ライフサイエンスコーパス: ictal

1 We propose that normal and ictal activities coexist: a separatrix acts as a barrier

2 In these patients, ictal activities spread to frontal (lateral premotor are

3 effective as inhibition of mTOR in reducing ictal activity and cell death.

4 dually and asynchronously recruited into the ictal activity during the course of seizures.

5 by ICE, scalp EEG demonstrated no concurrent ictal activity in six, nonictal-appearing rhythmic delta

6 iode (LED), on the frequency and duration of ictal activity in the presence and absence of RuBi-GABA.

7 delta in two, and intermittently correlated ictal activity in two.

8 izures that (1) progression from preictal to ictal activity was characterized in seizure-onset zones

9 Ictal activity was quantified by measurement of lactate

10 de useful insight into the primary source of ictal activity, aiding both experimental and clinical in

11 nterictal spike generator and could initiate ictal activity, suggesting that human cerebellum may bec

12 alorhodopsin activation rapidly induced full ictal activity.

13 ning 3 days after injury virtually abolished ictal activity.

14 ted signalling contributes to interictal and ictal activity.

15 that is suspicious for but not diagnostic of ictal activity.

16 Endocannabinoid involvement in post-ictal analgesia in GEPRs was evaluated, using focal bila

17 antagonist (capsazepine) did not affect post-ictal analgesia in GEPRs.

18 ptors in PAG are critical for mediating post-ictal analgesia in GEPRs.

19 /side) into PAG significantly decreased post-ictal analgesia in GEPRs.

20 This study evaluated if post-ictal analgesia occurs in GEPRs, following audiogenic se

21 e brain sites and mechanisms, mediating post-ictal analgesia, are unclear.

22 sults indicate that AGS in GEPRs induce post-ictal analgesia, which is the first observation of this

23 ngs suggest an important role of PAG in post-ictal analgesia.

24 connections and intracranial EEG, across pre-ictal and ictal periods in 45 seizures from nine patient

25 physiological measurements, specifically for ictal and interictal brain networks.

26 reoperative seizures, neuroimaging findings, ictal and interictal ECoG measures were preoperatively o

27 l drug-resistant epilepsy is associated with ictal and interictal epileptic activity.

28 the full regression model incorporating both ictal and interictal measures [R(2) 0.44; Area under the

29 and the frequent subtle differences between ictal and interictal patterns.

30 A total of 36 subtraction ictal and interictal perfusion studies were analysed in

31 Subtraction ictal and interictal single photon emission computed tom

32 lpropyleneamine Oxime (Tc-99 m HMPAO) during ictal and interictal state confirmed by video-electroenc

33 te for explaining the timing and duration of ictal and possibly postictal headaches.

34 The contrasting clinical profiles of ictal and postictal arrhythmias suggest different pathom

35 The duration of ictal and postictal generalized EEG suppression periods

36 inical study provides a neural substrate for ictal and postictal headache.

37 ernative stable attractors, representing the ictal and postictal states, emulate the observed dynamic

38 for developing strategies that prevent fatal ictal apnea.SIGNIFICANCE STATEMENT Apnea during and foll

39 Postictal rather than ictal arrhythmias seem of greater importance to the path

40 patterns of (post)ictal cardiac arrhythmias: ictal asystole (103 cases), postictal asystole (13 cases

41 le, we observed 76 clinical seizures with 26 ictal asystole episodes, 15 of which led to syncope.

42 During ictal asystole events, 4 patients had left temporal seiz

43 ober 2003 to July 2013 for all patients with ictal asystole events.

