ライフサイエンスコーパス: i.t.

1 i.t. DC administration combined with RT induces a potent

2 i.t. injections were delivered to L1 as sympathetic neur

3 selective CCKB receptor antagonist L-365260 i.t. dose-dependently inhibited mustard oil hyperalgesia

4 dose (0.01-0.001 microg) goat anti-rat IL-6 i.t. administration (P=0.025) significantly decreased al

5 hresholds are elevated by approximately 70%, i.t. nociceptin substantially attenuates jump thresholds

6 The administration of TNF70-80 i.t. to CBA/J mice 7 days prior to, but not concomitantl

7 d-type, but not TLR9(-/-), mice administered i.t. reconstituted anti-legionella immunity and restored

8 Morphine, administered i.t. at a maximally effective dose (80 micrograms), inhi

9 is a much more potent antihyperalgesic after i.t. as compared to s.c. administration.

10 hoalveolar lavage (BAL) cells 1-3 days after i.t. challenge with hapten in the HIPIF lung, but not lu

11 ookhaven Medical Research Reactor 24 h after i.t. injection, which was timed to coincide with 2.5 h a

12 +CD25+Foxp3+ Tregs as late as 24 hours after i.t. LPS normalized resolution in Rag-1-/- mice.

13 d P-selectin-deficient (E(-)P(-)) mice after i.t. SRBC challenge.

14 d to directly measure target occupancy after i.t. dosing.

15 compartment, were much more pronounced after i.t. than after i.v. challenge.

16 without effect on the tail-flick test after i.t. injection in mice.

17 d a significant growth delay of tumors after i.t. injection of Ad5/Ad35.IR-E1A/TRAIL, whereas adenovi

18 An i.t. co-injection of reactive red 2 (100 micrograms) and

19 FR) or F98(WT) tumor cells, rats received an i.t. injection of BSD-EGF (approximately 60 microg (10)B

20 c receptor antagonist phentolamine (i.p. and i.t.) but not by the opioid receptor antagonist naloxone

21 thalamic (1.5 x 10(12) vg per thalamus) and i.t. infusion (3.9 x 10(13) vg).

22 tion was combined with radiation therapy and i.t. AdsGRP94 injections, local tumor growth and pulmona

23 tly evident starting from day 14 in i.v. and i.t. rUCMS cell-transplanted rats compared with sham-tra

24 m spacer exhibited profound antinociception (i.t. ED50 = 0.0146 pmol/mouse) that was 2000x greater th

25 ontrolled tumor growth to the same degree as i.t. injection of S. typhimurium, and together, these tw

26 body refractoriness to systemic LPS, because i.t. administration followed by i.p. administration did

27 hdrawal, an effect differentially altered by i.t. pretreatment with monoaminergic antagonists (100 nm

28 of HBO2 was also significantly attenuated by i.t. pretreatment with a rabbit antiserum against rat dy

29 cement of formalin-induced pain behaviors by i.t. bicuculline is not secondary to enhanced peripheral

30 these effects were differentially blocked by i.t. pretreatment with the nAChR antagonists mecamylamin

31 The granulomatous inflammation elicited by i.t. challenge predominantly involved alveolar spaces an

32 Pulmonary LPS tolerance was induced by i.t. administration of 100 ng LPS at time 0 and 48 h.

33 -3 activity, an increase that was reduced by i.t. BDFMK administration.

34 nmol of NMDA in rats prepared with a chronic i.t. cannula.

35 A(B)), and no significant effects of chronic i.t. morphine treatment were observed in brain sections.

36 In conclusion, i.t. or i.v. challenge with C. parvum in sensitized rats

37 In contrast, i.t. application of the micro-selective antagonist D-Phe

38 In contrast, i.t. instillation of LT-HDM-pulsed DCs induced a similar

39 In contrast, i.t. pretreatment with 3 microg of naltriben (NTB), a de

40 Conversely, i.t. administration of TGF-beta1 potently inhibited neur

41 were treated for 7 days with 0.11 mg/kg/day i.t. morphine, and receptor activation of G-proteins was

42 LP brachytherapy and ELP-K(12)/CpG delivered i.t. inhibited 4 T1 tumor growth and strongly decreased

43 gliomas compared with 33.2%ID/g after direct i.t. injection and 12.3%ID/g in F98(WT) gliomas.

