ライフサイエンスコーパス: hypoxic response

1 nt mechanism to control the magnitude of the hypoxic response.

2 le progression, signal transduction, and the hypoxic response.

3 levels in vitro and in vivo, to inhibit the hypoxic response.

4 rtant addition to models of the invertebrate hypoxic response.

5 at these signaling cascades may modulate the hypoxic response.

6 t transactivation, associated with a blunted hypoxic response.

7 d certain metabolites, that can modulate the hypoxic response.

8 se in VEGF expression at senescence is not a hypoxic response.

9 HIF, the master transcription factor for the hypoxic response.

10 1alpha (HIF1alpha), the key molecule in the hypoxic response.

11 iptional regulators of genes involved in the hypoxic response.

12 ace each other in a feedback loop during the hypoxic response.

13 rhabditis elegans and, thus, differ from the hypoxic response.

14 a role in facilitating and/or sustaining the hypoxic response.

15 d greater than those produced by the natural hypoxic response.

16 is a global transcriptional regulator of the hypoxic response.

17 Oligomycin (2 microg) abolished the hypoxic response.

18 s with a means to identify regulators of the hypoxic response.

19 or deletion of the HIF-1 site eliminated the hypoxic response.

20 gene expression, cell survival and promoting hypoxic response.

21 and their potential roles in regulating the hypoxic response.

22 a inhibits BK/Kv to initiate or maintain the hypoxic response.

23 of HIF1A, a master transcription factor for hypoxic response.

24 closely related isoforms in fine-tuning the hypoxic response.

25 for O(2)-dependent protein stability and the hypoxic response.

26 criptional activators mediating the metazoan hypoxic response.

27 ork that functions to fine-tune the cellular hypoxic response.

28 velopment of a chemical understanding of the hypoxic response.

29 m-selective fashion and without triggering a hypoxic response.

30 oduce additional layers of complexity to the hypoxic response.

31 ndrial loss through oxo-nitrative stress and hypoxic response.

32 may partly explain the heterogeneity in the hypoxic response.

33 CSM, opiorphins are master regulators of the hypoxic response.

34 mportant role in cellular oxygen sensing and hypoxic response.

35 factors (HIFs), the master regulators of the hypoxic response.

36 ent therapeutic strategies aim to target the hypoxic response.

37 nflammatory responses, matrix metabolism and hypoxic responses.

38 five ERFVII factors play roles in regulating hypoxic responses.

39 tes transcription from the vegf locus during hypoxic responses.

40 a role in the species-related differences in hypoxic responses.

41 heart tube or following induction of ectopic hypoxic responses.

42 nine methyltransferases may be important for hypoxic responses.

43 xic responses (20% increase) to pathological hypoxic responses (-14% decrease, P < 0.05).

44 Subsequently, we measured hypoxic responses after combined alpha- and beta-adrener

45 hat BETi dually targets angiogenesis and the hypoxic response, an effective combination at reducing t

46 ins may participate in signaling cascades of hypoxic response and angiogenesis.

47 m network of EPAS1, elucidating its roles in hypoxic response and angiogenesis.

48 s for its biological roles, including in the hypoxic response and ASPP family function.

49 uppressed induction of many marker genes for hypoxic response and constitutive activation of others.

50 for virulence and was sufficient to induce a hypoxic response and death in the absence of bacteria.

51 We report that ATE1 centrally controls the hypoxic response and glycolysis in mammalian cells by pr

52 have important implications for the role of hypoxic response and HIF-1alpha in development, and in c

53 standing both the molecular mechanism of the hypoxic response and human adaptation to high altitude.

54 hypoxia, with hyperglycaemia suppressing the hypoxic response and hypoglycaemia stimulating it.

55 Hypoxic response and inflammation both involve the actio

56 ulated glucose metabolism, consistent with a hypoxic response and iron deprivation.

57 To identify genes regulated by the hypoxic response and not other effects of chronic anemia

58 sm, the production of neurotransmitters, the hypoxic response and the biosynthesis of secondary metab

59 ed us to examine the interaction between the hypoxic response and the circadian clock in vivo.

