ライフサイエンスコーパス: imidazole

1 limidazole was found to be the most abundant imidazole.

2 by delta vs epsilon-nitrogen ligation of the imidazole.

3 as triethylamine, trimethylamine oxide, and imidazole.

4 bles a modular approach for the synthesis of imidazoles.

5 t is also applicable to preparation of fused-imidazoles.

6 tizing properties of small alkyl-substituted imidazoles.

7 can coordinate with one or more of the His37 imidazoles.

8 Within the present study, five imidazoles (1-butylimidazole, 1-ethylimidazole, 2-ethyli

9 The most appealing series contain imidazole, 1,2,4-triazole, or benzimidazole rings fused

10 nknown phosphoryl-substituted 4,5-dihydro-1H-imidazoles, 1,4,5,6-tetrahydropyrimidines, and thioamide

11 Imidazole-1-sulfonyl azide and salts thereof are valuabl

12 ules via a key guanylation step employing di(imidazole-1-yl)methanimine (6) followed by a two-fold cy

13 otosensitizer, where bmip = 2,6-bis(3-methyl-imidazole-1-ylidine)-pyridine, with simultaneous femtose

14 Photosensitized reactions involving imidazole-2-carboxaldehyde (IC) have been experimentally

15 Piperazine-1,4-diylbis(6-benzo[d]imidazole-2-yl)pyridine-2-yl)methanone, 7, was identifie

16 diene, IMes = 1,3-bis(2,4,6-trimethyl-phenyl)imidazole-2-ylidene) in the presence of an excess of par

17 s a byproduct ([(i)Pr2Im] = 1,3-di(isopropyl)imidazole-2-ylidene).

18 Mes)], (IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene)] was first acti

19 Mes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto s

20 -d-ribofuranose and 1'-beta-[1-naphtho[2,3-d]imidazole]-2'-deoxy-d-ribofuranose and their use for qua

21 he imidazole ring to yield trisubstituted NH-imidazoles (23%-69%, three steps).

22 dology afforded twenty-nine disubstituted NH-imidazoles (23%-85% yield).

23 ing covalent inhibitor, the tetrasubstituted imidazole 3-acrylamido-N-(4-((4-(4-(4-fluorophenyl)-1-me

24 ones, and (iii) 1,2-dihydro-3H-pyrrolo[1,2-c]imidazole-3-ones.

25 A 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (1) lithium derivative was foun

26 ening campaign intriguingly afforded the non-imidazole 4-(3-azetidin-1-yl)pyrimidin-2-amine 11b as a

27 ere solved in complex with 4-(4-chlorophenyl)imidazole (4-CPI).

28 rmation of 6-imino-5,6-dihydropyrrolo[3,4- d]imidazole-4(3 H)-one (IPIMO) derivative.

29 IIP-IDC) is synthesized by polymerization of Imidazole-4,5-dicarboxylic acid functionalized Allyl chl

30 MPK activator 5-amino-1-beta-D-ribofuranosyl-imidazole-4-carboxamide (AICAR) or adenovirus expressing

31 methyl)pyrrolidin-3-yl)-5-fluoro-1H-benzo [d]imidazole (42) with IC50 values of 44 and 50 nM, respect

32 its flexible inner loop of the 4-methylidene-imidazole-5-one (MIO) domain compared with that of dicot

33 ene-stabilized Si2Cl2 (2) and substituted 1H-imidazole (9), combination of the corresponding Fe(CO)4-

34 Imidazole, a well-known (1)O2 scavenger, was incorporate

35 zation of TRPV1 by histamine, its metabolite imidazole acetaldehyde, and supernatants from biopsy spe

36 effect could be reproduced by histamine and imidazole acetaldehyde.

37 The relationship between imidazole acidity and carbon dioxide capture is explored

38 However, they require unstable ascorbate or imidazole activation.

39 NTAmers are highly stable but upon imidazole addition, they decay rapidly to pMHC monomers,

40 These imidazole alkaloids could thus be applicable as specific

41 t study aimed at the identification of novel imidazole alkaloids derived from histamine or histidinol

42 based method for the quantitation of several imidazole alkaloids in tomato products.