44 Our data indicate that direct i.t. injection can selectively deliver BSD-EGF to EGFR-p

45 tomatic CNS therapy that consisted of either i.t. methotrexate (MTX) and CRT or intensified i.t. MTX

46 ptomatic CNS therapy that consists of either i.t. MTX plus CRT or intensified i.t. MTX alone results

47 ized to receive systemic therapy with either i.t. MTX and CRT (regimen A, n = 317) or intensified i.t

48 promoted de novo TLS formation, facilitating i.t. CD8(+) T cell effector responses independent of lym

49 Finally, i.t. administration of a TLR4 antagonist attenuated prur

50 Following i.t. injection of 131I-BSD-EGF, 21.8% of the injected do

51 algesic actions of these compounds following i.t. administration are not observed in non-pregnant or

52 In contrast, following i.t. injection of BSD-EGF, only 0.01-0.1% ID/g was local

53 phocyte recruitment into the lungs following i.t.-SRBC challenge is subset specific and time dependen

54 day after implantation mice were tested for i.t. [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO)

55 9H is essential in preventing morbidity from i.t. infection.

56 Furthermore, i.t. DC plus RT treatment of s.c. tumor in mice bearing

57 Furthermore, i.t. oncolytic adenovirus injection resulted in suppress

58 se of rats to monitor DRG toxicity in future i.t. AAV studies.

59 Given i.t., A-85380 (1 and 10 nmol/rat) decreased the latency

60 ver, when CAP-treated rats sensitized to HEL i.t. at day 0 were rechallenged with HEL i.t. at day 14,

61 HEL i.t. at day 0 were rechallenged with HEL i.t. at day 14, the lungs showed decreased numbers of OX

62 Following highest i.t. dose of nociceptin employed (20 nmol), the gestatio

63 Increased susceptibility in i.t. infection was associated with higher brain CFU, low

64 No tolerance was induced i.t., but marginal tolerance (3-fold) was observed via t

65 Conversely, injection (i.t.) of purified recombinant Wnt5a stimulates the expre

66 pidly up-regulated by intrathecal injection (i.t.) of gp120.

67 Furthermore, intensified i.t. MTX may protect against late bone marrow relapse.

68 and CRT (regimen A, n = 317) or intensified i.t. MTX alone (regimen B, n = 319).

69 s of either i.t. MTX plus CRT or intensified i.t. MTX alone results in a similar 5-year EFS outcome.

70 t. methotrexate (MTX) and CRT or intensified i.t. MTX alone.

71 Interestingly, i.t. administration of CART (55-102) significantly enhan

72 Treg transfer into i.t. LPS-exposed Rag-1-/- mice also corrected the elevat

73 Intrathecal (i.t.) administration of the delta opiate receptor-select

74 Intrathecal (i.t.) administration of the gamma-aminobutyric acid (GAB

75 Intrathecal (i.t.) administration of the non-selective cholecystokini

76 Intrathecal (i.t.) application of reactive red 2 (6-200 micrograms) c

77 Intrathecal (i.t.) gabapentin injection reduced late-phase, but not e

78 Intrathecal (i.t.) injection of 3 or 10 micrograms of CGP 35348 antag

79 Intrathecal (i.t.) pre-treatment with the test compounds 5-methyl-3-p

80 Intrathecal (i.t.) pretreatment with 1 microg of 7-benzylidinenaltrex

81 die in 12.1 +/- 2.1 days after intrathecal (i.t.) implantation of 5 x 10(5) 9L rat gliosarcoma cells

82 stration of normal goat IgG and intrathecal (i.t.) administration of IL-6 neutralizing antibody, norm

83 st that concurrent systemic and intrathecal (i.t.) therapy may be more effective than i.t. therapy al

84 In the mouse tail-flick assay, intrathecal (i.t.) NNTA produced antinociception that was ~100-fold g

85 was sensitive to antagonism by intrathecal (i.t.) pretreatment with the kappa- and mu-selective opio

86 In contrast, intrathecal (i.t.) yohimbine pretreatment (30 microg) completely bloc

87 that can be elicited following intrathecal (i.t.) application of 5-HT to an in situ'isolated' spinal

88 Intensified intrathecal (i.t.) chemotherapy without cranial radiation therapy (CR

89 e, we demonstrate that a local, intrathecal (i.t.) injection of bone marrow stromal cells (BMSCs) fol

90 t study evaluated the effect of intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of

91 nt study examined the effect of intrathecal (i.t.) morphine administration on receptor/G-protein coup

92 In rats, intrathecal (i.t.) administration of nociceptin is without effect on

93 The results indicate that intrathecal (i.t.) administration of the COX-2 inhibitor, SC58238, an

94 els of acute pain whereas their intrathecal (i.t.) administration has been reported to be antinocicep

95 Rats were implanted with intrathecal (i.t.) catheters for drug delivery and DC-compatible elec

96 stimulus used was peri-spinal (intrathecal, i.t.) application of the Human Immunodeficiency Virus ty

97 lumbosacral subarachnoid space (intrathecal; i.t.).

