ライフサイエンスコーパス: hyponatremia

1 l tolerated, with only one grade 4 toxicity (hyponatremia).

2 s LGI1 antibodies were associated with serum hyponatremia.

3 were alcoholics and 33 (92%) presented with hyponatremia.

4 hildren due to the risk of hospital-acquired hyponatremia.

5 udies primarily focused on the importance of hyponatremia.

6 al at risk for the unexpected development of hyponatremia.

7 in patients with euvolemic and hypervolemic hyponatremia.

8 hat cerebral salt wasting is a rare cause of hyponatremia.

9 e two grade 4 toxicities: duodenal ulcer and hyponatremia.

10 d in patients with euvolemic or hypervolemic hyponatremia.

11 AVP receptor antagonism in the treatment of hyponatremia.

12 ectrolyte-free water--might be of benefit in hyponatremia.

13 med to identify risk factors associated with hyponatremia.

14 rmone secretion (SIADH) is a common cause of hyponatremia.

15 the mortality risk previously attributed to hyponatremia.

16 Risk varied continuously with worsening hyponatremia.

17 ia with renal involvement, coagulopathy, and hyponatremia.

18 e central nervous system typical of clinical hyponatremia.

19 ners tend to develop conditions that lead to hyponatremia.

20 ese rats had significant water retention and hyponatremia.

21 outcome was a primary position diagnosis of hyponatremia.

22 atients are normonatremic and never manifest hyponatremia.

23 lydipsic schizophrenic patients with chronic hyponatremia.

24 der that can occur after rapid correction of hyponatremia.

25 d encephalopathy that is caused by untreated hyponatremia.

26 e risk for myelinolysis due to correction of hyponatremia.

27 ally evolve several days after correction of hyponatremia.

28 wer elimination, prolonged antidiuresis, and hyponatremia.

29 ere is a research gap regarding heat-related hyponatremia.

30 associated with an immediate exacerbation of hyponatremia.

31 mphocyte count, anemia, hypoalbuminemia, and hyponatremia.

32 s constitute a leading cause of drug-induced hyponatremia.

33 ebo in outpatients with chronic SIAD-induced hyponatremia.

34 UTs are a promising drug target for treating hyponatremia.

35 clearance, and four patients developed mild hyponatremia.

36 to differentiate hypotonic from nonhypotonic hyponatremia.

37 e complication of overly rapid correction of hyponatremia.

38 ting with concurrent grade 3 hypokalemia and hyponatremia.

39 e 3 nonhematologic toxicity was asymptomatic hyponatremia.

40 ic patients and may result in fewer cases of hyponatremia.

41 ntiate between depletional versus dilutional hyponatremia.

42 included hospitalization with hypokalemia or hyponatremia.

43 rload edemas and high-vasopressin-associated hyponatremias.

44 wo patients in the hypotonic group developed hyponatremia, 1 in each group developed hypernatremia, 2

45 (27%), leukopenia (16%), fatigue (11%), and hyponatremia (10%).

46 died: normonatremic animals and animals with hyponatremia (105 mmol/L) of 3-d duration.

47 per liter or less); 0.6 percent had critical hyponatremia (120 mmol per liter or less).

48 rum sodium (>135 mEq/L) at OLT, whereas mild hyponatremia (125-134 mEq/L) was present in 615 (28.3%)

49 e thrombocytopenia (16%), fatigue (15%), and hyponatremia (13%).

50 ences were observed in the primary outcomes (hyponatremia 44% vs 67% (p=0.29); liver toxicity 6% vs 0

51 encephalopathy (50% versus 27.5%; P = 0.04), hyponatremia (67.5% versus 22.5%; P < 0.001), acute kidn

52 ic encephalopathy (50% vs. 27.5%; P = 0.04), hyponatremia (67.5% vs. 22.5%; P < 0.001), acute kidney

53 cases in patients receiving dabrafenib) and hyponatremia (8 and 6 cases, respectively) were also rep

54 0 mg/m2) and one anorexia, hypoglycemia, and hyponatremia (800 mg/m2).

55 prised fatigue (22%), hypertension (9%), and hyponatremia (9%).

