ライフサイエンスコーパス: imidazole ring

1 ily involving rupture of and addition to the imidazole ring.

2 also consistent with trapping at C-2 of the imidazole ring.

3 y the "windshield wiper" motion of the His51 imidazole ring.

4 is coordinated with it through the N on the imidazole ring.

5 rome P450 inhibition absolutely requires the imidazole ring.

6 is attributed to the positive charge of the imidazole ring.

7 firmed to be the N epsilon 2 position in the imidazole ring.

8 mposed of two pyrimidine rings fused with an imidazole ring.

9 on process involving the amine moiety of the imidazole ring.

10 o intramolecular interactions with the His41 imidazole ring.

11 odified isoprene subunit to a functionalized imidazole ring.

12 irectly observed at the N1' positions of the imidazole rings.

13 the metal at the N(delta) position of their imidazole rings.

14 pyridine ring installed at position 2 of the imidazole rings.

15 The reaction constructs N-fused imidazole rings.

16 tivity by exogenous proton donors containing imidazole rings.

17 Using these spectra, we have assigned the imidazole ring (1)H and (15)N chemical shifts of the pro

18 ract with the phosphate-ribose moiety or the imidazole ring abolish cGMP binding.

19 The two nitrogen atoms of the imidazole ring act as directing groups for regioselectiv

20 with the ligand act to position the His-435 imidazole ring against the Trp-457 indole ring, allowing

21 solved by demonstrating that the axial His25 imidazole ring also rotates counterclockwise with respec

22 In the solid state, all display coplanar imidazole rings, an anti relationship of amide groups, a

23 cyclic structure incorporates the histidine imidazole ring and a newly formed pyrrole derived from t

24 s a result of the repulsion from the adenine imidazole ring and a tendency of purine-purine dinucleot

25 NMR changes in chemical shifts indicate the imidazole ring and amide nitrogen atoms to the N terminu

26 ons are preferentially protonated in the His imidazole ring and consist of multiple conformers that d

27 Noncovalent interactions between the imidazole ring and other functional groups play an impor

28 (carboxylate) bonds with the spinning of the imidazole ring and syn-anti isomerization of the termina

29 two hydroxamic acid moieties, the histidine imidazole ring and the alkylammonium groups on ExoMN, co

30 The juxtaposition between the imidazole ring and the steroid D ring appears to be impo

31 aliphatic carbons tracing along the edge of imidazole ring and the terminal epsilon-amino group occu

32 noncovalent interactions between the central imidazole ring and two flanking aromatic rings possessin

33 ins, we design a framework featuring pendant imidazole rings and copper-chelating salicylaldoxime, kn

34 pH values, cross-peaks were assigned to the imidazole rings and their patterns interpreted.

35 with the porphyrin core, the CO ligand, the imidazole ring, and/or the phenyl rings.

36 ta-aminoalanine fragment, the pyrimidine and imidazole rings, and the amide nitrogen of the beta-hydr

37 AR and inter-AR hydrogen bonds involving the imidazole ring; and (3) the hydrophobic interaction asso

38 es that bind the phosphate-ribose moiety and imidazole ring are critical for high affinity binding.

39 c bulk around other positions of the His 166-imidazole ring are much less severe, as indicated by the

40 ll of the compounds show that the phenol and imidazole rings are close to coplanar and are connected

41 construct of M2 in lipid bilayers, that the imidazole rings are hydrogen bonded even at a pH of 7.8

42 However, the planes of the purine and imidazole rings are twisted approximately 57 degrees in

43 nt repositioning and flipping of the His-175 imidazole ring as crucially required in the trigger hypo

44 interactions between the metal ions and the imidazole ring as well as by the conjugated molecular ba

45 teraction restricting both the motion of the imidazole ring as well as the terminal carboxylate confo

46 oscopy clearly show that all three histidine imidazole rings at positions 6, 13 and 14 in Abeta 1-16

47 ied endogenous biogenic amine composed of an imidazole ring attached to an ethylamine side chain.

48 nt study originate from changes in the His93 imidazole ring azimuthal angle.