98 Administration of A-134974 intrathecally (i.t.) was more potent (ED(50)=10 nmol) in relieving tact

99 ylketone (BDFMK) administered intrathecally (i.t.) in a reversible spinal cord ischemia model (RSCIM)

100 When administered intrathecally (i.t.) to the lumbar spinal cord, GSK189254 produced robu

101 and AAVrh8-HEXB administered intrathecally (i.t.), with 75% of the total dose (1 x 10(14) vector gen

102 oses of 0.001 and 0.003 nmol, intrathecally (i.t.) blocked the hyperalgesia induced by 11.1 nmol of N

103 mice intravenously (i.v.) or intrathecally (i.t.), at a range of doses, either before or after disea

104 y in vivo, Ap4m1-KO mice were intrathecally (i.t.) injected with 5 x 1011, 2.5 x 1011, or 1.25 x 1011

105 spinal cord (10 or 25 microg intrathecally [i.t.] in 5 microl saline) induced pupillary dilatation w

106 del, we examined the effects of intrathymic (i.t.) injection of P5-primed alloreactive T cells on gra

107 Intratracheal (i.t.) administration of 10(6) CFU of L. pneumophila indu

108 model of ALI, we administered intratracheal (i.t.) LPS to mice and observed peak lung injury 4 days a

109 t different time points after intratracheal (i.t.) instillation of Escherichia coli LPS.

110 Using an intratracheal (i.t.) infection method, we discovered that the respirato

111 An intratracheal (i.t.) injection of bacterial LPS caused increased genera

112 nary LPS tolerance induced by intratracheal (i.t.) administration of LPS.

113 epsis, followed 24 h later by intratracheal (i.t.) administration of PSEUDOMONAS: aeruginosa.

114 ged after 2 weeks with either intratracheal (i.t.) or i.v. C. parvum.

115 onia caused by L. pneumophila Intratracheal (i.t.) administration of L. pneumophila induced the upreg

116 cited in the lung by a single intratracheal (i.t.) challenge in mice sensitized with hapten (2,4,6-tr

117 Specifically, intratracheal (i.t.) administration of CpG ODN (30 microg) 48 h before

118 oduced in C57BL/6 mice by the intratracheal (i.t.) administration of bleomycin (BLM).

119 al studies, we found that the intratracheal (i.t.) administration of L. pneumophila to mice deficient

120 sham surgery, followed by the intratracheal (i.t.) administration of P. aeruginosa or saline.

121 onia, we hypothesize that the intratracheal (i.t.) administration of TNF70-80 would augment lung inna

122 stration of c-di-GMP prior to intratracheal (i.t.) challenge with Klebsiella pneumoniae stimulates pr

123 ce were highly susceptible to intratracheal (i.t.) Cryptococcus neoformans infection relative to BALB

124 Upon intratracheal (i.t.) instillation of circRNA LNPs into mice, circRNA wa

125 imed and then challenged with intratracheal (i.t.) SRBC.

126 stores, and then challenged intratracheally (i.t.) with hen egg lysozyme (HEL).

127 Mice were challenged intratracheally (i.t.), intravenously (i.v.), or intraperitoneally (i.p.)

128 noculated with live E. coli intratracheally (i.t.) with or without adenosine or a non-hydrolyzable AT

129 R4(-/-), or MyD88(-/-) mice intratracheally (i.t.) with recombinant cHSP60 (50 microg), UV-killed C.

130 FU of Klebsiella pneumoniae intratracheally (i.t.), resulting in the time-dependent expression of IL-

131 (i.n.) plus orally and then intratracheally (i.t.), followed by envelope protein boosting, elicits br

132 lus recombinant IL-33, were intratracheally (i.t.) administered to induce allergic airway inflammatio

133 murine breast cancer tumor upon intratumor (i.t.) injection.

