ライフサイエンスコーパス: hypoxic condition

1 reducing the expression of FAK and PKC under hypoxic condition.

2 pathway was activated in myeloma cells under hypoxic condition.

3 epatoma cell increased gene expression under hypoxic condition.

4 ngly, loss of PQM-1 increases survival under hypoxic conditions.

5 Deceased donor kidneys are preserved in cold hypoxic conditions.

6 iple negative breast cancer cells only under hypoxic conditions.

7 mucosa permeability and in inflammatory and hypoxic conditions.

8 me activation and curtailed thrombosis under hypoxic conditions.

9 ced by EndMT-promoting, proinflammatory, and hypoxic conditions.

10 myocytes and skeletal muscle in ischemic and hypoxic conditions.

11 highest growth performance when subjected to hypoxic conditions.

12 proliferation of host progenitor cells under hypoxic conditions.

13 trated to be repressed and less efficient in hypoxic conditions.

14 alnexin prevents fission and mitophagy under hypoxic conditions.

15 ell as sickling of SCD erythroid cells under hypoxic conditions.

16 tection of (19)F signal in cells grown under hypoxic conditions.

17 umulation of lipid inclusions in response to hypoxic conditions.

18 d transcriptional activity under normoxic or hypoxic conditions.

19 itize them to drugs that are activated under hypoxic conditions.

20 causing increased O2 release from heme under hypoxic conditions.

21 molecule's cytotoxicity in both normoxic and hypoxic conditions.

22 wth, and development under both normoxic and hypoxic conditions.

23 drial fission and subsequent mitophagy under hypoxic conditions.

24 tosis, which abrogated BCSC enrichment under hypoxic conditions.

25 ng that they retain high activity even under hypoxic conditions.

26 unction of EM CD4(+) T cells in normoxic and hypoxic conditions.

27 2-aminoimidazoles through bioreduction under hypoxic conditions.

28 to be biologically relevant, particularly in hypoxic conditions.

29 ronal stem cells to keep proliferating under hypoxic conditions.

30 fected glucose uptake and bone resorption in hypoxic conditions.

31 n by IL-10-deficient Th1 cells stimulated in hypoxic conditions.

32 hole-body plethysmography under normoxic and hypoxic conditions.

33 newborn rat preparations under normoxic and hypoxic conditions.

34 ifferent breast cancer cell lines exposed to hypoxic conditions.

35 X, contributes to cancer cell survival under hypoxic conditions.

36 acid and cholesterol metabolism genes under hypoxic conditions.

37 ecific signaling pathways under normoxic and hypoxic conditions.

38 rticles for monitoring lactate levels during hypoxic conditions.

39 endothelial cells cultured under normoxic or hypoxic conditions.

40 nfection and downregulated during anemia and hypoxic conditions.

41 rete proregenerative exosomes in response to hypoxic conditions.

42 reby stabilizing HIF under both normoxic and hypoxic conditions.

43 ytic metabolic switch and was enhanced under hypoxic conditions.

44 uman placenta and cultured under standard or hypoxic conditions.

45 regulate an enhanced sensory response under hypoxic conditions.

46 some cell types continue to replicate under hypoxic conditions.

47 ) in live mammalian cells under normoxic and hypoxic conditions.

48 e efficiently than other phytoplankton under hypoxic conditions.

49 veal altered miRNA maturation in cells under hypoxic conditions.

50 model system of mammalian cell growth under hypoxic conditions.

51 maintenance of cell-cycle progression under hypoxic conditions.

52 unction, was significantly upregulated under hypoxic conditions.

53 sponses and rescued functional parameters in hypoxic conditions.

54 gnaling and cell fate decisions triggered by hypoxic conditions.

55 on of the EGFR HRE prevented induction under hypoxic conditions.

56 -1alpha does not activate this program under hypoxic conditions.

57 in vitro migration, and tumorigenicity under hypoxic conditions.

58 it promotes increased HIF degradation under hypoxic conditions.

59 a potential application of the biosensor in hypoxic conditions.

