ライフサイエンスコーパス: identical-by-descent

1 o test whether any rare variants were shared identical by descent.

2 fspring by causing parts of the genome to be identical by descent.

3 ted sibling pairs than on regions not shared identical by descent.

4 individual inherits two haplotypes that are identical by descent.

5 n long stretches of genomic sharing that are identical by descent.

6 Mamu-B*17-containing MHC haplotypes that are identical by descent.

7 of identical base composition that were not identical by descent.

8 ffected breeds indicated that the allele was identical by descent.

9 ng strategy to test if those shared CNAs are identical by descent.

10 e-sex sibling pairs will share fewer alleles identical by descent.

11 siblings did not share two HLA-DRB1 alleles identical by descent.

12 lecting genomic segments/haplotypes that are identical-by-descent.

13 ohort will often share long-range haplotypes identical-by-descent.

14 ere homozygous for a mutant allele inherited identical-by-descent.

15 iblings who do not share both MHC haplotypes identical-by-descent.

16 irs (7.6%) did not share parental haplotypes identical by descent across the MHC, suggesting that onl

17 mples revealed that they were homozygous and identical by descent across their genome.

18 ch allows for differences in sharing alleles identical-by-descent across different types of ARPs.

19 stimation demonstrated that this mutation is identical by descent among horse breeds.

20 air of individuals sharing a haplotype tract identical by descent and (iii) assembly of polyploid gen

21 available SNPs to locate genes that are not identical by descent and that contain nonsynonymous codi

22 s based on sibling amount of sharing that is identical by descent are widely available, for both auto

23 ere HD affected, estimates of allele sharing identical by descent at and around the HD locus were adj

24 y sampled sib pairs share half their alleles identical by descent at any locus, whereas a critical as

25 ted proportion of alleles shared by brothers identical by descent at each marker location.

26 method uses the proportion of alleles shared identical by descent at genotyped loci to estimate IBD s

27 n the estimated proportion of alleles shared identical-by-descent at each marker position.

28 dia) showed higher levels of allele sharing, identical by descent, at RGS4.

29 ve-pair studies, the distribution of alleles identical by descent between pairs of affected relatives

30 teroduplexes, likely representing DNA shared identical by descent between the two individuals, are re

31 Homozygosity for a haplotype that was identical by descent between two of the affected individ

32 e majority of restriction fragments that are identical by descent between two related humans.

33 xtended chromosomal segments that are shared identical by descent between very distantly related indi

34 t of affected horses to detect a homozygous, identical-by-descent block spanning approximately 2.5 Mb

35 ess the expected proportions of genes shared identical by descent by a sib pair, in terms of the gene

36 should be found more often on regions shared identical by descent by affected sibling pairs than on r

37 hat a variant or a set of variants is shared identical-by-descent by some or all affected relatives p

38 ysis of common disease and in the search for identical-by-descent chromosome regions that carry an ae

39 , during the haplotyping process, from their identical-by-descent copies.

40 alized appropriately, show which alleles are identical by descent despite the presence of untyped ind

41 NA microarray technology to map the selected identical by descent DNA fragments.

42 The number and length of identical-by-descent DNA segments (IBD) yield the most p

43 ty (BMI > or = 40; n = 59) shared haplotypes identical-by-descent for the region containing the OB ge

44 dentified 45 sib-pairs that were concordant (identical by descent) for a locus on chromosome 2 which

45 which the mutant alleles are expected to be identical by descent from a common founder and the regio

46 idual inherits chromosomal segments that are identical by descent from each parent.

47 insertion polymorphisms will prove useful as identical by descent genetic markers for the study of hu

48 ed Alu insertion polymorphisms will serve as identical-by-descent genetic markers for the study of hu

49 We present a method for detecting identical-by-descent haplotype segments in phased genoty

50 mportant genomic features that manifest when identical-by-descent haplotypes are inherited from paren

51 thod for efficiently identifying clusters of identical-by-descent haplotypes in biobank-scale sequenc

52 DR3/4-DQ8 siblings of patients with T1D for identical-by-descent HLA haplotype sharing (the number o

53 y in the proportion of the genome they share identical by descent, i.e. in their realised or actual r

54 ling pairs who inherited both apo(a) alleles identical by descent (IBD) (r = .85) than in those that

55 aracterizing genomic regions that are shared identical by descent (IBD) among individuals can yield i

56 Allele sharing identical by descent (IBD) and multipoint maximum likeli

57 to estimate the proportion of allele sharing identical by descent (IBD) and the probability of sharin

58 fference of sib pairs with the shared allele identical by descent (IBD) at marker locus for linkage t

59 to identify an approximately 12-Mbp interval identical by descent (IBD) between the affected individu

60 kage as measured by increased allele sharing identical by descent (IBD) by affected family members.