56 Thirteen percent had hyponatremia (a serum sodium concentration of 135 mmol p

57 Last, AVP may contribute to hyponatremia, a powerful predictor of poor outcome in HF

58 G5 treatment-related AE (TRAE), one G4 TRAE (hyponatremia, A), and 53% (A) versus 41% (B) G3 TRAEs.

59 ed hazard ratio, 3.06 [CI, 2.04 to 4.58]) or hyponatremia (adjusted hazard ratio, 1.68 [CI, 1.24 to 2

60 Hyponatremia affects approximately 5% of adults and 35%

61 he risk for illness and death from untreated hyponatremia against the risk for myelinolysis due to co

62 paration of a late-stage intermediate of the hyponatremia agent, mozavaptan.

63 to a greater extent than in cells exposed to hyponatremia alone.

64 Nausea, emesis, fatigue, dehydration, and hyponatremia also were more frequent with vorinostat.

65 ndrome that can cause hypotension and shock, hyponatremia, altered mental status, and death if untrea

66 The incidence of CPM correlates with hyponatremia, although its overall incidence is low.

67 nts included in the study, 1,215 (11.2%) had hyponatremia and 277 (2.5%) had hypernatremia at admissi

68 In patients admitted with mild hyponatremia and 48 hr-[Na] greater than 5 mmol/L, no si

69 an increased urine Na+ concentration despite hyponatremia and a decreased urine K+ concentration desp

70 f 1.5 L/d or more was identified to estimate hyponatremia and AKI in the included patients with devic

71 inage of 1.5 L/d or more was associated with hyponatremia and AKI, even after adjusting for various c

72 monitoring important disease states such as hyponatremia and diabetes.

73 aintain cell volume, and that in response to hyponatremia and EtOH withdrawal their volume increases

74 ing toxicities (n = 1 for each) were grade 3 hyponatremia and herpes zoster reactivation and grade 4

75 Hyponatremia and hyperkalemia in infancy can represent a

76 The impact of hyponatremia and hypernatremia on 6-mo and 1-yr direct m

77 outcomes were mean sodium level at 24 hours, hyponatremia and hypernatremia, weight gain, hypertensio

78 as the association of increasing severity of hyponatremia and in-hospital mortality assessed using mu

79 Hyponatremia and increasing body temperature may be rela

80 r the treatment of chronic rather than acute hyponatremia and is more likely to occur with a rapid ra

81 of the clinically debilitating condition of hyponatremia and its associated syndromes.

82 ice were fed a low-salt diet, they developed hyponatremia and mild metabolic alkalosis, symptoms char

83 t this stage, investigations commonly showed hyponatremia and MRI hippocampal high T2 signal; functio

84 patients without polydipsia and intermittent hyponatremia and normal subjects.

85 nown reasons, in schizophrenic patients with hyponatremia and polydipsia, thereby placing them at inc

86 Hyponatremia and the hepatorenal syndrome result from wa

87 Hyponatremia and the syndrome of inappropriate secretion

88 arathon runners to estimate the incidence of hyponatremia and to identify the principal risk factors.

89 7%) due to hyperkalemia, in 1 (0.37%) due to hyponatremia, and in 0 due to reduction in kidney functi

90 7%) due to hyperkalemia, in 2 (0.37%) due to hyponatremia, and in 3 (0.56%) due to reduction in kidne

91 re postparacentesis circulatory dysfunction, hyponatremia, and mortality.

92 Ascites, hyponatremia, and other findings indicative of hemodynam

93 ism, colitis, diarrhoea, decreased appetite, hyponatremia, and pneumonitis (each in two [1%]) in thos

94 ia, hyperbilirubinemia, renal insufficiency, hyponatremia, and prothrombin time prolongation (all P <

95 inuation due to events such as hyperkalemia, hyponatremia, and reduction in kidney function.

96 cators, including diabetes, hypoalbuminemia, hyponatremia, and relative hypocreatininemia.

97 ic reactions included hypotension, vomiting, hyponatremia, anemia, thrombocytopenia, and infection at

98 ients sustaining rapid correction of chronic hyponatremia are at risk of osmotic demyelination syndro

99 al agents currently used in the treatment of hyponatremia are limited by inconsistent response and ad

100 lele were 2.4-6.4 times as likely to exhibit hyponatremia as subjects without the minor allele (after

101 in the renal water retention and dilutional hyponatremia associated with chronic heart failure.

