ライフサイエンスコーパス: hypoplastic

1 horoid plexus, either failed to form or were hypoplastic.

2 devoid of these cell types and were severely hypoplastic.

3 l mutants, endocardial cushions are markedly hypoplastic.

4 ers in homozygous ATF4 mutants were pale and hypoplastic.

5 the anterior lobe, but the anterior lobe was hypoplastic.

6 y arise from neural ectoderm, were extremely hypoplastic.

7 identified 2 ENAM mutations in kindreds with hypoplastic ADAI, 1 novel (g.4806A>C, IVS6-2A>C) and 1 p

8 ARgamma L466A knock-in (PPARKI) mice exhibit hypoplastic adipocytes, hypoadiponectinemia, increased s

9 H expression in the paraventricular nucleus, hypoplastic adrenal glands and decreased stress-induced

10 s identified in one family segregating local hypoplastic AI as a dominant trait.

11 ions may be dose-dependent, with generalized hypoplastic AI segregating as a recessive trait and loca

12 etermine the generality of ENAM mutations in hypoplastic AI, we sequenced the ENAM gene in ten Turkis

13 n a Caucasian family with autosomal dominant hypoplastic AI.

14 n ten Turkish families segregating autosomal hypoplastic AI.

15 calized enamel pitting in carriers to severe hypoplastic AI.

16 family with three of the six children having hypoplastic AI.

17 ancreata developing without beta-catenin are hypoplastic, although their early progenitors appear nor

18 gnificant short stature with brachyolmia and hypoplastic amelogenesis imperfecta (AI) with almost abs

19 ns in the ENAM gene have been found to cause hypoplastic amelogenesis imperfecta (AI), with phenotype

20 uited two Hispanic families with generalized hypoplastic amelogenesis imperfecta (AI).

21 enotype was consistent with the diagnosis of hypoplastic amelogenesis imperfecta.

22 typic analyses of Shox2(-/-) mice revealed a hypoplastic and defectively differentiated DMP, likely a

23 Cask(-/-) (het/null) kidneys were moderately hypoplastic and demonstrated impaired aggregation of SIX

24 Enamel from amelogenin (Amelx) null mice is hypoplastic and disorganized, similar to that observed i

25 h large contributions of Wt1-/- cells showed hypoplastic and dysgenic testes, with seminiferous tubul

26 Morphant hearts were hypoplastic and dysmorphic and exhibited significantly r

27 double-knockout (DKO) kidneys were severely hypoplastic and dysplastic and demonstrated rapid, prema

28 The thymus was hypoplastic and exhibited an abnormal distribution of ep

29 mid-gestation, Tmem67 mutant cerebella were hypoplastic and had aberrantly high canonical Wnt/beta-c

30 enamel crystallography and microstructure in hypoplastic and healthy enamel.

31 The exocrine compartment of mutant mice was hypoplastic and individual acini produced few zymogen gr

32 All cultured incisors of Tbx1-/- mice were hypoplastic and lacked enamel, while thorough histologic

33 These include hypoplastic and mispatterned cranial ganglia, dysmorphog

34 l crypts of Villin(Cre);Dclk1(f/f) mice were hypoplastic and more apoptotic 24 h post-total body irra

35 ic day (E) 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants

36 plicated posteriorly, while the inner ear is hypoplastic and shows neither a vestibular apparatus nor

37 The affected enamel can be hypoplastic and/or hypomineralized.

38 Pancreata of Bmi1(-/-) mice were hypoplastic, and the exocrine pancreas was replaced with

39 Diamond-Blackfan anemia (DBA) is a hypoplastic anemia characterized by impaired production

40 response to nucleosomal stress underlies the hypoplastic anemia in myelodysplastic syndromes (MDS) wi

41 n of the RPS14 gene is a key effector of the hypoplastic anemia in patients with myelodysplastic synd

42 sponsiveness to erythropoietin, resulting in hypoplastic anemia.

43 s (where s indicates short) cause congenital hypoplastic anemia.