60 mide mustard, is preferentially activated in hypoxic conditions.

61 lator of ECM remodeling by fibroblasts under hypoxic conditions.

62 for inhibiting cardiomyocyte apoptosis under hypoxic conditions.

63 skeletal muscle homeostasis under otherwise hypoxic conditions.

64 feeding with special formula and exposure to hypoxic conditions.

65 role in mediating the effects of IL-11 under hypoxic conditions.

66 production of IL-11 in cells cultured under hypoxic conditions.

67 al changes of microencapsulated islets under hypoxic conditions.

68 oting and sustaining protein synthesis under hypoxic conditions.

69 l progenitors, released erythropoietin under hypoxic conditions.

70 ne-induced replication stress is enhanced in hypoxic conditions.

71 atigue after inspiratory loading under acute hypoxic conditions.

72 tabolic dysfunction in adipose tissues under hypoxic conditions.

73 lets and adenomas cultured under normoxic or hypoxic conditions.

74 ss roots of chickpea seedlings in aerated or hypoxic conditions.

75 n of several genes and a growth defect under hypoxic conditions.

76 duced by anticancer drugs or radiation under hypoxic conditions.

77 ve resting skeletal muscle homeostasis under hypoxic conditions.

78 e degradation of aromatic hydrocarbons under hypoxic conditions.

79 afforded the heart by Txnip deficiency under hypoxic conditions.

80 or cap-dependent translation of IGFBP3 under hypoxic conditions.

81 f hepatocellular carcinoma (HCC) cells under hypoxic conditions.

82 rine-acting factors primarily released under hypoxic conditions.

83 sustains mitochondrial ATP production under hypoxic conditions.

84 nd various processes by which cells adapt to hypoxic conditions.

85 fectively reduced the level of Su-OCT4 under hypoxic conditions.

86 photobleaching-based dosimetry failed under hypoxic conditions.

87 human HCC cell lines (Huh7 and Hep3B) under hypoxic conditions.

88 F-1alpha protein which occurs normally under hypoxic conditions.

89 n diaphragm fatigability persist under acute hypoxic conditions.

90 to promote the survival of the species under hypoxic conditions.

91 Importantly, IFN secretion was reduced under hypoxic conditions.

92 ry cycle, including active expiration, under hypoxic conditions.

93 PDT outcomes should be achievable even under hypoxic conditions.

94 atory cytokine levels in the organoids under hypoxic conditions.

95 atial distributions or temporal evolution of hypoxic conditions.

96 is rendered transcriptionally inactive under hypoxic conditions.

97 y influence radioresponse specifically under hypoxic conditions.

98 type I IFN pathway were downregulated under hypoxic conditions.

99 se (ERK), and some cells were cultured under hypoxic conditions.

100 ic flux, and cytotoxicity under normoxic and hypoxic conditions.

101 t transform into an invasive phenotype under hypoxic conditions.

102 t includes a period of differentiation under hypoxic conditions.

103 ues during late gestation in both normal and hypoxic conditions.

104 on was increased in response to TNFalpha and hypoxic conditions.

105 ulosis meets its nutrient requirements under hypoxic conditions.

106 as a switch to augment Notch signaling under hypoxic conditions.

107 t cellular functions under both normoxic and hypoxic conditions.

108 MTX release, and cellular MTX delivery under hypoxic conditions.

109 ncrease in bone resorption that occurs under hypoxic conditions.

110 NLRX1 significantly reduced apoptosis under hypoxic conditions.

111 er, neurological deficits are abundant under hypoxic conditions.

112 esting that the pathogen requires Msh1 under hypoxic conditions.

113 eterminant of acute thrombotic events during hypoxic conditions.

114 l epithelium under normal, inflammatory, and hypoxic conditions.

115 ith NFKB2 expression and its induction under hypoxic conditions.

116 g high levels of ROS under both normoxic and hypoxic conditions.

117 dren were not reparative unless subjected to hypoxic conditions.

118 he important oxidoreductases expressed under hypoxic conditions.

119 tive oxygen species (ROS) and sickling under hypoxic conditions.

