ライフサイエンスコーパス: hypothermia

1 odds ratio (with an odds ratio <1.0 favoring hypothermia).

2 nd to assess the outcome of deep therapeutic hypothermia.

3 ated by PA and this increase was reversed by hypothermia.

4 or heating pad was used to avoid generalized hypothermia.

5 be at greater risk of suffering harm due to hypothermia.

6 enhanced the neuroprotective effects of mild hypothermia.

7 by dihydrocapsaicin (DHC) produces reliable hypothermia.

8 reased among patients undergoing therapeutic hypothermia.

9 MC-specific Munc13-4 KO mice developed less hypothermia.

10 hysiological effects such as hypotension and hypothermia.

11 d thermoregulation, resulting in spontaneous hypothermia.

12 of block in patients undergoing therapeutic hypothermia.

13 ighly variable among subjects and altered by hypothermia.

14 ture applications involving therapeutic deep hypothermia.

15 l for a full reversibility of the effects of hypothermia.

16 -alpha hyperproduction and attenuates septic hypothermia.

17 istration in patients undergoing therapeutic hypothermia.

18 sed to manage overt shivering in therapeutic hypothermia.

19 Exposure: Induction of therapeutic hypothermia.

20 blockade in patients undergoing therapeutic hypothermia.

21 lems including QTc interval prolongation and hypothermia.

22 ilitates intra-cardiopulmonary resuscitation hypothermia.

23 induced conditioned taste aversion (CTA) and hypothermia.

24 ary resuscitation and the use of therapeutic hypothermia.

25 l and neurological benefit with mild induced hypothermia.

26 ncephalopathy of newborns) or intraoperative hypothermia.

27 trogen-sensitive MPA neurons during bouts of hypothermia.

28 logical perturbations, including spontaneous hypothermia.

29 gnals do not contribute to adenosine-induced hypothermia.

30 e high-power delta oscillations or sustained hypothermia.

31 emperature), resulting in hypometabolism and hypothermia.

32 ad diarrhea, 8 bloody stools, 4 fever, and 1 hypothermia.

33 in asphyxiated patients with HIE undergoing hypothermia.

34 arrest (6.0%) were treated with therapeutic hypothermia; 1524 of these patients (mean [SD] age, 61.6

35 ement (NREM)-like sleep but with undesirable hypothermia [18, 19].

36 ypotension (276 of 491 policies [56.2%]) and hypothermia (181 of 228 policies [79.4%]), specifying al

37 hermia: -28% +/- 3% and normothermia to mild hypothermia: -20% +/- 5%) was of comparable effect size

38 +/- 4%, normothermia: -27% +/- 6%, and mild hypothermia: -27% +/- 9%).

39 For more than a decade, mild induced hypothermia (32 degrees C-34 degrees C) has been standar

40 who were receiving mechanical ventilation to hypothermia (32 to 34 degrees C for 24 hours) in additio

41 agement) to standard care (control group) or hypothermia (32 to 35 degrees C) plus standard care.

42 Hypothermia (32-34 degrees C) can mitigate ischemic brai

43 ntional complications were more frequent for hypothermia (32.9% vs 9.1%; P < .001), delayed extubatio

44 trolled trial comparing moderate therapeutic hypothermia (33 degrees C during the first 24 hours) wit

45 (40% end-tidal concentration) combined with hypothermia (33 degrees C) for 24 h (n = 55; xenon group

46 o receive either inhaled xenon combined with hypothermia (33 degrees C) for 24 hours (n = 55 in the x

47 ment Scale (AIS) grades A-C, we induced cord hypothermia (33 degrees C) then rewarming (37 degrees C)

48 We combined hypothermia (33-35 degrees C for 1 h) with phenothiazine

49 C), normothermia (38.0 degrees C), and mild hypothermia (33.0 degrees C) on left ventricular contrac

50 370 donors who had been randomly assigned to hypothermia (34-35 degrees C) or normothermia (36.5-37.5

51 l model of acute ischemic stroke by inducing hypothermia, a condition shown by itself to reduce the t

52 In this trial, induced hypothermia added to standard care was not associated wi

53 nsplant, external defibrillation/therapeutic hypothermia, advances in surgical myectomy, and alcohol

54 mL at normothermia, and 41 +/- 3 mL at mild hypothermia; all p < 0.05).

