ライフサイエンスコーパス: hypothermic

1 DKO were extremely cold-sensitive and became hypothermic.

2 lobal Et2 knockout mice were also profoundly hypothermic.

3 malnourished, underweight, hypoglycemic, and hypothermic.

4 rapeutic agents have been studied under both hypothermic (1-8 degrees C) and normothermic settings.

5 ological deficit scores were observed in the hypothermic-2 hours animals.

6 ized into 4 groups (n=6 each): normothermic, hypothermic-2 hours, hypothermic-5 hours, and hypothermi

7 Mild hypothermic (30 degrees C) culture of zygotes after micr

8 al severity score, were randomized to either hypothermic (32-34 degrees C) or normothermic (37-39 deg

9 =6 each): normothermic, hypothermic-2 hours, hypothermic-5 hours, and hypothermic-8 hours.

10 ypothermic-2 hours, hypothermic-5 hours, and hypothermic-8 hours.

11 A total of 192 patients (103 hypothermic, 89 nonhypothermic) were studied.

12 RPM8 channels (by cold) are required for the hypothermic action of M8-B.

13 anesthetics, questioning to what extent the hypothermic action of THC is specific (i.e., mediated vi

14 axis, inhibition of both the production and hypothermic action of TNF-alpha, and suppression of infl

15 or phenotype, delta1 or delta2, mediates the hypothermic actions of delta agonists.

16 That PAF possesses hypothermic activity and mediates LPS-induced hypothermi

17 examined the mechanisms responsible for the hypothermic activity of APAP.

18 The hypothermic activity was independent of TRPV1 since APAP

19 ts had reduced energy expenditure and became hypothermic after fasting or cold stress.

20 ust before rewarming commenced (hypotensive, hypothermic), after rewarming (hypotensive, normothermic

21 eceptor agonists and to exhibit CB1-mediated hypothermic and analgesic effects.

22 Experiment 2 compared ethanol's initial hypothermic and delayed hyperthermic effect across age b

23 to defend their body temperature and enter a hypothermic and hypometabolic state known as torpor.

24 chanisms and circuitry that regulate extreme hypothermic and hypometabolic states, and enables geneti

25 ys an important role in the induction of the hypothermic and hypometabolic torpid state in hibernatin

26 cating that GLP-1R activation contributes to hypothermic and hypophagic effects of hindbrain CART, wh

27 t a mean (SD) of 16 (5) and 15 (5) hours for hypothermic and noncooled groups, respectively.

28 Hypothermic and noncooled infants were term (mean [SD],

29 Sedative medications in both hypothermic and nonhypothermic patients may confound the

30 ery bypass grafting (CABG) (n = 6; low SOE), hypothermic and normothermic CABG (n = 3; moderate to lo

31 Mini-Mental State Examination scores in the hypothermic and normothermic groups were 27.4 +/- 3.8 an

32 rence in the incidence of impairment between hypothermic and normothermic groups.

33 aim of this study was to evaluate sequential hypothermic and normothermic machine perfusion (NMP) as

34 Hypothermic and normothermic oxygenated machine perfusio

35 ad good discrimination for mortality in both hypothermic and normothermic patients.

36 The combined use of ex vivo hypothermic and normothermic perfusion may be a useful s

37 In both settings, hypothermic and normothermic techniques are in clinical

38 ic genetic ablation of HDAC3 become severely hypothermic and succumb to acute cold exposure.

39 It possesses analgesic, hypothermic, and antipsychotic-like properties.

40 A subpopulation of diabetic NOD mice became hypothermic, and tau hyperphosphorylation further extend

41 A subgroup of hypothermic animals (n = 12) were returned to normotherm

42 survive the reperfusion period, whereas all hypothermic animals and 11 of 12 of the hypothermic anim

43 all hypothermic animals and 11 of 12 of the hypothermic animals that were returned to normothermic c

44 Hypothermic animals were kept under these temperature co

45 hibition of PI3/Akt enlarged infarct size in hypothermic animals.

