ライフサイエンスコーパス: immediate-early gene

1 on or expression of ICP27, a multifunctional immediate-early gene.

2 tency to reactivation requires expression of immediate early genes.

3 g variables examined and differed from other immediate early genes.

4 ssessed by quantifying mRNA levels for other immediate early genes.

5 -related genes and a decreased expression of immediate early genes.

6 The first wave includes conserved immediate early genes.

7 se that is similar to that of protein-coding immediate early genes.

8 horylation and, in most cases, expression of immediate early genes.

9 at limit transcription of plasticity-related immediate early genes.

10 CMV infection by targeting the expression of immediate-early genes.

11 sses in expression of VSV protein and MHV-68 immediate-early genes.

12 rogenic genes and the ubiquitously expressed immediate-early genes.

13 te the transcription of many proinflammatory immediate-early genes.

14 virus, and genetically dependent upon viral immediate-early genes.

15 d the induction of the expression of several immediate-early genes.

16 n by MAP kinase, activates the expression of immediate-early genes.

17 , which regulates cellular proliferation and immediate early gene activation, CaMKII-mediated signali

18 We found dosage-dependent activation of immediate early genes after 1 h.

19 Immediate early gene analysis and single unit recordings

20 Immediate early gene analysis identified T-types exhibit

21 l protein 0 (ICP0) of HSV-1 is encoded by an immediate early gene and plays a fundamental role during

22 ty and neurons double-labeled with c-Fos, an immediate early gene and the tracer were increased signi

23 old higher levels of expression of mRNAs for immediate early genes and 2- to 5-fold higher levels of

24 nes that responded to fight outcome included immediate early genes and genes involved in neuroplastic

25 timulation, activated ERK1/2 is recruited to immediate early genes and phosphorylates INTS11, the cat

26 Insulin-stimulated expression of immediate early genes and proliferation were also potent

27 Although cell adhesion also can regulate immediate early genes and proliferation, the mechanism f

28 mulus-dependent recruitment of Integrator at immediate early genes and their enhancers.

29 revealed widespread changes in expression of immediate early genes and their targets, supporting the

30 tamine prevents Cav1.2-mediated induction of immediate early genes and transcription factors, and ina

31 or that is functionally deleted for all five immediate-early genes and the 15-kb internal repeat regi

32 of proper viral entry, normal expression of immediate early genes, and viral DNA replication.

33 ished prior to the stimuli, predominantly at immediate-early genes, and identified specific TF ensemb

34 activity-induced transcription of a neuronal immediate early gene; and 3) in vivo in Drosophila melan

35 tes an initial and transient increase of the immediate early gene apc/ebp mRNA, a prolonged increase

36 The immediate early gene Arc (also Arg3.1) produces rapid ch

37 the plasticity related behaviourally-induced immediate early gene Arc is altered within the CA3 and t

38 Here, we report that the immediate early gene Arc is required for activity-depend

39 Visualization using the immediate early gene Arc revealed sparser and more robus

40 al neurons expressing the plasticity-related immediate early gene Arc.

41 to global synaptic plasticity, requires the immediate early gene Arc.

42 ellar Purkinje cells, as did deletion of the immediate early gene Arc.

43 th the BLA and IC based on activation of the immediate early gene Arc; however, we found that infusio

44 tivity-dependent manner from the loci of the immediate early genes Arc and Fos.

45 These genes included altered levels of the immediate early genes arc, fosB, and nr4a3, as well as g

46 sitive correlation between expression of the immediate-early gene Arc (activity-regulated, cytoskelet

47 Experience-induced expression of immediate-early gene Arc (also known as Arg3.1) is known

48 e cells (IGCs), many of which upregulate the immediate-early gene Arc after male-male social experien

49 We show that the plasticity-associated immediate-early gene Arc is selectively expressed in IGC

50 ed on the detection of the expression of the immediate-early gene Arc, used as a marker of neuronal a

51 significant increases in mRNA expression of immediate early genes (Arc, Egr1), Bdnf and its receptor

52 ade signal that induces transcription of the immediate early genes, Arc and c-Fos.

