ライフサイエンスコーパス: immortalized cell

1 ose frequency was intensified in the treated immortalized cells.

2 duced apoptotic and proliferation changes in immortalized cells.

3 by alpha3beta1 and TGFbeta is a property of immortalized cells.

4 apoptosis in cancer cells, but not in normal/immortalized cells.

5 terns, and expression of hTERT in cancer and immortalized cells.

6 ry keratinocytes, Id3 is upregulated only in immortalized cells.

7 cancer and how it promotes transformation in immortalized cells.

8 ctively in cancer cells and not in normal or immortalized cells.

9 reased in response to UVB in HFK, but not in immortalized cells.

10 sion was upregulated in primary HFK, but not immortalized cells.

11 pression was significantly increased only in immortalized cells.

12 redominantly localized in the nucleus in the immortalized cells.

13 ells but is present in cancerous tissues and immortalized cells.

14 with the same efficiency in normal and hTERT-immortalized cells.

15 nts, ZNF217-transduced cultures gave rise to immortalized cells.

16 d EGFR levels comparable with those of E6/E7-immortalized cells.

17 er genomic instability, such as malignant or immortalized cells.

18 ivity upon an endogenous target gene only in immortalized cells.

19 f endogenous target genes both in mortal and immortalized cells.

20 icts previous experiments using trypsinized, immortalized cells.

21 gthening of telomeres in telomerase-negative immortalized cells.

22 nd differentiation potential, or have become immortalized cells.

23 t induction of apoptosis in both primary and immortalized cells.

24 f CSF-1 was found to induce apoptosis in the immortalized cells.

25 at are T-cell-immunodeficient can reject EBV-immortalized cells.

26 P-1 and NF-kappaB transactivation in the HPV-immortalized cells.

27 ion, and tested them in primary cultured and immortalized cells.

28 ivated in the majority of cancer tissues and immortalized cells.

29 7), characteristically expressed on in vitro-immortalized cells.

30 ed in normal somatic cells but is present in immortalized cells.

31 the levels of hTR in primary, precrisis, and immortalized cells.

32 erase activity were observed in the parental immortalized cells.

33 as shown to induce tumorigenic phenotypes in immortalized cells.

34 nvironment, which impacts viral infection in immortalized cells.

35 al AAV serotypes and a number of primary and immortalized cells.

36 ting that this phenomenon is not specific to immortalized cells.

37 was maintained and could activate ERK1/2 in immortalized cells.

38 c defects that we observe are not evident in immortalized cells.

39 ts in normal cells but it is disconnected in immortalized cells.

40 proliferation of normal cells but transforms immortalized cells.

41 Notably, unlike immortalized cells, all treated cell populations eventua

42 Immortalized cells also expressed SV40 large T antigen.

43 nuous expression of cooperating oncogenes in immortalized cells, although essential for anchorage-ind

44 nit of telomerase, which is highly active in immortalized cells and >85% of human cancers but is quie

45 ion was tested in vitro using KIT-expressing immortalized cells and primary human mast cells.

46 on of ITPR1 induced TDP-43 nuclear export in immortalized cells and primary neurons and strongly pote

47 used to transfer mtDNA into rapidly dividing immortalized cells and, thereby, respiratory-deficient t

48 ucible gene in glial-derived cells including immortalized cells, and appears to be transcriptionally

49 etbp1-immortalized cells compared with other immortalized cells, and are induced shortly after Setbp1

50 shly prepared primary cells, isogenic cells, immortalized cells, and cancer cell lines.

51 models tested (e.g., between primary cells, immortalized cells, and in cocultures of immortalized hu

52 ansposition in up to 91% of actively growing immortalized cells, and we demonstrated that L1 retrotra

53 cultured keratinocytes, while expression by immortalized cells appears to be independent of the exog

54 ositive cytokeratin staining showed that the immortalized cells are keratinocytes; cell surface level

55 se results support a model in which HPV16 E7-immortalized cells are primed to undergo apoptosis, give

56 This analysis revealed that common immortalized cells are related to adult muscle precursor

57 We have immortalized cells at several stages along this pathway

58 Expression of this mutant in HPV16-immortalized cells attenuates the growth of these cells,

59 (BCL-2) to early-infected (MCL-1/BCL-2) and immortalized cells (BFL-1).