46 hermic ex vivo kidney perfusion (NEVKP) with hypothermic anoxic machine perfusion (HAMP) and static c

47 rol of 5-HT2AR, but its acute hypolocomotor, hypothermic, anxiogenic, and antinociceptive effects are

48 y lower serum levels of mMCP-1 and were less hypothermic at 30-minute post-challenge compared to unin

49 Of 38,520 patients, 1,921 (5.0%) were hypothermic at admission.

50 Both the hypothermic (at 20 degrees C) and febrile (at 30 degrees

51 After the hypothermic bout, all animals showed a massive increase

52 perature), preproghrelin knockout mice enter hypothermic bouts associated with reduced sleep, culmina

53 laboratory studies identifying mechanisms of hypothermic brain protection are reviewed.

54 ent increases tissue oxygenation during deep hypothermic bypass and after circulatory arrest.

55 ukocyte/endothelial cell interactions during hypothermic bypass are mild with both alpha-stat and pH-

56 egarding the optimal pH strategy during deep hypothermic bypass in children.

57 ystolic and diastolic function after 3 hr of hypothermic cardioplegic arrest (114+/-4 mm Hg vs. 83+/-

58 ere quantified before, during and after deep hypothermic cardiopulmonary bypass (CPB) in nine neonate

59 r in animals treated with epinephrine during hypothermic cardiopulmonary resuscitation when compared

60 t when it is administered during therapeutic hypothermic cardiopulmonary resuscitation.

61 -0.61%]), and highest with on-pump CABG with hypothermic circulatory arrest (5.3% [95% CI, 2.0%-11%])

62 ry following cardiopulmonary bypass and deep hypothermic circulatory arrest (CPB/DHCA) in a pediatric

63 strategies to minimize the duration of deep hypothermic circulatory arrest (DHCA) and efforts to ame

64 Wistar rats (n = 24) underwent CPB with deep hypothermic circulatory arrest (DHCA) and were divided i

65 r, aortic arch repair, requiring either deep hypothermic circulatory arrest (DHCA) or antegrade cereb

66 nfant cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest (DHCA) to investigate pos

67 lie SCP strategies as an alternative to deep hypothermic circulatory arrest (DHCA).

68 cerebral perfusion (ACP) compared with deep hypothermic circulatory arrest (DHCA).

69 7 involving cardiopulmonary bypass with deep hypothermic circulatory arrest (DHCA).

70 tory arrest (MHCA; n = 61) plus SACP vs deep hypothermic circulatory arrest (DHCA; n = 53) in childre

71 CU stay (P=0.08), and cumulative duration of hypothermic circulatory arrest (HCA) (P=0.09) approached

72 Hypothermic circulatory arrest (HCA) provides neuroprote

73 a cerebral metabolic deficit observed after hypothermic circulatory arrest (HCA).

74 ent coarctation surgery with the use of deep hypothermic circulatory arrest (HCA).

75 retrospective analysis, we compared moderate hypothermic circulatory arrest (MHCA; n = 61) plus SACP

76 No evidence exists that profound hypothermic circulatory arrest (PHCA) improves survival

77 male) underwent thoracic aortic surgery with hypothermic circulatory arrest between 2002 and 2017 in

78 nary bypass to 18 degrees C followed by deep hypothermic circulatory arrest for 120 mins.

79 rdiopulmonary bypass before instituting deep hypothermic circulatory arrest for 45 minutes.

80 grade cerebral perfusion (RCP) with profound hypothermic circulatory arrest has been subject to much

81 he advent of cardiopulmonary bypass and deep hypothermic circulatory arrest have allowed the open rep

82 between regional cerebral perfusion and deep hypothermic circulatory arrest on 1-year outcomes; no di

83 ds of replacing the aortic arch without deep hypothermic circulatory arrest or even cardiopulmonary b

84 The use of RCP with profound hypothermic circulatory arrest was associated with a red

85 levels after cardiopulmonary bypass and deep hypothermic circulatory arrest with calpain inhibition w

86 t, on-pump with arrested heart, on-pump with hypothermic circulatory arrest).

87 hophysiologic process in a rat model of deep hypothermic circulatory arrest, and that intestinal inju

88 en employing cardiopulmonary bypass and deep hypothermic circulatory arrest, is associated with syste

89 0 mins after cardiopulmonary bypass and deep hypothermic circulatory arrest, p = .05).

90 stinal mast cells as central players in deep hypothermic circulatory arrest-associated responses, and

91 rrier function were preserved following deep hypothermic circulatory arrest.

92 een low-flow cardiopulmonary bypass and deep hypothermic circulatory arrest.

93 outcomes after thoracic aortic surgery with hypothermic circulatory arrest.