60 ll molecules, DNA and RNA demethylation, the hypoxic response and the formation of collagen.

61 an clarify a possible connection between the hypoxic response and the stability of in-vitro preparati

62 mediators of gene networks implicated in the hypoxic response and the switch to glycolysis that occur

63 py of the VHL gene leads to up-regulation of hypoxic response and tumor formation within central nerv

64 aptation, and cis-regulatory elements during hypoxic response and UV protection.

65 including dysregulation of genes involved in hypoxic responses and angiogenesis.

66 e metabolic changes consistent with enhanced hypoxic responses and increased glycolysis.

67 on with hydroxyurea in SCD is independent of hypoxic responses and that genetic variation at SNP rs60

68 natural product biosynthesis, the mammalian hypoxic response, and DNA repair.

69 nases, including those involved in the human hypoxic response, and highlight the power of serial femt

70 hromatin modifications, DNA methylation, the hypoxic response, and immunity.

71 o growth and angiogenesis), immune function, hypoxic response, and oxidative modification of extracel

72 oteins involved in cellular energy pathways, hypoxic response, and RA signaling.

73 at low oxygen plays an important role in the hypoxic response, and the model indicates that the Ofd1

74 esistance to oxidative stress, regulation of hypoxic responses, and apoptosis.

75 Critical mediators of the hypoxic response are the hypoxia-inducible factors HIF-1

76 Thus, hypoxic responses are important for the establishment of

77 Hypoxic responses are largely mediated by the transcript

78 Many hypoxic responses are mediated by hypoxia-inducible fact

79 In diverse types of organisms, cellular hypoxic responses are mediated by prolyl 4-hydroxylases

80 ed during hypoxia, their individual roles in hypoxic responses are still poorly understood.

81 ional activity of HIFs-and consequently, the hypoxic response-are regulated by post-translational mod

82 These findings define VHL-1 and the hypoxic response as an alternative longevity and protein

83 ession of components of the VEGF pathway and hypoxic responses as predictive markers for radiographic

84 onse element, GTAC, is required also for the hypoxic response, as is a trans-acting locus, CRR1.

85 , reaffirming the importance of CRR1 for the hypoxic response, but indicating also the contribution o

86 The A2R antagonist, CSC, inhibited the KDR hypoxic response by 42% +/- 7.8% (P = 0.008) at 10 micro

87 r studies that nitric oxide may regulate the hypoxic response by direct reaction with the HIF hydroxy

88 of G9a is a crucial factor in mediating the hypoxic response by down-regulating the expression of sp

89 BMAL1 modulates the circadian hypoxic response by enhancing the transcriptional activi

90 iquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degrada

91 uncovered that KLF6 govern inflammatory and hypoxic response by regulating HIF1alpha expression in m

92 The induction of a hypoxic response by VACV is reminiscent of the biochemic

93 tion of a key transcription factor mediating hypoxic responses by blocking the binding of HDACs.

94 In ISL1+ CPCs, induction of hypoxic responses caused CHD by repressing Isl1 and acti

95 Hypoxic responses (delta VE/delta SaO2) were significant

96 eract to regulate and fine tune the cellular hypoxic response depending on the period and length of h

97 stress and potent induction of the cellular hypoxic response, despite normoxic conditions.

98 The role of the hypoxic response during metastasis was analysed in migra

99 lved in regulatory networks and the Enduring Hypoxic Response (EHR), hold promise for developing new

100 n of an abasic site at a key base within the hypoxic response element (HRE) of the vascular endotheli

101 Caco2 cells stably expressing a hypoxic response element (HRE)-driven luciferase promote

102 riptional complex forming on the VEGF gene's hypoxic response element and that the presence of Ref-1/

103 ucleotide-specific base modifications in the hypoxic response element of the VEGF gene in lung vascul

104 AP1 DNA recognition sequences present in the hypoxic response element of the VEGF gene.

105 Il22 promoter contains a putative conserved hypoxic response element suggesting that the transcripti

106 Overexpression of catalase abolishes hypoxic response element-luciferase expression during hy

107 on a 64-mer sequence encompassing a minimal hypoxic response element.