43 ton of massadine and related dimeric pyrrole-imidazole alkaloids is a synthetic challenge.

44 d B are broad-spectrum antibacterial pyrrole-imidazole alkaloids that have a complex polycyclic skele

45 screened for the occurrence of the described imidazole alkaloids.

46 n previously, oligomers derived from achiral imidazole amino acids fold into canonical helices.

47 Then, among a small set of poly-imidazole analogs, compounds showing the highest theoret

48 to the low-spin state (S = 1/2) of all known imidazole analogs.

49 led lipidoid library containing imidazole or imidazole analogues to perform a structure-activity corr

50 This has allowed us to introduce several imidazole anchoring groups along the polymer chain for t

51 vatives and also for the differences between imidazole and 1,2,4-triazole analogues.

52 Ornithine, imidazole and atropine (acetylcholine inhibitor) inhibit

53 A small library of imidazole and imidazolium reactivators was successfully

54 can be readily condensed to give a range of imidazole and pyrazine derivatives.

55 mpared to furan, and small but noticeable in imidazole and pyrrole and in thiazole and thiophene.

56 e examined the redox activities of pyridine, imidazole and their alkyl derivatives using a cell-free

57 ecifically encapsulates guests incorporating imidazole and thiazole moieties, including drugs and pep

58 The imidazole and triazole series with the short -CH2- linke

59 Three series of biarylpyrazole imidazole and triazoles are described, which vary in the

60 N-Acyl imidazoles and catalytic isothiourea hydrochloride salts

61 offer binding pockets exposed with arrays of imidazoles and lysines.

62 tion reaction concept is extended to include imidazoles and pyrazoles, giving imidazolo- and pyrazolo

63 tion with nitriles to N-tetrafluoroethylated imidazoles and rhodium-catalyzed ring-opening, and cycli

64 reening of ALP inhibitors, including Na3VO4, imidazole, and arginine.

65 3-dicarbonyl compounds with indole, pyrrole, imidazole, and pyrazole nucleophiles via an allylic link

66 Pyrroles, imidazoles, and pyrazoles substituted with a formyl grou

67 coupling of sp(2) C-H bonds with pyrazoles, imidazoles, and sulfonamides.

68 We introduce a set of multicoordinating imidazole- and zwitterion-based ligands suited for surfa

69 llulose (CNC) modified with 1-(3-aminopropyl)imidazole (APIm) is proposed as a reversible coagulant f

70 ted macrophages indicates that ornithine and imidazole are two top-scoring metabolites in Mtb-infecte

71 Chiral substituted furans and imidazoles are key intermediates to access biologically

72 rates the laboratory studies by showing that imidazoles are present in ambient aerosol samples in mea

73 Imidazoles are widely discussed in recent literature.

74 tic ion-imprinted polymer was synthesized by imidazole as a new ligand and grafted onto the surface o

75 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole as an electron donor, time-resolved infrared m

76 chloroauric acid as precursor and N-dodecyl imidazole as functional monomer, gold nanoroots (AuNRs)

77 ne group at the homopropargylic position and imidazole as the catalyst to deliver 2,4-cyclohexadienon

78 s or ring cleavage was only observed for the imidazoles as expected from the general mechanism of oxi

79 porphyrin moiety with a covalently tethered imidazole axial "base" donor ligand) has been identified

80 amesitylporphyrin dianion), with and without imidazole axial ligands.

81 proton is transferred to the hydrogen-bonded imidazole base.

82 rovided improved oral bioavailability in the imidazole-based 13-membered macrocycle to the 12-membere

83 -SHEATH hyperpolarization of a wide range of imidazole-based antibiotics and chemotherapeutics.

84 ion reaction using novel N,P-ligated iridium imidazole-based catalysts (Crabtree type).

85 ave designed and synthesized a series of new imidazole-based compounds structurally related to an ant

86 Nimorazole belongs to the imidazole-based family of antibiotics to fight against a

87 orks (ZIFs) can be tuned by mixing different imidazole-based linkers within the same structure.