60 ration of many cell types, primary cells and immortalized cells, by inducing a G1 arrest.

61 sent at dramatically higher levels in Setbp1-immortalized cells compared with other immortalized cell

62 2 phosphorylation was observed in c-Myc from immortalized cells compared with primary cells.

63 Immortalized cells contained structurally intact HRX-ENL

64 Surprisingly, as the resulting immortalized cells containing active telomerase continue

65 fection, but this has mostly been limited to immortalized cell culture models.

66 o three passages of CVB3 in primary, but not immortalized, cell cultures.

67 er, rhythms of peripheral tissue explants or immortalized cells damp partially or completely.

68 s rhythmicity to other cells was compared in immortalized cells derived from the suprachiasmatic nucl

69 RPKD nephrectomy specimens and conditionally immortalized cells derived from these cysts.

70 The immortalized cells differentiate efficiently into mature

71 More importantly, the immortalized cells displayed characteristics typical of

72 The hTERT-immortalized cells divided in basic fibroblast growth fa

73 Suppression of either gene in Setbp1-immortalized cells drastically reduces their colony-form

74 cells is smaller than that produced in other immortalized cells due to cleavage.

75 The metabolic support provided by the immortalized cells equaled that observed after transplan

76 mutations, we generated a wide collection of immortalized cells (EWIma cells) tolerating EWSR1-FLI1 e

77 These immortalized cells exhibited "prostaspheres" in nonadher

78 Immortalized cells exhibited a CD4(+)CD25(+)CD3(-) pheno

79 rganotypic raft cultures, however, the hTERT-immortalized cells exhibited a maturation delay on termi

80 These immortalized cells exhibited low p53 levels at late pass

81 Moreover, the immortalized cells exhibited no oncogenicity, and no up-

82 ever, the DHS compartment in pluripotent and immortalized cells exhibits higher mutation rates than t

83 Variable proportions of immortalized cells expressed B7-1/B7-2 molecules and FAS

84 to E6 + E7-immortalized cells, the Myc + E7-immortalized cells expressed high levels of p53 protein

85 Immortalized cells expressed stem cell markers that incl

86 Finally, combinatorial screenings on immortalized cells followed by in vivo targeting establi

87 s of the biosynthetic pathways in cloned EBV-immortalized cells from patients with IgA nephropathy in

88 As controls, we showed that EBV-immortalized cells from patients with lupus nephritis an

89 The immortalized cells had a signature comparable to MDV-tra

90 ere genetically stable, highly attenuated in immortalized cells, had defects in replication and sprea

91 These immortalized cells have a decreased capacity to differen

92 tably, similar to parental normal cells, Rho-immortalized cells have WT p53 and intact G(1) cell cycl

93 roduction of HRAS(V12) or KRAS(V12) into the immortalized cells, however, allowed them to form s.c. t

94 f transposon insertion sites from tumors and immortalized cells identified more than 200 frequently m

95 e for the antitumor response elicited by EBV-immortalized cells in athymic mice.

96 her demonstrate the usefulness of telomerase-immortalized cells in studying this cellular phenotype.

97 Although the potential use of telomerase-immortalized cells in the clinic remains controversial,

98 In addition, in contrast to drug-treated, immortalized cells in vitro, mature motor neurons rarely

99 Patient-derived cells as well as immortalized cells in which PARN is disrupted show decre

100 Overexpression of c-Myc in immortalized cells increases cell proliferation, inhibit

101 Adenoviral transduction of hCLCA2 into immortalized cells induces p53, CDK inhibitors p21 and p

102 ely active NFATc1 mutant (caNFATc1) in these immortalized cells inhibits their differentiation into m

103 dylinositol 3-kinase/PKB pathway, whereas in immortalized cells, insulin-stimulated phosphorylation w

104 cerns associated with the transplantation of immortalized cells into human patients.