44 Ictal asystole had a mean prevalence of 0.318% (95% CI 0

45 Ictal asystole is a rare, serious, and often treatable c

46 Ictal asystole>6 s is strongly associated with ictal syn

47 Ictal asystole, bradycardia and AV-conduction block were

48 In 10 patients with ictal asystole, we observed 76 clinical seizures with 26

49 stictal AV-conduction block (2 cases), (post)ictal atrial flutter/atrial fibrillation (14 cases) and

50 le (13 cases), ictal bradycardia (25 cases), ictal atrioventricular (AV)-conduction block (11 cases),

51 eluded recognition because emetic and other ictal autonomic manifestations were dismissed as non-epi

52 cortex, these short EEEs were accompanied by ictal behaviour detectable with simultaneous surface ele

53 tiform electrocorticography and simultaneous ictal behaviour, and examined post-traumatic epilepsy in

54 ity that undetected ischemic hypoxia, due to ictal blood flow restriction, could contribute to neurod

55 (103 cases), postictal asystole (13 cases), ictal bradycardia (25 cases), ictal atrioventricular (AV

56 opolamine treatment reduced the incidence of ictal bradycardia and SUDEP in DS mice.

57 sting heart-rate variability and episodes of ictal bradycardia associated with the tonic phases of ge

58 Prolonged atropine-sensitive ictal bradycardia preceded SUDEP.

59 monitoring, brain MR imaging, interictal and ictal brain perfusion SPECT, SISCOM, and (18)F-FDG PET w

60 The most challenging technical problem in ictal brain SPECT for localization of an epileptogenic f

61 (99m)Tc-ethylcysteinate dimer ((99m)Tc-ECD) ictal brain SPECT studies were retrospectively analyzed

62 y smaller in the reduced model incorporating ictal but not interictal measures (R(2) 0.40; Area under

63 nical profiles associated with various (post)ictal cardiac arrhythmias.

64 identified seven distinct patterns of (post)ictal cardiac arrhythmias: ictal asystole (103 cases), p

65 There was no evidence of pre-ictal change in the spike spatial distribution for any p

66 Seizure onset and first ictal change within insula functional subdivision correl

67 However, the ictal characteristics of these rat models, including SWD

68 ared to HCs, but significantly longer in the ictal compared to interictal phase.

69 oncordance (4/13; 31%) = 9/13; 69%] and late ictal [concordant plus (1/9; 11%) + some concordance (4/

70 rms of two distinct spatial territories: the ictal core and penumbral territories.

71 method for using them to identify the small ictal core regions.

72 In contrast, within the ictal core territories, regions characterized by intense

73 The pre-ictal decrease in spike rate is not consistent with spik

74 ubtedly provides a major contribution to the ictal decrease in total firing and the ictal increase of

75 However ictal deja vu occurs more frequently and is accompanied

76 50 epileptic patients with ictal deja vu, 50 non-epileptic patients attending gener

77 Post-ictal depression of consciousness occurs after generaliz

78 s of stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) sometimes found on prolonged

79 d find a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus (DGH) to t

80 m microelectrodes and macroelectrodes during ictal discharges in both the seizure core and penumbra (

81 types reduced the frequency and duration of ictal discharges in some trials, while completely blocki

82 guinea pig brain during focal interictal and ictal discharges induced in the limbic network by intrac

83 n an intensive care unit setting, can detect ictal discharges not readily apparent on scalp EEG, and

84 Using video/EEG analysis, we detect ictal discharges that coincide with convulsive seizures

85 excitatory connections, may underlie the pre-ictal discharges that govern interictal-ictal transition

86 Ictal discharges were induced in proepileptic conditions

87 period of silence ranging from 67 to 135 s, ictal discharges were re-established with similar durati

88 Even after the termination of ictal discharges, during the post-ictal period, loss of

89 type significantly reduced the occurrence of ictal discharges, principal cell stimulation resulted in

90 ctivity alone may underlie the generation of ictal discharges.

91 ment of strategies to confine propagation of ictal discharges.

92 ivity to persistent, prolonged synchronized (ictal) discharges.

93 ocus blocked ictal propagation and shortened ictal duration at the focus.

94 We revealed that the reduced ictal duration was a direct consequence of the ictal pro

95 eictal depolarization, with no effect on the ictal duration, whereas SLEs were blocked by glutamate r

96 We characterized ictal (during a seizure) and interictal (between seizure

97 cal outcome may be modest in the presence of ictal ECoG and neuroimaging data.

98 Both patterns were followed by generalized ictal EEG discharges and behavioral seizures.

99 The pro-ictal effect of delayed photostimulation of PV+ interneu

100 rapidly switches from an anti-ictal to a pro-ictal effect within a few seconds of seizure initiation.