102 The prevalence of hyponatremia associated with coronavirus disease 2019 an

103 SALT-1 and SALT-2, and 85% continued to have hyponatremia at entry in SALTWATER.

104 Hyponatremia at hospital admission is a well-known risk

105 All patients had hyponatremia at randomization in SALT-1 and SALT-2, and

106 ting toxicity-grade 3 transient asymptomatic hyponatremia at the 1.0-mg/kg dose level.

107 dose-limiting toxicity was reported (grade 3 hyponatremia at the 20 mg dose), therefore the maximum t

108 We investigated the effect of hyponatremia at the time of OLT on mortality and morbidi

109 to dilute urine but seldom develop baseline hyponatremia before ESRD.

110 Hyponatremia before liver transplant (LT) increases risk

111 For acute or severely symptomatic hyponatremia, both guidelines adopted the approach of gi

112 for patients with head injury, alkalosis, or hyponatremia, but in large volumes may lead to metabolic

113 , carries the risk of water intoxication and hyponatremia, but treatment options are scarce.

114 represent a new approach to the treatment of hyponatremia by blocking tubular reabsorption of water b

115 d hyponatremia (HAH) with community-acquired hyponatremia (CAH) in HF patients with respect to outcom

116 me expansion, excessive water retention with hyponatremia can occur in the absence of increases in aq

117 ent hyponatremia in previous studies, and 2) hyponatremia can significantly alter brain morphology on

118 Chronic hyponatremia (CH) was induced 3 d before the hypothalami

119 d with a marked increased rate of subsequent hyponatremia compared to use of other medications indica

120 come of mild, moderate, and severe admission hyponatremia compared with normonatremia among coronavir

121 iew discusses the diagnosis and treatment of hyponatremia, comparing the two guidelines and highlight

122 e a difference; regardless of volume status, hyponatremia complicating intracranial disease should be

123 Each level of worsening hyponatremia conferred 43% increased odds of in-hospital

124 Hyponatremia developed in 21 percent, and there were sig

125 However, there are few data about hyponatremia developing during hospitalization in patien

126 ons for the few patients in whom symptomatic hyponatremia develops.

127 ebrospinal fluid white-cell counts or severe hyponatremia did.

128 recommend limiting the correction of severe hyponatremia during the first 24 hours to prevent osmoti

129 xibility protects against the development of hyponatremia even in the face of water intake that can a

130 controlling for confounders including pre-LT hyponatremia, every 5 mmol/L increase in delta sodium as

131 atures associated with positive LP UATs were hyponatremia, fever, diarrhea, and recent travel.

132 Hyponatremia frequently poses a therapeutic challenge in

133 eport a newborn with severe hyperkalemia and hyponatremia from autosomal recessive pseudohypoaldoster

134 en requiring IVFs are at risk for developing hyponatremia from numerous stimuli for arginine vasopres

135 The improvement was more pronounced in the hyponatremia group with respect to ADL (DeltaADL: 14.3 +

136 n-small cell lung cancer) who presented with hyponatremia had inappropriately elevated levels of AVP.

137 The present study compares hospital-acquired hyponatremia (HAH) with community-acquired hyponatremia

138 Resolution of hyponatremia has a beneficial impact on the geriatric pa

139 Hyponatremia has emerged as an important cause of race-r

140 experience with AVP receptor antagonists for hyponatremia has shown that these agents augment free wa

141 Patients with polydipsia and intermittent hyponatremia have greater ventricle-brain ratios (VBRs)

142 xis), ascites and some of its complications (hyponatremia, hepatic hydrothorax), hepatorenal syndrome

143 factor even in patients without preexisting hyponatremia; however, isolated hypernatremia may be sol

144 Hyponatremia, hyperkalemia, and reduction in kidney func

145 Thiazide/amiloride-treated mice showed hyponatremia, hyperkalemia, hypercalcemia, metabolic aci

146 dosterone deficiency, signs of which include hyponatremia, hyperkalemia, hypovolemia, elevated plasma

147 or a composite of hypokalemia, hyperkalemia, hyponatremia, hypernatremia, hypomagnesemia, hypophospha

148 Laboratory examination revealed hyponatremia, hyperpotassemia, hypoproteinemia, hypogamm

149 Electrolyte imbalance (hyponatremia, hypochloremia, hyperkalemia) further confi

150 ributed to PS-341 included thrombocytopenia, hyponatremia, hypokalemia, fatigue, and malaise.