55 enon combined with hypothermia compared with hypothermia alone resulted in less white matter damage a

56 triatum significantly (P < 0.01) faster than hypothermia alone, accompanied by more obvious (P < 0.01

57 matose survivors of OHCA, in comparison with hypothermia alone, inhaled xenon combined with hypotherm

58 h sexes consumed enough THC to trigger acute hypothermia, analgesic, and locomotor responses, and tha

59 itory stimuli in 94 comatose patients, under hypothermia and after re-warming to normal temperature.

60 tive agents offer promise when combined with hypothermia and are entering clinical trials.

61 ge cohort of patients undergoing therapeutic hypothermia and at investigating its added value on exis

62 urvival (>50%) of wild-type mice and reduced hypothermia and bacterial titers compared with vehicle-t

63 y tended to improve visceral organ function, hypothermia and combi treatment had no beneficial effect

64 rs improved the severity of shock, including hypothermia and decreased circulating IL-27p28.

65 Both hypothermia and drinking during stimulation occurred in

66 that FcER1 and mast cells were required for hypothermia and elevated serum mMCP-1.

67 The mechanisms involved in hypothermia and fever during systemic inflammation (SI)

68 specific WD-dependent disease factors (e.g., hypothermia and frequency of neutrophils in the blood) d

69 y phenotypes of hypothermia, suggesting that hypothermia and HSP90 inhibition may regulate these proc

70 sted the hypothesis whether mild therapeutic hypothermia and hyperoxia would attenuate postshock hype

71 -sensitive neurons in the MPA can coordinate hypothermia and hypometabolism in mice.

72 receptor subtypes, fully blocked CR-induced hypothermia and increased weight loss during CR independ

73 diated systemic anaphylaxis, as indicated by hypothermia and increases in plasma tryptase levels.

74 Tumors also attenuated sickness behaviors (hypothermia and lethargy) compared to LPS-treated contro

75 Anaphylaxis severity was evaluated based on hypothermia and mortality.

76 Depletion of neutrophils protected against hypothermia and mortality.

77 leads to exacerbation of LPS-induced septic hypothermia and neutrophil influx.

78 s were 33.0 degrees C and 36.8 degrees C for hypothermia and normothermia groups.

79 ased energy expenditure and are resistant to hypothermia and obesity.

80 rrent clinical practices such as therapeutic hypothermia and pharmacologically induced coma for many

81 Further, histamine-mediated hypothermia and regulation of endothelial tight junction

82 respiratory involvement, but accompanied by hypothermia and severe epileptic seizures preceding deat

83 evaluate the association between therapeutic hypothermia and survival after in-hospital cardiac arres

84 igh arctic muskoxen (Ovibos moschatus) adopt hypothermia and tested the hypothesis that individual pl

85 citrulline-NO pathway promotes CR-triggered hypothermia and that leucine enkephalin directly control

86 The duration of hypothermia and the warming temperature seem to be criti

87 al energy as heat to protect animals against hypothermia and to counteract metabolic disease.

88 -infected mice exhibited neurological signs, hypothermia, and behavioral alterations characteristic o

89 apitulated the cardiac rhythm abnormalities, hypothermia, and early death seen in RTT male mice.

90 KO mice showed improved survival, attenuated hypothermia, and less proinflammatory cytokine productio

91 bited strong CNS side effects, in catalepsy, hypothermia, and motor incoordination assays.

92 factors, including anesthesia, transfusions, hypothermia, and postoperative complications, as probabl

93 of cooling, target temperature, duration of hypothermia, and rewarming protocols were extracted.

94 ould exhibit a greater degree of spontaneous hypothermia, and thus require less active cooling to att

95 isk of bias randomized trials which compared hypothermia applied for at least 24 hours and convention

96 hether the beneficial effects of therapeutic hypothermia are due to preserved autophagy and mitophagy

97 Cooling and hypothermia are profoundly neuroprotective, mediated, at

98 Hypothermia as a first line measure to reduce intracrani

99 sing efforts have focused on pharmacological hypothermia as a treatment option for stroke.

100 ived in-hospital cardiac arrest, therapeutic hypothermia, as compared with therapeutic normothermia,

101 te macrophage colony-stimulating factor) and hypothermia at 18 hours.