101 study investigates the temporal dynamics of ictal electrical activity induced by injection of the GA

102 of single neurons before, during, and after ictal electroencephalogram (EEG) discharges.

103 owed atypical handedness, a left perisylvian ictal electroencephalographic focus, and a lesion in lef

104 erential spectral and spatial shifts of post-ictal electroencephalography activity in simple partial,

105 ad unilateral temporal seizure foci based on ictal electroencephalography and structural magnetic res

106 ells, an essential component in the onset of ictal epileptic events.

107 tor 1) fast hemodynamic changes during inter-ictal epileptic seizures and 2) temperature variations d

108 RIs, but electroencephalography demonstrated ictal epileptiform activity in 7 patients (24%).

109 mens, where the occurrence of interictal and ictal epileptiform activity was confirmed by either ster

110 grained spatiotemporal distribution of inter-ictal epileptiform discharges (IEDs) across different sl

111 Ictal epileptiform electroencephalographic changes were

112 e concordance (4/20; 20%) = 17/20; 85%] than ictal-established [entirely concordant/concordant plus (

113 g associated with imminent recruitment to an ictal event.

114 g seizures and recovers after the end of the ictal event.

115 nd can display depolarizing block during the ictal event.

116 We discovered a novel phenomenon, in which ictal events are preceded by preictal vasoconstriction o

117 ked seizures in which the individual seizure-ictal events are self-limiting.

118 g of blood vessel diameter in a rat model of ictal events elicited with focal injection of 4-aminopyr

119 ctured temporal sequences during spontaneous ictal events in hippocampal and neocortical circuits in

120 e generation and propagation of seizure-like ictal events is accurately analyzed by a combination of

121 Assessing neuronal involvement in ictal events is pivotal to understanding seizure dynamic

122 Ictal events occurring in temporal lobe epilepsy patient

123 ultiunit activity analyses indicate that the ictal events of spasms are initiated in infragranular co

124 ium indicator to measure prolonged seizures (ictal events) and brief interictal events.

125 ghly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were

126 oride loading by itself did not trigger full ictal events, even with additional electrical stimulatio

127 view that principal cell discharges dominate ictal events, the ictal sequences were predominantly com

128 ly later, and firing persists throughout the ictal events.

129 eriods without behavioural or electrographic ictal events.

130 HS) have seizures with fear, which is called ictal fear (IF), due to epileptic activity within the br

131 rominent automatisms, sensory aura, and post-ictal fear and speech arrest.

132 Though synchronous ictal firing characterizes cortical and thalamic activit

133 abolism and cerebral blood flow (CBF) to the ictal focus.

134 Depending on the ictal frequency pattern, desynchronization can occur lat

135 Pv interneurons at the focus failed to block ictal generation and induced postinhibitory rebound spik

136 , enhancing neuronal synchrony and promoting ictal generation.

137 In conclusion, preictal and ictal haemodynamic changes in refractory focal seizures

138 e aim of this study was to identify specific ictal hand postures (HPs) as localizing signs of the epi

139 ed the cellular correlates of interictal and ictal HFO events.

140 dily identified, to investigate the basis of ictal high frequency activity at the cortical (subdural)

141 urther understand the neuronal correlates of ictal high frequency LFPs using multielectrode array rec

142 t measure to detect delayed-onset, sustained ictal high frequency oscillations based on cross-frequen

143 eural mechanism for delayed-onset, sustained ictal high frequency oscillations, and provide a practic

144 king correlation between EZ localization and ictal HP.

145 We analyzed presence and latency of ictal HP.

146 We found that ictal HPs were present in 72.5% of patients with frontal

147 Regions with ictal hyperperfusion are suggested to reflect seizure on

148 Early ictal hypometabolism, transient decreases in cell swelli

149 The significance of ictal hypoperfusion is not well understood.

150 Understanding the cause of this peri-ictal hypoventilation may lead to preventative strategie

151 Ictal hypoxemia and hypercapnia may contribute to SUDEP.

152 Ictal hypoxemia has been reported in small series of cas

153 t to determine the incidence and severity of ictal hypoxemia in patients with localization-related ep

154 Ictal hypoxemia occurs often in patients with localizati

155 thus conclude that EEEs lasting 0.8-2 s are ictal in the rat.

