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2 expression and silencing studies of FOSL1 in immortalized and primary HPMEC demonstrated that baselin
3 c sonoporation method to deliver plasmids to immortalized and primary human cell types, based on pore
4 ted T-cell lines promote KSHV infectivity in immortalized and primary human oral epithelial cells.
7 ) and upregulation of interleukin (IL)-17 in immortalized and primary patient-derived malignant and n
8 cells from two people exposed to DENV4 were immortalized and screened to identify DENV-specific clon
10 derived nonneuronal cell lines (cancerous or immortalized) and found significant subpopulations that
12 1970s when Georges Kohler and Cesar Milstein immortalized antibody-producing mouse B-lymphocytes by f
16 o escape contact inhibition, and transformed immortalized astrocytes, supporting AVIL being a bona fi
18 V-2 isolates, compromised in the capacity to immortalize B cells, infect CD3(+) T cells ex vivo and p
19 for HPA-1a, named 26.4, was derived from an immortalized B cell from an alloimmunized woman who had
23 te adhesion deficiency (LAD) patient-derived immortalized B lymphocytes, where nearly 70% of alleles
24 e used iPSCs derived from Epstein-Barr virus-immortalized B-lymphocytes to verify that the hyperexcit
27 ls; this can be replicated using LAE and SAE immortalized basal cell lines derived from healthy nonsm
29 Cai and adenosine were measured in fresh or immortalized blood lymphocytes incubated with 0-10 mM 4-
30 circadian manner and is induced during both immortalized bone marrow derived stromal cell (iBMSC) as
31 ween miR-181a and the circadian machinery in immortalized bone marrow stromal cells and adipose deriv
33 ntial to enhance the cell viability of human immortalized bronchial epithelial cell line of Beas-2B.
36 ma cells, stable overexpression of BAP1 into immortalized but non-transformed melanocytes did suppres
37 orced expression of MCM8 in RWPE1 cells, the immortalized but non-transformed prostate epithelial cel
38 estricted to keratinocyte-derived cell lines immortalized by HPV due to the lack of experimental syst
40 umor immunotherapy models have reconstituted immortalized cancer cell lines with immune components, o
46 to rodent models, we explored the use of an immortalized cell line derived from human dorsal root ga
49 ally, we have demonstrated the utility of an immortalized cell line to produce a high yield of exosom
50 studies in UB/OC-1 cells, an organ of Corti immortalized cell line, showed that R-PIA reduced cispla
52 rence detector in situ assay in a variety of immortalized cell lines and primary human airway smooth
53 -based ontology that contains information of immortalized cell lines and relevant experimental compon
54 ral nervous tissue or exogenously expressing immortalized cell lines as common mechanisms throughout
58 ansforming primary human CD4(+) T cells into immortalized cell lines indistinguishable from patient-d
60 ng (ChIP-seq) analyses have focused on a few immortalized cell lines whose activities and physiology
62 cell culture tools, including primary cells, immortalized cell lines, human stem cells, and their mor
74 In addition, in contrast to drug-treated, immortalized cells in vitro, mature motor neurons rarely
75 esent at attenuated levels, in spontaneously immortalized cells provide insights into the role of oxi
76 t 100-fold more selective for AML than solid immortalized cells such as HEK293 or human peripheral bl
77 the prevailing mutation type in the treated immortalized cells was A:T->C:G transversion, with a uni
79 models tested (e.g., between primary cells, immortalized cells, and in cocultures of immortalized hu
80 ere genetically stable, highly attenuated in immortalized cells, had defects in replication and sprea
81 nd swine influenza viruses replicated in the immortalized cells, which generally yielded higher-titer
82 hotosensitization-induced mutagenesis in the immortalized cells, which were present at attenuated lev
83 n vivo and ex vivo, but is not needed in non-immortalized cells, while PAK4 overexpression in untrans
88 established as a potent hCAR deactivator in immortalized cells; whether it inhibits hCAR activity un