102 in both groups received systemic therapeutic hypothermia at 32 degrees C to 34 degrees C for 24 hours

103 th nonshockable rhythm, moderate therapeutic hypothermia at 33 degrees C for 24 hours led to a higher

104 2014, and either treated or not treated with hypothermia at 355 US hospitals were identified.

105 ly reported that inhaled xenon combined with hypothermia attenuates brain white matter injury in coma

106 s significantly attenuated infection-induced hypothermia, augmented leukocyte recruitment and bacteri

107 h, in vivo T cell activation caused maternal hypothermia, bradycardia, systemic inflammation, cervica

108 Neuromuscular blockade alone does not cause hypothermia but allowed acute respiratory distress syndr

109 xytocin modestly reduced activity and caused hypothermia but only the latter was attenuated by the V(

110 sm and variable mA(3)AR efficacy, but strong hypothermia by 9 depended on A(1)AR, which reflects CNS

111 Importantly, a single 8 hour treatment of hypothermia by DHC after stroke provided long-term impro

112 Interestingly, hypothermia by DHC also significantly reduced secondary

113 we investigate the effects of TRPV1-mediated hypothermia by DHC on long-term ischemic stroke injury a

114 Hyperoxia and hypothermia can attenuate tissue hypoxia due to increase

115 In patients with traumatic brain injury, hypothermia can reduce intracranial hypertension.

116 and confounded by the choice of anesthesia, hypothermia, cardioplegia, and traumatic myocardial inju

117 mimetic activity, including antinociception, hypothermia, catalepsy, locomotor activity, and in the d

118 cardiac arrest, inhaled xenon combined with hypothermia compared with hypothermia alone resulted in

119 -hospital cardiac arrest, use of therapeutic hypothermia compared with usual care was associated with

120 lass of telomerase modulators in response to hypothermia conditions.

121 cal pancreatic hypothermia, without systemic hypothermia, could lessen the severity of AP induced by

122 rats with AP, transgastric local pancreatic hypothermia decreases pancreatic necrosis, apoptosis, in

123 sis that individual plasticity in the use of hypothermia depends on reproductive status.

124 (ip) were inactive or weak in inducing mouse hypothermia, despite mA(1)AR full agonism and variable m

125 Preventing hypothermia did not affect its sleep-inducing actions su

126 an preoptic area neurons produced a profound hypothermia due to cutaneous vasodilatation.

127 ptor ALK7 in BAT resulted in fasting-induced hypothermia due to exaggerated catabolic activity in bro

128 Tailoring hypothermia duration to ischemia duration may improve ou

129 armacological activation of IGF-1R prevented hypothermia during calorie restriction.

130 have suggested that induction of therapeutic hypothermia during cardiopulmonary resuscitation (CPR) m

131 patients were assigned to either therapeutic hypothermia during CPR (618 patients) or standard prehos

132 technique for induction of mild therapeutic hypothermia during CPR is a rapid infusion of large-volu

133 l 10.2% of patients allocated to therapeutic hypothermia during CPR were alive at hospital discharge

134 These results show that muskox females use hypothermia during periods of resource scarcity, but als

135 enced by patients undergoing controlled deep hypothermia during surgery.

136 the 13-lined ground squirrel, endure severe hypothermia during torpor followed by periodic rewarming

137 The hypothermia elicited by adenosine kinase inhibition (wit

138 In this randomized trial, mild therapeutic hypothermia failed to show a substantial beneficial effe

139 LPS induced hypothermia followed by fever in Wistar rats, whereas, i

140 REW, which is akin to the in vivo changes of hypothermia followed by REW observed during IBA.

141 g agents for patients undergoing therapeutic hypothermia following cardiac arrest.

142 ization in a 1:1 fashion to mild therapeutic hypothermia for 24 hours or control.

143 Hypothermia for 72 hours at 33.5 degrees C for neonatal

144 ising novel therapy, after the initiation of hypothermia for birth asphyxia would result in further i

145 suggest improved outcome by mild therapeutic hypothermia for cardiogenic shock after acute myocardial

146 t 47 encephalopathic babies recruited to the Hypothermia for Encephalopathy in Low and middle-income

147 ical trial to assess efficacy of therapeutic hypothermia for in-hospital cardiac arrest.

148 With the current practice of therapeutic hypothermia for neonatal encephalopathy, disability rate

149 near-term neonates who received therapeutic hypothermia for neonatal encephalopathy.