134 Intratumoral (i.t.) injection of S. typhimurium led to tumor cell apop

135 er than Ad5 transduction after intratumoral (i.t.) injection of CD46-expressing tumors.

136 ution studies rats received an intratumoral (i.t.) injection of (125)I-labeled BSD-EGF and were eutha

137 improve the intracerebral and intratumoral (i.t.) uptake of a heavily boronated macromolecule (dendr

138 tions of Toca 511, followed by intratumoral (i.t.) injection of Toca 511, and a 7-day course of oral

139 raft model (Granta 519 cells), intratumoral (i.t.) vector administration alone had high oncolytic eff

140 phase 1 study (NCT04059588) of intratumoral (i.t.) 2141-V11, an Fc-engineered anti-CD40 agonistic ant

141 Our results indicate that only intratumoral (i.t.) injections of CpG-ODN induce an antitumor response

142 e rats received either i.v. or intratumoral (i.t.) injection of 131I-labeled boronated starburst dend

143 We showed that systemic or intratumoral (i.t.) injection of adenovirus vectors into mice increase

144 Our results show that a single intratumoral (i.t.) treatment of AA15V LNP-sSE-SCTs suppresses tumor g

145 injectable depot for sustained intratumoral (i.t.) delivery of an iodine-131 ((131)I) radionuclide an

146 Here, we demonstrate that intratumoral (i.t.) administration of recombinant interleukin-12 (rIL-

147 lso tested our hypothesis that intratumoral (i.t.) delivery of dendritic cells that had been transduc

148 Previous work showed that intratumoral (i.t.) injection of CARG-2020 exhibits robust efficacy ag

149 Two intratumoral (i.t.) injections of (10)B-enriched N5-2OH were administe

150 following intravenous (i.v.), intratumoral (i.t.), or combined i.v. + i.t. Lm delivery.

151 CT26 tumors were treated with intratumoral (i.t.) injections of a recombinant NDV modified to contai

152 rcoma tumors were treated with intratumoral (i.t.) injections of bone marrow-derived unpulsed DCs in

153 n relieving the OA pain (ED(50)=0.0027 mg/kg i.t.).

154 ppression of primary and metastatic lesions, i.t. replication and necrosis, vector entrance into the

155 malin nociceptive test, 0.001 nmol LY235959 (i.t.) significantly reduced the number of Phase 2 flinch

156 Thus, LY235959 (i.t. or s.c.) has NMDA receptor antagonist activity as d

157 5-Tyr (Me)2-Orn8]-Vasotocin [OTA]; 25 microg i.t. in 5 microl saline) significantly attenuated the pu

158 Pretreatment with 0.3 microg i.t. bicuculline neither enhanced nor suppressed formali

159 Low doses (0.01-0.001 microg) i.t. normal goat and rat IgG significantly attenuated me

160 Chronic morphine (10 microg, i.t.; twice daily for 6 d) induced a time-dependent upre

161 Moreover, i.t. BMSCs reduced CCI-induced spontaneous pain and axon

162 -650394 (an SGK1 antagonist; 100 nm, 10 mul, i.t.) not only exhibited effects similar to the kalirin

163 nal kalirin mRNA expression (10 mug, 10 mul; i.t.) reduced SNL-induced allodynia, kalirin and pNR2B e

164 d these studies to compare the standard i.n./i.t. regimen with additional mucosal administration rout

165 y (3.4 nmol, i.c.v.) and spinally (4.3 nmol, i.t.).

166 einstatement at all doses tested (3-30 nmol, i.t.).

167 The i.p., but not i.t., administration of IL-10 Abs given just before P. a

168 y an acceptably safe and efficacious dose of i.t.-administered AAV9/AP4M1, supporting an investigatio

169 he present study investigated the effects of i.t. and systemic administration of A-85380, a novel nAC

170 s, and this upregulation caused migration of i.t.-injected BMSCs to DRGs through the CXCL12 receptor

171 Combination treatment of i.t. DCs plus RT was superior to s.c. injections of tumo

172 studies and a reconsideration of the use of i.t. chemotherapy for patients with neoplastic meningiti

173 the right caudate nucleus of normal rats or i.t. in rats bearing either F98(EGFR) or F98 wild-type (

174 shed when co-administered with phentolamine (i.t.).