44 or branching of arteries were detected, but hypoplastic anomalies were observed.

45 eat arteries (n=7), coarctation of the aorta/hypoplastic aortic arch (n=5), tetralogy of Fallot (n=1)

46 We examined the presence of hypoplastic, aplastic or fetal PCoAs, vertebral dominanc

47 ayed severe vascular abnormalities including hypoplastic arterial wall, short/absent brachiocephalic

48 At birth, mutant mice display a hypoplastic atrioventricular (AV) node and then develop

49 mutations causing non-syndromic, generalized hypoplastic autosomal-recessive amelogenesis imperfecta

50 g in the developing myocardium resulted in a hypoplastic AV node, with specific loss of slow-conducti

51 ia (SAA) is a rare disorder characterized by hypoplastic bone marrow and progressive pancytopenia.

52 ruction, while the olfactory bulb is acutely hypoplastic but recovers fully with age.

53 The oculomotor nerve was most severely hypoplastic, but the abducens was also affected.

54 owed severely reduced sinus horn myocardium, hypoplastic caval veins, and a persistent left inferior

55 Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a si

56 n-induced hypoplastic lungs as well as human hypoplastic CDH lungs.

57 In fact, they suffered from a severely hypoplastic cerebellum due to a significant inhibition o

58 ngly, ciliary conditional mutant mice have a hypoplastic cerebellum in which the proliferation of cer

59 rized by delayed closure of the fontanel and hypoplastic clavicles that result from defective intrame

60 whether pregestational diabetes could cause hypoplastic coronary artery disease in humans.

61 Hypoplastic coronary artery disease is a congenital coro

62 However, the etiology and pathogenesis of hypoplastic coronary artery disease remain undefined.

63 entriculomegaly, white-matter abnormalities, hypoplastic corpus callosum, congenital heart defects, a

64 aberrant endodermal pouch morphogenesis, and hypoplastic cranial cartilages.

65 a decreased proliferation of mesenchyme and hypoplastic cushions that failed to septate the ventricu

66 VEGFR3 in epidermal keratinocytes exhibited hypoplastic cutaneous lymph capillaries and increased Na

67 deficient in bcl-2 (bcl-2-/-) develop renal hypoplastic/cystic dysplasia, a condition that leads to

68 Mutant mice develop brittle teeth with hypoplastic dentin and molars with an enlarged pulp cham

69 Nkx2-5 loss of function can be attributed to hypoplastic development of the relevant structures in th

70 The Runx2 null epidermis is hypoplastic, displaying reduced expression of Keratin 14

71 sh embryos, synectin knockdown resulted in a hypoplastic dorsal aorta and hypobranched, stunted, and

72 Acinar tissue formed in the hypoplastic dorsal bud, but endocrine maturation was gre

73 However, it is hypoplastic due to reduced proliferation of basal kerati

74 The mice developed a hypoplastic dysplastic collecting system.

75 notype reminiscent of human congenital mixed hypoplastic/dysplastic disorders.

76 ox/flox);Tie2-cre mice die before E14.5 with hypoplastic ECs, reduced cell proliferation and altered

77 (MeHg) during development, many neurons are hypoplastic, ectopic, and disoriented, indicating disrup

78 ntricular septal defect), hypoplastic lungs, hypoplastic/ectopic kidneys, aplastic adrenal glands and

79 the dental epithelium by K14-cre resulted in hypoplastic enamel and reduced density in X-ray radiogra

80 rved clinically, the surface of ENAM-mutated hypoplastic enamel can appear to be normal, yet severe s

81 delG mutation, the phenotype was generalized hypoplastic enamel with shallow horizontal grooves in th

82 , mutations in the human enamelin gene cause hypoplastic enamel, often with horizontal grooves, but t

83 d, exhibiting horizontal grooves of severely hypoplastic enamel.

84 f amelogenin (p.M1T and p.W4S), resulting in hypoplastic enamel.

85 ss the labial surface in comparison with the hypoplastic enamel.