156 works in absence seizures, in particular the ictal increase in firing of substantia nigra GABAergic n

157 and animal models with absence seizures, the ictal increase in thalamic inhibition is enhanced by the

158 o the ictal decrease in total firing and the ictal increase of T-type calcium channel-mediated burst

159 to travel backwards to the original focus of ictal initiation.

160 to demonstrate the improved success rate of ictal injection by use of the automatic injector in the

161 o not meet seizure criteria, also termed the ictal interictal continuum, are pervasive on electroence

162 Severe ictal-interictal continuum burden correlated with initia

163 34 +/- 14 yr; 88% male), 22 (14%) had severe ictal-interictal continuum including electrographic seiz

164 Severe ictal-interictal continuum patterns, including electrogr

165 d to as "ictal-interictal continuum"; severe ictal-interictal continuum was defined as greater than o

166 odic, or ictal patterns were referred to as "ictal-interictal continuum"; severe ictal-interictal con

167 med to describe the prevalence and burden of ictal-interictal patterns, including electrographic seiz

168 sistently predicted the timing or failure of ictal invasion, and revealed a surprisingly small and sl

169 mic hamartomas present with isolated fits of ictal laughter (gelastic epilepsy) or a combination of g

170 ery of the mean firing rate was close to pre-ictal levels also within this time frame, suggesting tha

171 ve potentials, which appeared to trigger the ictal-like activities, remained.

172 mulative duration of 4-aminopyridine-induced ictal-like activities, with a slower time course in epil

173 experimental model, the onset and offset of ictal-like discharges are well-defined mathematical even

174 escribe the onset, time course and offset of ictal-like discharges as well as their recurrence.

175 As an experimental model system, we used ictal-like discharges induced in vitro in mouse hippocam

176 induced preictal discharges (PIDs) preceding ictal-like events.

177 ons included transient discharges leading to ictal-like field events with frequency spectra as in vit

178 s induces persistent prolonged synchronized (ictal-like) discharges in CA3 that are associated with t

179 stic link between Ca(V)1.1 mutations and the ictal loss of muscle excitability during an attack of we

180 duced model incorporating interictal but not ictal measures (R(2) 0.27; Area under the ROC curve: 0.7

181 the role of cortical-subcortical networks in ictal neocortical dysfunction and may reveal treatments

182 These findings suggest that ictal neocortical slow waves represent an altered cortic

183 totoxicity is the prevalent model to explain ictal neurodegeneration.

184 riven by capillary blood flow restriction in ictal neurodegeneration.

185 When the stimulated ictal onset area was hyperperfused, 82% of studies demon

186 Six patients had postcingulate ictal onset identified by stereotactic EEG (SEEG) evalua

187 ng connectivity was demonstrated between the ictal onset zone and hyperperfused regions, while connec

188 AFI was extremely sensitive to the ictal onset zone and may be a useful mapping technique w

189 wed a higher concordance with electrographic ictal onset zone from scalp EEG recording.

190 ter repetitive electrical stimulation of the ictal onset zone.

191 termine bandwidths with significant power at ictal onset.

192 e FPs markedly increased to a maximum at the ictal onset.

193 cation, were diminished, disappearing at the ictal onset.

194 was significantly better (P < 0.05) for the ictal-onset phase [entirely concordant/concordant plus (

195 ases that underwent invasive evaluation, the ictal-onset phase-related maps had a degree of concordan

196 In the remaining 14 cases, the ictal-onset phase-related maps had a degree of concordan

197 trographic seizure onset) and ictal phases, 'ictal-onset'; 'ictalestablished' and 'late ictal', were

198 eptic seizure can trigger a headache during (ictal) or after (postictal) the termination of the event

199 ses in ETCO2, supporting the assumption that ictal oxygen desaturation is a consequence of hypoventil

200 Ictal patterns on scalp-electroencephalography are often

201 Rhythmic, periodic, or ictal patterns were referred to as "ictal-interictal con

202 The defining feature of the 'ictal penumbra' is the contrast between the large amplit

203 tory of recruited neurons and a surrounding 'ictal penumbra'.