175 rom an ELP-K(12) depot dramatically prolongs i.t. retention to more than 21 days as compared to solub

176 earing F98(EGFR) gliomas, which had received i.t. BSD-EGF and BNCT, had a MST of 45 +/- 5 days compar

177 tumors (P = 0.0032), and rats that received i.t. BSD-EGF in combination with i.v. BPA had a MST of 5

178 Similarly, i.t. co-injection of almost equipotent dosages of reacti

179 y of the PDGFR kinase domain, after a single i.t. dose and has efficacy at 0.03 mg/kg, in the rat mon

180 rol tumors, apoptosis induction and a single i.t. injection of virus produced an interconnected and d

181 e group of 15 patients treated with standard i.t. MTX during the same time interval.

182 t comparable to those achieved with standard i.t. therapy.

183 es systemic CD8(+) T cell immunity targeting i.t. bacteria.

184 ve concluded that CED is more effective than i.t. injection as a way to deliver boronated EGF to EGFR

185 al (i.t.) therapy may be more effective than i.t. therapy alone.

186 These findings demonstrate that i.t. 2141-V11 is safe and promotes immune-privileged tum

187 ive T cells on graft survival and found that i.t. administration of the P5-primed T cells on day -7 a

188 We report here that i.t. delivery of protocells, with modified chemistry sup

189 These findings indicate that i.t. administration of CpG ODN can stimulate multiple co

190 These results reveal that i.t. application of morphine affects specific subpopulat

191 The present study shows that i.t. administration of BDFMK reduced caspase-3 activity,

192 The i.t. administration of bacteria to CLP-, but not sham-,

193 The i.t. administration of fasudil, a Rho kinase inhibitor,

194 ce undergoing CLP followed 24 h later by the i.t. administration of saline or P. aeruginosa was 58% a

195 The kappa-antagonist, norBNI, decreased the i.t. potency, and the activity was virtually abolished i

196 Finally, the i.t., but not intraperitoneal, administration of the TLR

197 Furthermore, the i.t. GSK189254 effect was abolished when co-administered

198 In the i.t. model using CBA/J mice, low Ab doses were disease e

199 oup was 13.8 months versus 2.3 months in the i.t. MTX group (P = .003).

200 dialysis, levels of 5-HT, but not NE, in the i.t. space of the lumber region of the spinal cord were

201 le for the slower growth of recurrences; the i.t. injection of collagenase increased the growth rate

202 We also show that the i.t. injection of HSV after caspase-8 activation or pacl

203 ys prior to, but not concomitantly with, the i.t. delivery of 3 x 10(3) CFU of K. pneumoniae resulted

204 mal hyperalgesia and mechanical allodynia to i.t. gp120 were blocked by spinal pretreatment with drug

205 Rag-1-/- and C57BL/6 WT mice were exposed to i.t. LPS.

206 gitation tests) were observed in response to i.t. gp120.

207 n Klebsiella pneumonia, animals were treated i.t. with 5 x 10(8) PFU of a nonreplicating adenoviral v

208 Rs humanized mice bearing orthotopic tumors, i.t. 2141-V11 promoted de novo TLS formation, facilitati

209 cal refractory state can be induced with two i.t. LPS exposures.

210 Unexpectedly, i.t. Lm alone recruited neutrophils to tumors, which bec

211 CD8(+) T cells that infiltrated tumors upon i.t. Lm delivery.

212 v.), intratumoral (i.t.), or combined i.v. + i.t. Lm delivery.

213 comparison of the efficacy of an i.v. versus i.t. approach using AAV9, which should greatly inform th

214 to Aspergillus fumigatus and challenged via i.t. instillation with live A. fumigatus conidia.

215 te pulmonary clearance of L. pneumophila, we i.t. administered 5 x 10(8) PFU of a recombinant adenovi

216 dings support a paracrine mechanism by which i.t. BMSCs target CXCL12-producing DRGs to elicit neurop

217 d in treating leptomeningeal metastases with i.t. administered 125IUdR.

218 ts in bacterial clearance were observed with i.t. recombinant IFN-gamma treatment.

219 ations were maintained much longer than with i.t. dosing.

220 Splenocytes from mice treated with i.t. DCs plus RT contained significantly more tumor-spec

221 Mice bearing s.c. CT26 tumors treated with i.t. injections of recombinant NDV expressing IL-2 showe

222 Treatment with i.t. administered 125IUdR (500 microCi/rat) significantl