49 hat electron-withdrawing groups at C5 on the imidazole ring benefit potency and that oxygen-containin

50 ine side chain, whereas zoledronate (with an imidazole ring) binds more strongly, since the ring is p

51 s inhibited strongly by azoles containing an imidazole ring but not by those tested containing a tria

52 compute the (13)C NMR shieldings of all the imidazole ring carbons ((13)C(gamma), , and ) for each o

53 Polar substituents like imidazole rings, carboxylic acids and alcohols still lea

54 ", noncoordinating nitrogen of the histidine imidazole ring could be observed from the Rieske protein

55 n several cases, the tautomeric state of the imidazole ring could not be derived from inspection of t

56 ox-related changes in the positioning of the imidazole ring during redox cycling and greatly decrease

57 tudy on the influence of substituents in the imidazole ring established that a CF3 group at position

58 At high pH, its imidazole ring exists primarily as the normally unfavore

59 II, this leucine abuts a phenylalanine whose imidazole ring extends into the substrate binding cavity

60 e tyrosine D and that proton transfer to the imidazole ring facilitates the efficient oxidation/reduc

61 we propose that it enables a reaction-driven imidazole ring flip mechanism, overcoming a major dilemm

62 The His-175 imidazole ring flips becoming almost perpendicular to th

63 of such intermediates or benzylation of the imidazole ring followed by milder ammonolysis of the imi

64 on from the terminal COOH group onto the His imidazole ring, forming imidazoline radical intermediate

65 cationic NM-N7-dG adduct that can yield the imidazole ring-fragmented lesion, N(5)-NM-substituted fo

66 e of the intact protein protects the His(34)-imidazole ring from depegylation.

67 This binding site is surrounded by four imidazole rings from the top and four indole rings of Tr

68 ctive side chains may be substituted for the imidazole ring (generally needs to be side chain protect

69 Histidine's imidazole ring has a pK(a) of 6, making this an attracti

70 epresents an unusual "dual reduction" of the imidazole ring (i.e., hydroboration of the C horizontal

71 rbene (C4) centers in the same five-membered imidazole ring (III), has been prepared by lithiation of

72 The replacement of the imidazole ring in 1 with a pyrrole ring in 2 makes the k

73 etween a substrate and the deltaN of HIS42's imidazole ring in an HRP/substrate binding complex, obta

74 hosphate synthase catalyzes formation of the imidazole ring in histidine biosynthesis.

75 ur data show that deprotonation of the His89 imidazole ring in myr(+)MA destabilizes the salt bridge

76 ation and, finally, by introducing a charged imidazole ring in place of the phenolic OH making it dic

77 significantly depress the pKa of the buried imidazole ring in the native state.

78 uld raise the pK(a) of His-54 and freeze the imidazole ring in the place optimal for forming an ion p

79 ant roles in the recognition of the oxidized imidazole ring in the substrate bases, and the Watson-Cr

80 aintenance of residual interactions with the imidazole ring in the unfolded N-terminal subdomain appe

81 l values for residues within 5A of the His41 imidazole ring indicate that a significant degree of res

82 ta nitrogen and proton resonances of the H63 imidazole ring indicates that the hydrogen bond between

83 he same magnitude as the rotation of the H63 imidazole ring induced by mutation.

84 te with its benzo ring pointing to F150, its imidazole ring inserted between residue D112 and residue

85 The aromatic imidazole ring interacts with a helix dipole, similar to

86 as a structure in which the pi-system of the imidazole ring is extended by the acylimine bond, which

87 Instead, the imidazole ring is nearly perpendicular to its placement

88 e ribose-OH protons and N epsilon 2 of His51 imidazole ring is partially contributed by the "windshie

89 3 and neighboring residues indicate that the imidazole ring is positively charged.

90 An oxygen atom at the 2-position of the imidazole ring is required for aerobic activity.

91 sphate concentration for which the axial His imidazole ring is rotated by approximately 20 degrees fr

92 to be a shared hydrogen between the His-134 imidazole ring ligated to Fe2 of the [2Fe-2S] cluster an

93 protonation state and tautomeric form of the imidazole ring, making them excellent indicators of pH o

94 hile 8-oxoA's lack of flexibility and closed imidazole ring may contribute to Fpg's inability to exci

95 acin mixture, binds to Co(II) via the His-10 imidazole ring N(epsilon), the thiazoline nitrogen, and

96 A computational model with constrained imidazole rings (necessary for reproducing spin states),

97 scopy, we have successfully detected the two imidazole ring nitrogens, one near the "exact cancellati

98 unit of 2 into the olefinic C-H bond of the imidazole ring of 1 and four-membered cyclic silylene (4

99 e cobalt(III) complex to the nitrogen of the imidazole ring of a histidine residue.