150 therapeutic approaches to induce therapeutic hypothermia for treating drug-resistant fever, and for i

151 occurred in 67 of 138 patients (49%) in the hypothermia group and in 56 of 130 (43%) in the control

152 ome did not differ significantly between the hypothermia group and the normothermia group (36% [48 of

153 val did not differ significantly between the hypothermia group and the normothermia group (49% [81 of

154 ays did not differ significantly between the hypothermia group and the normothermia group (81.3% and

155 pilepticus on the first day was lower in the hypothermia group than in the control group (11% vs. 22%

156 Adverse events were more frequent in the hypothermia group than in the control group.

157 a total of 29 of 284 patients (10.2%) in the hypothermia group were alive with a CPC score of 1 or 2,

158 y higher in patients in the mild therapeutic hypothermia group with a slower decline ( P for interact

159 of 364 neonates were randomly assigned to 4 hypothermia groups: 33.5 degrees C for 72 hours (n = 95)

160 d criteria donors who received targeted mild hypothermia had improved 1-year graft survival.

161 Therapeutic hypothermia has been used to attenuate the effects of tr

162 Recently, the neuroprotective therapy of hypothermia has emerged as the standard of care, and oth

163 Physical hypothermia has long been considered a promising neuropr

164 Therapeutic hypothermia (HT) is standard care for moderate and sever

165 Therapeutic hypothermia (HT) is standard care for term infants with

166 Therapeutic hypothermia (HT) to 33.0-34.0 degrees C for 72 h provide

167 Therapeutic hypothermia (HT), comprising the standard of care for in

168 otected NTHi-infected mice from weight loss, hypothermia, hypoxemia, and respiratory compromise.

169 rt conducting a randomized clinical trial of hypothermia in acute respiratory distress syndrome and t

170 t also induced transient and estrus-specific hypothermia in animals fed ad libitum.

171 In a recent trial, targeted mild hypothermia in brain-dead organ donors significantly red

172 Early therapeutic hypothermia in children with severe traumatic brain inju

173 the dorsomedial hypothalamus (DMH) promoted hypothermia in cold-exposed restrained rats, but attenua

174 We excluded trials investigating therapeutic hypothermia in indications already supported by internat

175 of performing a randomized clinical trial of hypothermia in patients with acute respiratory distress

176 the hemodynamic effects of mild therapeutic hypothermia in patients with cardiogenic shock complicat

177 r, the effectiveness of moderate therapeutic hypothermia in patients with nonshockable rhythms (asyst

178 cold-exposed restrained rats, but attenuated hypothermia in rats challenged with a high dose of bacte

179 Mild hypothermia in the donor safely reduced the rate of dela

180 ituted Sash) were given LPS to induce septic hypothermia in the presence or absence of indicated inhi

181 Titrated Hypothermia in the range 32-35 degrees C as the primary

182 exia, administration of APAP evoked a marked hypothermia in wildtype and Trpv1(-/-) mice, but only re

183 lls are indispensable for LPS-induced septic hypothermia, in which TNF-alpha plays an essential role

184 Complications of perioperative hypothermia include coagulopathy and increased transfusi

185 We discuss complications of hypothermia including shivering, electrolyte abnormaliti

186 o normothermia and from normothermia to mild hypothermia increased left ventricular contractility to

187 ted oral OVA challenge resulted in diarrhea, hypothermia, increased hematocrit, high OVA-specific ser

188 Therapeutic hypothermia induced a significant increase in autophagic

189 Surprisingly, our data show that hypothermia-inducing LepRb(POA) neurons are glutamatergi

190 Hypothermia initiated at 3.5 hours after stroke signific

191 nfants with hypoxic-ischemic encephalopathy, hypothermia initiated at 6 to 24 hours after birth compa

192 Hypothermia initiated at 6 to 24 hours after birth may h

193 To estimate the probability that hypothermia initiated at 6 to 24 hours after birth reduc

194 Hypothermia initiated at less than 6 hours after birth r

195 ncluding incidence of diarrhea, incidence of hypothermia, intestinal TH2 immune response, and serum O

196 Unintentional intraoperative hypothermia is a well-described risk factor for surgical

197 Early introduction of mild therapeutic hypothermia is an established treatment goal.

198 ndomized evidence indicates that therapeutic hypothermia is associated with higher mortality and no d

199 till might be a possibility that therapeutic hypothermia is beneficial in a specific setting, routine

200 trality (30 degrees C), a condition in which hypothermia is blunted.