108 se reporter construct under the control of a hypoxic response element.

109 factor-1 (HIF1), the master regulator of the hypoxic response, enhances tumorigenesis and influences

110 that rapidly and efficiently attenuates the hypoxic response, even at modest CITED2 concentrations.

111 HIF1alpha, which in addition to its roles in hypoxic responses exerts an independent effect on radior

112 tabilization of a high level of the critical hypoxic response factor and pro-survival protein HIF-1al

113 receptor nuclear translocator (ARNT) and the hypoxic response factor HIF-1alpha.

114 bsence of treatment and instead implicates a hypoxic response following the surgical biopsy.

115 the two copies of this motif upstream of the hypoxic response gene alpha-crystallin.

116 hage functions by promoting inflammatory and hypoxic response gene programming.

117 enes that shape biofilm architecture and the hypoxic response genes required for growth in the low-ox

118 crease dramatically, and mRNA encoding other hypoxic response genes, such as those encoding hypoxia-i

119 of a transcriptional program that mimics the hypoxic response have been documented in cultured cells

120 Exposure of HCAECs to 1% O(2) resulted in a hypoxic response (HIF-1alpha stabilization), dysfunction

121 ty of transcriptional regulators involved in hypoxic response (Hif1a) and emergency granulopoiesis (C

122 We also evaluate two markers of a brain hypoxic response (hif1alpha, hsf) to determine whether s

123 f the major transcriptional regulator of the hypoxic response, HIF1alpha, is modulated by the interpl

124 lates the master transcription factor of the hypoxic response, hypoxia-inducible factor-alpha (HIF-al

125 One of the key mediators of the hypoxic response in animal cells is the hypoxia-inducibl

126 The hypoxic response in animals is mediated via the transcri

127 droxylases that act as oxygen sensors in the hypoxic response in animals.

128 We found that loss of the hypoxic response in astrocytes does not cause anemia in

129 ction is a virtually constant feature of the hypoxic response in both normal and transformed cells, r

130 The hypoxic response in cells and tissues is mediated by the

131 chondrial complex II substrate, restored the hypoxic response in cybrid cells, suggesting that electr

132 uncovered the molecular underpinnings of the hypoxic response in ECs; however, there is a need for co

133 and nuclear import adaptor Nro1 regulate the hypoxic response in fission yeast by controlling activit

134 irect measure of oxygen supply and mediate a hypoxic response in fission yeast.

135 The hypoxic response in humans is regulated by the hypoxia-i

136 example of this is the relationship between hypoxic response in individual tissues, and the effect t

137 The chief mediator of hypoxic response in mammalian tissues is the transcripti

138 ctor 1 (HIF-1) is a central regulator of the hypoxic response in many cell types.

139 ble transcription factors (HIFs) mediate the hypoxic response in metazoans.

140 that Giardia induces a transient epithelial hypoxic response in normoxic conditions, revealing a hit

141 ndicate that MUC1 acts as a modulator of the hypoxic response in pancreatic cancer cells by regulatin

142 lly, discovery of a shared activation of the hypoxic response in pheochromocytomas with mutations in

143 that a regulatory protein that controls the hypoxic response in S. cerevisiae controls filamentous g

144 We postulated that the hypoxic response in sickle cell disease (SCD) contribute

145 genic specificity to the PGC-1alpha-mediated hypoxic response in skeletal muscle cells.

146 lism (glycolysis and respiration) are a core hypoxic response in some, but not all, fungal species.

147 ns of HO-2, including its involvement in the hypoxic response in the carotid body, which involves int

148 e-activated K(+) channel, is involved in the hypoxic response in the carotid body.

149 Many cell types undergo a hypoxic response in the presence of low oxygen, which ca

150 Spaceflight exposure appears to effect a hypoxic response in the roots of agar-grown plants that

151 eduction of lung metastases by dampening the hypoxic response in tumor cells.