151 findings included diarrhea, hypoalbuminemia, hyponatremia, hypokalemia, hypocalcemia, and hypomagnese

152 f inducing severe hypokalemia in addition to hyponatremia, hypotension, and worsening renal function.

153 he condition of patients with mild or marked hyponatremia improved (P<0.001 for all comparisons).

154 n, remain under investigation for dilutional hyponatremia in ADHF.

155 eatures of myelinolysis by rapidly reversing hyponatremia in animals.

156 Most cases of hyponatremia in children are due to the syndrome of appr

157 Causes of hyponatremia in children include the syndrome of appropr

158 lts in a high incidence of hospital-acquired hyponatremia in children.

159 Hyponatremia in cirrhosis has prognostic value and novel

160 ICE 8: Diagnostic workup for the etiology of hyponatremia in cirrhosis should include dietary and med

161 er of poor survival previously attributed to hyponatremia in heart failure.

162 Thus, hyponatremia in hospitalized patients with a diagnosis o

163 ient management of asymptomatic hypervolemic hyponatremia in liver cirrhosis entails both sodium and

164 gement of severe or symptomatic hypervolemic hyponatremia in liver cirrhosis includes both sodium and

165 otic stimuli is a common cause of dilutional hyponatremia in neurological disorders.

166 Chronic symptomatic hyponatremia in postmenopausal women can be associated w

167 Chronic hyponatremia in postmenopausal women is a common clinica

168 in patients with polydipsia and intermittent hyponatremia in previous studies, and 2) hyponatremia ca

169 Our objective was to quantify the rate of hyponatremia in routine clinical care for patients presc

170 te was used to estimate the burden of severe hyponatremia in Stockholm by 2050.

171 nts who have euvolemia and hypervolemia with hyponatremia in the short term (</=30 days), but their s

172 The occurrence of hyponatremia in these patients has been associated with

173 inappropriate antidiuretic hormone SIADH and hyponatremia in these patients.

174 ed aspartate aminotransferase level (in 9%), hyponatremia (in 8%), and diarrhea (in 6%).

175 Treatment options to address the hyponatremia induced by the syndrome of inappropriate an

176 ced ascorbic acid uptake, namely evidence of hyponatremia-induced oxidative stress.

177 The hyponatremia-induced shift in water from the extracellul

178 , we showed that rapid correction of chronic hyponatremia induces severe alterations in proteostasis

179 CF due to elevated sweat chloride, recurrent hyponatremia, infantile FTT and lung disease identified

180 Infection, hypotension, hyponatremia, insomnia or stress, and benzodiazepine use

181 Hyponatremia is a common and challenging disorder.

182 Hyponatremia is a common and potentially severe adverse

183 Hyponatremia is a common condition with nonspecific symp

184 Hyponatremia is a common water balance disorder that oft

185 Acute hyponatremia is a potentially serious complication after

186 imal and human studies revealed that chronic hyponatremia is a previously unrecognized cause of osteo

187 Although hyponatremia is a risk factor for adverse events in CKD

188 Hyponatremia is a secondary cause of osteoporosis.

189 In conclusion, hyponatremia is a significant independent predictor of 6

190 Hyponatremia is associated with inappropriately elevated

191 Even mild hyponatremia is associated with increased hospital stay

192 Hyponatremia is associated with lethal outcome in ALF.

193 Hyponatremia is associated with reduced survival in pati

194 The treatment for hyponatremia is chosen on the basis of duration and symp

195 Hyponatremia is common in patients with conditions such

196 Hyponatremia is defined by a serum sodium level of less

197 Hyponatremia is frequently associated with neurological

198 Hypotonic hyponatremia is further differentiated on the basis of u

199 Although hyponatremia is known to be associated with osteoporosis

200 findings indicate that oxcarbazepine-induced hyponatremia is not attributable to the syndrome of inap

201 At present, therapy for acute and chronic hyponatremia is often ineffective and poorly tolerated.

202 Hyponatremia is the most common disorder of electrolyte

203 Hyponatremia is the most common electrolyte disorder and

204 ium deficiency, is the culprit in dilutional hyponatremia, isotonic saline administration may further

205 d 88 hospitalized patients with SIAD-induced hyponatremia <130 mmol/L at the University Hospital Base

206 mEq/L) was present in 615 (28.3%) and severe hyponatremia (<125 mEq/L) in 65 (3.0%).