100 from proton NMR at the active site histidine imidazole ring of bovine pancreatic sPLA(2) in the prese

101 ms: the coordinating epsilon-nitrogen of the imidazole ring of each histidine ligand (A = [3.45, 3.71

102 ents revealed that oxidation occurred on the imidazole ring of each substrate.

103 c GTP cyclohydrolase III that hydrolyzes the imidazole ring of GTP but does not remove the resulting

104 onment which dictates the orientation of the imidazole ring of H248, one of the metal binding ligands

105 The hydrogen bond formed between the imidazole ring of H41 and the backbone carbonyl of E14 o

106 mobile; the hydrogen bond formed between the imidazole ring of H41 and the backbone nitrogen of D34 i

107 The pK(a) of the imidazole ring of H48 was shown to be shifted from 5.7 f

108 gen bond between the carbonyl of F58 and the imidazole ring of H63 remains intact in this mutant.

109 The imidazole ring of His 287 is almost orthogonal relative

110 to the peptidic NH group of Gly 110 and the imidazole ring of His 66.

111 yl group was located on the C4 carbon of the imidazole ring of His(10).

112 chain hydroxyl is away from the plane of the imidazole ring of His(187).

113 nd the hydroxyl group is in the plane of the imidazole ring of His(187).

114 observations led us to hypothesize that the imidazole ring of His(229) may function to facilitate th

115 l structures of hGSTM1a-1a indicate that the imidazole ring of His107 is oriented toward the substrat

116 aA, predicts a hydrogen bond between ATP and imidazole ring of His136, which is disrupted when Gln is

117 ld-type papain due to the flexibility of the imidazole ring of His159.

118 In particular, in the P23T mutant, the imidazole ring of His22 switches from the predominant Ne

119 he phenol ring of tyrosine to stack with the imidazole ring of His263, thus competing for the substra

120 The imidazole ring of His291-alpha in E1b coordinates to the

121 lved in donor-acceptor interactions with the imidazole ring of His291.

122 e contribution of interactions involving the imidazole ring of His41 to the pH-dependent stability of

123 a distal phosphate group of the DNA and the imidazole ring of His71.

124 During the reaction, the imidazole ring of His73 rotates ~105 degrees , which shi

125 ations were offered for this result: (a) the imidazole ring of His75 is required for charge delocaliz

126 Interestingly, protein interaction with the imidazole ring of histamine differs significantly betwee

127 The imidazole ring of histidine 12 protrudes from one side,

128 that the structure and electostatics of the imidazole ring of histidine are critical for its functio

129 the fraction of the tautomeric forms of the imidazole ring of histidine in proteins as a function of

130 tep takes place when a proton resides on the imidazole ring of I-His376 and the large active-site clu

131 is not the Se atom, but instead might be the imidazole ring of the His141 residue which is located in

132 ydrogen bond from His-435 that positions the imidazole ring of the histidine above the pyrrole ring o

133 roduct induced by insufficient space for the imidazole ring of the mutant phenylalanine residue.

134 r and the flexibility of substituents on the imidazole ring of the NHC on catalytic performance are a

135 ophilic attack of OH(-) on C-8 to cleave the imidazole ring of the purine.

136 Replacement of the imidazole ring of the scaffold with triazole or cyclic u

137 The fact that the imidazole ring of the wild-type covalent uridylyl-enzyme

138 ecific role for the lysine in polarizing the imidazole ring of this histidine.

139 ues and predominant tautomeric states of the imidazole rings of His26 (pKa approximately 7.1, N epsil

140 se combined data demonstrate that protonated imidazole rings of histidine residues mediate a pH-respo

141 In the model, the imidazole rings of the His ligands are held in a somewha

142 The imidazole rings of the two key catalytic residues, His7

143 report here the pK(a) values of each of the imidazole rings of the two ligating histidines (His134 a

144 ution on the phenyl at the 2-position of the imidazole ring on biological activity.

145 ucleobases within genomic DNA, including the imidazole ring opened N(6)-(2-Deoxy-alpha,beta-D-erythro

146 d the dose-dependant formation of persistent imidazole ring-opened AFB(1)-DNA adducts.