88 Here, we describe optimization of the imidazole-based macrocyclic series and our initial progr

89 f native and VX-phosphonylated hAChE with an imidazole-based oxime reactivator, RS-170B.

90 In this field, we have recently reported an imidazole-based peptidomimetic that has shown PCSK9 inhi

91 g the integrity of chemical structure of the imidazole-based pharmaceuticals.

92 onverted into a range of 1-methyl-2-nitro-1H-imidazole-based precursors of bioreductive prodrugs.

93 tion of the first structurally characterized imidazole-based radical 2.

94 nnels and has implications for the design of imidazole-based synthetic proton channels.

95 reported procedures includes that oxazoles, imidazoles, benz(ox/othi/imid)azoles, and indole are fou

96 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole (BIH) as sacrificial reductant.

97 onal theory (DFT) calculations indicate that imidazole binds to the copper complexes.

98 The CYP2B6 inhibitor 4-(4-chlorophenyl)imidazole blocked NO-dependent CYP2B6 degradation, sugge

99 e the syntheses and reactivity of three Ntau-imidazole bonded Cu(II) 2 O2 species at solution tempera

100 Synthetic monodentate imidazole-bonded Cu(II) 2 O2 species self-assemble in a

101 The greater amount of H2O2 production by the imidazole bound complex under fast electron transfer is

102 e present a crystal structure of a monomeric imidazole-bound AfGcHK globin domain at 1.8 angstrom res

103 histidine sequences reversibly, oxidation of imidazole-bound Co(II) or Ru(II) is known to result in a

104 n order to evaluate the feasibility of using imidazole-bound metal oxidation as a means of attaching

105 n this study, 3-amine-N-[3-(N-pyrrole)propyl]imidazole bromide (APPIBr) ionic liquid was successfully

106 ydrophobic substituents at the 2 position on imidazole can significantly improve both charge reductio

107 or of the monophosphate derivative 5-amino-4-imidazole carboxamide ribonucleoside 5'-phosphate (ZMP),

108 nd alpha-alkylation, respectively, of 2-acyl imidazoles catalyzed by a chiral-at-metal rhodium-based

109 synthetic steps) and its microwave-assisted imidazole-catalyzed domino rearrangement to generate the

110 omising antimycobacterial activity, with the imidazole-CH2- series (7) showing low MIC values (6.25-2

111 FQX in conjunction with ligand-directed acyl imidazole chemistry enables covalent labeling of AMPA-ty

112 ansion-induced PDT enhancement by controlled imidazole chemistry.

113 as designed based on our lead acyclic phenyl imidazole chemotype.

114 on was found between aerosol particle pH and imidazole concentration.

115 mploying catalytic HBr and DMSO, followed by imidazole condensation with aldehydes.

116 nd polybases (e.g., polyamines, pyridine and imidazole containing polymers, cationic polysaccharides,

117 of optically active (poly)hydroxy furans and imidazoles containing multiple stereocenters with good y

118 ne-pot synthesis of highly substituted fused imidazole-containing 5,5- and 5,6-fused bicyclic heteroc

119 variety of lipidoids ex vivo and identified imidazole-containing lipidoids that are particularly pot

120 These structures reveal that the imidazole core acts as an H-bond acceptor for the cataly

121 terocyclic core modifications to replace the imidazole core as well as various linkers to the P1 grou

122 mation of the organic product containing the imidazole coupled to aromatic substrate via a new C-N bo

123 method for catalyst development, we prepared imidazole-covered MNPs that accelerate the hydrolysis of

124 Treatment with the oxindole/imidazole derivative C16 rescued oHSV-1 replication in m

125 ould contain anti-archaeal compounds such as imidazole derivatives in most cases.

126 ect functionalization of rationally designed imidazole derivatives through electrophilic fluorination

127 Here, we tested a range of imidazole derivatives to discover improved charge reduci

128 Thiophene, oxazole, and imidazole derivatives were used as aryl moieties.

129 These new imidazole derivatives will be immediately beneficial for

130 l or full H(3)R agonists have typically been imidazole derivatives.