105 the improper dependency of H3K27me3 by mC in immortalized cells is likely to be fundamental to cancer

106 ata have shown that DNA repair in telomerase-immortalized cells is normal.

107 d cells and required for the survival of EBV-immortalized cells, lead to a number of studies demonstr

108 pid initiation of this checkpoint both in an immortalized cell line (mIMCD3) and in second-passage IM

109 ed from supernatant of an Epstein-Barr virus-immortalized cell line and identified as fragments of ca

110 AT(4) receptor in epithelial HK-2 cells (an immortalized cell line derived from adult human proximal

111 to rodent models, we explored the use of an immortalized cell line derived from human dorsal root ga

112 mor-tropic properties of HB1.F3.C1 cells, an immortalized cell line derived from human fetal telencep

113 Here, we use Oli-neu cells, an immortalized cell line derived from primary murine oligo

114 nd other reasons, we created a conditionally immortalized cell line derived from the OSN lineage, whi

115 Lysate proteins from an immortalized cell line from a MMTV-neu mouse model and f

116 rowth factor (bFGF), we used a conditionally immortalized cell line from rat hippocampal neurons (H19

117 iation, we have investigated a conditionally immortalized cell line from rat hippocampal neurons (H19

118 ng on the neural crest, we have generated an immortalized cell line from young Hensen's node.

119 of either normal human keratinocytes or the immortalized cell line HaCaT.

120 Expression in the immortalized cell line HC11 correlated with slow or arre

121 whether and to what extent the conditionally immortalized cell line hFOB 1.19 can serve as a surrogat

122 , and PC-3 cell lines, HEK293 cells, the EBV-immortalized cell line IB4, and the Burkitt's lymphoma c

123 Furthermore, inducing OPN expression in an immortalized cell line increased cell proliferation.

124 An immortalized cell line obtained from human retina was in

125 ization of Na+-dependent GSH transport in an immortalized cell line of human cerebrovascular endothel

126 resident immune cells of the brain, and the immortalized cell line of human microglia-SV40.

127 An immortalized cell line representing the primitive erythr

128 The conditionally immortalized cell line should prove useful in identifyin

129 The aim of this study was to obtain an immortalized cell line that exhibits characteristics of

130 -conditioned medium (BSN-CM) derived from an immortalized cell line thought to originate in the early

131 s and human dermal microvascular endothelial immortalized cell line to delineate the cellular signali

132 ally, we have demonstrated the utility of an immortalized cell line to produce a high yield of exosom

133 ChR) expressed in hair cell precursors in an immortalized cell line UB/OC-2 developed from the organ

134 mal somatic tissues, placenta, sperm, and an immortalized cell line, a visualization tool that has be

135 studies in UB/OC-1 cells, an organ of Corti immortalized cell line, showed that R-PIA reduced cispla

136 th factors rapidly induced PKD activation in immortalized cell lines (e.g. Swiss 3T3 and Rat-1 cells)

137 production in two estrogen-responsive, human immortalized cell lines (hFOB/ER3 and hFOB/ER9) that dis

138 B cells in vitro results in establishment of immortalized cell lines (lymphoblastoid cell lines (LCL)

139 transformation has been shown in vitro with immortalized cell lines and in vivo using retroviral tra

140 NA is expressed in several human tissues and immortalized cell lines and is only expressed during the

141 on a combination of in vitro screening with immortalized cell lines and low-throughput animal models

142 sosomal phenotypes and cell toxicity in both immortalized cell lines and neurons.

143 marrow organoids also support the growth of immortalized cell lines and primary cells from healthy d

144 ectious B. burgdorferi strain N40 to several immortalized cell lines and primary cultured cells, incl

145 rence detector in situ assay in a variety of immortalized cell lines and primary human airway smooth

146 (2) the multiplexed, on-chip sorting of both immortalized cell lines and primary immune cells with an

147 -based ontology that contains information of immortalized cell lines and relevant experimental compon

148 ction of hsp70 gene expression have utilized immortalized cell lines and temperatures above the physi

149 rcadian clock is present in the liver and in immortalized cell lines and temporally regulates physiol

150 ssues, but is upregulated in the majority of immortalized cell lines and tumors.

