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1 tions, consistent with suppression of their 'immortality'.
2 telomerase (EC 2.7.7.49) to promote cellular immortality.
3 rk of cancer cells which enables replicative immortality.
4 exhibit comparable patterns of mortality and immortality.
5 tinue in this eternal cycle, termed germline immortality.
6 length maintenance is crucial to cancer cell immortality.
7 the hotspot mutations that confer tumor cell immortality.
8  CN through generations, supporting germline immortality.
9 ing how much telomerase is required for cell immortality.
10 ase pathway for telomere maintenance to gain immortality.
11 al role in chromosome stability and cellular immortality.
12 mere length, is sufficient to result in cell immortality.
13 e been overcome in a cancer cell's quest for immortality.
14 tion of the potential to achieve replicative immortality.
15 ibutes to the acquisition and maintenance of immortality.
16 ic BCL-2 family proteins to enforce cellular immortality.
17 east cells to overcome senescence and attain immortality.
18 m in addition to hTERT expression to achieve immortality.
19 ast known proliferative blockade to cellular immortality.
20 and essential feature of germ cells is their immortality.
21 el and may facilitate cell transformation to immortality.
22 maintenance mechanism to achieve replicative immortality.
23 allowing cancer cells to achieve replicative immortality.
24 to the role of telomere regulation in cancer immortality.
25 ere-based proliferative barriers and achieve immortality.
26  critical for the development of replicative immortality.
27 sent the genetic underpinnings of tumor cell immortality.
28 lomere length and are essential for germline immortality.
29 echanism (TMM) is permissive for replicative immortality and a hallmark of human cancer.
30 key pathways required to support replicative immortality and anchorage independent growth, a predicto
31     The roles of telomerase in both cellular immortality and cancer are vibrant areas of current rese
32           Telomerase is associated with cell immortality and cancer, which may by related to the abil
33 me end-replicating enzyme, drives human cell immortality and cancer.
34 e tumor cells is sufficient to reverse their immortality and cause a phenotype that is, by all genera
35 its medusae reproduce, hinting at biological immortality and challenging our understanding of aging.
36 on of telomeric repeats and may promote cell immortality and hence malignancy.
37 significant role in establishing cancer cell immortality and is under suspicion for its potential con
38 genetic changes, which follow acquisition of immortality and loss of senescence, are of consistent so
39                                   To acquire immortality and malignancy, the cultured finite lifespan
40 c DNA (TTAGGG)n, may be involved in cellular immortality and oncogenesis.
41  to investigate the contribution of cellular immortality and oncogenic transformation of primary huma
42 n of telomerase is crucial for cells to gain immortality and proliferation ability, we examined the r
43 elomere and genome stability to ensure their immortality and shed light on the regeneration medicine
44 rk is critical to understanding how cellular immortality and totipotency are retained, gained, and lo
45 suggest the existence of a suppressor of SCC immortality and tumour development at chromosome 6q14.3-
46 elomerase, which has been linked to cellular immortality and tumour progression.
47              The enzyme is required for cell immortality, and its activity has been detected in the v
48 s, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells.
49 ve (RSD)-2 and RSD-6 is to promote germ cell immortality at high temperature.
50 opose that RSD-2 and RSD-6 promote germ cell immortality at stressful temperatures by maintaining tra
51 Our previous work showed that acquisition of immortality at the dysplasia stage of oral cancer progre
52 te telomerase, contributing to proliferative immortality, but the molecular events driving TERT activ
53   Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase re
54                 Cancers overcome replicative immortality by activating either telomerase or an altern
55  both aging and rejuvenating lineages retain immortality by reaching their respective states of physi
56                       To achieve replicative immortality, cancer cells must activate telomere mainten
57                       To achieve replicative immortality, cancer cells must activate telomere mainten
58 e activity is closely linked to the cellular immortality characteristic of late stage carcinogenesis,
59 tenet of the biology of aging where germline immortality comes at the cost of an aging soma [T.
60 rowth potential before progression to clonal immortality could occur.