201 Moderate therapeutic hypothermia is currently recommended to improve neurolog

202 These findings indicate that TRPV1-mediated hypothermia is effective in reducing both primary cortic

203 Peritoneal hypothermia is feasible and achieves rapid cooling with

204 The proposed mechanism for uridine-induced hypothermia is inhibition of adenosine transport by urid

205 Therapeutic hypothermia is likely a beneficial treatment following t

206 lipopolysaccharide-induced SI, an increased hypothermia is observed in neurogenic hypertension, whic

207 We conclude that, after TSCI, hypothermia is potentially beneficial by reducing cord i

208 Importance: Therapeutic hypothermia is used for patients following both out-of-h

209 We investigated the association between the hypothermia/ischemia ratio and functional outcome in a s

210 n models to estimate the association between hypothermia/ischemia ratio and the primary outcome, adju

211 We defined hypothermia/ischemia ratio as total targeted temperature

212 Although a larger hypothermia/ischemia ratio was associated with good func

213 citation Outcomes Consortium site, a greater hypothermia/ischemia ratio was associated with increased

214 However, the required degree of hypothermia, length of its use, and its timing are uncer

215 hypometabolism (lowered metabolic rate) and hypothermia (lowered body temperature) can be effective

216 2 cells, mast cells, and eosinophils, shock (hypothermia), mast cell degranulation (increased serum m

217 Prior studies suggest hypothermia may be beneficial in acute respiratory distr

218 Therapeutic hypothermia may increase survival with good neurologic o

219 appropriate included pre- and intraoperative hypothermia (median temperature <34 degrees C), acidosis

220 ion, which are all associated with increased hypothermia mediated by increased heat loss, but not by

221 ptogenetic excitation of WSNs triggers rapid hypothermia, mediated by reciprocal changes in heat prod

222 Febrile-range hyperthermia worsens and hypothermia mitigates lung injury, and temperature depen

223 re 34 degrees C), or "combi" (hyperoxia plus hypothermia) (n = 9 each).

224 the form of heat, thereby defending against hypothermia, obesity, and diabetes.

225 degrees C partially reverses the effects of hypothermia on monocyte function.

226 monstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms

227 We evaluated the effect of induced hypothermia on neurologic outcomes in patients with conv

228 The effect of hypothermia on signaling pathways initiated by cerulein

229 High-dose CP55,940 did not produce hypothermia or rimonabant-precipitated withdrawal in CB1

230 AMD, however, should be used with caution in hypothermia or the other scenarios that slow hERG channe

231 thermia via each AR, adenosine did not cause hypothermia (or bradycardia or hypotension) in QKO mice,

232 Total Body hypothermia plus Xenon (TOBY-Xe) was a proof-of-concept,

233 We have previously shown that hypothermia prolongs the proinflammatory response wherea

234 Patients allocated to therapeutic hypothermia received a mean (SD) of 1193 (647) mL cold s

235 Hypothermia reduces intracranial hypertension in patient

236 bability of reduced death or disability with hypothermia relative to the noncooled group (adjusted po

237 Hypothermia results initially from an internal redistrib

238 Deep hypothermia reversed most of these alterations probably

239 A brief exposure to deep hypothermia reversed the deterioration produced by PA in

240 I of the Anterior Insular Cortex, while deep hypothermia reversed this effect.

241 We thus urge caution when using hypothermia-rewarming therapeutically in TSCI.

242 Cord hypothermia-rewarming, applied to awake patients, did no

243 light on potential biological advantages of hypothermia risk reduction for endothermic animals and s

244 Hypothermia shows promise for stroke neuroprotection, bu

245 a" (standard resuscitation, but FIO2, 1.0), "hypothermia" (standard resuscitation, but core temperatu

246 symptomatic and/or lethal coinfections, and hypothermia strongly correlated with mortality.

247 pothermia alone, inhaled xenon combined with hypothermia suggested a less severe myocardial injury as

248 tes the quiescence and latency phenotypes of hypothermia, suggesting that hypothermia and HSP90 inhib

249 thermoregulatory site that worked as a fever-hypothermia switch.