120 ell as the improved anticancer effects under hypoxic conditions.

121 al but more pronounced differentiation under hypoxic conditions.

122 es and U251 cells under normal and stressed (hypoxic) conditions.

123 was stimulated by acute neuronal injury and hypoxic conditioning.

124 n normoxia (21% O(2)) but also remarkably in hypoxic conditions (1% O(2)).

125 In this study, under hypoxic conditions (1% O2), we examined the effect of PE

126 hypertrophy response under both normoxic and hypoxic conditions (26% lower than control surgery, p <

127 ve effect did occur on embryo survival under hypoxic conditions (3.0 mg L(-1)).

128 Under hypoxic conditions, a decrease in the IC50 of MTX and MT

129 the auxin efflux carrier PIN2 is reduced at hypoxic conditions, a response that is suppressed by RAP

130 e by dietary intervention under normoxic and hypoxic conditions; a moderate dose of nitrate administe

131 This temperature rise resulted in hypoxic conditions across the entire Baltic sea as revea

132 We hypothesized that MM-associated hypoxic conditions activate EMT-related proteins and pro

133 th low light fluence under both normoxic and hypoxic conditions, after activation by intracellular GS

134 rotected Salmonella grown under normoxic and hypoxic conditions against the bacteriostatic activity o

135 in both ALCL and NSCLC, we found that under hypoxic conditions, ALK directly regulated the abundance

136 Here, we demonstrate that hypoxic conditions alone enhance permeability and giant

137 Extreme hypoxic conditions along the coast, leading to what are

138 gene expression of which is increased under hypoxic conditions, also increased the Pck anaplerotic a

139 e survival of hepatocyte cell lines grown in hypoxic conditions, an effect that is overcome by preind

140 hat are known ERBB2 targets, suggesting that hypoxic conditions and ERBB2 overexpression share both p

141 s in neuroblastoma cells was increased under hypoxic conditions and following hypoxia-inducible facto

142 embrane enzyme, mediates cell survival under hypoxic conditions and is overexpressed in solid maligna

143 ible factor (HIF), which is stabilized under hypoxic conditions and mediates IEC homeostatic response

144 individuals appear to be less able to resist hypoxic conditions and this is the size range that is th

145 observed when ARPE-19 cells are grown under hypoxic conditions and when pre-treated with lutein prio

146 that C. elegans requires RQ for survival in hypoxic conditions and, finally, we establish a high thr

147 n E7-mediated G1 checkpoint abrogation under hypoxic condition, and the function could possibly be in

148 from pyruvate to acetate is activated under hypoxic conditions, and ACS recovers carbon that would o

149 mammary epithelial cells under normoxic and hypoxic conditions, and applying in silico mathematical

150 s site was required for adaptation of Mtb to hypoxic conditions, and growth on solid media.

151 increasing sRBC occlusion under normoxic and hypoxic conditions, and increasing sRBC adhesion in our

152 lls move through capillaries under transient hypoxic conditions, and offer novel possibilities for de

153 PK pathway, impairs cellular migration under hypoxic conditions, and regulates a set of genes related

154 ced by EndMT-promoting, proinflammatory, and hypoxic conditions, and supports the acquirement of a me

155 SRC, glycolytic reserve was not tapped under hypoxic conditions, and, under hypoxia, glucose metaboli

156 ncluding cell proliferation, viability under hypoxic condition, anti-apoptotic properties, resistance

157 In contrast, under a hypoxic condition, AR could increase miR-185-5p expressi

158 mechanisms of fungal growth in these in vivo hypoxic conditions are poorly understood.

159 Although hypoxic conditions are present in IPF, hypoxia's role as

160 lop embedded in a low-oxygen niche, and that hypoxic conditions are required to regulate the producti

161 Here we show that hypoxic conditions, as are often found in subregions of

162 The hypoxic conditions at high altitudes present a challenge

163 Instead, we show that in hypoxic conditions ATMIN expression is repressed.

164 es in normoxic tissues but is retained under hypoxic conditions because of reduction and binding to m

165 n enhanced cell-killing effect is seen under hypoxic conditions both in vitro and in vivo.