151 These immortalized cell lines are capable of maintaining HPV-3

152 Immortalized cell lines are commonly used for in vitro s

153 These immortalized cell lines are highly proliferative and the

154 orly understood, in part because appropriate immortalized cell lines are not available.

155 iteria for selecting study subjects for whom immortalized cell lines are preferable to merely extract

156 ral nervous tissue or exogenously expressing immortalized cell lines as common mechanisms throughout

157 ficantly higher levels of CpG methylation in immortalized cell lines as compared to primary murine fi

158 nolayers indicated that AP activated ENaC in immortalized cell lines as well as post-transplant, prim

159 Ectopically expressed NLRP2 in immortalized cell lines assembles an inflammasome and in

160 hiPSC-CMs may be advantageous over immortalized cell lines because they possess similar fun

161 ce to primary bronchial epithelial cells and immortalized cell lines by up-regulating eukaryotic cell

162 Conventional immortalized cell lines can be easily edited or screened

163 more, our results raise the possibility that immortalized cell lines can be used for replacement of s

164 In the 'Immortalized cell lines column, the 'Expansion/Scalabili

165 h-regulatory genes by de novo methylation in immortalized cell lines could be reversed, possibly rest

166 Both neuronal and non-neuronal immortalized cell lines deficient for murine Lrp1 displa

167 n OLs cultured from jp and normal CNS and in immortalized cell lines derived from jp and normal OLs.

168 ne receptor adhesion-related kinase (Ark) in immortalized cell lines derived from migratory but not p

169 Two immortalized cell lines derived from the day 11.5 embryo

170 A, RNA, protein and metabolites derived from immortalized cell lines from a family quartet of parents

171 f AAV vectors and adenovirus (Ad) vectors in immortalized cell lines from CF patients and in nasal ep

172 The BCL-6 immortalized cell lines had a phenotype consistent with

173 The CD133(+) cells from these immortalized cell lines had high proliferative potential

174 To address these issues, immortalized cell lines have been generated.

175 ndary recipients and could be established as immortalized cell lines in liquid cultures.

176 ent replication in primary cells and certain immortalized cell lines in vitro and, in all likelihood,

177 pacity and could be readily established into immortalized cell lines in vitro.

178 Research in transformed immortalized cell lines indicates the cadherin-related f

179 ansforming primary human CD4(+) T cells into immortalized cell lines indistinguishable from patient-d

180 s studies mostly used small sample sizes and immortalized cell lines instead of primary cells.

181 icroarray expression data sets obtained from immortalized cell lines of the individuals represented i

182 er current industry standard assays that use immortalized cell lines or animal models.

183 a single cell type using in vitro assays in immortalized cell lines or isolated cell populations, it

184 Several immortalized cell lines serve as models for procholecyst

185 ys in iPS cell-derived macrophages and other immortalized cell lines showed increased HIV-1 replicati

186 CPR can be used not only with immortalized cell lines such as fibroblasts and Jurkat T

187 -infected p53-deficient B cells gave rise to immortalized cell lines that could be maintained by CD40

188 However, these studies have all been done in immortalized cell lines that do not capture the complexi

189 itions by using dominant mutants of Cdc42 in immortalized cell lines that may introduce nonspecific e

190 y of genetic diseases such as cancer and for immortalized cell lines that might be used in research a

191 kinases (IKK-1 and IKK-2) were identified in immortalized cell lines that regulate NF-kappa B activat

192 We generated mixed immortalized cell lines that stably maintained their cha

193 logical assays that have been performed with immortalized cell lines to be applied to spheroids.

194 f RhoA signaling function is from studies in immortalized cell lines utilizing inhibitors or dominant

195 A panel of immortalized cell lines was challenged with the RAD51-st

196 Several immortalized cell lines were established from the livers

197 The primary line and the telomerase-immortalized cell lines were treated with either ultravi

198 ng (ChIP-seq) analyses have focused on a few immortalized cell lines whose activities and physiology

199 A screen of human tissues and immortalized cell lines with this antibody reveals AIPL1

200 The availability of a model with immortalized cell lines would remove the considerable ba

201 ith heparan sulfate (the receptor for RSV on immortalized cell lines).

