ライフサイエンスコーパス: immaturity

1 isplay mixed pancreatic islet phenotypes and immaturity.

2 these cells exhibit hallmarks of functional immaturity.

3 r VIII (FVIII) by taking advantage of immune immaturity.

4 e to xlmiR16, ensuring maintenance of oocyte immaturity.

5 itable for neonates with their pharmacologic immaturity.

6 had prolonged survival and increased myeloid immaturity.

7 sus normal DCs, indicating their comparative immaturity.

8 ession, and CCR transcripts, consistent with immaturity.

9 orphologic and ultrastructural appearance of immaturity.

10 of aspirin-treated cells was consistent with immaturity.

11 in the untreated group, were associated with immaturity.

12 ffer after overcoming its present commercial immaturity.

13 lems, depressive symptoms, anxiety/fear, and immaturity.

14 alnutrition (MAM) with persistent microbiota immaturity.

15 erm infants because of gastrointestinal (GI) immaturity.

16 f "fetalness" with a quantitative measure of immaturity.

17 ng periods, being detectable with markers of immaturity.

18 nfants at risk of vulnerabilities related to immaturity.

19 temporal modelling confirmed their relative immaturity.

20 hPSC-CMs associated with their developmental immaturity.

21 ly been associated with neonatal immune cell immaturity.

22 onsidering their vulnerability and digestive immaturity.

23 ded by maternal antibodies and immune system immaturity.

24 are determined by the state of blood vessel immaturity.

25 ts, in an otherwise general context of motor immaturity.

26 response, suggesting sarcoplasmic reticulum immaturity.

27 heart lesions are frequently born with brain immaturity.

28 2-4) is thus often attributed to hippocampal immaturity.(5-7) The hippocampus of human infants has be

29 a (BPD), also called chronic lung disease of immaturity, afflicts approximately one third of all extr

30 ower ETV6::RUNX1 frequency, immunophenotypic immaturity (all P < .001), and strong expression of CD34

31 ese results may be limited by HIO epithelial immaturity and a short flux time.

32 In summary, neonatal metabolic immaturity and breastmilk bile acids are central determi

33 t potential associations between immunologic immaturity and clinical outcomes in this vulnerable popu

34 ch may predispose to cellular and functional immaturity and compromise the formation of neural networ

35 and morbidity due to a combination of organ immaturity and iatrogenic injury.

36 infants can be reduced due to immunological immaturity and immunosuppression by RSV-specific materna

37 rs and transcription factors associated with immaturity and immunosuppression.

38 ed solutions to issues such as cardiomyocyte immaturity and inability to recapitulate adult heart val

39 are genetic disease that manifests as sexual immaturity and infertility.

40 However, their relative immaturity and insufficient endowment of critical cell t

41 the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading t

42 t valves have been limited by the structural immaturity and mechanical properties of the valve constr

43 oach that takes advantage of the immunologic immaturity and normal developmental properties of the fe

44 nt and disease but are characterized by cell immaturity and off-target cell fates.

45 l deregulation that associates with cellular immaturity and reorganization of beta cell TF networks,

46 Lung immaturity and resultant surfactant deficiency cause res

47 lations corrected for confounders, including immaturity and severity of illness, were used to explore

48 d in part to their persistent gut microbiota immaturity and that specific regions of the brain that n

49 ed to identify potential anatomic origins of immaturity and whether correction of immature fistulas p

50 a role for RFRP-3 in preserving reproductive immaturity, and challenge the view that stimulatory pept

51 DCs in vitro was dependent on pDC viability, immaturity, and class II MHC mismatch and blocked by MEK

52 tions for bracing due to their age, skeletal immaturity, and degree of scoliosis.