131 ctrode surface followed by its reaction with imidazole derivatives.

132 organic molecules such as benzocarbazole and imidazole derivatives.

133 The contact of imidazolium and imidazole-derived PDA with various bacterial strains inc

134 with the [M8L12] (M=In/Cr, L=dinegative 4,5-imidazole-dicarboxylate) cubane-like structure.

135 ine enhances AMPK mediated autophagy whereas imidazole directly kills Mtb by reducing cytochrome P450

136 re of L as well as the rotational freedom of imidazole donor moieties around C-N bond make it a speci

137 We found that diamidophosphate (DAP) and imidazole drive the formation of 2',3'-cyclic phosphate

138 s - with the BM3 DM heme domain bound to the imidazole drugs clotrimazole and tioconazole, and to the

139 tures, we morphed this hit class into potent imidazoles, exemplified by compound 3.

140 inct metal-chelating groups, lipoic acid and imidazole, for the surface functionalization of QDs.

141 abled the rapid union of the key pyrrole and imidazole fragments.

142 The structure of melt-quenched zeolitic imidazole framework (ZIF) glasses can provide insights i

143 F NP) consisting of both silica and zeolitic imidazole framework (ZIF).

144 as based on the utilization of magnetic zinc-imidazole frameworks (ZIF-4), as a highly efficient medi

145 ISPR/Cas9 encapsulated by nanoscale zeolitic imidazole frameworks (ZIFs) with a loading efficiency of

146 robable mechanism for the formation of these imidazoles from hydroxyiminoimine intermediates has also

147 A new, one-pot synthesis of imidazoles from imines, acid chlorides, and N-nosyl imin

148 This series yields several non-imidazole full agonists with potencies varying with the

149 repared with azide, cyanide, and substituted imidazole functionalities, by adding nucleophiles to an

150 yclic arenes (pyridine, quinoline, pyrazole, imidazole, furan, thiophene, benzofuran, and indole) and

151 Imidazole glycerol phosphate synthase (IGPS) is a V-type

152 yme catalysis thanks to the chemistry of its imidazole group that can serve as nucleophile, general a

153 In addition, the imidazole groups attached to the cationic polymer segmen

154 tain poly-histidine chains (poly-His), whose imidazole groups generate (14) N-quadrupolar-peaks that

155 ar bridging of Cu(I) by Cys thiolate and His imidazole groups, whereas the coordination of Cu(II) inv

156 les becomes thiophene > thiazole > pyrrole > imidazole > furan > oxazole.

157 romaticity decreases in the order thiazole > imidazole > oxazole; in combination with previous result

158 Palladium-catalyzed C-H bond arylation of imidazoles has been applied to pharmaceuticals such as B

159 The intrinsic acidity of these imidazoles has not heretofore been measured; these exper

160 te heme (9<=pH<=11) and the penta-coordinate imidazole heme (6<=pH<=8.5) reproduces well the heme lig

161 Three crystal structures complexed with imidazole, HOL, and His with NAD(+) provided in-depth in

162 nce for the existence of various imidazolium-imidazole hydrogen-bonding geometries in the histidine t

163 The imidazole (Im) deoxyribonucleoside was chosen as a highl

164 Both water-associated and hydrogen-bonded imidazole-imidazolium histidine quaternary structures ha

165 Many imidazole (IMZ) derivatives of pharmaceutical interest,

166 oxalyl boronates to afford substituted boryl imidazoles in a regiocontrolled fashion.

167 y studies, no quantitative information about imidazoles in ambient aerosol particles is available.

168 g to a series of fluorinated polysubstituted imidazoles in gram scale.

169 g alpha-hydroxyiminoimines to trisubstituted imidazoles in high yields under mild conditions.