86 ntial component of mTORC2, survive despite a hypoplastic epidermis and disruption in late stage termi

87 morphic facies, brachydactyly, seizures, and hypoplastic external genitalia.

88 By contrast, flt4 null larvae displayed hypoplastic facial lymphatics and severe lymphedema.

89 radicular dentin in these mice showed severe hypoplastic features, which were likely caused by disrup

90 n of a single fused lower incisor within the hypoplastic fused mandible.

91 xhibited abnormal genital morphogenesis with hypoplastic genitalia, a single cloacal opening, and per

92 ral positioning of the urethral orifice; and hypoplastic genitalia.

93 Consistent with hypoplastic heart defects, compared to patents the proba

94 We compared the two shunts in infants with hypoplastic heart syndrome or related anomalies.

95 phenotypes were observed in mutant embryos: hypoplastic heart tubes with misaligned cardioblasts and

96 Tbx20-null mice exhibit severely hypoplastic hearts and express Tbx2, which is normally r

97 ion in proliferative myocytes and results in hypoplastic hearts.

98 The affected mother had several shallow hypoplastic horizontal grooves in the lower anterior tee

99 MMP20 in a proband with autosomal-recessive hypoplastic-hypomaturation amelogenesis imperfecta.

100 These regions of the heart are severely hypoplastic in mutant mice lacking the myocyte enhancer

101 Purkinje network both of which were severely hypoplastic in Nkx2.5(Cre/+) littermates.

102 We found that hematopoietic tissues were hypoplastic in Ssbp2(-/-) mice, and the frequency of lym

103 mutant mice, in which the exocrine tissue is hypoplastic, in order to reveal a possible requirement f

104 logic anomalies, such as growth retardation; hypoplastic jaws crowded with multiple supernumerary, ye

105 ce had renal agenesis, and the remainder had hypoplastic kidneys and developed tubulocystic abnormali

106 Loss of function of GAS1 in vivo results in hypoplastic kidneys with reduced nephron mass due to pre

107 By postnatal day 4, 65% of BMP7 CKO mice had hypoplastic kidneys, but glomeruli demonstrated normal p

108 of EBF1 from Foxd1 lineage cells resulted in hypoplastic kidneys, poorly differentiated peripheral gl

109 ydronephrosis, hydroureter, and occasionally hypoplastic kidneys, whereas Cask-null mice do not.

110 ause most compound heterozygous embryos show hypoplastic kidneys.

111 or recessive MYH6 mutations in patients with hypoplastic left heart and reduced systemic right ventri

112 unction by echocardiography in patients with hypoplastic left heart and their first-degree relatives

113 The molecular underpinnings of hypoplastic left heart are poorly understood.

114 Hypoplastic left heart is a severe human congenital hear

115 iology is indicated by an association of the hypoplastic left heart phenotype with terminal 11q delet

116 h dominant right ventricle (66% vs. 36%) and hypoplastic left heart syndrome (HLHS) (47% vs. 13%).

117 dy was designed to identify disease loci for hypoplastic left heart syndrome (HLHS) and evaluate the

118 is (AVS), coarctation of the aorta (COA) and hypoplastic left heart syndrome (HLHS) are congenital ca

119 Outcome of stage 1 palliation (S1P) for hypoplastic left heart syndrome (HLHS) has improved coin

120 oppler (PVD) flow patterns in the fetus with hypoplastic left heart syndrome (HLHS) have been correla

121 Hypoplastic left heart syndrome (HLHS) is a complex cong

122 Hypoplastic left heart syndrome (HLHS) is a fatal congen

123 Hypoplastic left heart syndrome (HLHS) is a severe cardi

124 Hypoplastic left heart syndrome (HLHS) is among the most

125 y blood flow after the Norwood operation for hypoplastic left heart syndrome (HLHS) is critical to ea

126 women into 4 groups: "HLHS/TGA" fetuses with hypoplastic left heart syndrome (HLHS) or transposition

127 t (heritability) in families identified by a hypoplastic left heart syndrome (HLHS) proband.