53 is becoming increasingly recognized that CNS immaturity at birth affects ischemic injury and recovery

54 for reduced cognitive test scores and their immaturity at birth is directly proportional to the mean

55 Because of their immaturity at birth, it is possible to study very early

56 in survivors of preterm birth and related to immaturity at birth, postnatal growth and neurodevelopme

57 re closely spaced (morphological features of immaturity) at 4 months of age than in wild-type (WT) li

58 Despite their "immaturity", band forms are capable of mediating crucial

59 40 degrees , apex T7 or caudal, and skeletal immaturity based on estimated remaining growth of at lea

60 In infants, rod photoreceptor immaturity before the site of adaptation accounts for el

61 Such problems are due to not only immaturity but also the pathologic factors (such as infe

62 of virus was not the result of immunological immaturity but correlated with the induction of a nonpro

63 Brain immaturity but not brain injury was associated with impa

64 This is in part attributable to their immaturity but the sensitivity of measurement tools may

65 ty to infection result not out of a state of immaturity, but rather reflect adaptation to the particu

66 This may be due in part to foveal immaturity, but the very low levels of serum and skin ca

67 ought to exploit the newborns' immune system immaturity by inducing a state of immune tolerance that

68 during developmental periods of hippocampal immaturity can promote lifelong changes in symptoms and

69 Cs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may d

70 Despite these correlations with immaturity, CD34+CD4+ MK precursors were unable to produ

71 Despite their immunological immaturity, chronically HIV-infected children develop br

72 Exactly what this immaturity consists of and when the responses of these r

73 Premature skin immaturity contributes to elevated water loss, problems

74 ood donors to evaluate whether immunological immaturity contributes to the inability to mount a fully

75 maternal measles antibodies and immunologic immaturity dampen immunogenicity of the current vaccine

76 -beta (TGF-beta) was responsible for NK cell immaturity during infancy.

77 ere lobulo-alveolar hypoplasia and secretory immaturity during pregnancy and lactation.

78 asculature with increasing signs of vascular immaturity during tumor progression.

79 that primary tumors can further increase HA immaturity even before secondary tumor formation, mimick

80 Immaturities exist at multiple levels of the developing

81 Lung immaturity following preterm birth frequently results in

82 y both quantitative and qualitative response immaturities for relative disparity information.

83 ted prenatally and then remain in a state of immaturity for long periods.

84 n should be made during the period of visual immaturity for possible causes of amblyopia that might b

85 nd second, what are the implications of this immaturity for the basal ganglia?

86 biosynthesis genes and proper repression of immaturity genes.

87 Such immaturity hampers their application in assessing drug s

88 cate that both receptoral and postreceptoral immaturities have a role in the elevation of infants' ov

89 nction of these subsets is unknown but their immaturity hints against memory.

90 mental differences have been interpreted as "immaturity." However, more recent studies have demonstra

91 igh risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regula

92 ich Eomes was deleted reverted to phenotypic immaturity if T-bet was present or downregulated NK line

93 ompensate for metabolic and gastrointestinal immaturity, immunologic compromise, and maternal psychos

94 high levels of neural noise and significant immaturities in contrast sensitivity.

95 ur measurements is not simply inherited from immaturities in encoding absolute disparity or retinal i

96 Response immaturities in infants were mild; the overall strength

97 man developmental imaging studies have found immaturities in localized brain activity in children and

98 veloping human visual pathway, starting with immaturities in photon efficiency and spatial sampling i

99 r retinal image contrast but rather reflects immaturities in the computations needed to represent rel

100 patial sampling in the retina and on through immaturities in the early and later stages of cortical p

101 h abnormalities of brain structure and brain immaturity in a significant portion of neonates with cri

102 Continued RA activation resulted in lung immaturity in both cases, but the phenotypes were remark

103 L-12 from activated CB may contribute to the immaturity in CB cellular immunity and contribute, in pa

104 more, exogenous IL-12 may compensate for the immaturity in CB cellular immunity and have the potentia

105 This immaturity in CD4(+) RTE effector function may contribut

106 to achieve enduring repair of gut microbiota immaturity in childhood malnutrition and improve clinica

107 ular rivalry may be the result of a specific immaturity in dichoptic, cross-orientation suppression.

108 nally, glucocorticoids cause transcriptional immaturity in enteric neurons, acetylcholine deficiency,

109 To assess the role of vascular immaturity in germinal matrix hemorrhage (GMH), we evalu

110 ceptibility has been attributed partially to immaturity in immune cell function.

111 gical profiles indicative of cortical delays/immaturity in middle childhood, based on relatively grea

112 opment of allergic disease is preceded by an immaturity in neonatal B cell phenotype.

