ライフサイエンスコーパス: idiotype

1 immunodominant epitopes in autologous tumor idiotype.

2 on suggesting that this is a public (common) idiotype.

3 seem to induce antibodies that bind the OKT3 idiotype.

4 he B-cell receptor (BCR), otherwise known as idiotype.

5 demonstrated significant bias toward the VH3 idiotype.

6 drophobic patch (HP) responsible for the 9G4 idiotype.

7 e in the regulation of autoantibodies, their idiotypes.

8 xclusively producing chimeric Abs with human idiotypes.

9 e partially antagonized by corresponding IgG idiotypes.

10 erized by local production of polyclonal IgE idiotypes.

11 RNP) as well as reactivity against the 16/6 idiotype (16/6 Id).

12 Anti-idiotype 3H1 mimics a distinct and specific epitope of C

13 mature dendritic cells (DC) loaded with anti-idiotype 3H1 or CEA could reverse CEA unresponsiveness a

14 Here, we have combined the anti-idiotype 3H1 with the CTL peptides of CEA to augment bot

15 In this study, we identify an idiotype (44.1-Id) that dominates the PPS14-specific IgG

16 eby providing membrane expression of the 5H7 idiotype (5H7scFv-GPI).

17 b (ADX40) chemically conjugated to the tumor idiotype A20 and tested it in a murine lymphoma model.

18 xpressing murine follicular lymphoma-derived idiotype A20 mAb.

19 n increase in the PC response and in TEPC 15 idiotype(+) Ab production.

20 a from 40 of 47 patients showed an anti-anti-idiotype (Ab3) response.

21 T15-idiotype Abs, whose heavy (H) chain variable region is e

22 irst practical clinical application of cross-idiotype analysis.

23 ated anti-idiotype antibody induces a strong idiotype and antigen-specific response in mice.

24 cteria lack affinity maturation use the 44.1-idiotype and are dependent on marginal zone B cells.

25 cells demonstrated reconstitution of the 5H7 idiotype and binding to soluble HLA-A2.

26 light-chain variable-region (VL)-associated idiotype and had functional activities similar to those

27 ondary response highly enriched for the 44.1-idiotype and lacking affinity maturation.

28 oximated the SCA derivative in terms of both idiotype and metatype, confirming identical active site

29 ration of a family of antibodies with common idiotypes and affinities for fluorescein ranging over fi

30 ons that induce the production of regulatory idiotypes and that the presence or absence of these idio

31 ly defined cross-reactive human anti-Hib PRP idiotypes and was biased towards lambda light-chain expr

32 Anti-idiotype (anti-Id) antibody can induce tumor dormancy in

33 We developed a murine monoclonal anti-idiotype (anti-Id) antibody, 3H1, which mimics a specifi

34 Tumor-specific anti-idiotype (anti-Id) monoclonal antibodies (MoAbs) to B-ce

35 o CP and PNAG bound together via an apparent idiotype-anti-idiotype interaction.

36 ens.IMPORTANCEAnti-idiotype vaccines utilize idiotype-anti-idiotype network theory, eliminating the n

37 nti-cardiolipin antibodies (the latter by an idiotype-anti-idiotype reaction).

38 in autoimmunity through a network involving idiotype-anti-idiotype reactions termed 'autoantigen com

39 ooled sera of multiple donors resulting from idiotype/anti-idiotype (Id/anti-Id) interactions.

40 Focusing on an idiotype/anti-idiotype pair embedded in an environment s

41 Here, we produced a panel of anti-idiotype antibodies able to specifically recognize the i

42 h that is analogous to the isolation of anti-idiotype antibodies and were able to isolate peptides th

43 (ELISA) assays for idiotype protein or anti-idiotype antibodies in serum.

44 Anti-idiotype antibodies, in addition to cytotoxic T cells, a

45 active disease in patients treated with anti-idiotype antibodies.

46 treated with 52 courses of custom-made anti-idiotype antibodies.

47 acterize the structural footprint of an anti-idiotype antibody (E1) specific for a potent, fully huma

48 itic cells (DCs) pulsed with the murine anti-idiotype antibody 3H1 as a tumor vaccine.