204 The aim of this study was to verify whether ictal perfusion changes, both hyper- and hypoperfusion,

205 computed tomography can demonstrate complex ictal perfusion patterns.

206 sponses at these electrodes were compared to ictal perfusion values noted at these locations.

207 n, cerebral blood flow increases in the post-ictal period and cerebral blood flow decreases during or

208 amics across space and throughout the entire ictal period are rare.

209 ripple rates and (2) ripple rates during the ictal period were higher compared with fast ripple rates

210 events appear to be very similar to the pre-ictal period, albeit with slightly lower firing rates.

211 nterneurons appears to peak early in the pre-ictal period, and can display depolarizing block during

212 ination of ictal discharges, during the post-ictal period, loss of consciousness, decreased responsiv

213 s and regions of secondary spread during the ictal period.

214 ring generalization or in the immediate post-ictal period.

215 -locked to glutamatergic barrages in the pre-ictal period.

216 cluding the alternation between 'normal' and ictal periods (slow time scale).

217 s and intracranial EEG, across pre-ictal and ictal periods in 45 seizures from nine patients with uni

218 the last migraine attack not just during pre-ictal periods, but interictally as well.

219 tructure-function coupling from pre-ictal to ictal periods.

220 using statistical parametric mapping to map ictal phase-related haemodynamic changes consistent acro

221 hich abruptly turns into a higher frequency "ictal" phase.

222 ceding the electrographic seizure onset) and ictal phases, 'ictal-onset'; 'ictalestablished' and 'lat

223 (area under the curve=0.83): age >=54 years, ictal piloerection, lowered self-reported mood, reduced

224 al wavefront acts as the forcing term of the ictal process, while the macroscopic, centimeter-sized n

225 providing new localizing information on the ictal processes and epileptogenic zone.

226 interneurons distant from the focus blocked ictal propagation and shortened ictal duration at the fo

227 tal duration was a direct consequence of the ictal propagation block, probably by preventing newly ge

228 Here we report the dissection of ictal propagation in the hippocampal-entorhinal cortex (

229 e seizure spread and the exact directions of ictal propagation remain largely unknown.

230 ngthening mechanisms underlying cessation of ictal propagation should inspire new rationales for deep

231 Ictal propagation-related haemodynamic changes were also

232 The mean brain-PAD in TLE with inter-ictal psychosis was 10.9 years, which was significantly

233 h quantification of seizure type using inter-ictal recordings.

234 All patients showed significant ictal-related haemodynamic changes.

235 seizure onset and body mass index influenced ictal-related hypoxemia.

236 read EEG synchronization, and slowing of the ictal rhythm as the seizure approaches termination.

237 phase-locked to the low-frequency (1-25 Hz) ictal rhythm, correlated with strong multi-unit firing b

238 ma amplitude and the low-frequency (1-25 Hz) ictal rhythm.

239 Brief potentially ictal rhythmic discharges in critically ill patients are

240 Brief potentially ictal rhythmic discharges were identified before seizure

241 Brief potentially ictal rhythmic discharges, termed B(I)RDs, have been des

242 the following point assignments: (1) brief (ictal) rhythmic discharges (B[I]RDs) (2 points); (2) pre

243 seizure onset at sub-lobar/gyral level when ictal scalp-electroencephalography is not helpful.

244 rons can significantly inhibit the spread of ictal seizures and largely rescue behavioural deficits i

245 In this study, we retrospectively analyzed ictal semiology of 489 temporal lobe or frontal lobe sei

246 l cell discharges dominate ictal events, the ictal sequences were predominantly composed of fast-spik

247 Our study offers simple ictal signs that appear to clarify differential diagnosi

248 arison with the findings of invasive EEG and ictal single-photon emission computed tomography, using

249 lly generated EEEs that occurred in the same ictal sites as obvious complex partial seizures, were el

250 al features and spatial distribution of post-ictal slow waves with comprehensive spatial coverage.