113 Presymptomatic immaturity in neonatal T-cell function is a consistent a

114 he most direct means of achieving phenotypic immaturity in NOD bone marrow-derived DCs aiming at prev

115 the former but not the latter, adolescents' immaturity in prefrontal cortex function may limit their

116 ing program may provide new insights to lung immaturity in preterm neonates and the increase in organ

117 e ETP immunophenotype and genomic markers of immaturity in T-cell ALL.

118 CD4 expression correlated with markers of immaturity in that CD4 was enriched among CD34+ cells, a

119 Functional immaturity in the afferent neural pathways may limit the

120 r of two of adults' and that there is little immaturity in the motor capabilities of the accommodativ

121 data provide clear evidence that there is no immaturity in the phenylalanine hydroxylation pathway.

122 photopic hill is hypothesized to result from immaturity in the relative contributions of ON and OFF b

123 Relative adrenocortical immaturity in the twin fetus may reflect a specific endo

124 Thus, it could be argued that relative immaturity in twins may explain their increased suscepti

125 arly vulnerable to the effects of microbiota immaturity in undernourished children.

126 nefficient mDC stimulation and immunological immaturity in young infants may contribute to reduced im

127 ponse to visual stimulation exhibits several immaturities, including a high density of active neurons

128 MRI scans showed that white-matter damage of immaturity, including periventricular leukomalacia (PVL)

129 ence may represent up to 70% of hepatocytes (immaturity index of 70%).

130 However, because of immunologic immaturity, infants may have relative protection from hy

131 Deaths related to pulmonary causes, immaturity, infection, and central nervous system injury

132 own to express molecular markers of neuronal immaturity into adulthood; however, the impact of their

133 As immaturity is a key factor in NEC, Epo regulation of ZO-

134 Lung immaturity is a major cause of morbidity and mortality i

135 Immaturity is also evident in less severe forms of malnu

136 Evidence is accumulating that this immaturity is causally related to the pathogenesis of un

137 ese results provide evidence that microbiota immaturity is causally related to undernutrition and rev

138 This period of dental immaturity is particularly prolonged in modern humans.

139 To determine what critical immaturity is responsible for the poor binocular stereop

140 tions and is characterized by chronic vessel immaturity leading to lower extremity amputations.

141 predicted values suggested that the critical immaturity limiting infant stereopsis is the well-known

142 r cardiac tissue engineering; however, their immaturity limits their potential applications.

143 Suppression of SOX6 deactivates these immaturity loci, accelerating the transition to mature,

144 Immaturity, low fidelity and heterogeneity remain barrie

145 Sertoli cells, which continue to express the immaturity markers anti-Mullerian hormone and thyroid ho

146 fewer NK cells that expressed inhibitory and immaturity markers, whereas NK cells from narrow neutral

147 Even at 10 weeks, islets expressed immaturity markers.

148 nd tolerogenic mechanisms, and immune system immaturity, maternal pre-natal immunization aims to boos

149 ayer relative to 21 day old pups, suggesting immaturity may contribute to exposure of the epithelium

150 stimulation of mDC by RSV and immunological immaturity may contribute to reduced immune responses an

151 diabetes (T1D), yet functional and metabolic immaturity may limit their long-term therapeutic potenti

152 on-inhibition imbalance, and dendritic spine immaturity, mirroring autistic phenotypes.

153 on augmenting the immunologic and functional immaturities of premature infants and ameliorating the r

154 The infants' mfERG responses indicated immaturities of processing in the central retina.

155 In conclusion, notable immaturities of the T cell compartment in ELGAN/ELBW neo

156 Immaturity of alveolar macrophages (AMs) around birth co

157 Immaturity of ascending catecholamine pathways may parti

158 Immaturity of brain, pituitary and adrenal elements or e

159 L-15 from activated CB may contribute to the immaturity of CB cellular immunity and delayed immune re

160 5 from cord blood (CB) may contribute to the immaturity of CB immunity and potentially delay immune r

161 IL-15 administration may compensate for the immaturity of CB immunity.

162 esponse to stimulation may contribute to the immaturity of CB immunity.

163 Given these bright spots and the relative immaturity of coastal marine ecosystem restoration, it i

164 terized by specific behaviors reflecting the immaturity of decision-making abilities.