49 dies suggested that vaccination with an anti-idiotype antibody 3H1, which mimics a specific epitope o

50 confirmed (CR/CRu) to CVP and making an anti-idiotype antibody are 2 independent factors that each co

51 This material reacts with an anti-idiotype antibody by Western blotting, ELISA, and affini

52 The C3d-conjugated anti-idiotype antibody induces a strong idiotype and antigen-

53 We have reported that anti-idiotype antibody response and FcgammaRIIIa 158 valine/v

54 demonstrate the utility of employing an anti-idiotype antibody to monitor a patient's specific immune

55 to inhibit mAb HGAC 39.G3 binding to an anti-idiotype antibody with approximately 1000-fold greater a

56 embryonic antigen (CEA), and that of an anti-idiotype antibody, 3H1, which mimics CEA and can be used

57 We generated an anti-idiotype antibody, designated CeaVac, that is an interna

58 nds the same protein and is superior to anti-idiotype approaches.

59 Here, we developed a novel anti-idiotype aptamer (termed A14#1) with extraordinary speci

60 monstrated the general applicability of anti-idiotype aptamers as capture reagents in quantification

61 Together, our data indicate that anti-idiotypes are a valuable tool for the study and inductio

62 Since idiotypes are different in each tumor, a personalized va

63 cination strategies using the tumor-specific idiotype as a target antigen, this review focuses on the

64 ipheral B lymphocytes (that express the same idiotypes as the antibodies produce).

65 tion by shuffled gammadelta TCR chains of an idiotype associated with a specific anatomic site indica

66 eacted with Hib PS and expressed HibId-1, an idiotype associated with the kappaII-A2 V region.

67 anti-dsDNA autoantibodies expressed the same idiotypes associated with the in vivo IgG anti-dsDNA res

68 to expand and ablate variable heavy 3 (VH3) idiotype B cells.

69 ic, suggesting that SpA cross-linking of VH3 idiotype B-cell receptors and activation via attached pe

70 Idiotype-based immunotherapy has been explored in myelom

71 Idiotype-based vaccination has produced an apparent prol

72 112, and day 168) were assessed via an anti-idiotype binding assay and characterised via non-compart

73 tor protein (BLA-BLIP) complex with two anti-idiotype binding proteins (Affimer proteins) as recognit

74 ab appears to delay humoral responses to the idiotype but may still allow cellular responses.

75 in specificities not only expressed the same idiotype, but rearranged the same light (V(L)) and heavy

76 We have developed a method of targeting idiotype by using a semisynthetic personalized therapeut

77 ere can promote informed targeting of peanut idiotypes by indirect marker-assisted selection.

78 We developed an anti-CAR19 idiotype chimeric antigen receptor (alphaCAR19) to speci

79 dy elicits an anti-antibody response or anti-idiotype, consequently producing a disease-inciting auto

80 ections, schistosome-specific cross-reactive idiotypes (CRI) are present in the sera of mice with mod

81 the use of photopheresis to generate an anti-idiotype cytotoxic T-cell response.

82 This idiotype-derived mimotope of PC is a useful tool for und

83 The tumor idiotype differs, however, from patient to patient, maki

84 and cellular immune mechanisms recruited by idiotype-directed DNA vaccines in the 38C13 murine B cel

85 show that second-generation, chemokine-fused idiotype DNA vaccines, when combined with myotoxins that

86 king of this TCR with an antibody to the TCR idiotype elicited vigorous T cell hybridoma activation,

87 idoma method or by expression of recombinant idiotype-encoding sequences in mammalian or plant-based

88 Among them, Nb61 (Ab2) targeted the idiotype epitope of mAb-1E7 and blocked mAb-1E7's bindin

89 dicated that there are at least two dominant idiotypes expressed in the human anti-alphaGal populatio

90 etermined, and the specificity, isotype, and idiotype expression of antibodies to C. neoformans capsu

91 nses of the mice to GXM and P13 and antibody idiotype expression were analyzed by an enzyme-linked im

92 ficant inter- and intrastrain differences in idiotype expression.

93 ase, and three Fab complexes with their anti-idiotype Fabs.

94 Use of DNA encoding an ld/GM-CSF (idiotype/granulocyte-macrophage colony-stimulating facto

95 osition, lymphocytes expressing the lymphoma idiotype have been detected in the splenic marginal zone

96 While Ab's specific for tumor idiotype have been well described in patients with B cel

97 erapeutic vaccines targeting B cell lymphoma idiotype have reached an advanced stage of clinical deve

98 based on tumor idiotype (Id) has shown anti-idiotype humoral immune responses in 40%-50% and cellula

99 in BALB/c mice frequently expresses the 2H1 idiotype (Id) and is restricted in variable gene usage.