61                  The development of cellular immortality has been implicated as an important factor i
62 s review examines the mechanisms of germline immortality-how germline cells reset the aging of cells-
63 on the dominance of cellular senescence over immortality, immortal human cell lines have been assigne
64 determination of proliferative mortality and immortality in bacterial populations.
65 intain genomic stability and confer cellular immortality in cancer and stem cells.
66 lls experience multiple barriers to cellular immortality in culture (mortality mechanisms 0, 1, and 2
67  broad dependence on telomerase for germline immortality in metazoans.
68 terized by serum independence in culture and immortality in vivo, when compared with wild type contro
69 bute to a molecular understanding of Hydra's immortality, indicate an evolutionarily conserved role o
70 sors, resist cell death, promote replicative immortality, induce angiogenesis, support invasion and m
71 phase transition between finite lifetime and immortality (infinite proliferation) of the cell populat
72  cells, and reveal the principles of episome immortality intrinsic to the human genome.
73          In Caenorhabditis elegans, germline immortality involves proteostasis renewal at the beginni
74     Our results show that the acquisition of immortality is a crucial and rate-limiting step towards
75                                  Replicative immortality is a hallmark of cancer cells governed by te
76                                  Replicative immortality is a hallmark of cancer, and can be achieved
77                                  Replicative immortality is a hallmark of cancer, driven by the activ
78                                  Replicative immortality is achieved in vitro by overcoming two morta
79                Squamous cell carcinoma (SCC) immortality is associated with p53 and INK4A dysfunction
80                                    Potential immortality is observed in several species (e.g. prickly
81 mechanism of replicative senescence and cell immortality is still unclear.
82 nce telomerase plays a critical role in cell immortality, it is an attractive target for a selective
83 mmation, genomic instability and replicative immortality, just to name a few cancer hallmarks.
84 n programs in vitro and in vivo, replicative immortality, malignancy, rapid tumor growth, pigmentatio
85                                  Solving the immortality mechanism represents a major step toward sel
86 ibit telomerase reactivation and attain full immortality much more rapidly.
87 e is thought to be essential for replicative immortality, MYC, in conjunction with cofactors, confers
88 tinued proliferation of human stem cells and immortality of cancer cells(2).
89  maintenance, and supports the proliferative immortality of cancer cells.
90 ans infection on the continuing survival and immortality of human peripheral blood mononuclear cells
91 The key to this methodology is the intrinsic immortality of normal intestinal stem cells (ISCs) and c
92 etic ground state required for the continued immortality of the C. elegans germ line.
93 ltigenerational RNAi inheritance and promote immortality of the germ-cell lineage.
94 has thus been proposed to be a basis for the immortality of the germline and of malignant cells.
95 s poorly understood, although central to the immortality of the germline.
96 elomeres (ALT), is essential for replicative immortality of tumor cells, although its regulatory mech
97 sfection with telomerase was shown to confer immortality on several types of human cells.
98  to try to confer some of the germ lineage's immortality on the somatic body.
99 f reactive oxygen species (ROS) during tumor immortality, proliferation and metastasis.
100 ther, these observations imply that cellular immortality promotes epigenetic adaptation to highly pro
101          In Caenorhabditis elegans, germline immortality requires the maternal contribution from four
102 r output from stem cells as well as inducing immortality, self-renewal, and tumorigenesis in myeloid
103    The majority of human tumor cells acquire immortality through expression of the catalytic subunit
104 pected role for NRSS in maintaining germline immortality through maintenance of a vulnerable genomic
105 e between cellular life and death, achieving immortality through pathologic enforcement of survival p
106 combination pathway which grants replicative immortality to approximately 10% of all cancers.
107 lls are distinct from somatic cells in their immortality, totipotency, and ability to undergo meiosis
108 ence of cells with stem-cell properties (ie, immortality, transplantability, and resistance to therap
109 ify the genes that are required for germline immortality, we isolated Caenorhabditis elegans mutants
110     A hallmark of tumor cells is replicative immortality, which can be achieved, in part, by the acti
111 telomeres (ALT) to sustain their replicative immortality, yet there are currently no targeted therapi

 
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