94 Previously, PtK1 cells in hypothermic conditions (23 degrees C) were shown to have

95 reperfusion (Normothermic), or given 1 h of hypothermic conditions (28 degrees C) either during the

96 was induced by cell stress under hypoxic or hypothermic conditions and prevented by specific removal

97 in which primary human HSPCs cultured under hypothermic conditions are maintained in a quiescent sta

98 ption factors Fos and pCREB under normal and hypothermic conditions in this neonatal model of focal i

99 fferences in simple behaviors or growth, all hypothermic conditions significantly reduced mortality r

100 samples undergoing open chest surgery under hypothermic conditions when compared to the warm.

101 on of NMP, comparison of subnormothermic and hypothermic conditions, the different logistical approac

102 e prevented and/or more easily treated under hypothermic conditions.

103 ed pressures and under both normothermic and hypothermic conditions.

104 orneal endothelial cells can be preserved in hypothermic conditions.

105 o ischemia-reperfusion under normothermic or hypothermic conditions.

106 e recovery after myocardial infarction under hypothermic conditions.

107 s that functional HCEnCs can be preserved in hypothermic conditions.

108 In this study, we used hypothermic continuous machine perfusion preservation to

109 iopulmonary resuscitation when compared with hypothermic controls.

110 tween both variables is observed during deep hypothermic CPB in all subjects.

111 significantly decreased CBF and CMRO2 during hypothermic CPB.

112 3-30 min following injection with a maximal hypothermic effect of -1.3 degrees C.

113 ure studies on the clinical potential of the hypothermic effect.

114 WT mice, tolerance developed to CB1-mediated hypothermic effects of CP55,940 earlier than to antiallo

115 her wild-type or FAAH(-/-) mice enhanced the hypothermic effects of exogenous anandamide, a response

116 completely abolished the sleep-promoting and hypothermic effects of glycine.

117 pinephrine; hypothermic placebo control; and hypothermic epinephrine.

118 Three groups (n=6) were studied: hypothermic EPR (H-EPR; 0 degrees C flush; target temper

119 Hypothermic ex situ perfusion (HESP) systems are used to

120 Hypothermic ex situ perfusion with an oxygenated acellul

121 The hypothermic group was exposed to 10 degrees C during 30

122 96-hr cerebral performance categories of the hypothermic group were significantly lower than control

123 For patients in the hypothermic group, 54.5% were impaired on at least one t

124 CCL2, and interleukin-10 compared with the "hypothermic" group when controlling for cohort and timin

125 n the normothermic groups compared with both hypothermic groups (p < .01).

126 Animals in the hypothermic groups received rapid cooling, which was sta

127 mperature was significantly decreased in the hypothermic groups.

128 (Cu+) pups, copper-deficient (Cu-) pups were hypothermic, had lower brain copper levels and markedly

129 ly shorter, less branched, and less spiny in hypothermic hamsters compared with active animals.

130 These results suggest that 24-hour hypothermic HMP may help preservation of hepatocyte func

131 Following 24-hour hypothermic HMP with University of Wisconsin (UW) soluti

132 Hypothermic hyperkalemic cardioplegia results in signifi

133 roreflex control of RSNA could contribute to hypothermic hypotension and may primarily reflect an eff

134 nt hypothermia within 60 min and exhibited a hypothermic induction profile analogous to 3-iodothyrona

135 The primary outcome occurred in 19 of 78 hypothermic infants (24.4%) and 22 of 79 noncooled infan

136 Eighty-three hypothermic infants were maintained at 33.5 degrees C (a

137 ellular ice formation and to protect against hypothermic injury.

138 chemia and orthotopic liver transplantation (hypothermic ischemia).

139 Hypothermic kidney storage causes preservation injury an

140 Hypothermic machine organ perfusion (HMP) offers opportu

141 occurring within the preserved kidney during hypothermic machine perfusion (HMP) are not well charact

142 Supplemental oxygenation of the standard hypothermic machine perfusion (HMP) circuit has the pote

143 vestigate whether supplemental oxygen during hypothermic machine perfusion (HMP) could improve the ou

144 Clinical trial data suggest that continuous hypothermic machine perfusion (HMP) during the entire pr

145 Hypothermic machine perfusion (HMP) for preservation led

146 Hypothermic machine perfusion (HMP) has become standard

147 Dynamic preservation of organ grafts by hypothermic machine perfusion (HMP) has regained broader

148 The mechanism through which oxygenated hypothermic machine perfusion (HMP) improves viability o

149 There is increasing support for the use of hypothermic machine perfusion (HMP) in an attempt to red

150 regarding the outcomes of kidneys undergoing hypothermic machine perfusion (HMP) in patients in the U

151 Hypothermic machine perfusion (HMP) is in its infancy in

152 sate partial pressure of oxygen (PO2) during hypothermic machine perfusion (HMP) is unknown.