250 C) and identified a novel mechanism by which hypothermia synchronises the circadian clock: cooling in

251 of age were randomly assigned to therapeutic hypothermia (target temperature, 33.0 degrees C) or ther

252 of age were randomly assigned to therapeutic hypothermia (target temperature, 33.0 degrees C) or ther

253 Therapeutic hypothermia (TH) at 33.5 degrees C for 72 h is the only

254 Treatment with therapeutic hypothermia (TH) improves the long-term neurodevelopment

255 ensive meta-analysis to quantify benefits of hypothermia therapy for traumatic brain injuries in adul

256 alth burden for millions of infants, despite hypothermia therapy.

257 The intervention group had therapeutic hypothermia to a temperature of 32-33 degrees C for 72 h

258 progression of auditory discrimination from hypothermia to normothermia has a high predictive value

259 Abrupt temperature shift from hypothermia to normothermia incurred on reperfusion of o

260 An increase in auditory discrimination from hypothermia to normothermia was observed for 33 out of 9

261 d on the change of decoding performance from hypothermia to normothermia.

262 eurological survival for the overall cohort (hypothermia-treated group, 17.0% [246 of 1443 patients];

263 ted group, 17.0% [246 of 1443 patients]; non-hypothermia-treated group, 20.5% [725 of 3529 patients];

264 were matched by propensity score to 3714 non-hypothermia-treated patients (mean [SD] age, 62.2 [17.5]

265 for 24 hours (n = 55 in the xenon group) or hypothermia treatment alone (n = 55 in the control group

266 degrees C) for 24 h (n = 55; xenon group) or hypothermia treatment alone (n = 55; control group).

267 Hypothermia treatment did not alter these relationships.

268 Prospective hypothermia treatment in eight acute respiratory distres

269 To our knowledge, hypothermia trials have not been performed in infants pr

270 out classic indications for mild therapeutic hypothermia underwent randomization in a 1:1 fashion to

271 al depletion of mitochondrial ROS results in hypothermia upon cold exposure, and inhibits UCP1-depend

272 ardiac arrest, induction of mild therapeutic hypothermia using a rapid infusion of large-volume, intr

273 The hypothermia usually abates within 4 h but is sometimes l

274 ac power index at 24 hours (mild therapeutic hypothermia versus control: 0.41 [interquartile range, 0

275 While adenosine agonists cause profound hypothermia via each AR, adenosine did not cause hypothe

276 Hypothermia was abolished in mice pre-treated with resin

277 Therapeutic hypothermia was also associated with lower rates of favo

278 Mild hypothermia was associated with a nonsignificant improve

279 Therapeutic hypothermia was associated with an increase in mortality

280 Mild hypothermia was associated with higher 1-year graft surv

281 After adjustment, therapeutic hypothermia was associated with lower in-hospital surviv

282 st, adenosine 5'-monophosphate (AMP)-induced hypothermia was attenuated in QKO mice, demonstrating ro

283 rge electrolytic DMH lesions on cold-induced hypothermia was due to suppressed thermogenesis.

284 The lacking efficacy of hypothermia was most likely due to more pronounced barri

285 Hypothermia was the most common contributory cause of pr

286 Because LPS causes both fever and hypothermia, we originally thought that the DMH containe

287 intra-arterial verapamil and intra-arterial hypothermia were also assessed in combination with reper

288 ormothermic, those who underwent therapeutic hypothermia were associated with 18% reduction in mortal

289 ds: Neonates with HIE undergoing therapeutic hypothermia were enrolled.

290 continuously, and 4 possible definitions of hypothermia were explored, including temperature nadir,

291 tion sites showed that sites associated with hypothermia were more anteroventral than those associate

292 , and lead to more severe LPS-induced septic hypothermia when reconstituted into mast cell-deficient

293 halamic preoptic area reduced the CR-induced hypothermia, whereas chemogenetic activation of prodynor

294 g from hyperthermia to normothermia and mild hypothermia, whereas left ventricular contractility incr

295 and ultrarapid method to induce and maintain hypothermia, which appears feasible in cardiac arrest pa

296 By combining hypothermia with phenothiazines, we significantly enhanc

297 encephalopathy treated with mild therapeutic hypothermia within 24 hours after cardiac arrest.

298 n Wistar rats, whereas, in SHR, a maintained hypothermia without fever were observed.

299 We investigated whether local pancreatic hypothermia, without systemic hypothermia, could lessen

300 setting, routine application of therapeutic hypothermia would better be avoided outside the settings