170 fords 1-N-methy-2,5-bishet(aryl)-4-het(aroyl)imidazoles in highly regioselective fashion in most of t

171 t access to highly diverse, multisubstituted imidazoles in isolated yields up to 83% under mild condi

172 ng higher level of alkaloid compounds (e.g., imidazoles) in rice straw burning HULIS was consistent w

173 the binding modes of several trisubstituted imidazole inhibitors in complex with the EGFR kinase dom

174 Previous studies of trisubstituted imidazole inhibitors led to the serendipitous discovery

175 d rotating ring disk electrochemistry), when imidazole is bound to the heme (Fe(Im)Cu), this same sel

176 Herein, the gas-phase acidity of a series of imidazoles is examined both experimentally and computati

177 ective synthesis of 1,2,4,5-tetrasubstituted imidazoles, is reported.

178 fluconazole, propiconazole, tebuconazole and imidazoles: ketoconazole, prochloraz) was investigated i

179 g activated monomer with displacement of the imidazole leaving group.

180 onded Cu(II) 2 O2 species, hinting that Ntau-imidazole ligation, conserved in all characterized Ty, h

181 eral mechanism of oxidative ring openings of imidazoles, likely affecting the bioactivity of these BT

182 onding weakening of the trans-axial histidyl imidazole linkage at lower pH.

183 The imidazole linked-2D-polymer exhibits ultrahigh proton co

184 t molecules and the chemical function of the imidazole linker is essential for directing the swing ef

185 effect of chemical functionalization of the imidazole linker on the framework dynamics.

186 asing polarity (-CH3, -CHO, and -NO2) on the imidazole linkers provide control over the degree of rot

187 etween exposure to antibiotics (beta-lactam, imidazole, macrolide, nitrofurantoin, quinolone, sulphon

188 e conditions and at 80 degrees C, a DMAP- or imidazole-mediated clean and rapid conversion of cyclic

189 e to the proton sponge effect enabled by the imidazole moieties in the SMOF NPs.

190 endosomal escape promoted by the protonated imidazole moieties.

191 The imidazole moiety of caffeine was critical for the specia

192 Moreover, the imidazole moiety was found to abstract the sulfur atom f

193 ycles investigated, compound 23, carrying an imidazole moiety, exhibited the highest potency in this

194 oly(organophosphazenes) hydrogel lacking the imidazole moiety, which physically interacts with macrop

195 the hydrophobic region I and methylation of imidazole-N1 position increased the activity and reduced

196 The complex structure revealed the imidazole nitrogen atom of 24 to coordinate with the hem

197 amine undergoes one-electron oxidation on an imidazole nitrogen that produces a radical.

198 Both imidazole nitrogens can be phosphorylated, forming 1-pho

199 narrow (15)N chemical exchange peaks for the imidazole nitrogens, indicating fast proton shuttling th

200 The probes composed of two naphthoquinone-imidazole (NQIM) derivatives as signal motifs that are c

201 In addition, SAR with substituted imidazoles on improvement of antiviral activity is discl

202 ening a detailed lipidoid library containing imidazole or imidazole analogues to perform a structure-

203 d that sequence-defined pentamers containing imidazole or pyrrole groups in specific locations provid

204 Intranasal delivery of ornithine or imidazole or the two together restricts Mtb growth.

205 tylenic aldehydes as C4 synthons, and simple imidazoles or benzimidazoles as C2 synthons.

206 para-linked phenylenes connected to oxazole, imidazole, or nitro-substituted pyrrole.

207 nal group such as an amide, carboxylic acid, imidazole, or phenol appeared to negatively affect amino

208 gonucleotide, in combination with an N-alkyl imidazole organocatalyst.

209 -alkylnitriliumboranes and 2-aminopyridines, imidazoles, oxazoles, or isoxazoles leads to the incorpo

210 al techniques, the binding mechanism of that imidazole peptidomimetic was predicted.

211 I) 2 O2 cores bonded by three histidine Ntau-imidazoles per Cu center.

212 hotosystem II (PSII)-inspired [Ru(bpy)2(phen-imidazole-Ph(OH)((t)Bu)2)](2+), in which Ru(III) generat

213 rin and its promising reactivity to form the imidazole-phenol coupled product yields viability to the

214 f TRPV1 antagonists constructed on a benzo[d]imidazole platform that evolved from a biaryl amide lead

215 Here the authors show an injection of imidazole poly(organophosphazenes), a hydrogel with ther

216 Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a hydrogel wit

217 using a synthetic alkylating agent (pyrrole-imidazole polyamide indole-seco-CBI conjugate; KR12) tha

218 Pyrrole-imidazole polyamides bind to a P.Z-containing DNA duplex

219 hetic genetic information by hairpin pyrrole-imidazole polyamides is described.