153 Although hypothermic machine perfusion (HMP) preservation has bee

154 start time of oxygenation during continuous hypothermic machine perfusion (HMP).

155 cine kidneys with a heparin conjugate during hypothermic machine perfusion (HMP).

156 assigned using permuted blocks to oxygenated hypothermic machine perfusion (HMPO(2)), the other to HM

157 Hypothermic machine perfusion (MP) has the potential to

158 Hypothermic machine perfusion (MP) preservation is used

159 PNF and DGF in 335 DCD kidneys preserved by hypothermic machine perfusion at our center between 1 Ja

160 to determine whether a novel, oxygenated and hypothermic machine perfusion device (HMP Airdrive syste

161 Hypothermic machine perfusion is systematically used.

162 sure renovascular circulating volumes during hypothermic machine perfusion of donor kidneys.

163 analyses of Randomized Controlled Trials for hypothermic machine perfusion of kidneys.

164 UW solution used with continuous hypothermic machine perfusion preservation can rescue ca

165 Hypothermic machine perfusion preservation has the poten

166 Hypothermic machine perfusion pretreatment facilitated d

167 Three livers were perfused with hypothermic machine perfusion, 1 full liver graft underw

168 nation, procurement biopsy and assessment on hypothermic machine perfusion, a significant number of p

169 nt 0, 30, or 60 min of warm ischemia, before hypothermic machine perfusion.

170 ing specialized pressurized chambers; during hypothermic machine perfusion; with the addition of oxyg

171 jected to 60 min of warm ischemia before the hypothermic machine preservation during 22 hr.

172 uring in situ preservation (ISP) rather than hypothermic machine preservation.

173 eath renal grafts compared with conventional hypothermic methods.

174 n proposed as a resuscitative measure during hypothermic models of preservation, the aim of this stud

175 of this study was to evaluate the effects of hypothermic MP with an acellular perfusate in human uppe

176 "normothermic" (n = 54 C1; n = 31 C2), and "hypothermic" (n = 29 C1; n = 20 C2).

177 2%); "normothermic" (n = 4,067; 32.8%); and "hypothermic" (n = 3,614; 29.1%).

178 therapeutic levels within 3 h and augmented hypothermic neuroprotection.

179 d storage with subsequent HOPE treatment and hypothermic nitrogenated perfusion, where oxygen was rep

180 uld buy time for transport and repair during hypothermic no flow followed by resuscitation, or it cou

181 e IRI have mainly focused on ways to improve hypothermic organ preservation and reduce the nephrotoxi

182 to the endothelium of corneal grafts during hypothermic organ preservation.

183 tocellular carcinoma (HCC), with and without hypothermic oxygenated liver perfusion (HOPE) before tra

184 Although (dual) hypothermic oxygenated machine perfusion ([D]HOPE) resus

185 Experimental studies have shown that dual hypothermic oxygenated machine perfusion (DHOPE) is asso

186 sessment has long been considered a limit of hypothermic oxygenated machine perfusion (HOPE).

187 Although hypothermic oxygenated machine perfusion performed using

188 We aimed to determine whether hypothermic oxygenated machine perfusion would improve o

189 We have used hypothermic oxygenated perfusion (HOPE) for donation aft

190 Hypothermic oxygenated perfusion (HOPE) has been shown t

191 Hypothermic oxygenated perfusion (HOPE) was designed to

192 A novel perfusion approach, hypothermic oxygenated perfusion (HOPE), used for DCD li

193 s pretreated with the new machine perfusion "Hypothermic Oxygenated PErfusion" (HOPE) in an attempt t

194 s a durable measure in both normothermic and hypothermic patient groups.

