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1 to tolerance but is because of immunologic 'ignorance'.
2 seless destruction who thrive in poverty and ignorance.
3 mes to imagine the breathtaking scope of our ignorance.
4 tolerance in B cells, a state termed clonal ignorance.
5 tional inactivation because of immunological ignorance.
6 cific for the Sm that remain tolerant due to ignorance.
7 f B cells and not as a result of true clonal ignorance.
8 cells and contribute to the origin of clonal ignorance.
9 ssibly reflecting a bias towards attributing ignorance.
10 to remain unrealized and potentially lost in ignorance.
11 tion does not erode our awareness of our own ignorance.
12 riosity focused on dispelling uncertainty or ignorance.
13 al was largely a reflection of immunological ignorance.
14 ncluding clonal deletion, anergy, and clonal ignorance.
15 rmally induce B cell anergy or B cell clonal ignorance.
16 they allow for representations of egocentric ignorance.
17 ne attack through immune system exclusion or ignorance.
18 tively maintain tolerance are quiescence and ignorance.
19 earance is not attributable to immunological ignorance.
20 ve T cells, creating a state of tolerance or ignorance.
21 gen-dependent activation to preserve clonal "ignorance."
26 oblems in aDNA studies are contamination and ignorance about taphonomy (transportation, incorporation
28 y used in protein biophysics even though our ignorance about the HX mechanism makes data interpretati
29 obos are capable of attributing knowledge or ignorance about the location of a hidden food reward to
30 e factor uncertainties are most sensitive to ignorance about water-oil ratio (WOR) and steam-oil rati
33 l, GITR stimulation overcomes self-tolerance/ignorance and enhances T cell-mediated antitumor activit
34 LA I knockdown hESC(siRNA+IB) provoke T-cell ignorance and experience largely mitigated xenogeneic re
36 ation which is not due to immune deletion or ignorance and is associated with early development of a
38 surrounding neurodiversity, often fuelled by ignorance and misinformation, contribute to the marginal
39 individuals for their efforts to overcome my ignorance and set me on the straight and narrow path to
40 hese findings question the concept of clonal ignorance and show that physiological concentrations of
41 and the understanding of tumor immunological ignorance and support intratumoral vaccination as a stra
43 or differentiation antigens can break immune ignorance and tolerance to self and induce protective tu
44 eness (clonal exhaustion-deletion and immune ignorance) and their regulation removed much of the hist
45 iated by clonal deletion, (ii) T-cell clonal ignorance, and (iii) nondeletional T-cell tolerance medi
47 production for decision-makers, uncertainty, ignorance, and risk related to their development, valida
48 actions aimed toward addressing uncertainty, ignorance, and risk, which operationalise the precaution
49 throughout the life of a T cell: quiescence, ignorance, anergy, exhaustion, senescence and death.
50 h afflicted with a remarkable degree of self-ignorance, are able to realize their values in their liv
51 male antigen HY, we evaluated whether tumor ignorance as determined by lack of a systemic immune res
53 article first discusses the reasons for this ignorance before reviewing the basic mechanisms that con
63 ots as extensions of the self, and strategic ignorance emerged as key mechanisms through which profes
65 e decisions is to identify the causes of our ignorance (i.e., why an unexpected event might have occu
68 is challenge, unpacking what uncertainty and ignorance in relation to NAM innovation means, and encou
69 that apes can represent (and act on) others' ignorance in some form, strategically and appropriately
75 to a CTL response and that a similar type of ignorance may explain why HPV-associated cervical cancer
77 and safety knowledge gaps, institutionalized ignorance, nondecision/inaction, and outdated (or unfulf
78 results suggest a novel mechanism for T cell ignorance of agonist MHC-peptide complexes based on domi
80 numerous infectious and metabolic diseases, ignorance of amyloid structure has hindered similar appr
82 i-LFA-1 therapy was not simply due to clonal ignorance of donor Ags in that the majority of recipient
83 tary immunisation, and most caregivers cited ignorance of either vaccine importance or availability a
84 oductive females at nesting beaches and (ii) ignorance of factors regulating recruitment to the early
85 and use it to examine the effect of manager ignorance of household decisions on resource management
86 h to improved toxicity and spectrum has been ignorance of how Cyt1Aa crystallizes in vivo and of its
89 onservativeness after Bonferroni correction, ignorance of linkage disequilibrium (LD) between neighbo
91 tended to avoid nutritional problems, plead ignorance of nutrition principles, and delegate the nutr
92 dedicated field research has brought us from ignorance of our closest relatives to the discovery that
93 d that simple self-referential judgement and ignorance of perceived hypocrites is sufficient to promo