220 s been working on the development of pyrrole-imidazole polyamides that bind to the minor groove of DN

221 increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine

222 idine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects

223 Imidazole propionate is a novel microbially produced met

224 Furthermore, imidazole propionate levels were increased in subjects w

225 three European countries have elevated serum imidazole propionate levels.

226 contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation

227 ds, sugars, organic acids, amides, triazine, imidazole, protein, and biological tissue.

228 ling, notably for 4-[3-(benzyloxy)propyl]-1H-imidazole (proxyfan) [e.g., strong bias toward phosphory

229 We reported previously that a pyrrole-imidazole (Py-Im) polyamide designed to bind the consens

230 We find treatment with this pyrrole-imidazole (Py-Im) polyamide exhibits sequence selectivit

231 Pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of

232 zofuran, and indole) and NH azaheterocycles (imidazole, pyrazole, indole, azindole, purine, indazole,

233 Several reactions are applied to alkenyl imidazoles, pyrazoles, and triazoles to provide products

234 We report artificial imidazole-quartet water channels with 2.6 A pores, simil

235 n synthase (GS), we identified a substituted imidazole, (rac)-2-methoxy-4-(1-(2-(1-methylpyrrolidin-2

236 ce dependence of the PCET rate constant when imidazole rather than hydrogen phosphate serves as the p

237 ineered into structural homologs lacking the imidazole residue, alpha-l-rhamnosidase activity was est

238 ced different products: namely, pyrazine and imidazoles, respectively.

239 However, imidazole restored the activity of BcelPL6-H271N to 2.5%

240 aliphatic carbons tracing along the edge of imidazole ring and the terminal epsilon-amino group occu

241 s inhibited strongly by azoles containing an imidazole ring but not by those tested containing a tria

242 unit of 2 into the olefinic C-H bond of the imidazole ring of 1 and four-membered cyclic silylene (4

243 aA, predicts a hydrogen bond between ATP and imidazole ring of His136, which is disrupted when Gln is

244 he phenol ring of tyrosine to stack with the imidazole ring of His263, thus competing for the substra

245 During the reaction, the imidazole ring of His73 rotates ~105 degrees , which shi

246 ution on the phenyl at the 2-position of the imidazole ring on biological activity.

247 A substrate appears mainly stabilized by its imidazole ring through a pai-pai interaction with the si

248 ed by bromination and Suzuki coupling in the imidazole ring to yield trisubstituted NH-imidazoles (23

249 N1 (1-pHis) or N3 (3-pHis) positions of the imidazole ring, we detect for the first time phosphoisof

250 cationic NM-N7-dG adduct that can yield the imidazole ring-fragmented lesion, N(5)-NM-substituted fo

251 recognizes and excises the highly mutagenic imidazole ring-opened AFB1-deoxyguanosine adduct (AFB1-F

252 undergoes either spontaneous depurination or imidazole-ring opening yielding formamidopyrimidine AFB1

253 ins, we design a framework featuring pendant imidazole rings and copper-chelating salicylaldoxime, kn

254 construct of M2 in lipid bilayers, that the imidazole rings are hydrogen bonded even at a pH of 7.8

255 s reflect the rotational motion of histidine imidazole rings that coordinate the coppers in the TNC.

256 N(delta1) and N(epsilon2) of adjacent His37 imidazole rings, providing direct evidence for the exist

257 per-chelating salicylaldoxime, known as zinc imidazole salicylaldoxime supramolecule.

258 the 1-(3',4',5'-trimethoxyphenyl)-2-aryl-1H-imidazole scaffold and designed as cis-restricted combre

259 trategy, which focused on replacement of the imidazole scaffold and the design of new P1 groups, led

260 inhibitors based on the 1,4,5-trisubstituted imidazole scaffold which are appended with aliphatic lin

261 oarenes furnished the desired trisubstituted imidazole scaffolds.