195 Base deficit in hypothermic patients did not discriminate between patien

196 Hypothermic patients did not have an increased incidence

197 Compared with the nonhypothermic patients, hypothermic patients had higher 28-day (50.0% vs 24.9%,

198 These data suggest that hypothermic patients should be warmed to febrile range t

199 otropic drugs are frequently administered in hypothermic patients to support an assumed inadequate ci

200 Hypothermic patients were 3 times more likely than normo

201 For hypothermic patients, 16.8% were impaired from their Com

202 eas TP hearts received three cycles of 2 min hypothermic perfusion (26 degrees C) interspersed by 3 m

203 Other hearts received a single 6 min hypothermic perfusion (SHP) before ischaemia.

204 preconditioning (TP), induced by short-term hypothermic perfusion and rewarming, may protect hearts

205 Oxygenated hypothermic perfusion enables the evaluation of kidneys

206 support the use of active oxygenation during hypothermic perfusion of kidneys from donors with intact

207 s, long cold ischemia time (CIT) and/or poor hypothermic perfusion parameters.

208 The inclusion of liver hypothermic perfusion permits safe TVE.

209 elin (ET), is significantly increased during hypothermic perfusion preservation (HPP) of kidneys subj

210 findings suggest that full portability in a hypothermic perfusion preservation device seems feasible

211 hosphate (ATP) resynthesis during oxygenated hypothermic perfusion was compared to evaluate the "ex v

212 ation by 32% when measured at the end of the hypothermic period.

213 With arterial hypotension, postarrest, hypothermic piglets had a significant decrease in the pe

214 c placebo control; normothermic epinephrine; hypothermic placebo control; and hypothermic epinephrine

215 resections performed using standard TVE with hypothermic portal perfusion and venovenous bypass betwe

216 Liver resection using standard TVE with hypothermic portal perfusion and venovenous bypass is as

217 n of molecular tools to study the effects of hypothermic preservation and reperfusion and to screen n

218 The allografts were subjected to 4-hr hypothermic preservation and transplanted to the fully m

219 Standard hypothermic preservation at +4 degrees C (refs.

220 times longer by supercooling as compared to hypothermic preservation at +4 degrees C.

221 ules and in a canine autotransplant model of hypothermic preservation injury.

222 metabolism in a large animal model of renal hypothermic preservation injury.

223 Supplementing the kidney with oxygen during hypothermic preservation is not common practice.

224 A period of NMP after hypothermic preservation is the most commonly used strat

225 Both methods of hypothermic preservation of kidneys currently used clini

226 in its minimally altered state by combining hypothermic preservation with targeted strategies that c

227 In the second model (hypothermic preservation), IPC was not protective.

228 EPR uses a cold aortic flush to induce deep hypothermic preservation, followed by resuscitation with

229 After 24-hour hypothermic preservation, HMP livers showed lower releas

230 ts on renal graft function are described for hypothermic preservation.

231 eness of static cold storage in ice (CS) and hypothermic pulsatile machine perfusion (MP) as methods

232 All kidneys underwent continuous hypothermic pulsatile machine perfusion until transplant

233 we studied donated human kidneys undergoing hypothermic pulsatile perfusion deemed unsuitable for tr

234 During hypothermic pulsatile perfusion preservation (HPPP), oxy

235 hine-perfused using the Newcastle continuous-hypothermic pulsatile preservation system before transpl

236 Hypothermic rats had lower serum potassium and higher bl

237 Hypothermic rats showed improved neurologic recovery at

238 Hypothermic rats were rewarmed gradually over 1 hr.

239 ncture, we observed that mice became rapidly hypothermic reaching a threshold temperature of 28 degre

240 tire preservation period or only for 2 hr of hypothermic reconditioning (HR) subsequent to convention

241 e machine perfusion after cold storage (CS) (hypothermic reconditioning) has been proposed as a conve

242 injections of NT69L resulted in a diminished hypothermic response and a diminished anticataleptic eff

243 d in early adulthood displayed an attenuated hypothermic response following the second LPS treatment

244 Stimulation produced a strong hypothermic response in 62% (13/21) of mice (core temper

245 This partial attenuation of the hemorrhagic hypothermic response indicates that an intact POAH is ne

246 Supracollicular decerebration eliminated the hypothermic response observed in intact rats to hindbrai

247 r preproghrelin gene product, attenuates the hypothermic response of preproghrelin knockout mice.