100 We propose that the anti-idiotype (Id) binds to rituximab molecules bound univale

101 derived autologous tumor immunoglobulin (Ig) idiotype (Id) conjugated to keyhole limpet hemocyanin (K

102 The idiotype (Id) determinant on the multiple myeloma (MM) p

103 uble protein tumor Ag, the tumor-specific Ig idiotype (Id) expressed by a murine B cell lymphoma.

104 The unique immunoglobulin idiotype (Id) expressed by each B-cell lymphoma is a tar

105 zed immunotherapy of lymphoma based on tumor idiotype (Id) has shown anti-idiotype humoral immune res

106 nation with tumor-specific immunoglobulin or idiotype (Id) is a promising new form of immunotherapy f

107 is lower, and the dominant DEX-specific J558 idiotype (Id) is not detected in TdT(-/-) mice when comp

108 The idiotype (Id) of the Ig expressed on the surface of non-

109 tumor protection than a traditional lymphoma idiotype (Id) protein vaccine, and in combination with c

110 Idiotype (Id) protein, secreted by myeloma cells, is a t

111 istocompatibility complex (MHC) II, and anti-idiotype (Id) radiolabeled with 131-iodine.

112 Clinical studies of idiotype (Id) vaccination in patients with lymphoma have

113 e therapeutic efficacy by adding antimyeloma idiotype (Id)-keyhole limpet hemocyanin (KLH) vaccine to

114 munoglobulin, the variable regions of which [idiotype (Id)] can serve as a target for active immunoth

115 ice immunized with the BCL1 lymphoma-derived idiotype (Id+) IgM and subsequently challenged with BCL1

116 multiple donors resulting from idiotype/anti-idiotype (Id/anti-Id) interactions.

117 mmunoglobulin expressed by B-cell lymphomas (idiotype [Id]) can serve as a target for active immunoth

118 ells, carries unique antigenic determinants (idiotype [Id]) that can be regarded as a tumor-specific

119 lls contains a unique antigenic determinant (idiotype [Id]) that may serve as a tumor-specific antige

120 Idiotypes (Ids) are unique epitopes of Ab V regions and

121 Idiotypes (Ids), the unique portions of tumor immunoglob

122 e between Abs that recognize an autoantigen (idiotypes; IDs) and Igs that bind such Abs (anti-IDs) is

123 VH3 plasmablast expansions and increased VH3 idiotype Ig; however, the mechanisms for staphylococcal

124 nt-specific immunization with immunoglobulin idiotype (Ig-Id present on the surface of most B-cell NH

125 survival of all 20 patients mounting an anti-idiotype immune response are significantly prolonged com

126 3H recipients reconstituted with marrow from idiotype immune, but not nonspecifically immune, donors

127 to prove a causal relationship between anti-idiotype immunity and improved clinical outcome.

128 d 38C13 scFv generate >10 micrograms/ml anti-idiotype immunoglobulins.

129 determined the crystal structure of two anti-idiotypes in complex with iglb12 and used these anti-idi

130 Polyclonal IgE idiotypes in patients with CRSwNP are functional, promot

131 T15 antibodies, the dominant and protective idiotype induced in mice by PC immunization, self-associ

132 ion with a multimerized version of this anti-idiotype induced the proliferation of transgenic murine

133 bound together via an apparent idiotype-anti-idiotype interaction.

134 ng the case previously studied using an anti-idiotype, involvement of the splenic marginal zone could

135 The F4 idiotype is a heavy chain determinant expressed almost e

136 Therapeutic vaccination against idiotype is a promising strategy for immunotherapy of B-

137 d, a small peptide with affinity for a tumor idiotype is identified by screening a library, chemicall

138 the experimental fact that the level of anti-idiotypes is low in autoimmune patients but high in heal

139 Ig receptor expressed by malignant B cells, idiotype, is a tumor-specific antigen and an attractive

140 mmunization with DNA constructs encoding the idiotype (ld) of a murine B-cell lymphoma induced specif

141 GH1002 was elicited with the syngeneic anti-idiotype mAb MK2-23 which mimics the determinant defined

142 Both idiotype mAbs were able to induce a similar antitumor pr

143 adjuvant peptide is crosslinked to the anti-idiotype mimetic by chemical means without modifying oth

144 B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs).

145 We isolated and characterized an anti-idiotype monoclonal antibody 3H1, which mimics a distinc

146 ab as a synthetic cytokine and a set of anti-idiotype nanobodies (AIP(VHH)) as synthetic receptors.