262 The occurrence of imidazoles seems to be favored at sites with strong biom

263 ea sequence bearing two appropriately spaced imidazole side chains for zinc coordination.

264 nds that Cd(2+) binds exclusively to the His imidazole side chains of the repeat segment, with a diss

265 ctrum are attributed to zinc coordination by imidazole side chains.

266 tadiene, and siloxane backbones with grafted imidazole side-chains, with dissolved Li(+), Cu(2+), or

267 ough modulating the degree of freedom of the imidazole site as well as tuning the relative surface co

268 nitrogen heterocycles such as pyrazines and imidazoles starting from alpha-diketones using phosphine

269 in vivo pharmacological profiles and the non-imidazole structure of 14d make it a promising tool comp

270 rbaldehydes leads to the synthesis of alkoxy/imidazole-substituted 1,3-dihydrofuro[3,4-b]quinolines v

271 thod has been developed for the synthesis of imidazole-substituted allenes by the reaction of 1,1,3-t

272 The use of an imidazole-substituted decaborane as a hypergolic "trigge

273 xperimental evidence for the formation of an imidazole-substituted isoporphyrin and its promising rea

274 -trimethoxybenzene or 4-methoxyphenol to the imidazole-substituted isoporphyrin led to formation of t

275 t of the N substituent size and shape on the imidazole substrate shows that compared to N-Me, N-iPr a

276 enhance the OP(AA) and OP(*OH) by TMs while imidazoles suppress them.

277 ,5-dicyclohexylimidazole (DCHIm), a tethered-imidazole system, and sodium derivatives of 3,5-dimethox

278 method for preparation of the nonaromatic 4H-imidazole tautomer in the core.

279 by itraconazole but not by ketoconazole, an imidazole that does not block cholesterol export.

280 Orteronel (TAK-700) is a substituted imidazole that was developed for the treatment of castra

281 thiophene, benzo[b]thiophene, furan, indole, imidazole, thiazole, oxazole, pyrazole) have been involv

282 u(II) toward the His37 cluster, allowing one imidazole to form a coordination complex with Cu(II).

283 icle size expansion due to the conversion of imidazole to hydrophilic urea, resulting in instantaneou

284 catalyzed Michael addition of alpha1(I) H932 imidazole to the alpha,beta-unsaturated aldol.

285 or the direct modification of nonaromatic 2H-imidazoles to afford novel polyfluoroarylated azaheteroc

286 n the linker between the biaryl pyrazole and imidazole/triazole group.

287 d diarylation at the C2- and C5-positions of imidazole unit has also been performed.

288 ntaining the unnatural P.Z base-pair when an imidazole unit is aligned with a P nucleotide.

289 fficiently coupled at the C5-position of the imidazole units, which are widely decorated.

290 ach to the synthesis of 2,4(5)-disubstituted imidazoles was developed based on ketone oxidation, empl

291 fied 2,3,6-tri(hetero)arylated imidazo[1,2-a]imidazoles was generated in good yields.

292 , and excretion (ADME) properties of neutral imidazoles, we extended our ligands with carboxylic acid

293 for the novel 4-(perfluorophenyl)-5-aryl-2H-imidazoles were comprehensively studied.

294 Tetra-substituted imidazoles were designed as dual inhibitors of c-Jun N-t

295 of the obtained perfluoroaryl-substituted 2H-imidazoles were found to be of particular interest as pr

296 as C-beta-d-glucosaminyl 1,2,4-triazoles and imidazoles were synthesized and tested as inhibitors aga

297 reduced-nitrogen-containing organics (i.e., imidazoles), were first investigated for their effects o

298 ew 4(5)-(2-hydroxyphenyl)-2,5(4)-substituted imidazoles, which are known to be good coordinating liga

299 he 2-(beta-d-glucosaminyl)-4(5)-(2-naphthyl)-imidazole with a Ki value of 143 nM against human liver

300 We have prepared a set of trisubstituted imidazoles with a rigidized 7-azaindole hinge binding mo