89 GAs present several limitations due to their immortalized characteristics, and NHAs represent an inno
90 heir ability to increase the permeability of immortalized choroid plexus epithelium monolayers in vit
91 ty, we have developed multiple conditionally immortalized clonal preadipocyte lines from white adipos
94 n complex, partially restores TERC levels in immortalized DKC1 mutant cells, but it remains unknown i
99 idbody (cytokinesis) during cell division in immortalized epithelial cells as well as breast, ovarian
100 differentiation of an enucleation-competent immortalized erythroblast cell line (BEL-A) support both
101 ablish the use of reticulocytes derived from immortalized erythroblasts as a powerful model system to
105 lecules were evaluated for two conditionally immortalized fetal NSC lines derived from the cortical a
107 a overexpression in either HeLa cells or TAg-immortalized fibroblasts, suggesting additional restrict
109 ld-type YAP, or constitutively active YAP in immortalized FTSECs, induced cell proliferation, migrati
112 .3 and 3.4 muM), was evaluated in telomerase immortalized gingival keratinocytes (TIGKs) by measuring
113 this hypothesis, primary rat hepatocytes or immortalized H4IIEC3 rat hepatoma cells were treated wit
114 We observed that knockdown of AE2 sensitized immortalized H69 human cholangiocytes to not only bile s
115 single-cell movement and signaling in human immortalized HaCaT keratinocytes treated with soluble or
116 able tissues from genetically engineered and immortalized HEK293 cells with well-characterized electr
117 the mechanism by which that occurs, using an immortalized hematopoietic progenitor cell line, EML-C1,
120 ing positive-strand RNA virus replication in immortalized hepatocytes and identified an unexpected ro
121 ach, we generated and subsequently subjected immortalized heterozygous R349P desmin knock-in myoblast
122 Here, we found that TGFbeta treatment of immortalized HSCs (i.e. LX-2 cells) induces phosphorylat
124 lthough the MLL-CHD fusion protein failed to immortalize HSPCs in myeloid conditions in vitro, it cou
128 ty of (a) an in vitro model using hTERT/Cdk4 immortalized human bronchial epithelial cell lines to id
129 d a quantitative global proteome analysis of immortalized human bronchial epithelial cells (HBEC3-KT)
134 owever, have been hampered by the lack of an immortalized human cell line derived from oligodendrocyt
135 ne, mirrored their Neuro-2a activity in four immortalized human cell lines and in a human neuroprogen
136 sing for the identified compounds in several immortalized human cell lines as well as normal diploid
137 from karyotypically normal primary and hTERT-immortalized human cell lines to catalog NORs in terms o
139 e pluripotent, primary, differentiating, and immortalized human cells, and demonstrate that a class o
140 on the integrity of tight monolayers of the immortalized human cerebral microvascular endothelial ce
141 hour MMC treatment of primary and telomerase immortalized human corneal limbal epithelial (HCLE) cell
143 Herein we describe the generation of an immortalized human endometrial stromal cell line that us
144 ignaling proteins in decidualized telomerase-immortalized human endometrial stromal cells (dT-HESCs)
145 A workflow was established using telomerase-immortalized human epithelial cells that revealed highly
146 ypersensitivity to oxidative stress in hTERT-immortalized human foreskin fibroblasts (HFF-hTERT).
147 nse of pocket epithelium-derived, telomerase-immortalized human gingival keratinocytes (TIGKs) to mic
148 he current study establishes the response of immortalized human glomerular endothelial cells (GEnC) t
150 epatocellular carcinoma (HepG2) cell line or immortalized human hepatocytes (IHH) and activation of i
151 r Ab-dependent cell-mediated cytotoxicity of immortalized human hepatocytes in the presence of CD55-b
152 CV-infected hepatoma cells (Huh7.5 cells) or immortalized human hepatocytes inhibited C3 convertase a
154 TRPV3 channels endogenously expressed in an immortalized human keratinocyte cell line (HaCaT) and in
157 omotes breast cancer initiation in models of immortalized human mammary epithelial cells (HMECs).