147 i-idiotype vaccines and identified that anti-idiotype nanobodies could mimic the antigen on amino aci

148 ainst different pathogens are prepared, anti-idiotype nanobody vaccines can be easily produced agains

149 Anti-idiotype vaccines utilize idiotype-anti-idiotype network theory, eliminating the need for extern

150 Anti-idiotype of (natural) autoantibodies participate in the

151 ty mAb (MB2A4) with fine specificity for the idiotype of rituximab.

152 The idiotype of the Ig expressed by a B-cell malignancy (Id)

153 resses and secretes clonally derived Ig, the idiotype of which can serve as a tumor-specific antigen,

154 erated specific immune responses against the idiotypes of their tumor Ig.

155 tudies, we generated an antibody against the idiotype on the A20 B-cell lymphoma line.

156 The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represen

157 anti-La/SS-B antibodies are antiidiotypes to idiotypes on anti-dsDNA and that they both mask and down

158 ccines, based on dendritic cells pulsed with idiotype or tumor lysate, have been met with limited suc

159 , B cells expressing IgG and IgA of the same idiotype or V(H) family and the same CDR3 length as thos

160 ll lymphoma patients with tumor-specific Ig (idiotype, or Id) chemically coupled to the immunogenic f

161 hown to retain a conformational determinant (idiotype) ordinarily expressed exclusively by such Vgamm

162 Focusing on an idiotype/anti-idiotype pair embedded in an environment such as the cen

163 rst detailed molecular comparison of an anti-idiotype paratope specific for a human antibody with its

164 strate that the resultant semisynthetic anti-idiotype peptibodies kill tumor cells in vitro with spec

165 samples were examined by flow cytometry for idiotype positive cells, and by polymerase chain reactio

166 inducing a mimotope response including VH3 (idiotype)-positive antibodies to GXM in G2 but not G4 mi

167 associated with the classical protective T15 idiotype-positive NAbs, whereas those without DFL16.1 co

168 es and that the presence or absence of these idiotypes predicts, and possibly determines, subsequent

169 b) reactive with a supratypic cross-reactive idiotype present on Ig encoded by a subgroup of Ig V(H)4

170 idoma-generated vaccines, we found that anti-idiotype production was even more highly associated with

171 st that treatment with vaccines comprised of idiotype protein may be associated with improved clinica

172 inked immunosorbent assay (ELISA) assays for idiotype protein or anti-idiotype antibodies in serum.

173 om lymphoma patients actively immunized with idiotype protein specifically recognized multiple, uniqu

174 tic cells pulsed ex vivo with tumor-specific idiotype protein to stimulate host antitumor immunity wh

175 We evaluated the ability of a new idiotype protein vaccine formulation to eradicate residu

176 Lymphoma idiotype protein vaccines have shown therapeutic potenti

177 The idiotype protein, secreted by myeloma plasma cells, is a

178 The manufacturing of autologous tumor idiotype proteins is being rapidly refined by the use of

179 Idiotype proteins were produced either by the hybridoma

180 These include the idiotype proteins, breakpoint cluster region (bcr)-abl a

181 Occasionally, CTLs responded to autologous idiotype-pulsed DCs and to allogeneic primary myeloma ce

182 n antibodies (the latter by an idiotype-anti-idiotype reaction).

183 ty through a network involving idiotype-anti-idiotype reactions termed 'autoantigen complementarity'.

184 ies, the precise antigenic epitopes in human idiotype recognized by autologous T cells remain largely

185 ltispecificity) that impact current views on idiotype regulation, autoimmunity, and B cell selection

186 Although anti-idiotype responses are theoretically possible against hu

187 ent with CAMPATH-1H can lead to patient anti-idiotype responses which may be exacerbated by the unusu

188 bcutaneous alemtuzumab made substantial anti-idiotype responses.

189 ibutes to the generation of Ab diversity and idiotype restriction.