152 echanism that is critical for regulating the hypoxic response in tumors.

153 to a more comprehensive understanding of the hypoxic response in vertebrates.

154 NOX1-derived ROS also influenced hypoxic response in vivo because Nox1-deficient undiffer

155 To study the role of the transcriptional hypoxic response in vivo we have targeted the murine HIF

156 se findings reveal a second type of tracheal hypoxic response in which Sima activation conflicts with

157 Hypoxic responses in plants involve Plant Cysteine Oxida

158 ophagitis (EoE), contributing to maladaptive hypoxic responses in the esophageal epithelium.

159 us research efforts, the role of Plk3 in the hypoxic response induced by hypoxia or nickel is not com

160 HIF1a stabilization can overcome the blunted hypoxic response induced by insulin resistance.

161 our studies revealed that the photoreceptor hypoxic response initiates and drives type 3 neovascular

162 CSN activities during normoxia and kept the hypoxic responses intact.

163 zheimer patients differentially affected the hypoxic response, involving the generation of AICD.

164 The hypoxic response is an ancient stress response triggered

165 The hypoxic response is controlled by a family of hypoxia-in

166 The need for hypoxic response is likely due to interrupted wound vasc

167 The hypoxic response is manifested in many pathophysiologica

168 The hypoxic response is mediated by the alpha-subunit of the

169 The finding that the metazoan hypoxic response is regulated by oxygen-dependent posttr

170 An important component of the hypoxic response is the activation of the hypoxia-induci

171 A critical issue in understanding the hypoxic response is the identification of hypoxia-regula

172 key question surrounding HIF-1alpha and the hypoxic response is the role of this transcription facto

173 One well-characterized component of the hypoxic response is transcriptional activation of genes

174 est that Hph, in addition to its function in hypoxic response, is a regulator of cellular growth and

175 restored" hypoxic response, like the control hypoxic response, is inhibited by the adenosine A(1) rec

176 or 1-alpha (HIF-1alpha), a key player in the hypoxic response, is kept under stringent regulation.

177 with AXL reduces HIF-1a levels altering the hypoxic response leading to a reduction of hypoxia-induc

178 In conclusion, up-regulation of the hypoxic response leads to decreased expression of hepcid

179 This "restored" hypoxic response, like the control hypoxic response, is

180 n important physiological contributor to the hypoxic response, linking it to innate immunity and infl

181 evealed a direct interconnection between the hypoxic response, lipid catabolism, lipid anabolism and

182 tely balanced interplay between the cellular hypoxic response, mediated by hypoxia-inducible factor-1

183 nd 8-phenyltheophylline, did not inhibit the hypoxic response of KDR mRNA at A1R inhibitory concentra

184 The hypoxic response of respiratory neurones within the pre-

185 gainst Pur alpha also revealed a loss in the hypoxic response of the beta(2) integrin promoters.

186 HAF, thus, switches the hypoxic response of the cancer cell from HIF-1alpha-depe

187 two regulatory functions contributes to the hypoxic response of the cell.

188 hmic slice' is a good model for studying the hypoxic response of the respiratory network under in vit

189 he receptor is dispensable for the classical hypoxic response of transcriptional upregulation and sec

190 (HIF)-1alpha is an important mediator of the hypoxic response of tumor cells and controls the up-regu

191 important role for mir-210 in regulating the hypoxic response of tumor cells and tumor growth.

192 for miR-4521 in regulating GC metastasis and hypoxic response of tumor cells as well as the therapeut

193 Understanding the spatially heterogeneous hypoxic response of tumors is critical.

194 ic deletion of Cox4i2 mimicked the defective hypoxic responses of Epas1-null mice.

195 The Siah E3 ubiquitin ligases regulate the hypoxic response pathway by modulating the turnover of t

196 xygen concentration, and drugs targeting the hypoxic response pathway modulate this response in vitro

197 racts with HIF1beta, and attenuates the HIF1 hypoxic response pathway.