202 Two independent HPV16 E6-immortalized cell lines, alphaE6#1 and alphaE6#2, that s

203 In contrast, two independent HPV16 E7-immortalized cell lines, alphaE7#1 and alphaE7#2, both o

204 ads from 46 primary cell types, 42 cancer or immortalized cell lines, and 26 tissues.

205 HRV-C cannot be propagated in immortalized cell lines, and currently sinus organ cultu

206 s including porcine fetal cells, stem cells, immortalized cell lines, and marrow stromal cells are un

207 to exhibit significant promoter activity in immortalized cell lines, and these elements could intera

208 pathways were conducted using established or immortalized cell lines, and when HBx was expressed in t

209 e of PA, LF(N)-Acr enters human cells (e.g., immortalized cell lines, embryonic stem cells, and 3D ce

210 l human ovarian surface epithelial cells and immortalized cell lines, four of the seven ovarian carci

211 Furthermore, in immortalized cell lines, high SRC-3 enhances resistance

212 cell culture tools, including primary cells, immortalized cell lines, human stem cells, and their mor

213 In contrast to immortalized cell lines, in NHBEs strong retinoid-induce

214 Despite extensive focus on aggresomes in immortalized cell lines, it remains unclear if the aggre

215 (nuDNA) in 72,275 single cells derived from immortalized cell lines, patient-derived xenografts and

216 o assist endocytic exit, which works well on immortalized cell lines, was of little value because of

217 An alternative to primary cells is immortalized cell lines, which are cost effective, easil

218 TING pathway was observed across primary and immortalized cell lines, which retained the ability to a

219 s enhanced bacterial adhesion to primary and immortalized cell lines.

220 protein nephrin, and colocalizes with it in immortalized cell lines.

221 wth suppressive effects on normal primary or immortalized cell lines.

222 for association with the FcR gamma-chain in immortalized cell lines.

223 anel of human and nonhuman primary cells and immortalized cell lines.

224 to phorbol ester-treated cells or a panel of immortalized cell lines.

225 , B cells infected by the virus readily form immortalized cell lines.

226 that control cellular growth and to generate immortalized cell lines.

227 utilizing both primary cells and established immortalized cell lines.

228 factors are required for postentry events in immortalized cell lines.

229 otprints is not an artifact of commonly used immortalized cell lines.

230 pecies induce cytoskeletal reorganization in immortalized cell lines.

231 te lines compared to the less progressed but immortalized cell lines.

232 ition characteristic of fibroblasts and many immortalized cell lines.

233 h were recurrently affected in the set of 25 immortalized cell lines.

234 DNA directly from white blood cells or from immortalized cell lines.

235 l human mammary epithelial cells and benign, immortalized cell lines.

236 Chk1 DDR under stress conditions in multiple immortalized cell lines.

237 itial lead compound, FQI1, in two telomerase immortalized cell lines.

238 ompetent primary sheep endothelial cells and immortalized cell lines.

239 ial agents when delivering genes to multiple immortalized cell lines.

240 A knockdown was employed in human normal and immortalized cell lines.

241 n transform primary human B lymphocytes into immortalized cell lines.

242 HDR studies have focused on transformed and immortalized cell lines.

243 sing stably expressed non-native proteins in immortalized cell lines.

244 y murine choroid plexus epithelial cells and immortalized cell lines.

245 atic tissues, and particularly so in various immortalized cell lines.

246 ethodology to study human microglia, such as immortalized cells lines, stem cell-derived microglia, c

247 termine cell polarity in lower eukaryotic or immortalized cells, little is known about the transcript

248 Immortalized cells maintain telomere length through eith

249 omere dysfunction and segregation defects in immortalized cells maintaining telomeres by either the a

250 In human immortalized cells, MARCH5 knockout leads to the accumul

251 Interestingly, this transgene also immortalized cells of the thyrotrope lineage that expres

252 Immortalized cells or enriched primary hematopoietic ste

253 rmalities, whereas populations of cdk4/hTERT-immortalized cells or hTERT-immortalized cells that had