53 At the molecular level, immediate early genes are among the synaptic plasticity

54 R) and the 5-HT2c receptor (5-HT2cR), and an immediate early gene associated with neuronal plasticity

55 on factor ELK-1 stimulates the expression of immediate early genes at the onset of the cell cycle and

56 ew mechanistic insights on the regulation of immediate early genes by anesthesia and hypothermia.

57 ychostimulant addiction, blocks induction of immediate early genes by DRD1 stimulation, and prevents

58 hat Ikaros did not bind to either of the EBV immediate early genes BZLF1 and BRLF1.

59 n compared with vehicle-pretreated rats, the immediate early gene c-Fos (a marker of neuronal activat

60 in the nTS was measured by expression of the immediate early gene c-Fos [c-Fos-like immunoreactivity

61 ssed LC activity by measuring changes in the immediate early gene c-fos and the enzyme tyrosine hydro

62 unctions, we have used the expression of the immediate early gene c-Fos as a marker for neurons activ

63 APOS and NTS also showed expression of immediate early gene c-FOS in the hindbrain in AMN+LEP-t

64 anscriptional activation of mPeriod1 and the immediate early gene c-Fos in the SCN in response to a p

65 ons to light, and enhances expression of the immediate early gene c-fos in the SCN, which is involved

66 rescent protein was under the control of the immediate early gene c-fos promoter as well as time-laps

67 Neuronal activity mapping using the immediate early gene c-fos reveals the engagement of dis

68 sion in the LS, stress-induced expression of immediate early gene c-fos, and anxiety-related and depr

69 Analysis of neuronal activity, using the immediate early gene c-fos, demonstrated a reduced neuro

70 erential patterns of immunoreactivity of the immediate early gene c-Fos, with a blunted response to t

71 es expression of the protein products of the immediate early genes c-fos and arc in new and mature gr

72 ssed long-term changes in activity-dependent immediate early genes c-Fos and Arc/Arg3.1 in auditory a

73 nsistent modulation of the expression of the immediate early genes c-fos and egr-1 upon change in num

74 n levels of the learning- and memory-related immediate early genes c-Fos and Egr-1 were normalized or

75 as confirmed by immunohistochemistry for the immediate-early gene c-Fos and behavioral tracking, whic

76 partly facilitated by the expression of the immediate-early gene c-fos and the resulting transcripti

77 Experiment 1 assessed the expression of the immediate-early gene c-fos in rats that discriminated no

78 We first compared expression of the immediate-early gene c-Fos in the medial (VP-m) and late

79 experiments indicated that expression of the immediate-early gene c-fos was aberrantly elevated in th

80 ylation and expression of the product of the immediate-early gene c-Fos were assessed by immunohistoc

81 ing neurons was detected by staining for the immediate-early gene c-fos, thus supporting earlier find

82 , functional magnetic resonance imaging, and immediate early gene (c-fos) expression to assess the hy

83 sions also produced widespread reductions in immediate-early gene (c-fos) expression in a network of

84 n patterns with extracellular recordings and immediate-early gene (c-Fos) expression.

85 a quantitative analysis of expression of the immediate early gene cFos and generalized linear mixed-e

86 at fear conditioning drove expression of the immediate early genes cFos and Nr4a2 in the hippocampus,

87 n-specific markers, retrograde tracings, and immediate early gene colocalizations.

88 Moreover, upregulation of immediate early genes, complement factors, apoptosis, an

89 Cholinergic signaling induces Arc/Arg3.1, an immediate early gene crucial for synaptic plasticity.

90 ne resulted in decreased expression of viral immediate early genes during infection.

91 actor and tumor suppressor, is induced as an immediate-early gene during hepatic stellate cell (HSC)

92 of artificial aptazymes into the adenoviral immediate early gene E1A enables small-molecule-triggere

93 The adenovirus immediate early gene E1A initiates the program of viral

94 The immediate-early gene early growth response 3 (Egr3) is a

95 in (ERK/MAP) kinase signaling but not on the immediate early gene EGR-1.

96 t a common point involving activation of the immediate early gene Egr-1.

97 We report activation of the immediate-early gene Egr-1 in the lateral amygdala (LA),

98 was identified as a downstream target of the immediate early gene Egr1.