198 ment of new agents targeting portions of the hypoxic response pathway.

199 ed as direct oxygen sensors in the mammalian hypoxic response pathway.

200 results have uncovered a previously unknown hypoxic-response pathway that may be conserved throughou

201 d vessels, leading to the activation of both hypoxic response pathways and oxidative stress pathways

202 ortantly, expression of GPD1L attenuates the hypoxic response, preventing complete HIF-1alpha inducti

203 identify regulatory elements involved in the hypoxic response, promoter regions of the mouse Flt-1 an

204 ding the evolutionary pressure to develop a 'hypoxic response' provides a framework to investigate th

205 ion of DNA repair is an integral part of the hypoxic response, providing molecular insights into the

206 iofilm master regulators Efg1 and Ndt80, and hypoxic response regulator Upc2.

207 mutant of dosR, which encodes the immediate hypoxic response regulator, failed to adapt to low-oxyge

208 ar mechanisms by which SUMOylation regulates hypoxic responses remain unclear.

209 We found that acute hypoxic response results in increased lung metastatic tu

210 ulmonary thromboembolism, or (3) upregulated hypoxic responses secondary to anemia, low O2 saturation

211 ha (HIF-1alpha) is the main regulator of the hypoxic response, the upstream mechanisms required for i

212 at independent of its function in regulating hypoxic response, the VHL gene plays a critical role in

213 but additional nutrient signals may tune the hypoxic response through control of unassembled Rps23 or

214 chanism that serves to maintain the cellular hypoxic response through HIF-alpha- and microRNA-depende

215 P1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stabili

216 Our findings link the innate immune hypoxic response to tumor progression through induction

217 actase persistence, to skin pigmentation, to hypoxic response, to arsenic tolerance.

218 biquitin ligase associated with the cellular hypoxic response, to be the ubiquitin E3 ligase that med

219 moting ubiquitination and degradation of the hypoxic response transcription factor HIF-1.

220 e investigated the need for a highly related hypoxic response transcription factor, HIF-2alpha.

221 ces pombe regulate lipid homeostasis and the hypoxic response under conditions of low sterol or oxyge

222 ucible factors (HIFs) activity and trigger a hypoxic response under normoxic conditions, such as iron

223 itor that stabilizes HIF-alpha and elicits a hypoxic response via a different mechanism, that is the

224 idence from these experiments indicates that hypoxic response via HIF-1alpha is an important positive

225 We show here how hypoxic response via the HIF transcription factors in on

226 During anemia, the hypoxic response via the transcription factor hypoxia-in

227 The hypoxic response was abolished while the response to U46

228 The hypoxic response was associated with reduced mitochondri

229 lated in pancreatic cancer cells even though hypoxic response was decreased in them.

230 More importantly, hypoxic response was improved by preconditioning islets

231 The hypoxic response was investigated by exposing normal (no

232 ioid system is involved in the regulation of hypoxic responses, we asked whether there are difference

233 Various degree reductions of the hypoxic response were also reported in studies which inv

234 Time-dependent hypoxic responses were assessed in the phrenic neurogram

235 In 5-d-old pups, early VE hypoxic responses were enhanced, and late VE were simila

236 These observations suggest that the hypoxic responses were selectively augmented in mutant m

237 n respiratory variables (baseline, hyperoxic/hypoxic responses) were not severely influenced by EMG+

238 essary for the yeast to quickly turn off its hypoxic response when oxygen is restored.

239 the epithelial-to-mesenchymal transition and hypoxic response, whereas down-regulation of the CPEB2A

240 period of depression and suppressed during a hypoxic response which we refer to as central apnoea.

241 e the HIF transcription factor, and induce a hypoxic response, which can be beneficial to treat anemi

242 role G9a plays as an epigenetic mediator of hypoxic response, which can be used as a diagnostic mark

243 in GBM stemness and tumor progression, where hypoxic responses within the tumor inhibit MBNL1 activit