147 recognizes and excises the highly mutagenic imidazole ring-opened AFB1-deoxyguanosine adduct (AFB1-F

148 could not be isolated and further led to an imidazole ring-opened product; in the case of pyridines,

149 amino-ethyl adducts of guanine, resulting in imidazole ring opening [formamidopyrimidine (Fapy)] and

150 rmamidopyrimidine (FAPY) adduct arising from imidazole ring opening of the initially formed trans-8,

151 N7-methylation of deoxyguanosine followed by imidazole ring opening.

152 undergoes either spontaneous depurination or imidazole-ring opening yielding formamidopyrimidine AFB1

153 The protonated imidazole ring, or imidazolium group, is shown to enhanc

154 istidine side chain, resulting in an altered imidazole ring orientation.

155 ty indicates that partial protonation of the imidazole ring permits cellular uptake of the analogues.

156 razine ring with a less bulky planar charged imidazole ring permitting binding to a narrower groove,

157 um of compound 1 showed that addition of the imidazole ring perturbs the frequency of the tyrosine ri

158 bottom of the antigen-binding site with the imidazole ring poised for nucleophilic attack.

159 N(delta1) and N(epsilon2) of adjacent His37 imidazole rings, providing direct evidence for the exist

160 imately 45 degrees rotation of the axial His imidazole ring, relative to that in mammalian globins.

161 In this "out" orientation, the imidazole ring releases the delta nitrogen's excess prot

162 lve His-water proton exchange facilitated by imidazole ring reorientations.

163 ns from the outer-shell atoms of a histidine-imidazole ring resulted in reasonable Debye-Waller facto

164 ly different values for the N-Fe-N angle and imidazole ring rotation angles are presented.

165 Asp(102)-His(57) H-bonds and moving His(57) imidazole rings, such as the reaction-driven ring flip.

166 s reflect the rotational motion of histidine imidazole rings that coordinate the coppers in the TNC.

167 A substrate appears mainly stabilized by its imidazole ring through a pai-pai interaction with the si

168 (iv) The His63 imidazole ring tilts upon 15 atm of oxygen treatment and

169 that singlet oxygen reacts with the histidyl imidazole ring to form an endoperoxide and then converte

170 + 2] cycloaddition of singlet oxygen to the imidazole ring to form an unstable endoperoxide, subsequ

171 attach the Ndelta1 nitrogen of the histidine imidazole ring to the metal, whereas histidine ligands f

172 onjugated molecular backbone that linked the imidazole ring to the nanoparticle cores.

173 ed by bromination and Suzuki coupling in the imidazole ring to yield trisubstituted NH-imidazoles (23

174 he distal histidine, leaving Nepsilon of the imidazole ring unprotonated and able to accept positive

175 distribution of the tautomeric forms for the imidazole ring varies significantly among different hist

176 th the N(tau) nitrogen atom of the histamine imidazole ring via an ion pair.

177 Peptidomimetics where the 5-position of the imidazole ring was linked to the hydrophobic scaffold sh

178 A product (A) with an oxidized imidazole ring was the only major product detected at ro

179 s287 is a residue in the Type 2 region whose imidazole ring was thought to hydrogen bond to the Type

180 ine specifically (13)C-labeled at C-2 of the imidazole ring was used, providing evidence for trapping

181 N1 (1-pHis) or N3 (3-pHis) positions of the imidazole ring, we detect for the first time phosphoisof

182 substituents on the 4 and 5 positions of the imidazole ring were synthesized.

183 to the vicinity of H13 and H14 of Abeta, and imidazole rings were incorporated to compete with H13/H1

184 f new phthalazine derivatives 1-4 containing imidazole rings were prepared.

185 s dependent on the presence of a neighboring imidazole ring, which has taken over as a less efficient

186 most versatile amino acids by virtue of its imidazole ring, which is capable of shuttling protons an

187 ision of FapyA likely result from the opened imidazole ring, while 8-oxoA's lack of flexibility and c

188 at by replacing the aryl substitution on the imidazole ring with a more polar carboxylic ester or ami

189 rocyclic core of these inhibitors by a fused imidazole ring with the triazine to provide imidazo[1,2-

190 between the angular position of the two His imidazole rings with respect to the Cu2S2(Cys) core plan

191 to 60% at C(5) and C(2) carbon atoms of the imidazole ring, with predominance of the C(5) products i