165 a cell is a challenge that partially lays in immaturity of dedicated analytical approaches.

166 r global adjustment, and conversely, greater immaturity of defense style was associated with a lower

167 enatal glucocorticoids correct the pulmonary immaturity of fetal sheep with CDH by physiologic, bioch

168 t fovea are absent near birth because of the immaturity of foveal cones, develop by 24 months, and ma

169 Consistent with the immaturity of GF MCs, degranulation-provoking compound 4

170 de a better mechanistic understanding of the immaturity of hESC/iPSC-vCMs but will also lead to impro

171 y approaches in an attempt to circumvent the immaturity of host defense and potentially reduce both t

172 model system, but disorganized mechanics and immaturity of hPSC-CMs on standard two-dimensional surfa

173 Currently, the immaturity of human cardiomyocytes derived from stem cel

174 Immaturity of innate immunity contributes to the increas

175 cles arise primarily because of the relative immaturity of integrated photonics manufacturing and the

176 Immaturity of iPSC-derived cardiomyocytes may be a signi

177 ion in the fetus may be characteristic of an immaturity of local defense, which is thought to predisp

178 were excluded from this analysis due to the immaturity of long-term survival data.

179 This has been attributed, in part, to the immaturity of neonatal dendritic cells that lack full ca

180 t defence has generally been ascribed to the immaturity of neonatal immune cells; however, the degree

181 The developmental immaturity of neonatal phagocytic function is associated

182 The immaturity of neonatal phagocytic immunity contributes t

183 ntermediates and highlighting the functional immaturity of NeuroD1-converted neurons.

184 The immaturity of neurons differentiated from human induced

185 gy will be discussed, including the cellular immaturity of organoid-derived hepatocytes, co-culture d

186 pothesis, this delay results from functional immaturity of pathways mediating FPS.

187 The immaturity of pluripotent stem cell (PSC)-derived tissue

188 l mutation and that the electrophysiological immaturity of PSC-derived cardiomyocytes does not preclu

189 experience frequent hypoxic episodes due to immaturity of respiratory control resulting in disturban

190 ain injury sequelae have signs of persistent immaturity of retinal vasculature and neuroretinal layer

191 deficiency is thought to reflect physiologic immaturity of T and B cell function and lack of previous

192 rfollicular epidermis and dermis, and severe immaturity of tail epidermal melanosomes, findings not o

193 Our results demonstrate that despite the immaturity of the auditory pathways, the AC is more adap

194 t was concluded that because of the relative immaturity of the body of evidence for each of the purpo

195 ber technique may be because of the relative immaturity of the circulating cells or to alterations in

196 The immaturity of the CNS at birth greatly affects injury af

197 ils as a result of suppression or functional immaturity of the cross-modal mechanisms.

198 otein in infants might be low because of the immaturity of the digestive system at that age.

199 ffect several conditions that are related to immaturity of the gastrointestinal tract.

200 mon condition among preterm infants owing to immaturity of the gastrointestinal tract.

201 nges in dauer larvae of Auanema, despite the immaturity of the gonad at the time of the microinjectio

202 e unclear but are most likely related to the immaturity of the host's immune and central nervous syst

203 ample, which is consistent with the relative immaturity of the human brain during early life compared

204 However, because of the intrinsic immaturity of the immune system of neonatal animals, neo

205 to infections has been assumed to be due to immaturity of the immune system, but the mechanism remai

206 spond poorly to conventional vaccines due to immaturity of the immune system.

207 f this condition may, in part, be due to the immaturity of the interactions between the physicochemic

208 between marmoset and Macaca is the relative immaturity of the marmoset fovea at birth, and its rapid

209 on that probably contributes to the relative immaturity of the neonatal immune response.

210 za infection to test the hypothesis that the immaturity of the neonatal immune system is responsible

211 Due to immaturity of the neonatal immune system, it has been as

212 Immunological immaturity of the neonate might result in an impaired re

213 Nevertheless, despite the immaturity of the neonate, there was evidence that synth

214 ernal plexiform layer reflected the relative immaturity of the olfactory bulb in the null mice.