166 Under hypoxic conditions, both cell types exhibited upregulati

167 n of MTA1, HSP90 and HIF1alpha complex under hypoxic condition but not under normoxic condition.

168 ased by RA synovial fibroblasts (RASF) under hypoxic conditions but not under normoxia or TNF-alpha t

169 d to drive HIF1-depedent tumorigenesis under hypoxic conditions, but also has HIF-independent activit

170 Under hypoxic conditions, but in the presence of normal convec

171 ized HIF-1alpha protein in both normoxic and hypoxic conditions by blocking its proteasomal degradati

172 operties, may protect the fetal growth under hypoxic conditions by improving uteroplacental perfusion

173 ls and tissues; it inhibited autophagy under hypoxic conditions by suppressing the conversion of LC3I

174 excessive accumulation of unfolded proteins, hypoxic conditions, calcium imbalance, and other stress

175 In this study, we show that hypoxic conditions cause the primary root to grow sidewi

176 Under hypoxic conditioning, CD8(+) T(C)2 cell differentiation

177 Under hypoxic conditions, cellular damage (lactate dehydrogena

178 indicate a diminished level of DNA damage at hypoxic conditions compared with those at normal conditi

179 Parallel experiments using cells grown under hypoxic conditions confirmed that a compromised ETC and

180 F-1alpha protein levels in both normoxic and hypoxic conditions, consistent with a role for MKK1 and

181 Only under hypoxic conditions could luciferase activity be detected

182 lls significantly reduced pHi in cells under hypoxic conditions, decreased gemcitabine-induced glycol

183 Hypoxic conditions, defined as dissolved oxygen (DO) con

184 h of cells cultured under chemically induced hypoxic conditions, displaying a specific activity again

185 s to altered cellular metabolic pathways and hypoxic conditions during fetal development; this stress

186 ustain high levels of aerobic activity under hypoxic conditions (e.g., birds that fly at high altitud

187 formation and activity under both basal and hypoxic conditions, emphasising the importance of glycol

188 se findings indicate that ANDV infection and hypoxic conditions enhance mTOR signaling responses, res

189 ificantly higher levels of association under hypoxic conditions for 2-nitroimidazole-containing BB2r-

190 to expose cells to either static or cycling hypoxic conditions for eight different time periods ther

191 Moreover, under hypoxic conditions found in the tumour microenvironment,

192 However, both under normoxic and hypoxic conditions, glucose was critical for EM CD4(+) T

193 We found that hypoxic conditions had strong negative effects on extent

194 Hypoxic conditions have been widely used as an in vitro

195 Hypoxic conditions have profound effects on the differen

196 In severely hypoxic condition, HIF-1alpha-mediated induction of Pdk1

197 Under hypoxic conditions, HIF-1alpha levels are greatly increa

198 As under hypoxic conditions hypoxia-inducible factor-1alpha (HIF-

199 We observed that under hypoxic conditions, IDH1-mutant cells exhibited increase

200 Our results indicate that under hypoxic conditions, immune response genes are differenti

201 Submersion and hypoxic conditions impede AhR-dependent Ccno induction.

202 ability is drastically affected in PC, under hypoxic condition in a hypoxia inducible factor 1alpha (

203 we found OPN expression to be upregulated by hypoxic condition in PC-3 prostate tumor cells.

204 nd increase survival of melanoma cells under hypoxic condition in vivo.

205 Neat1 is also up-regulated under hypoxic conditions in a HIF-2alpha-dependent manner, med

206 that inhibits proangiogenic signaling under hypoxic conditions in breast cancer cells.

207 n was decreased by histone acetylation under hypoxic conditions in cancer cells.

208 TG7 and impairs viability of HCC cells under hypoxic conditions in culture and in mice.

209 n ganglioside metabolism, is activated under hypoxic conditions in cultured skeletal muscle cells (C2

210 king in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells.