99 ockdown of Sap-1 decreased expression of the immediate early genes egr1 and fos and subsequent prolif

100 We showed that the immediate early gene Egr3 has long-term effects on drug-

101 ed GABABR activity reduced the expression of immediate-early gene-encoded protein Arc/Arg3.1, effecto

102 One of these immediate early genes encodes naked cuticle homolog 1 (N

103 the mouse ~85% of these neurons express the immediate early genes Erg-1 and c-Fos, indicating that t

104 pression of Bpifa2 in mice lacking Nur77, an immediate early gene expressed in the kidneys during AKI

105 deletion showed a lack of activity-triggered immediate early gene expression and altered sensory-rela

106 CaMPARI2 photoconversion was correlated with immediate early gene expression and higher FRs ex vivo a

107 ands of fibronectin suppressed serum-induced immediate early gene expression and S phase entry.

108 Recent work using immediate early gene expression as a marker of neural ac

109 usion that HCMV pUL97 kinase regulates viral immediate early gene expression by phosphorylation-media

110 s of training-induced transient waves of Arc immediate early gene expression critical for synaptic pl

111 Molecular analyses of neural activity via immediate early gene expression indicate a functional ro

112 e cell RNAseq analysis of neurons divided by Immediate Early Gene expression levels.

113 Immediate early gene expression patterns were informativ

114 Analysis of immediate early gene expression revealed parallel up-reg

115 kines such as TNF] can alter local astrocyte immediate early gene expression that, in turn, can provo

116 ity at cellular resolution through profiling immediate early gene expression using immunostaining and

117 lovian fear conditioning, activity-dependent immediate early gene expression, and in vivo electrophys

118 ar signal-regulated kinase (ERK) activation, immediate early gene expression, or expression of CCAAT/

119 pression in the ability of cocaine to induce immediate early gene expression.

120 A2 with no effect on neuronal firing rate or immediate early gene expression.

121 B phosphorylation that coordinately regulate immediate early gene expression.

122 ell measured using brain mapping analyses of immediate-early gene expression and produced a robust si

123 inhibitor, OSMI-1, affects initiation of HSV immediate-early gene expression and viral replication.

124 severely impaired behavioral stimulation of immediate-early gene expression in the mPFC, suggesting

125 s were dependent on progression beyond viral immediate-early gene expression, but not dependent on vi

126 ncy in vivo is associated with repression of immediate-early gene expression, deacetylation of histon

127 p90RSK phosphorylation and the induction of immediate-early gene expression.

128 rus 1 (HSV-1) to limit viral replication and immediate-early gene expression.

129 of glutamate receptors and singing-dependent immediate-early gene expression.

130 and immunohistochemical methods to quantify immediate-early gene expression.

131 Coexpression of immediate early genes (for example, Egr1, Fos, Dusp1) an

132 g-related transcripts including the expected immediate early gene Fos and Stk11, a master kinase of t

133 riatal DA was increased and the DA-regulated immediate early gene Fos was upregulated.

134 stochemical detection of the tracers and the immediate early gene Fos.

135 associated with increased expression of the immediate early genes Fos and FosB and the NMDA receptor

136 and Period2 (Per1 and Per2), as well as the immediate-early gene Fos in the SCN, dorsal hippocampus,

137 s and downstream early and late genes, while immediate early genes from other loci remain unaffected.

138 in disorders characterized by alterations in immediate early genes, further supporting the concept th

139 We found that activity-dependent immediate early gene H1a is critical for establishing no

140 report a novel role of an activity-dependent immediate early gene Homer1a (H1a) in these processes.

141 These changes are driven by the immediate early gene Homer1a and signaling from group I

142 receptor activation that is mediated by the immediate early gene Homer1a.

143 he mechanistic level, we show that the HSV-1 immediate early gene ICP22 binds the CD80 promoter and t

144 of roscovitine treatment, transfection with immediate early genes (IE), and infection with a recombi

145 only a small percentage of cells expressing immediate-early genes (IE) and early genes.

146 Immediate early gene (IEG) activity mapping has been wid

147 Serum response factor (SRF) mediates immediate early gene (IEG) and cytoskeletal gene express

148 In the cortex, the immediate early gene (IEG) ARC was increased in VNS rats

149 influenced neural activity in females, using immediate early gene (IEG) expression as a proxy for bra

150 Operant learning induces immediate early gene (IEG) expression in key corticostri

151 repair, as a key player in the regulation of immediate early gene (IEG) expression underlying the con

152 vity in the IL-PFC as evidenced by increased immediate early gene (IEG) expression.