128 progression of fetal aortic stenosis (AS) to hypoplastic left heart syndrome (HLHS) requires identifi

129 Hypoplastic left heart syndrome (HLHS) with intact or ve

130 Hypoplastic left heart syndrome (HLHS) with risk of poor

131 mmune model of structural CHD that resembles hypoplastic left heart syndrome (HLHS), a life-threateni

132 Here, we show that hypoplastic left heart syndrome (HLHS), a severe CHD, is

133 lvotomy, shunt type in staged palliation for hypoplastic left heart syndrome (HLHS), and strategies f

134 Congenital heart diseases (CHDs), including hypoplastic left heart syndrome (HLHS), are genetically

135 osis in an attempt to prevent progression to hypoplastic left heart syndrome (HLHS).

136 pulmonary connection (TCPC) in children with hypoplastic left heart syndrome (HLHS).

137 stic approach, management, and outcomes than hypoplastic left heart syndrome (HLHS).

138 including an unprecedented high frequency of hypoplastic left heart syndrome (HLHS).

139 event progression of aortic stenosis (AS) to hypoplastic left heart syndrome (HLHS).

140 egurgitation after staged reconstruction for hypoplastic left heart syndrome (HLHS).

141 critical congenital heart disease, including hypoplastic left heart syndrome (HLHS).

142 ntan pleural drainage (HR, 4.0; P<0.001) and hypoplastic left heart syndrome (HR, 2.0; P=0.01).

143 Fifty-two patients with hypoplastic left heart syndrome (median age, 6.6; range

144 Diagnoses were hypoplastic left heart syndrome (n=346), tricuspid atres

145 The most common diagnosis was hypoplastic left heart syndrome (n=80, 36.7%).

146 and suitable for follow-up of patients with hypoplastic left heart syndrome after Fontan palliation.

147 Infants born with hypoplastic left heart syndrome and an intact or highly

148 al defect for the treatment of neonates with hypoplastic left heart syndrome and an intact or restric

149 microdeletions of FOXF1 were associated with hypoplastic left heart syndrome and gastrointestinal atr

150 and improvement of outcomes in fetuses with hypoplastic left heart syndrome and intact atrial septum

151 en fetuses at 26 to 34 weeks' gestation with hypoplastic left heart syndrome and intact or highly res

152 A diagnosis of hypoplastic left heart syndrome and longer operative sup

153 bstructions and nitrogen dioxide and between hypoplastic left heart syndrome and particulate matter w

154 o, the progress in the 3-stage palliation of hypoplastic left heart syndrome and related single right

155 ll 5-year survival, particularly in cases of hypoplastic left heart syndrome and single ventricle.

156 in fetuses with aortic stenosis and evolving hypoplastic left heart syndrome and, in a subset of case

157 Patients with hypoplastic left heart syndrome are at higher risk of fa

158 culate matter was positively associated with hypoplastic left heart syndrome but inversely associated

159 First-stage palliation of hypoplastic left heart syndrome has been performed as a

160 Surgical management of hypoplastic left heart syndrome has changed the prognosi

161 protocols and a home surveillance system for hypoplastic left heart syndrome improves outcomes.

162 The proportion with hypoplastic left heart syndrome increased from 1/173 (1%

163 Hypoplastic left heart syndrome is a rare congenital hea

164 Hypoplastic left heart syndrome is a severe form of card

165 t ventricular (RV) function in patients with hypoplastic left heart syndrome is important during long

166 o with the modified Blalock-Taussig shunt in hypoplastic left heart syndrome or variants is currently

167 ation-derived indices of RV contractility in hypoplastic left heart syndrome patients after Fontan pa

168 orwood, Sano, and Hybrid, currently used for hypoplastic left heart syndrome pose a risk of myocardia

169 progressive improvement in surgical results, hypoplastic left heart syndrome remains one of the conge

170 Their role in management of hypoplastic left heart syndrome remains to be defined, e

171 m from failure was 79% (95% CI, 61%-89%) for hypoplastic left heart syndrome versus 92% (95% CI, 87%-