215 ed vulnerability is partly attributed to the immaturity of the prefrontal cortex, a brain region both

216 ry development if treated before 6 weeks and immaturity of the prostate gland if treated before 2 wee

217 ing the Na(+) current (I(Na)) because of the immaturity of the PSC-derived cardiomyocytes.

218 ive V1 neurons but, instead, by the relative immaturity of the spatial response properties and the ov

219 l weeks) period of time, possibly due to the immaturity of the tissue.

220 Despite the immaturity of the visual pathway, clearly demonstrated b

221 more vulnerable to severe infections due to immaturity of their immune system and emphasize the impo

222 the live attenuated measles vaccine due the immaturity of their immune system and the presence of ma

223 of neonates is likely ineffective due to the immaturity of their immune system, and neonate immunizat

224 e highly susceptible to infection due to the immaturity of their immune systems, and nosocomial infec

225 face a high risk of infection because of the immaturity of their immune systems.

226 d infants are thought to reflect in part the immaturity of their immune systems.

227 disease is thought to reflect, in part, the immaturity of their immune systems.

228 vulnerable to gastroenteritis because of the immaturity of their intestinal barrier, enteric nervous

229 premature experience hypoxic episodes due to immaturity of their respiratory and central nervous syst

230 ompared with maternal adults may reflect the immaturity of these brain regions in juvenile rats.

231 ltransferase (UGT) 1A1, it is now known that immaturity of UGT1A1, in combination with the overproduc

232 oblems of inhibition have been attributed to immaturity of, or severe damage to, the prefrontal corte

233 been hampered by limited expansion capacity, immaturity, off-target cells, and inability to access th

234 and mortality, however the impact of hepatic immaturity on PNAC is poorly understood.

235 To determine the effects of immaturity on responses to candidate vaccines, neonatal

236 erns of altered differentiation may indicate immaturity or accelerated maturation, as well as aberran

237 eins in premature infants, either because of immaturity or as a consequence of superimposed chronic l

238 vaccine recipients either because of immune immaturity or because passively delivered antibody inter

239 te matter (WM) at term-equivalent age due to immaturity or impairment is still difficult to identify.

240 alpha-amylase activity is reduced because of immaturity or malnutrition and that maltase-glucoamylase

241 there were decreases in deaths attributed to immaturity (P=0.05) and deaths complicated by infection

242 studies on hepatic drug metabolism show that immaturity, polymorphisms, and altered balance of differ

243 chromatin remodeling, and promoting cellular immaturity rather than apoptosis to yield metabolic dysf

244 , asphyxia-related conditions (APC = -9.43), immaturity-related conditions (APC = -3.44%), diseases o

245 the commonly encountered problem of hiPSC-CM immaturity that has hindered implementation of these hum

246 utrition, resulting in persistent microbiota immaturity that is not rescued by current nutritional in

247 ociated with significant relative microbiota immaturity that is only partially ameliorated following

248 Thus, rather than immaturity, the features of fetal and neonatal megakaryo

249 associated with migration and developmental immaturity, the genes that remain expressed in later pro

250 d that the mesocarp of SR maintained typical immaturity traits (e.g. small cell size, high amino acid

251 rons expressed markers of neuronal and glial immaturity (Tuj1, doublecortin, or NG2).

252 Despite their apparent immaturity, type-L neurons appear to have extended axons

253 ators of brain damage might be indicators of immaturity/vulnerability and illness severity.

254 uster A personality disorders in boys, while immaturity was an independent predictor of cluster B per

255 matter volume, and this relative anatomical immaturity was correlated with the severity of ASD socia

256 To test whether infant immaturity was due to spatial limitations or insensitivi

257 Persistent Extracellular matrix turnover and immaturity was shown by the elevated expression of prote

258 This immaturity was true not only for functional connections

259 r-deficient mice often show evidence of lung immaturity which can result in visible respiratory distr

260 in revealed an initial pattern of epithelial immaturity, which by 8 wk had normalized to that of matu

261 eak takes place during a prolonged period of immaturity, which confers advantages for communicative d

262 AM) and that their persistent gut microbiota immaturity, which is not durably repaired with current r

263 tivation also resulted in type II pneumocyte immaturity, which was apparent from their increased glyc