94 The development of therapies is hindered by ignorance of potential beneficiary patient subgroups.
95 ticized for their lack of flexibility, their ignorance of potential interaction between predictors, a
98 ufficient separation of glycemic levels, and ignorance of smoking history as a possible confounder.
99 l rise to ocean warming (notwithstanding our ignorance of the abyssal and Southern Oceans): the histo
101 ter in diabetic ketoacidosis underscored our ignorance of the controls in human fuel metabolism.
103 is molecular fossil record is constrained by ignorance of the function of their molecular antecedents
104 ly stages of the epidemic, assuming complete ignorance of the future environmental drivers, fail beca
105 shed pathogens is often severely hampered by ignorance of the genetic determinants of virulence, drug
107 in the nasopharynx is to maintain tolerance/ignorance of the large volume of harmless antigens and b
108 al was justified by "... our almost complete ignorance of the mechanism for the unfolding of the gene
109 t lignocellulosic biomass is hampered by our ignorance of the molecular basis for its properties such
110 cribe the current state of our knowledge and ignorance of the molecular mechanics underlying eukaryot
111 iotic multiresistant bacteria is hampered by ignorance of the natural history of resistance genes, th
114 s have often been attributed to disease, but ignorance of the relative importance and mode of action
116 far removed from its natural habitats and in ignorance of the selective pressures that have shaped it
117 and its function fully have been hampered by ignorance of the structural details of its interactions
118 the field has been significantly hampered by ignorance of the underlying intracellular pathways.
122 immunogenic tumors result in either complete ignorance or tolerance induction, suggesting inadequate
123 nt; thus, it must maintain a state of immune ignorance or tolerance not to overrespond to harmless en
124 ly basis and must maintain a state of immune ignorance or tolerance to these harmless stimuli to reta
125 to recognize the antigen (i.e. immunological ignorance) or to an active induction of an antigen-speci
127 nded mongooses, acting from behind a veil of ignorance over kinship, allocate postnatal care in a way
129 nded normally to i.p. challenge, implicating ignorance rather than anergy as the main reason for the
132 on the impartial thinking induced by veil-of-ignorance reasoning and cannot be explained by anchoring
136 Participants who first engaged in veil-of-ignorance reasoning subsequently made more utilitarian c
142 ved remain elusive, in large part because of ignorance regarding the numbers of proteins in regulator
147 Instead, they remain at a stage of "clonal ignorance"; that is, they do not proliferate and differe
148 ified (clonal exhaustion-deletion and immune ignorance) that linked organ engraftment and the acquire
149 f the degree of our current immunobiological ignorance, the availability of powerful new tools for di
152 of peripheral tissues is not attributable to ignorance, timing-based tolerance, or special circulatio
153 arenchyma contributes to the systemic immune ignorance to Ags localized exclusively within the brain.
154 uld counteract the intrinsic systemic immune ignorance to Ags localized exclusively within the brain.
156 nt challenge for mammalian cells to maintain ignorance to self-DNA under homeostatic conditions.
157 a differentiation scheme in which peripheral ignorance to Sm is maintained in mice by the differentia
159 ng must maintain a high threshold of immune 'ignorance' to innocuous antigens to avoid inflammatory d
160 clonal deletion and are examples of "clonal ignorance." To understand the genetic origin of Abs from
162 They look toward an available adult, convey ignorance via nonverbal gestures (flips/shrugs), and inc
163 de by others and myself that led us all from ignorance, via complete confusion, to our current state
164 philosopher John Rawls proposed the Veil of Ignorance (VoI) as a thought experiment to identify fair
165 k, where outcome probabilities are known, or ignorance, where outcomes are completely unknown and unk
166 ietal rewards are made from behind a veil of ignorance, which obscures the personal gains that result
167 nergy, senescence, cell death, exclusion and ignorance - with the ultimate aim of informing novel app