172 Hypoplastic left heart syndrome was the primary predicto

173 ted left ventricle predictably progresses to hypoplastic left heart syndrome when associated with cer

174 the following hypotheses: (1) patients with hypoplastic left heart syndrome who develop significant

175 cal data were reviewed for 138 children with hypoplastic left heart syndrome who underwent stage I su

176 rid approach achieves stage 1 palliation for hypoplastic left heart syndrome with different flow char

177 "Hypoplastic left heart syndrome" is an unsatisfactory te

178 ubtypes were associated with smaller HC, eg, hypoplastic left heart syndrome, -0.39 (95% CI, -0.58 to

179 Five-year survival varied by defect type: hypoplastic left heart syndrome, 38.0% (95% confidence i

180 The rarest CHD found was hypoplastic left heart syndrome, a phenotype never seen

181 the great arteries, interrupted aortic arch, hypoplastic left heart syndrome, and aortic coarctation,

182 cantly higher ORs for atrial septal defects, hypoplastic left heart syndrome, aortic stenosis, pulmon

183 ring 3-stage single-ventricle palliation for hypoplastic left heart syndrome, attrition after the Nor

184 fetal diagnosis of aortic stenosis/evolving hypoplastic left heart syndrome, more than twice as many

185 e aorta, transposition of the great vessels, hypoplastic left heart syndrome, oral cleft, abdominal w

186 um atrial septal defect, aortic coarctation, hypoplastic left heart syndrome, patent ductus arteriosu

187 Patients with hypoplastic left heart syndrome, pulmonary atresia intac

188 cular repair surgery in infant patients with hypoplastic left heart syndrome, where surgical removal

189 notypes, including the first mouse models of hypoplastic left heart syndrome.

190 unction, or interstage AVVR in children with hypoplastic left heart syndrome.

191 ogression of midgestation aortic stenosis to hypoplastic left heart syndrome.

192 tients undergoing first-stage palliation for hypoplastic left heart syndrome.

193 y for critical aortic stenosis with evolving hypoplastic left heart syndrome.

194 d function, possibly preventing evolution to hypoplastic left heart syndrome.

195 al of an alternative management strategy for hypoplastic left heart syndrome.

196 in cases of congenital heart disease such as hypoplastic left heart syndrome.

197 y improved the survival of infants born with hypoplastic left heart syndrome.

198 equiring intervention, to severe, as seen in hypoplastic left heart syndrome.

199 ormal mitral valve, aortic root dilation, or hypoplastic left heart syndrome.

200 with CHD exist, and these primarily focus on hypoplastic left heart syndrome.

201 rt diseases of heterogeneous origin, such as hypoplastic left heart syndrome.

202 agement of congenital heart disease, such as hypoplastic left heart syndrome.

203 ants together under the unsatisfactory term "hypoplastic left heart syndrome."

204 oplasty; shunt type in staged palliation for hypoplastic left heart syndrome; strategies for SCP.

205 e sought to identify genetic determinants of hypoplastic left heart with latent right ventricular dys

206 hypoplasia, ventricular septal defects, and hypoplastic left heart.

207 ect is a developmental defect referred to as hypoplastic left heart.

208 is in the structures principally affected in hypoplastic left heart.

209 oligogenic underpinnings of CHDs, including hypoplastic left hearts.

210 Patients with hypoplastic LH and borderline LV who underwent tradition

211 Management of patients with hypoplastic LH syndrome and borderline left ventricle (L

212 s with isolated coarctation and at least one hypoplastic LH valve (mitral or aortic Z-score <-2) who

213 sults in reduced foregut gene expression and hypoplastic liver and ventral pancreatic buds.

214 growth and branching remain defective and a hypoplastic lung develops on the right side only.

215 d cyclical prenatal mechanical strain on the hypoplastic lung of the ovine model of congenital diaphr

216 ung growth and morphologic maturation of the hypoplastic lung parenchyma.