207 Profound hyponatremia (<125 mmol/L) and lower baseline osmolality

208 sopressors (18%), pulmonary edema (14%), and hyponatremia<130 mmol/L (14%).

209 PRACTICE ADVICE 11: Recurrent or refractory hyponatremia management should involve a multidisciplina

210 Hyponatremia may worsen HE; it should be prevented as fa

211 Chronic symptomatic hyponatremia (mean [SD] sodium level 111 [12] mmol/L) wa

212 complications, specifically volume overload, hyponatremia, metabolic alkalosis, uremia, and hyperglyc

213 In a prospective study, patients with hyponatremia more frequently reported a history of falli

214 All 3 patients developed hyponatremia; none had faciobrachial dystonic seizures o

215 Mild, moderate, and severe hyponatremia occurred in 1,032 (22%), 305 (7%), and 36 (

216 Hyponatremia occurred in 30 participants (31%) with a me

217 Hyponatremia occurred in nearly a third of coronavirus d

218 es C, compared with the temperature at which hyponatremia occurred least frequently.

219 Hyponatremia occurred significantly more often in DCI pa

220 Hyponatremia occurs in a substantial fraction of nonelit

221 Hyponatremia occurs in up to 30% of patients with pneumo

222 timulation of ENaC likely contributes to the hyponatremia of adrenal insufficiency.

223 s to be elevated in nearly all patients with hyponatremia of malignancy.

224 A 76-y-old man with hypoosmolar hyponatremia of unknown origin was referred to the nucle

225 Treatment of hypotonic hyponatremia often challenges clinicians on many counts.

226 ver, data are sparse regarding the impact of hyponatremia on outcome following OLT.

227 ients, including four with fatigue, two with hyponatremia, one with muscle spasm, and one with atrial

228 oor outcomes than the rate of development of hyponatremia or the absolute decrease in the serum sodiu

229 y for mild attacks (mild pain, no paresis or hyponatremia) or until hemin is available.

230 d AHF patients may have renal insufficiency, hyponatremia, or an inadequate response to traditional d

231 Deaths result from hyperthermia, hyponatremia, or cerebral edema.

232 likely to have Child-Pugh class C cirrhosis, hyponatremia, or refractory ascites.

233 lar filtration rate <60 ml/min/1.73 m(2); 2) hyponatremia; or 3) diuretic resistance (urine output </

234 were highly correlated with the presence of hyponatremia (p < 0.00001).

235 C-reactive protein (CRP) (P = .0009); worse hyponatremia (P = .02); higher KSHV VL (P = .016), and h

236 l plasma ANP levels were not associated with hyponatremia (p = 0.73).

237 7 to 136.67 +/- 3.82 mmol/L) respectively in hyponatremia rats by diuresis.

238 In total, 111 patients with hyponatremia received oral tolvaptan for a mean follow-u

239 fter discontinuation of tolvaptan on day 30, hyponatremia recurred.

240 rminal pro-B natriuretic peptide levels, and hyponatremia reflected greater neurohormonal activation.

241 Hypochloremia, but not hyponatremia, remained associated with mortality with mu

242 Renal dysfunction, diuretic resistance, and hyponatremia represent treatment impediments.

243 servational study investigated the impact of hyponatremia resolution on the results of a comprehensiv

244 Abrupt correction of hyponatremia resulted in vigorous activation of both the

245 e; this may help to attenuate the developing hyponatremia resulting from water loading when vasopress

246 hiazide exposure on sodium concentration and hyponatremia risk.

247 he Study of Ascending Levels of Tolvaptan in Hyponatremia (SALT-1 and SALT-2).

