In Caenorhabditis elegans larvae, failure of hypodermal P-cell nuclear migration results in uncoordin

146 form the hermaphrodite vulva, a specialized hypodermal passageway used for egg laying and sperm entr

147 into numerous smaller vesicles that acquire hypodermal phagosome maturation markers, with vesicular

148 equires hypodermal actin and Arp2/3, and the hypodermal plasma membrane adjacent to newly formed exop

149 , resulting in a deformed vulva, and the P12 hypodermal precursor often differentiates into a second

150 erentiation even in blastomeres that are not hypodermal precursors in wild-type embryos.

151 EGL-15 is expressed in hypodermal cells, and hypodermal promoters can drive full clr-1 and egl-15 res

152 Mutations in mua-6 result in hypodermal rupture, muscle detachment from the bodywall,

153 suggesting that puf-9 and let-7 may mediate hypodermal seam cell differentiation by regulating commo

154 obust stage specificity of cell fates in the hypodermal seam cell lineages.

155 ls that express pal-1 and in the neighboring hypodermal seam cell precursors, which do not, as well a

156 28, and lin-29 specify the timing of lateral hypodermal seam cell terminal differentiation in Caenorh

157 results in ectopic Ptbx-2::gfp expression in hypodermal seam cells and gut.

158 l tip cell (DTC), intestine, and the lateral hypodermal seam cells but not in the main body hypoderma

159 the terminal differentiation of the lateral hypodermal seam cells during the larval-to-adult molt.

160 We find that OSM-11 is secreted from hypodermal seam cells into the pseudocoelomic body cavit

161 NCX-9 functions in hypodermal seam cells that secrete the axon guidance cue

162 upregulated during the last larval stage in hypodermal seam cells which is transcriptionally regulat

163 lutely required in a small subset of lateral hypodermal seam cells, adjacent to the vulva, for wild-t

164 the Golgi apparatus occurring exclusively in hypodermal seam cells, pharyngeal cells, and spermatheca

165 nes are expressed exclusively in the lateral hypodermal (seam) cells.

166 proliferation of the stem cell-like lateral hypodermal (seam) cells.

167 ontracts and pulls together the edges of the hypodermal sheet at the ventral midline.

168 To investigate myotactin's role in muscle-hypodermal signaling, we characterized the myotactin loc

169 ns in C. elegans are engulfed by surrounding hypodermal skin cells and are then broken up into numero

170 lar signaling pathway in which intestinal or hypodermal SPHK-1 signals through the neuronal G protein

171 fusion protein was secreted from the apical hypodermal surface of the embryo.

172 podermal seam cells but not in the main body hypodermal syncytium (hyp7) that underlies, synthesizes,

173 ective in the anchoring of nuclei within the hypodermal syncytium and in the migrations of the two di

174 hat lin-35 activity is required in the major hypodermal syncytium and not in the VPCs to inhibit vulv

175 n between the vulval precursor cells and the hypodermal syncytium at an early larval stage.

176 NA expression over 200-fold in the main body hypodermal syncytium, hyp 7.

177 uires that the VPCs do not fuse to the major hypodermal syncytium, hyp7.

178 ongly in seam cells, rather than in the main hypodermal syncytium, indicating that seam cells play th

179 Most of the epidermis consists of the hyp7 hypodermal syncytium, the nuclei of which are largely ge

180 n "inhibitory signal" from the adjacent hyp7 hypodermal syncytium.

181 tion of the heterochronic gene lin-42 causes hypodermal terminal differentiation to occur precociousl

182 es known to be required for proper timing of hypodermal terminal differentiation.

183 that heme homeostasis in the extraintestinal hypodermal tissue was facilitated by the transmembrane p

184 ers showed that CeRh1 is mainly expressed in hypodermal tissue, although it is also in other cell typ

185 tion at defined locations in the surrounding hypodermal tissue, whereas DMA-1 acts as the cognate rec

186 substantial local swelling of the underlying hypodermal tissue.

187 BR2 is localized in epidermal and hypodermal tissues at the root apex.

188 pathway that communicates from intestinal or hypodermal tissues to neurons to promote aversive learni

189 lon-1 is expressed in hypodermal tissues, which is the focus of body size dete

190 for larval seam cell specification, and for hypodermal to seam cell fate transformations induced by

191 An examination of hypodermal, visceral, and circulatory muscle showed that

192 Overexpression of hypodermal wrt-10 is sufficient to delay reproductive de