211 rategy was evaluated under both normoxic and hypoxic conditions in normal tissues as well as in a mur

212 K promoter constructs were then tested under hypoxic conditions in PC-12 cells, where NFkappaB is not

213 rate of oxygen (CMRO(2)) under normoxic and hypoxic conditions in rats.

214 Hypoxic conditions in the cornea affect epithelial funct

215 ajor roles of physiological and pathological hypoxic conditions in the maintenance of intestinal home

216 n measurements showed no oxygen depletion or hypoxic conditions in the microwell.

217 hether training or sleeping under normobaric hypoxic conditions in the weeks before the ascent would

218 ebral cortical neurons previously exposed to hypoxic conditions in vitro or experimental cerebral isc

219 ion endometrial stromal cells are exposed to hypoxic conditions in vitro, we observed a striking enha

220 d not improve EDL muscle contractility under hypoxic conditions in vitro.

221 Hypoxic conditions increased expression of genes previou

222 Under hypoxic conditions, increases in H3K9me3 occur in an oxy

223 to these MCT-disrupted cells in normoxic and hypoxic conditions induced a rapid drop in cellular ATP-

224 Here, we investigated how hypoxic conditions influence human T cell functions and

225 Moreover, under hypoxic conditions, inhibition of prolyl hydroxylase sig

226 esting that primary root growth direction at hypoxic conditions is antagonistically regulated by hypo

227 sex similarities are maintained under acute hypoxic conditions is unknown.

228 sponse of eukaryotic microbes to low-oxygen (hypoxic) conditions is strongly regulated at the level o

229 SCD pathology is erythrocyte sickling under hypoxic conditions, leading to vaso-occlusion and hemoly

230 Loss of KDM4A in hypoxic conditions leads to a decreased HIF-1alpha media

231 Under hypoxic conditions (<1% O(2)), the relationship between

232 s the R1-p53R2 enzyme for DNA replication in hypoxic conditions, mitochondrial DNA synthesis, and in

233 tivated in the presence of human PTECs under hypoxic conditions (modeling the fibrotic microenvironme

234 cidally, may be capable of suicidal and - in hypoxic conditions - nonsuicidal operation.

235 Hypoxic conditioning of NK cells may thus benefit their

236 The widespread hypoxic conditions of the tumor microenvironment can imp

237 of FDG uptake by any cell (upregulated under hypoxic conditions or other microenvironmental factors),

238 Under hypoxic conditions, overexpression of SUMO1gg (the activ

239 Under hypoxic conditions, PDAC cells had increased levels of H

240 erbate the intracellular acidity produced by hypoxic conditions, perhaps compromising cell growth and

241 The apparent establishment of stable hypoxic conditions prior to AD 1900 highlights the chall

242 In the presence of functional p53, hypoxic conditions promote apoptosis; however, the p53-d

243 itioning of ASCs using ascorbic acid (AA) or hypoxic conditions provided additional benefit.

244 ndingly, of internalized radioactivity under hypoxic conditions relative to 34.8%, 35.3%, 33.2%, and

245 In certain hypoxic conditions, replication stress occurs in the abs

246 e upregulation of HIF1alpha and HIF2alpha in hypoxic conditions required ALK activity and its downstr

247 transfer of T(C)2 cells differentiated under hypoxic conditioning restored lung allergic responses in

248 t exposure of ANDV-infected MECs and LECs to hypoxic conditions resulted in a 3- to 6-fold increase i

249 nally, applying CPOs against cancer cells in hypoxic conditions resulted in the dose dependent releas

250 ANDV infection in combination with hypoxic conditions resulted in the enhancement of hypoxi

251 agricultural soils especially when flooding (hypoxic conditions) results from over irrigation or freq

252 rofile and genomewide binding of EglN2 under hypoxic conditions reveal nuclear respiratory factor 1 (

253 Under normoxic or hypoxic conditions, SAD inhibited cell survival through

254 Organoids cultured under this hypoxic condition showed increased permeability, pro-inf

255 wever, GAD67-EGFP knock-in mice reared under hypoxic conditions showed no changes in total number of

256 associated with hypertension in humans under hypoxic conditions, shows a previously undocumented role

257 Under hypoxic conditions, stabilized hypoxia-inducible factor

258 cting the mouse to alternating hyperoxic and hypoxic conditions, strong and weak functional connectiv

259 und that miR-630, which is upregulated under hypoxic conditions, targets and downregulates Dicer expr

260 of endothelial cells more efficiently under hypoxic conditions than normoxic conditions.