254 or because cells with a disrupted (EGFR(-/-) immortalized cells) or neutralized (EGFR blocking antibo

255 the selection of rare, spontaneously arising immortalized cells, or the use of an entire viral genome

256 Late-passage immortalized cells (passage 30) showed a 25-fold increas

257 The cloned immortalized cells proliferate in culture at 33 degrees

258 esent at attenuated levels, in spontaneously immortalized cells provide insights into the role of oxi

259 Knockdown of E2 in immortalized cells reestablishes in a reversible manner

260 Remarkably, the immortalized cells retained the capacity for myogenic di

261 More importantly, these immortalized cells showed anchorage-independent growth a

262 However, Tax-immortalized cells stay dependent on IL-2, suggesting th

263 t 100-fold more selective for AML than solid immortalized cells such as HEK293 or human peripheral bl

264 Herein, a non-transformed, immortalized cell system was used to investigate the eff

265 ine inhibits growth in a non-transformed/non-immortalized cell system, possibly through an elevation

266 In human tumors and immortalized cells, telomeres are often maintained at a

267 r CD133 expression was detected in the hTERT-immortalized cells than in primary prostate cells.

268 All three types [EBV-immortalized cells that express a broad spectrum of the

269 ns of cdk4/hTERT-immortalized cells or hTERT-immortalized cells that had lost expression of p16INK4A

270 ed cells and ovarian cancer cells but not in immortalized cells that had not been transformed.

271 tosis but ultimately selecting for surviving immortalized cells that have sustained either p53 mutati

272 promyelocytic leukemia nuclear body found in immortalized cells that maintain telomeres in a telomera

273 In contrast to E6 + E7-immortalized cells, the Myc + E7-immortalized cells expr

274 In tumours and immortalized cells, this decline is halted through the a

275 he precisely opposite response of normal and immortalized cells to constitutive activation of the MAP

276 rocell-mediated transfer of chromosomes into immortalized cells to identify putative senescence-induc

277 e likely to contribute to the ability of EBV-immortalized cells to modulate immune responses, adhesio

278 surmise that additional genes are altered in immortalized cells to suppress the apoptotic pathway and

279 of PTX and Cs(+) were also observed in GH(3) immortalized cells transiently expressing ET(A) receptor

280 expression of these mutants failed to render immortalized cells tumorigenic, partial suppression of e

281 Compared with immortalized cells, tumorigenic cells had greater activa

282 e 1% of the human genome in both primary and immortalized cell types.

283 ata has revealed that while both primary and immortalized cells undergo growth arrest in suspension,

284 elomere structural proteins TRF1 and TRF2 in immortalized cells using the alternative lengthening of

285 the prevailing mutation type in the treated immortalized cells was A:T->C:G transversion, with a uni

286 roportion of the p53 protein in the Myc + E7-immortalized cells was localized to the cytoplasm, poten

287 Rho-immortalized cells were anchorage dependent and were una

288 from all three genotypes were the same, and immortalized cells were obtained from all cell cultures

289 orescence microscopy studies showed that the immortalized cells were phenotypically similar and respo

290 , HVS deltaSTP/c-ras- and HVS deltaSTP/v-ras-immortalized cells were principally CD4+ CD8+ double-pos

291 Both normal and immortalized cells were resistant to TRAIL-induced apopt

292 Immortalized cells were unable to induce leukemias after

293 established as a potent hCAR deactivator in immortalized cells; whether it inhibits hCAR activity un

294 y inactive, high molecular mass complexes in immortalized cells, which are converted into enzymatical

295 nd swine influenza viruses replicated in the immortalized cells, which generally yielded higher-titer

296 s shown to induce and maintain conditionally immortalized cells, which was accompanied by increased t

297 hotosensitization-induced mutagenesis in the immortalized cells, which were present at attenuated lev

298 ility complex (MHC) was expressed by >97% of immortalized cells, while class II MHC and intercellular

299 n vivo and ex vivo, but is not needed in non-immortalized cells, while PAK4 overexpression in untrans

300 sulting in the long run in the appearance of immortalized cells with high proliferative activity.