153 Furthermore, we found that expression of the immediate early gene (IEG) Homer1a (H1a) and its subsequ

154 ecursor protein (APP) and TIAM1, and between immediate early gene (IEG) proteins and the HSA21 protei

155 ering transcription factors and promoters of immediate early genes (IEG) accessible to PARP1-bound ph

156 us (SON) increases the expression of several immediate early genes (IEG) and the vasopressin gene.

157 The induction of expression of many cellular immediate early genes (IEG) involves the transcription f

158 Among these immediate early genes (IEG), members of the Early growth

159 thin this set of genes we identified several Immediate Early Genes (IEG), which were highly expressed

160 mory consolidation require expression of the immediate-early gene (IEG) Arc.

161 ulated cytoskeletal-associated protein (Arc) immediate-early gene (IEG) expression and changes in BLA

162 solidation is associated with CB1R-dependent immediate-early gene (IEG) expression and changes in exc

163 The induction of immediate-early gene (IEG) expression in brain nuclei in

164 s work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated

165 ons (10% focal ablation) with singing-driven immediate-early gene (IEG) labeling to explore the netwo

166 Arc, an immediate-early gene (IEG) product involved in dendritic

167 Arc is a cellular immediate-early gene (IEG) that functions at excitatory

168 ed cytoskeletal-associated protein (Arc), an immediate-early gene (IEG) whose expression is tightly l

169 We review the "Immediate Early Gene" (IEG) response, the starting point

170 tex, Satb1 binds to genomic loci of multiple immediate early genes (IEGs) (Fos, Fosb, Egr1, Egr2, Arc

171 al activation induces rapid transcription of immediate early genes (IEGs) and longer-term chromatin r

172 g-related elevation in the expression of the immediate early genes (IEGs) Arc/Arg3.1 and Egr-1 in the

173 Immediate early genes (IEGs) are activated as a first li

174 PAR-1) increases the expression of multiple immediate early genes (IEGs) associated with growth and

175 Profound induction of immediate early genes (IEGs) by neural activation is a c

176 n 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a

177 itiation and the release of paused RNAPII at immediate early genes (IEGs) following transcriptional a

178 Many immediate early genes (IEGs) have activity-dependent ind

179 Transcription of immediate early genes (IEGs) in neurons is highly sensit

180 tion factor (NELF) complex upon induction of immediate early genes (IEGs) in neurons.

181 Transcription of immediate early genes (IEGs) in response to extrinsic an

182 iption factor Elk-1 stimulates expression of immediate early genes (IEGs) in response to mitogens.

183 Alternatively, post hoc staining of immediate early genes (IEGs) indicates highly active cel

184 s been shown for Egr-2, all of which are the immediate early genes (IEGs) of the Erk1/2 pathway.

185 ence-driven induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1.

186 nges in the expression of several members of immediate early genes (IEGs) which are known to control

187 cators of functional activity, including the immediate early genes (IEGs) zif268 (egr1), c-fos, and a

188 In addition and unlike mammalian immediate early genes (IEGs), fly ARGs do not have short

189 fic expression patterns of JUN, FOS and EGR1 immediate early genes (IEGs), reflected by the presence

190 lize epidermal growth factor (EGF)-inducible immediate early genes (IEGs).

191 ch to dissect how Erk activity is decoded by immediate early genes (IEGs).

192 that closely resemble the dynamics of known immediate-early genes (IEGs) and this enables a comprehe

193 Immediate-early genes (IEGs) are rapidly activated after

194 Here, we used the expression of immediate-early genes (IEGs), protooncogene, c-Fos, and

195 tion elongation of the serum response genes (immediate early genes [IEGs]) FOS, EGR1, and cJUN.

196 Using immediate early gene imaging (c-Fos), fiber-sparing exci

197 trophysiological recordings, lesion studies, immediate-early gene imaging, transgenic mouse models, a

198 how that activation of a learning-associated immediate early gene in rat olfactory cortices is uninte

199 was induced in endothelial cells (ECs) as an immediate early gene in response to PH.