248 The hypothermic response of the f/f rats was markedly prolon

249 h2 knockin mice, indicating that the blunted hypothermic response relates directly to the low 5-HT(Ex

250 is were uninvolved in the attenuation of the hypothermic response to a high, shock-inducing dose of L

251 This study evaluated whether the hypothermic response to bacterial lipopolysaccharide (LP

252 ential active metabolites that modulated the hypothermic response to CR.

253 , the COX-1 inhibitor resulted in a profound hypothermic response to LPS and blocked LPS-induced Fos-

254 The prolonged hypothermic response to LPS in the f/f rats was accompan

255 tassium (GIRK) channels, we investigated the hypothermic response to several of these agents on Girk2

256 mg/kg, sc), a delta antagonist, blocked the hypothermic response to SNC-80 (35 mg/kg, im).

257 The hypothermic response to TNF-alpha (80 microg/kg iv) was

258 LPS-induced hypothermic response, infiltration of inflammatory cells

259 lated in an attempt to alter the hemorrhagic hypothermic response.

260 els also are involved in the alcohol-induced hypothermic response.

261 AH significantly exacerbated the hemorrhagic hypothermic response.

262 Hypothermic responses of rodents to the peripheral or in

263 tures, cocaine induced both hyperthermic and hypothermic responses.

264 Here we determined whether the new hypothermic resuscitation and preservation solution Hypo

265 onary bypass (CP/CPB) subjects myocardium to hypothermic reversible ischemic injury that can impair c

266 onary bypass with heat exchanger or a single hypothermic saline flush into the aorta, which proved su

267 cking this transporter are protected against hypothermic sepsis and bacteremia developing as a result

268 Finally, the deep hypothermic shock might represent a valuable therapeutic

269 Some mammals can enter a severe hypothermic state during hibernation in which metabolic

270 othermic mammals initiate and regulate these hypothermic states remains largely unknown.

271 Prolonged hypothermic storage causes ischemia-reperfusion injury (

272 Prolonged hypothermic storage elicits severe ischemia-reperfusion

273 During hypothermic storage in standard preservation solution, C

274 Hypothermic storage preservation causes disruption of ke

275 tabilize membranes and cells in vitro during hypothermic storage, probably by interacting with the pl

276 and enhances graft survival after prolonged hypothermic storage.

277 y allograft injury associated with prolonged hypothermic storage.

278 ing temperature and develops only under mild hypothermic stress (e.g., room temperature) but not at t

279 The hypothermic subjects were the oldest and had the most co

280 Monocyte incubation at hypothermic temperatures (34 degrees C) reduced HLA-DR s

281 uction of transplantation and routine use of hypothermic temperatures for kidney preservation, there

282 ma of body temperature (that is, became less hypothermic), than did animals with fewer social partner

283 on of A1ARs to be used in the induction of a hypothermic, therapeutically beneficial state in humans.

284 s with asphyxial encephalopathy who received hypothermic therapy had improved neurologic outcomes at

285 Whether hypothermic therapy improves neurodevelopmental outcomes

286 iation, hyperbaric oxygen therapy, hyper- or hypothermic therapy, and photodynamic therapy.

287 ent temperatures and food restriction induce hypothermic (torpor) bouts and characteristic metabolic

288 These findings demonstrate that a deeply hypothermic, torpor-like state can be pharmacologically

289 R agonist N6-cyclohexyladenosine to induce a hypothermic, torpor-like state in the (nonhibernating) r

290 Our goal was to decipher the effect of hypothermic total liquid ventilation on the systemic and

291 rker of brain injury, were reduced by 69% in hypothermic treated animals.

292 this study is to assess if a deep and short-hypothermic treatment can ameliorate this damage in a mo

293 bjecting the human muscle fiber fragments to hypothermic treatment successfully enriches the cultures

294 omes were observed in children who underwent hypothermic treatment with a 66% increase in mortality (

295 oduced by the asphyxia that was prevented by hypothermic treatment.

296 ntly, unwarmed anaesthetised patients become hypothermic, typically by 1-2 degrees C.

297 Contusion volume was larger in hypothermic vs. normothermic rats (44.3 +/- 4.2 vs. 28.6

298 were increased at the end of hypothermia in hypothermic (vs. normothermic) rats (p <.05), indicating

299 serum fentanyl concentrations were higher in hypothermic (vs. normothermic) rats at the end of both h

300 n addition, Lmx1b(f/f/p) mice rapidly became hypothermic when exposed to an ambient temperature of 4