261 s) are highly migratory predators adapted to hypoxic conditions that may be deleterious to their comp

262 d that in the presence of LPS or exposure to hypoxic conditions the cells produce higher C3 mRNA as w

263 In addition to measurements in hypoxic conditions, the detection limit of this biosenso

264 In hypoxic conditions, the HIF activation regulates the exp

265 Under hypoxic conditions, the HIF1alpha subunit accumulates be

266 Under hypoxic conditions, the trophoblast-like cell line JAR s

267 Here we demonstrate that under hypoxic conditions, the ubiquitin ligase Siah (seven in

268 Here, we identify, under hypoxic and non-hypoxic conditions, the unique spectroscopic trajectorie

269 veloping oocytes through vitellogenins under hypoxic conditions, thereby increasing survival rates of

270 Under hypoxic conditions, these processes are suppressed, enab

271 Sox9 allows the survival of OC cells upon hypoxic condition, through the activation of betaIII-tub

272 reatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone d

273 We used an in vitro assay under hypoxic condition to observe an increase of protein expr

274 We created short-term and long-term hypoxic conditions to simulate normal and retarded trans

275 fter 72 h of incubation in both normoxic and hypoxic conditions, unlike sulfonamide CA inhibitors tha

276 Under hypoxic conditions, upregulation of EMP2 promoted vascul

277 CA IX and XII was tested under normoxic and hypoxic conditions, using 2D and 3D in vitro cellular mo

278 on several meningioma cell lines cultured in hypoxic conditions validated the association of CA9 and

279 Estuarine hypoxic conditions varied spatially and temporally and w

280 old higher hydroxyl radicals than TiO2 under hypoxic conditions via N3-facilitated electron-hole redu

281 vidence that HIF1alpha can be degraded under hypoxic conditions via the 26 S proteasome and that MDM2

282 S100P elevation under hypoxic conditions was abrogated by silencing of Cav1 or

283 nary artery endothelial cell migration under hypoxic conditions was also reduced by pretreatment with

284 d 5-fluorouracil on cell proliferation under hypoxic conditions was demonstrated.

285 PA-824, active against M. tuberculosis under hypoxic conditions, was also evaluated.

286 ors that control VEGF mRNA translation under hypoxic conditions we established an in vitro translatio

287 nd because apoptosis is greatly increased in hypoxic conditions, we decided to investigate whether th

288 A549 LUAD cell lines cultured in normoxic or hypoxic conditions, we identified a subset of lncRNAs th

289 ine model of fetal development under chronic hypoxic conditions, we identify iFHRV in isolated fetal

290 Proinflammatory M1-polarizing stimuli and hypoxic conditions were responsible for enhanced NFAT5 e

291 tion, cell lines cultured under normoxic and hypoxic conditions were used.

292 a positive inotrope, especially under acidic/hypoxic conditions, whereas cTnI facilitates faster rela

293 ripotent state of animal stem cells requires hypoxic conditions, whereas higher oxygen tension promot

294 of CDCP1 impairs cancer cell migration under hypoxic conditions, whereas overexpression of HIF-2alpha

295 e glucose transporters SGLT1 and SGLT2 under hypoxic conditions which implies a possible correlation

296 We demonstrate that under hypoxic conditions, which induce p53 activity, the negat

297 oglobin-O(2) binding affinity of sea bass in hypoxic conditions with ambient (~650 muatm) or raised C

298 ve also been shown to be highly active under hypoxic conditions, with the activities of some complexe

299 Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM).

300 tic stem cell (HSC) pool is maintained under hypoxic conditions within the bone marrow microenvironme