200 was associated with decreased expression of immediate early genes in rat GC of both sexes, and with

201 Deletion of YAP/TAZ blocks the induction of immediate early genes in response to mitogenic stimuli.

202 associated with a striking up-regulation of immediate early genes in the prelimbic region of the med

203 ients tested had expression of the EBV major immediate-early gene in the blood indicative of active E

204 ed RNA polymerase II and drive expression of immediate-early genes in neurons.

205 that CIKS is essential for all IL-17-induced immediate-early genes in primary mouse embryo fibroblast

206 ng RNA (siRNA) reduced the expression of HSV immediate-early genes, in addition to reducing viral yie

207 Several of these p300 targets are immediate early genes, including FOS, implicating a prom

208 g one population expressing higher levels of immediate early genes indicative of a homeostatic activa

209 e have examined whether deletion of Narp, an immediate early gene induced by electroconvulsive seizur

210 e mice show deficient plasticity of striatal immediate early gene inducibility after repeated AMPH ad

211 these cortices in DH-compromised animals and immediate early gene induction profiles for amygdala-pro

212 stone H3 is a complex phenomenon involved in Immediate-early gene induction in metazoan eukaryotes.

213 t both receptor populations up-regulate many immediate early genes involved in growth and differentia

214 neural activity rapidly upregulates mRNAs of immediate early genes involved in synaptic plasticity, o

215 Arc/Arg3.1, an activity regulated immediate early gene, is essential for learning and memo

216 h as eukaryotic elongation factor 1A and the immediate early gene JunB.

217 1 was decreased along with the expression of immediate early genes like c-fos and Egr-1 by the diseas

218 ducible hnRNPK recruitment along a number of immediate early gene loci, including EGR1 and ZFP36, wit

219 of cohesins and loss of CTCF binding at the immediate early gene locus, suggesting that cohesins may

220 A whole brain immediate early gene mapping highlighted the dorsolatera

221 Immediate early gene mapping using zif268 in situ hybrid

222 95-mediated memory maintenance using ex vivo immediate-early gene mapping, in vivo neuronal recording

223 n the expression of c-Fos and C/EBPbeta, two immediate-early gene markers of neuronal activity.

224 efects in the expression or activity of this immediate-early gene may also contribute to the pathophy

225 Stabilization of a transiently expressed immediate early gene mRNA by a repeated training trial m

226 The immediate-early gene Narp (neuronal activity-regulated p

227 The immediate early gene neuronal activity-regulated pentrax

228 y presynaptic expression of the synaptogenic immediate early gene NPTX2 by pyramidal neurons.

229 ated transgenic mice expressing GFP from the immediate early gene Nr4a1 (Nur77) locus.

230 ct binding of HSV-1 ICP22, the product of an immediate early gene of HSV-1, to the promoter of CD80.

231 urthermore, abnormal expression of FosB, the immediate early gene of L-dopa induced dyskinesia (LID),

232 otein is essential for the expression of the immediate early genes of both herpes simplex virus (HSV)

233 n inducing Kruppel-like factor 2 and several immediate early genes of the AP1 and Egr family.

234 trongly turning on expression of both of the immediate early genes of the virus, probably by directly

235 that is required for transactivation of the immediate-early genes of herpes simplex virus (HSV).

236 overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal

237 e, upstream of the predicted promoter of the immediate early gene open reading frame 63 (ORF63).

238 Expression of the homer 1a (H1a) immediate-early gene produces a short homer protein that

239 ofilin and is modulated by expression of the immediate early gene product Arc.

240 and breadth of functional importance as the immediate early gene product Arc.

241 At excitatory glutamatergic synapses, the immediate early gene product Arc/Arg3.1 couples synaptic

242 The pattern of expression of the immediate early gene product cFos was used to identify k

243 at song production induced expression of the immediate early gene product Fos in trigeminal regions t

244 Colocalization of TH with the immediate early gene product Fos, an indirect marker of

245 in condition, Homer1a, an activity-dependent immediate early gene product, disrupted the persistent m

246 We utilized the immediate early gene product, early growth response prot

247 To identify activated neurons, the immediate early gene product, Fos protein, was labeled.

248 mapped expression of the activity-dependent, immediate-early gene product Fos in the brains of wild-t