217 hypoplasia observed in both nitrofen-induced hypoplastic lungs as well as human hypoplastic CDH lungs

218 the defective cell type in nitrofen-induced hypoplastic lungs due to a decreased ability to undergo

219 mine the fetal in vivo microRNA signature in hypoplastic lungs of human fetuses with severe isolated

220 lial branching and, by the end of gestation, hypoplastic lungs that cannot support life.

221 s arteriosus and ventricular septal defect), hypoplastic lungs, hypoplastic/ectopic kidneys, aplastic

222 mpensatory) upregulation of miR-200b in less hypoplastic lungs.

223 The hypoplastic LV in fetal HLHS samples demonstrates hypoxi

224 Conversely, mice over-expressing Cyp26b1 had hypoplastic lymph sacs and lymphatic vessels.

225 Blackfan anemia, a disorder characterized by hypoplastic, macrocytic anemia.

226 chial arch-specific enhancer also leads to a hypoplastic mandible and cleft palate formation in mice.

227 luding a bony fusion between the maxilla and hypoplastic mandible, resembling the bony syngnathia syn

228 results in the random presence or absence of hypoplastic mandibular arch-derived muscles at later dev

229 These changes resulted in the formation of a hypoplastic mandibular process and truncated Meckel's ca

230 ak1-deficient mutants display a round skull, hypoplastic maxilla and mandible, and cleft palate resul

231 For example, aplastic anemia and hypoplastic MDS can be difficult to distinguish in patie

232 xpress detectable levels of KGF message, the hypoplastic medullary TE compartment can be expanded by

233 ms, delayed primary branching of the UB, and hypoplastic metanephroi.

234 are also of clinical relevance as targeting hypoplastic muscles might present a novel preventative m

235 lts in profound cardiac defects that include hypoplastic myocardium and a deficiency of pericardial a

236 ecause of profound cardiac defects including hypoplastic myocardium, membranous ventricular septal de

237 n four of the 15 children (26.7%) including: hypoplastic nails and shortened fifth fingers (one), mic

238 during frontonasal development, which led to hypoplastic nasal process outgrowth, epithelial seam per

239 e factor 7 activity die at birth and display hypoplastic olfactory bulbs which lack peripheral innerv

240 1.19-1.54; P < .001) smaller for clinically hypoplastic ONs than for controls.

241 Mutations in the TBX3 gene can cause hypoplastic or absent mammary glands.

242 ty, presence of a daughter dome, presence of hypoplastic or aplastic A1 arteries and hypoplastic or f

243 d vessel phenotypes of Tbx1 heterozygotes as hypoplastic or aplastic at the conclusion of pharyngeal

244 Decipher also records 2 individuals with hypoplastic or bifid uvulae with copy number variants af

245 ation, dysgenesis of angle structures, and a hypoplastic or disorganized iris were also observed in t

246 e of hypoplastic or aplastic A1 arteries and hypoplastic or fetal PCoA, perpendicular height, width,

247 zygous Pax9neo mutants (Pax9neo/neo) exhibit hypoplastic or missing lower incisors and third molars,

248 dwarfism syndrome characterized by absent or hypoplastic patellae and markedly small ears(1)(-)(3).

249 the triad of short stature, microtia, and a/hypoplastic patellae.

250 congenital anomaly associated with absent or hypoplastic pectoralis major muscle and a wide spectrum

251 tract defects including persistent cloaca - hypoplastic perineum tissue between external urogenital

252 d that VEGF-C-deficient hearts have severely hypoplastic peritruncal vessels, resulting in delayed an

253 In addition, these mutants have hypoplastic pharyngeal arches, small or absent thymus an

254 nt AI with variable degrees of a distinctive hypoplastic phenotype due to pathogenic variants in LAMB

255 This hypoplastic phenotype is rescued by either replacement o

256 ands of betaTrcp1(-/-) female mice display a hypoplastic phenotype, whereas no effects on cell prolif

257 Some affected individuals exhibited hypoplastic phenotypes, in addition to the characteristi

258 lunar and atrioventricular heart valves, and hypoplastic, poorly differentiated lungs.