248 alyzed, there were 1274 patients (0.8%) with hyponatremia (serum sodium <135 mmol/L), 162,829 (97.3%)

249 ted with serum sodium concentration and with hyponatremia (serum sodium concentration < or =135 mEq/L

250 Hyponatremia (serum sodium concentration, <135 mmol per

251 In patients with hyponatremia, serum sodium levels significantly increase

252 xperience suggest that correction of chronic hyponatremia should be kept at a rate less than 10 mmol/

253 es, hepatic hydrothorax, volume overload, or hyponatremia should be referred for to transjugular intr

254 For most patients, the approach to managing hyponatremia should consist of treating the underlying c

255 Among 4,645 patient encounters, hyponatremia (sodium < 135 mmol/L) occurred in 1,373 (30

256 Hyponatremia (sodium level <135 mEq/L), the most prevale

257 ate (sodium level, 125-129 mEq/L) and severe hyponatremia (sodium level, <125 mEq/L), where the cumul

258 Patients with severe hyponatremia tended to have a longer stay in the ICU (me

259 we present a practical approach to managing hyponatremia that centers on two elements: a diagnostic

260 rements is associated with increased risk of hyponatremia that results in morbidity and mortality in

261 d at the pathogenesis and putative causes of hyponatremia, the case-specific clinical and laboratory

262 Hyponatremia, the most frequent electrolyte disorder, is

263 rst-line treatment for most forms of chronic hyponatremia, therapy to increase renal free water excre

264 ize sodium from bone stores during prolonged hyponatremia, thereby leading to a resorptive osteoporos

265 ments for hypertension, but thiazide-induced hyponatremia (TIH), a clinically significant adverse eff

266 In patients with euvolemic or hypervolemic hyponatremia, tolvaptan, an oral vasopressin V2-receptor

267 Hyponatremia treatment guidelines recommend limiting the

268 metabolic characteristics of overhydration, hyponatremia, uremia, hyperglycemia, and alkalosis.

269 ocin is not receptor-selective and may cause hyponatremia via V2 receptor mediated antidiuresis.

270 The rate of hyponatremia was 146 per 1,000 person-years for adults p

271 ing for age, sex, region, and comorbidities, hyponatremia was a significant independent predictor of

272 inositol content in animals with uncorrected hyponatremia was about 50% of that found in normonatremi

273 The occurrence of hyponatremia was also decreased by albumin, compared wit

274 A higher rate of hyponatremia was also observed with desmopressin when ta

275 Hyponatremia was apparent in the isotonic crystalloid- a

276 Morbidity associated with hyponatremia was assessed, including length of hospitali

277 Hyponatremia was associated with acute oxytocin but not

278 Increasing severity of hyponatremia was associated with encephalopathy, mechani

279 On univariate analyses, hyponatremia was associated with substantial weight gain

280 On multivariate analysis, hyponatremia was associated with weight gain (odds ratio

281 Hyponatremia was categorized as mild (sodium: 130-134 mm

282 Hyponatremia was defined as a serum sodium concentration

283 A clear seasonal pattern of heat-related hyponatremia was evident among older patients, especiall

284 d clinical trials, a high incidence of acute hyponatremia was observed in response to MDMA, which may

285 One grade 4 event, asymptomatic hyponatremia, was judged to be unrelated to GDC-0449.

286 orrection and very slow correction of severe hyponatremia were associated with an increased risk of m

287 Both types of hyponatremia were associated with increased mortality, l

288 ic patients with polydipsia and intermittent hyponatremia were first assigned to either normal fluid

289 sweat chloride, infantile FTT, and recurrent hyponatremia were homozygous for a novel missense varian

290 ic patients with (n = 6) and without (n = 8) hyponatremia were identified based on past and current i

291 rmalization of serum sodium in patients with hyponatremia were observed in the tolvaptan group but no

292 history of tick bite, thrombocytopenia, and hyponatremia were often absent at initial presentation.

293 The effects of hyperammonemia and hyponatremia were synergistic.

294 c fluid associated with a lower incidence of hyponatremia when compared with hypotonic fluid for main

295 monstrated that hypotonic fluids cause acute hyponatremia, whereas 0.9% sodium chloride (NaCl) effect

296 ody-mass-index extremes were associated with hyponatremia, whereas female sex, composition of fluids

297 with oxcarbazepine showed the development of hyponatremia, which in most instances was asymptomatic.

298 opeptin concentrations from 50 patients with hyponatremia who underwent hypertonic saline infusion.

299 ts preceding the seizure were remarkable for hyponatremia, with a blood sodium level of 122 mEq/L (12

300 luid is associated with a lower incidence of hyponatremia, without evidence of an increase in adverse