249 Our findings implicate an immediate-early gene product, Egr1, as part of the mecha

250 Consequently, induction of the immediate early gene products and transcription factors

251 A number of herpesvirus immediate early gene products play important roles in th

252 ion, SMin92 accumulated representative viral immediate-early gene products, early gene products, and

253 ffect on PML-NBs is similar to that of viral immediate-early gene products, such as infected cellular

254 TNFalpha and IL1 beta, as well as the immediate early gene protein Fos, were higher at the end

255 signals (male, female mouse urine) increased immediate early gene-protein (IEG) expression in both an

256 lified ERK1/2 activation, growth factor-like immediate early gene regulation and EGR1 protein express

257 Therefore, understanding of immediate early gene regulation might add insights into

258 Using immediate early gene reporter mice, active cells express

259 Immediate early genes, represented by AP-1 complex, are

260 previously that in white-throated sparrows, immediate early gene responses in the auditory pathway o

261 al amygdalar nucleus, and we used lesion and immediate-early gene studies to test our working hypothe

262 Here we show that after UV-C irradiation, immediate early genes such as activating transcription f

263 ced by tumor promoters (EGF, UV and TPA) and immediate early genes, such as c-myc, c-jun and c-fos.

264 d activation of multiple protein kinases and immediate early genes, such as cFos, enabling rapid and

265 Crest or Mef2, as well as activity-regulated immediate-early genes, such as fos and jun.

266 Our work defines TSP-1 as a novel immediate early gene that could be a potential therapeut

267 Arc is an immediate early gene that is unique among neuronal mRNAs

268 cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity

269 nes, including Arc, also known as Arg3.1, an immediate early gene that plays a significant role in me

270 onal activity causes the rapid expression of immediate early genes that are crucial for experience-dr

271 ting universally at active genes, except for immediate early genes that are strongly induced before M

272 aintaining seizure activity and induction of immediate early genes that control hippocampal excitabil

273 Abnormalities in the expression profile of immediate early genes that play a critical role in memor

274 (DUSP1); both known to be activity-dependent immediate early genes that respond to stimuli in the bra

275 The FGFR immediate early genes that were identified include those

276 -1) is encoded by mkp-1, a stress-responsive immediate-early gene that dephosphorylates MAPKs in the

277 eletal-associated protein (Arc/Arg3.1) is an immediate-early gene that has been widely implicated in

278 the levels of Arc (also known as Arg3.1), an immediate-early gene that is required for long-term memo

279 CCN1 is a product of an immediate-early gene that is transcriptionally induced i

280 hnique based on the cellular distribution of immediate early genes to examine the effect of LC activa

281 GNIFICANCE STATEMENT How does the pattern of immediate early gene transcription in the brain relate t

282 s function in herpes simplex virus 1 (HSV-1) immediate early gene transcription, our findings suggest

283 AP kinase (MAPK) phosphorylation to regulate immediate early gene transcription.

284 CTCF are required for the repression of KSHV immediate early gene transcription.

285 gene expression early in development, and in immediate early gene transcription.

286 n of methionine import, leading to decreased immediate-early gene translation without significant tox

287 aired in iLC, the transcription of the viral immediate early genes UL122 and UL123 and of the delayed

288 ventral hippocampus, whereas upregulation of immediate early genes was observed in both dorsal and ve

289 After CO2 asphyxiation, several immediate early genes were expressed at lower levels in

290 Cs induced a robust expression of a panel of immediate early genes, which included the Nr4a subfamily

291 Nur77 is an immediate early gene whose expression is rapidly upregul

292 imulates the expression of c-Fos, a neuronal immediate early gene with key roles in synaptic plastici

293 factor-induced expression of c-Fos and Egr2, immediate-early genes with promoter-proximally paused po

294 itially induce partially overlapping sets of immediate early genes without sustaining the response.

295 activation (as the expression pattern of the immediate early gene ZENK) during sleep in juvenile zebr

296 Thus, altered expression of the immediate early gene Zif268 may contribute to lower leve

297 ewborn neurons that depends on the inducible immediate early gene zif268, processes that are critical

298 nce imaging and in situ hybridization of the immediate early gene zif268, respectively.

299 scription factor ATF4 to the promoter of the immediate early gene zif268, which competitively inhibit

300 ntegration of newborn neurons, the inducible immediate early gene zif268/egr1.