259 A total of 14 children presented with hypoplastic portal vein (diameter<5 mm), of a total of 3

260 primordia was also affected, with absent or hypoplastic primordia, delayed expression of organ-speci

261 dysmorphic facial features, prenatal teeth, hypoplastic pubis and clavicles, osteopenia, and bent lo

262 ctrum, including great vessel malformations, hypoplastic pulmonary and aortic arch arteries, cardiac

263 from E19 control ((C)) and nitrofen-induced hypoplastic rat lungs ((N)).

264 istal symphysis of Meckel's cartilage became hypoplastic, resulting in the formation of a single fuse

265 and we observed that these animals displayed hypoplastic retinas and underdeveloped mammary glands an

266 ortic arch (n=5), tetralogy of Fallot (n=1), hypoplastic right heart (n=1), and common arterial trunk

267 myocardium results in tricuspid atresia with hypoplastic right ventricle associated with the loss of

268 sion of Hoxb1 in the anterior SHF results in hypoplastic right ventricle.

269 w heart beat rate (bradycardia) and severely hypoplastic SAN and sinus valves attributed to a signifi

270 nd its haploinsufficiency in mice results in hypoplastic SANs and rhythm abnormalities.

271 tal abnormalities, including Robin sequence, hypoplastic scapulae, and a missing pair of ribs.

272 features of disease include an opacified and hypoplastic sinus, a lateralized uncinate process, depre

273 Loss of COUP-TFII in the limbs leads to hypoplastic skeletal muscle development, as well as shor

274 ed dominant disorder characterized by patchy hypoplastic skin and digital, ocular and dental malforma

275 Fgf8 hypomorphs have hypoplastic SMGs, whereas conditional mutant SMGs exhibi

276 lasia and pulmonary hypoplasia, pale livers, hypoplastic spleen, thymus, and bone marrow, cardiac hyp

277 Cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized syno

278 Null males were found to have hypoplastic testes secondary to germ cell depletion.

279 s results in the formation of functional yet hypoplastic thymic tissue.

280 corpus callosum and anterior commissure, and hypoplastic to absent olfactory sulci, olfactory bulbs a

281 ere found, including infertility, relatively hypoplastic uteri, abnormal ovaries, stunted mammary gla

282 AF2ERKI homozygote female mice have hypoplastic uterine tissue and rudimentary mammary gland

283 rm atrial septum, display dilated atria with hypoplastic venous valves, and exhibit blood backflow fr

284 it BAF180 in mouse embryos results in severe hypoplastic ventricle development and trophoblast placen

285 loss of Grk2/3 results in dilated atria and hypoplastic ventricles, and the hearts of embryos deplet

286 due to congenital heart defects, to recruit hypoplastic ventricles, to create a two-ventricle circul

287 RXRalpha(-/-) embryos have a hypoplastic ventricular chamber and die in midgestation

288 CAVC), double outlet right ventricle (DORV), hypoplastic ventricular myocardium, and normal coronary

289 Ablation of BMP10 leads to hypoplastic ventricular wall formation, and elevated lev

290 The frequency of hypoplastic vessels decreased during embryogenesis, wher

291 ng recovery is attributable to remodeling of hypoplastic vessels.

292 h-derived levator veli palatini muscles were hypoplastic, which was associated with an earlier altere

293 The kidneys were hypoplastic with a thin cortex; a superficial layer of t

294 growth retardation, and the pituitaries are hypoplastic with an abnormal branching of the anterior l

295 s, and their islets and pituitaries remained hypoplastic with decreased proliferation.

296 Mutant kidneys are hypoplastic with fewer generations of nascent nephrons.

297 in we show that Six1(-/-) lungs are severely hypoplastic with greatly reduced epithelial branching an

298 null mice at postnatal 8 weeks are extremely hypoplastic with markedly decreased numbers of Ki67+ cel

299 er we show that Eya1(-/-) lungs are severely hypoplastic with reduced epithelial branching and increa

300 Wnt7b-null lungs are markedly hypoplastic, yet display largely normal patterning and c