158 xpression promotes tumorigenic phenotypes in immortalized human mammary epithelial MCF10A cells and,
159 found that compared with normal primary and immortalized human melanocytes, SIRT3 is significantly o
160 umbilical vein endothelial cells (HUVEC) and immortalized human microvascular endothelial cells (HMEC
164 blastoma multiforme (GBM) model derived from immortalized human neural stem/progenitor cells (hNSCs)
165 Rac exchange factor 2 (PREX2) using the same immortalized human NRAS(G12D) melanocytes as the origina
170 nt to provide IL-2-independent growth of Tax-immortalized human T cells and increase the tumor format
171 s from wild-type and Elf3 knockout mice, and immortalized human T/C-28a2 and murine ATDC5 cell lines
172 leading to a TFG-RET fusion which transforms immortalized human thyroid cells in a kinase-dependent m
173 TRPV4 to the plasma membrane of primary and immortalized human TM (hTM) cells, and to human and mous
175 study showing regulation of let-7 targets in immortalized human trophoblast cells by the ARID3B-compl
176 KSHV replication, we xeno-grafted telomerase-immortalized human umbilical vein endothelial cells that
180 vity is not required for PEDV replication in immortalized, IFN-deficient Vero cells, but is important
181 terovirus 71 (EV71), and that contrary to an immortalized intestinal cell line, enteroids induced ant
186 expression and DNA methylation using normal immortalized keratinocyte lines, NIKS, NIKS-16, NIKS-18,
187 ed cell populations of normal, spontaneously immortalized keratinocytes (NIKS) and NIKS stably transf
188 e expression profiles in human spontaneously immortalized keratinocytes (NIKs) expressing the early g
189 , rare cells positive for Lgr6 expression in immortalized keratinocytes and show that their frequency
190 otypic rafts, and human papillomavirus (HPV)-immortalized keratinocytes are altered in the presence o
191 rometric analysis of conditioned medium from immortalized keratinocytes showed that alpha3beta1 regul
197 orroborated in human lung cancer tissues and immortalized lung cancer cell lines via indirect immunof
199 ng cancer driver, its expression transformed immortalized lung epithelial cells while a transgenic mo
204 ected in the membrane-containing fraction of immortalized macrophages after caspase-11 activation by
205 noclonal antibodies (mAbs) manufactured from immortalized mammalian cell lines are becoming increasin
210 iopsies (n = 13), and primary peritoneal and immortalized mesothelial cells (MeT5A) by immunohistoche
211 ture models, such as SVG-A cells (SVGAs), an immortalized, mixed population of glial cells transforme
212 zed with EBV gp350 is capable of efficiently immortalizing monkey B cells in vitro and reproduces acu
214 fer NAI resistance in avian viruses grown in immortalized monolayer cells, especially those of the N3
215 We report that overexpression of HSPB8 in immortalized motor neurones decreased the accumulation o
216 yR2/phospholamban hyperphosphorylation in an immortalized mouse atrial cardiomyocyte cell-line (HL-1-
219 de CRISPR/Cas9 knockout screen in Kras(G12D) immortalized mouse embryonic fibroblasts (MEFs) to searc
220 its functions in cells, we deleted ELMOD2 in immortalized mouse embryonic fibroblasts and discovered
225 describe a genome-wide CRISPR/Cas9 screen in immortalized mouse macrophages aiming at the unbiased id
227 enriched in mouse Schwann cells compared to immortalized mouse motor neurons (MN-1), and is predicte
233 of a GFP-based NF-kappaB reporter system in immortalized murine bone marrow-derived macrophages (iBM
236 n-related gene and protein expression in the immortalized murine cementoblast cell line OCCM-30 after
239 aracterized an in vitro system of transduced immortalized murine macrophages expressing either WT or