251 y and source imaging to reconstruct the post-ictal slow-wave distribution.

252 uch transitions can arise from shifts in the ictal source of the activity.

253 Moderate redundancy was seen between PET and ictal SPECT (kappa = 0.452; p = 0.011).

254 that administers an automated injection for ictal SPECT after calculating the volume of tracer to be

255 Ictal SPECT and SISCOM successfully localized the seizur

256 The SISCOM (Subtraction Ictal Spect Co-registered to MRI) procedure was used to

257 , interictal SPECT, ictal SPECT, subtraction ictal SPECT coregistered to MR imaging (SISCOM), and int

258 However, cerebral blood flow increases on ictal SPECT correctly identified the hemisphere (left ve

259 MSI, FDG-PET, and ictal SPECT each have clinical value in predicting seizu

260 We analysed ictal SPECT from 59 secondarily generalized tonic-clonic

261 Ictal SPECT from secondarily generalized seizures has no

262 In the cases with all three tests (n = 27), ictal SPECT had the highest OR of 9.1 (p = 0.05).

263 t, with appropriate cautious interpretation, ictal SPECT in secondarily generalized seizures can help

264 eizure onset impossible 50% of the time with ictal SPECT in secondarily generalized seizures.

265 re-generalization and generalization phases, ictal SPECT showed significantly more regions of cerebra

266 y be achieved with addition of either PET or ictal SPECT to MSI.

267 h available comparison subgroups FDG-PET and ictal SPECT values were similar to MSI.

268 Tracer for ictal SPECT was injected using automated injection in 27

269 single photon emission computed tomography (ictal SPECT), providing a useful clinical tool for seizu

270 y (EEG), brain MR imaging, interictal SPECT, ictal SPECT, subtraction ictal SPECT coregistered to MR

271 of cerebral blood flow increase was seen on ictal SPECT, this was the correct localization 80% of th

272 th the combination of MSI and PET or MSI and ictal SPECT.

273 Increased pre-ictal spike rate was linked to improved predictability;

274 ikes associated with seizure initiation (pre-ictal spikes; PSs) is still undetermined.

275 me, suggesting that the more protracted post-ictal state cannot be explained by persistent cellular n

276 tion may contribute to the transition to the ictal state during temperature-induced seizures in Drave

277 ase in tracer uptake was observed during the ictal state in the medial temporal region, cerebellum, t

278 , particularly in relation to sleep and post-ictal state, can confound localization.

279 ve been proposed to represent transitions to ictal states in this context.

280 qualitatively and quantitatively analyse the ictal striatum activity as well as its synchronization w

281 urther compromised during the period of post-ictal suppression, during interictal bursts, and also at

282 me in the surround are consistent with early ictal surround inhibition as a precipitating event in se

283 ovascular and neurometabolic coupling in the ictal surround using optical imaging of light scattering

284 g pathological electric activity or inducing ictal symptomatology.

285 s were examined for their relationships with ictal syncope events.

286 emaker should be considered in patients with ictal syncope if they are not considered good candidates

287 Ictal syncope is more common in left than in right tempo

288 Characterization of ictal syncope predictors may aid in the selection of hig

289 tal asystole>6 s is strongly associated with ictal syncope.

290 + interneurons rapidly switches from an anti-ictal to a pro-ictal effect within a few seconds of seiz

291 ases in structure-function coupling from pre-ictal to ictal periods.

292 pre-ictal discharges that govern interictal-ictal transitions.

293 Ictal versus baseline interictal SPECT difference analys

294 we aimed to investigate state specific (i.e. ictal versus interictal) perfusional limbic networks in

295 , this correlation effect is specific to the ictal wavefront and is absent interictally or from actio

296 veral seconds after seizure onset, following ictal wavefront passage.

297 as well as shaping the evolving propagating ictal wavefront, although the exact mechanism of these c

298 sponse is particularly prominent ahead of an ictal wavefront.

299 gradient in modulating the susceptibility to ictal weakness and establishes bumetanide as a potential

300 'ictal-onset'; 'ictalestablished' and 'late ictal', were defined based on the evolution of the elect