190 The idiotype served as the tumor antigen.

191 Small molecules with idiotype-specific antibody targeting may be useful as re

192 m that antibody responses are the primary of idiotype-specific antitumor effects and support the opti

193 plenocytes with tumor cells failed to induce idiotype-specific cytotoxicity, and following vaccinatio

194 DNA vaccination can be largely attributed to idiotype-specific humoral immunity.

195 receptor (TCR) protein induces a protective, idiotype-specific immune response against a murine T-cel

196 safe to administer, and a viable option for idiotype-specific immune therapy in follicular lymphoma

197 , to test the principle of transfer of tumor idiotype-specific immunity with BM.

198 modified tobamoviral vector that encodes the idiotype-specific single-chain Fv fragment (scFv) of the

199 Association of idiotype-specific T cell responses with previously docum

200 in 5 FL patients and found an increase in FL idiotype-specific T cells after rituximab in 4 of 5 pati

201 In this study, we tested the efficacy of idiotype-specific Th2 cells for the treatment of mice wi

202 Analysis of the blocker mechanism indicated idiotype specificity, as (i) pyrano[2,3-c]pyrazoles did

203 tailed molecular comparison between the anti-idiotype surface and its analogous epitope located at th

204 The idea is to introduce an antigen or anti-idiotype that binds to the autoantibodies with high affi

205 GXM monoclonal antibody (MAb) 2E9 expresses idiotypes that are also found in naturally occurring ant

206 he bystander effect, molecular mimicry, anti-idiotype theory, antigenic complementarity, and dual-aff

207 s in complex with iglb12 and used these anti-idiotypes to identify rare naive human B cells expressin

208 inct B cell clones expressing characteristic idiotypes under genetic control and suggest that the 44.

209 reviously documented molecular remissions in idiotype-vaccinated patients suggests that the newly ide

210 f 136 follicular lymphoma patients receiving idiotype vaccination after induction chemotherapy.

211 n 1000 patients are now under way, which use idiotype vaccination after induction chemotherapy; one t

212 Idiotype vaccination in remission may prevent relapse in

213 orm of the Fc receptor in patients receiving idiotype vaccination regardless of their response to ind

214 Lymphoma idiotype vaccination represents a promising immunotherap

215 ted therapies, ie, monoclonal antibodies and idiotype vaccination.

216 de, vincristine, and prednisone) followed by idiotype vaccination.

217 ortant effectors of antitumor immunity after idiotype vaccination.

218 sed immune responses to a well-characterized idiotype vaccine in individuals with severe B-cell deple

219 It highlighted that the anti-idiotype vaccine using nanobody has a very good applicat

220 To enhance the immunogenicity of an anti-idiotype vaccine we incorporated a molecular adjuvant pe

221 opened in 2004, using rituximab followed by idiotype vaccine with maintenance booster vaccines conti

222 personalized (patient-specific) recombinant idiotype vaccines against follicular B cell lymphoma and

223 a strategy for producing nanobody-based anti-idiotype vaccines and identified that anti-idiotype nano

224 s support the conclusion that plant-produced idiotype vaccines are feasible to produce, safe to admin

225 Anti-idiotype vaccines are safer due to their absence of path

226 umor effects and support the optimization of idiotype vaccines designed to induce primarily T-cell im

227 While idiotype vaccines have shown promise for B-cell malignan

228 Immunotherapy with therapeutic idiotype vaccines offers promise for treatment of B-cell

229 We have developed several generations of idiotype vaccines that were tested in an animal model, t

230 he commercial production of traditional anti-idiotype vaccines using monoclonal and polyclonal antibo

231 ially for dangerous pathogens.IMPORTANCEAnti-idiotype vaccines utilize idiotype-anti-idiotype network

232 phase III trials for three first-generation idiotype vaccines will become available in the next seve

233 imple, low-cost strategy for developing anti-idiotype vaccines with nanobody technology.

234 simple, low-cost strategy for producing anti-idiotype vaccines with nanobody technology.

235 However, developing anti-idiotype vaccines with traditional monoclonal and polycl

236 sults in phase II trials of patient-specific idiotype vaccines, with very few side effects noted.

237 to overcome the barriers of patient-specific idiotype vaccines.

238 on each B-cell lymphoma has unique portions (idiotypes), which can be recognized by the immune system

239 The Vlambda2(+) antibodies express the 8.12 idiotype, which is expressed on anti-double-stranded-DNA

240 efficient system to produce patient-specific idiotypes with potential application as lymphoma vaccine

241 hypothesis that active immunization with the idiotype would evoke a polyclonal immune response that w

242 umatoid factors (mRF) that bear the WA cross-idiotype (Xid) are responsible for most cases of cryoglo