240 showed a significant increase in LPS-treated immortalized murine microglial cell line BV2 cells in an
241 human dental pulp stem cells (hDPSCs) and an immortalized murine odontoblast cell line (MDPC-23), to
244 blasts but is downregulated by H-Ras(V12) in immortalized NIH 3T3 cells through a mechanism involving
245 tial while not altering the proliferation of immortalized, noncancerous human peripheral airway cells
246 We developed an in vivo assay based on the immortalized nontumorigenic breast cell line MCF10A and
247 epletion was selectively lethal to tumor and immortalized normal cells expressing the mutant kinase B
249 down in ESCC cell lines (KYSE450 and T.Tn), immortalized normal esophageal epithelial cell lines (NE
250 in depletion can selectively induce death of immortalized normal fibroblasts IMR90E1A when combined w
252 ate that PML depletion in U2OS cells or TERT-immortalized normal human diploid fibroblasts results in
253 an papillomavirus 16 (HPV 16) E6 and E7 gene-immortalized normal human epidermal keratinocytes, we de
254 ssed in normal prostate epithelial cells and immortalized normal human prostate epithelial cells (RWP
255 dent of immortalization, as human telomerase-immortalized normal oral keratinocytes supported robust
256 xpressing pancreatic cancer cells and spares immortalized normal pancreatic duct cells, hTERT-HPNE.
257 arian cancer cell lines relative to those in immortalized normal surface epithelial cells and that su
259 into telomerase reverse transcriptase (TERT) immortalized oral keratinocytes (NOKs) that are capable
260 26 ovarian cancer cell lines, HGSOC tumours, immortalized ovarian surface epithelial cells and fallop
264 and chromatin opening during adipogenesis of immortalized preadipocytes derived from mouse brown adip
267 differentiation program, which culminates in immortalized, proliferating cells that partially resembl
268 Introduction of FOXA1 and HOXB13 into an immortalized prostate cell line reprogrammed the AR cist
269 pheroid culture from normal human primary or immortalized prostate epithelial cells, and their differ
274 nucleoprotein F (hnRNP F) in their RPTCs and immortalized rat renal proximal tubular cells (IRPTCs) w
276 ney effectively and reproducibly using mixed immortalized renal cells, and showed their application f
277 meshifted, from an intracellular location in immortalized renal epithelial cells of a patient affecte
278 laced DAs from the interphase centrosomes of immortalized retina pigment epithelial (RPE1) cells.
281 e applied CRISPR/Cas9 technology to generate immortalized sialylation-deficient podocytes (asialo-pod
282 -stimulated cell transformation of the HaCaT immortalized skin cell line and mutation of NFAT3 at Ser
285 IB formation is observed in a conditionally immortalized striatal neuron model of HD, and IB formati
286 nd tracheal respiratory epithelial cells and immortalized swine nasal epithelial cells (siNEC) and tr
288 low cytometry following transfection into an immortalized T-cell line and compared to that of a refer
289 tion and invasion compared to commonly used, immortalized TB cell lines and primary cells from term p
291 ng the establishment of EBV infection in HPV-immortalized tissues, we showed an HPV-induced interrupt
292 g a model of direct EBV infection into HPV16-immortalized tonsillar cells grown in organotypic raft c
293 uPA expression in TSC2-null tumor cells and immortalized TSC2-null angiomyolipoma cells, but not in
294 is, chromosome missegregation was induced in immortalized tubal epithelial cells, which proved acutel
296 ntigen deletions were cultured in cell lines immortalized using simian virus 40 (SV40) T antigen, sug
297 s [PBMCs], CD14(+) monocytes, and telomerase-immortalized vascular endothelial [TIVE] cells), from vi
298 blastoma cell proliferation, including cells immortalized via the telomerase-independent ALT mechanis