61 of unconditional probability of genes shared identical by descent (IBD) by relatives can be very diff

62 The proportion of alleles identical by descent (IBD) determines the genetic covari

63 correlation analyses based on alleles shared identical by descent (IBD) for independent obese affecte

64 alleles an individual carries at a locus are identical by descent (ibd) if they have descended from a

65 The detection of genetic segments of Identical by Descent (IBD) in Genome-Wide Association St

66 It has been successfully applied to identical by descent (IBD) segment identification and ge

67 this approach is very efficient for calling identical by descent (IBD) segments between all pairs of

68 relatedness, usually manifested as segments identical by descent (IBD), is ubiquitous in modern larg

69 als in the study share regions of the genome identical by descent (IBD), it is possible to use this i

70 high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008

71 We adopt the identical by descent (IBD)-based variance component meth

72 ithm to identify chromosomal segments shared identical-by-descent (IBD) and compared homozygosity at

73 e analysis confirmed that the haplotypes are identical-by-descent (IBD) and offered insight in the br

74 Using computationally detected DNA segments identical-by-descent (IBD) and runs of homozygosity (ROH

75 Widespread sharing of long, identical-by-descent (IBD) genetic segments is a hallmar

76 ent ancestors are likely to co-inherit large identical-by-descent (IBD) genomic regions.

77 We detected unusually high amount of shared identical-by-descent (IBD) genomic segments between seve

78 se allele heterogeneity and a high degree of identical-by-descent (IBD) haplotype sharing in this fou

79 The ability to identify segments of genomes identical-by-descent (IBD) is a part of standard workflo

80 Direct identical-by-descent (IBD) mapping is a technique, that

81 Inference of identical-by-descent (IBD) probabilities is the key in f

82 eling covariance between individuals, due to identical-by-descent (IBD) QTL alleles, on the basis of

83 Detection of Identical-By-Descent (IBD) segments provides a fundament

84 e number of sequence differences observed in identical-by-descent (IBD) segments together with a reco

85 genotyped samples by harnessing long (>4-cM) identical-by-descent (IBD) tracts shared among distantly

86 marker D5S500 (proportion of alleles shared identical by descent [ibd] = 0.68 +/- 0.05 [mean +/- SE]

87 20S119, D20S178, and D20S197 (allele sharing identical-by-descent [IBD], 0.56 for all three; P = 0.00

88 he realized proportion of the genome that is identical by descent (IBDG) is predicted better by the p

89 kage screen revealed a single locus that was identical by descent in affected children in both famili

90 The mutated BLM gene is inherited identical by descent in BS persons whose parents are cou

91 imating the probabilities of sharing alleles identical by descent in multipoint calculations and henc

92 Regions potentially shared identical by descent in patients were further characteri

93 dentified those regions most commonly shared identical by descent in patients with psoriasis.

94 iated with dark pigmentation in Africans are identical by descent in South Asian and Australo-Melanes

95 jor histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.

96 e was assessed by estimating allele sharing (identical by descent) in affected sibling pairs.

97 stimated proportion of marker alleles shared identical by descent is first partitioned into a compone

98 iers and 168 mutation carriers) carrying the identical-by-descent KCNQ1 p.Ala341Val (A341V) mutation

99 occur, resulting in genomic regions that are identical by descent, manifesting as runs of homozygosit

100 for strong and widespread selection against identical-by-descent marker homozygotes.

101 ertion presence or absence and will serve as identical-by-descent markers for the study of human evol

102 ther is the size of the most common class of identical-by-descent mutants in the sample, again tested

103 type consistent with a founder effect and an identical-by-descent mutation.

104 arently similar introgressions and CNVs were identical by descent or recurrent, we also performed who

105 enome for which both chromosomes were shared identical-by-descent, reducing the search space for caus

106 weight they attribute to each locus and two identical-by-descent segments-based estimators.

107 pproximately 67% of any AJ genome with long, identical-by-descent segments.

108 algorithm, DASH, which builds upon pairwise identical-by-descent shared segments to infer clusters o

109 conversion, and efficiently outputs pairwise identical-by-descent sharing data.

110 ed on multiplex sibship data, conditional on identical-by-descent sharing statuses.

111 nally and paternally derived alleles through identical-by-descent sharing, thus allowing for the disc

112 a parametric representation for the expected identical-by-descent statistic at an arbitrary locus, co

113 ving cases and controls, may share sequences identical-by-descent stretching on the order of 10s to 1

114 orphic L1 elements represent a new source of identical-by-descent variation for the study of human ev

115 is selectively neutral and if all copies are identical by descent with a copy that either was carried

116 ulated to have inherited chromosome segments identical-by-descent with exception of the mutated posit

117 histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a

118 region of the genome, more genetic material identical by descent, with and without the presence of a