ライフサイエンスコーパス: immune mechanism

1 plete knowledge of protective and pathogenic immune mechanism.

2 inhibits HCV replication by a novel, innate immune mechanism.

3 N-gamma mice was not mediated by an adaptive immune mechanism.

4 evolutionary conservation of the underlying immune mechanism.

5 uted to the evolutionary preservation of the immune mechanism.

6 irus infection because of other compensatory immune mechanisms.

7 suppressor mechanisms, pathogen insults, and immune mechanisms.

8 both TLR2-dependent and -independent innate immune mechanisms.

9 -cell dependent) and type II (IgG dependent) immune mechanisms.

10 lied VSV depends on both innate and adaptive immune mechanisms.

11 multiple cell types and both immune and non-immune mechanisms.

12 nes, indicating an association with multiple immune mechanisms.

13 y exclusive clinical phenotypes and opposing immune mechanisms.

14 uch as PSA, through both innate and adaptive immune mechanisms.

15 hrough the activation of innate and adaptive immune mechanisms.

16 ary response integrating innate and adaptive immune mechanisms.

17 ection and elucidated C3a-dependent adaptive immune mechanisms.

18 rigorously maintained by a number of innate immune mechanisms.

19 , but little is known about their intestinal immune mechanisms.

20 mplex underscore HCV-mediated attenuation of immune mechanisms.

21 confer comprehensive protection via multiple immune mechanisms.

22 ponse that includes both innate and adaptive immune mechanisms.

23 ted by activated innate immunity or acquired immune mechanisms.

24 provide insight into poorly understood host immune mechanisms.

25 ergy metabolism, gene expression, and innate immune mechanisms.

26 adaptive immune response more towards innate immune mechanisms.

27 pletion of T lymphocytes, implicating innate immune mechanisms.

28 in pathway, angiogenesis, AR chaperones, and immune mechanisms.

29 signals to macrophages, rather than adaptive immune mechanisms.

30 ccurs independently of conventional adaptive immune mechanisms.

31 , but little is known about their intestinal immune mechanisms.

32 o antigens not studied here or through other immune mechanisms.

33 angiogenesis and the tolerance of tumours to immune mechanisms.

34 ntrol in the absence of IL-4/IL-13-dependent immune mechanisms.

35 w antigen doses and dissected the associated immune mechanisms.

36 -positive breast cancer could be mediated by immune mechanisms.

37 trointestinal tract is regulated by distinct immune mechanisms.

38 se responses and providing new insights into immune mechanisms.

39 sponses by reprogramming innate and adaptive immune mechanisms.

40 imal models has impeded studies of antiviral immune mechanisms.

41 gh tumor intrinsic [1,2,4,12], but also host immune mechanisms [17-23].

42 e 1 interferon (T1-IFN) signaling are innate immune mechanisms activated upon viral infection.

43 The principal immune mechanism against biotrophic pathogens in plants

44 Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by

45 pe I interferons (IFN-I) is a crucial innate immune mechanism against viral infections.

46 activation, and unleash previously untapped immune mechanisms against cancer.

47 ritical role in disease development, but the immune mechanisms against pathobionts remain poorly unde

48 Although bacterial innate immune mechanisms against phage abound, the only documen

49 Immune mechanisms also affect treatment outcome, and cer

50 l stress or injury, with subsequent adaptive immune mechanisms amplifying the dactylitis inflammatory

51 s biology approach in studying tumor-related immune mechanism and consequent selection of therapeutic

52 While many of the immune mechanisms and components are known for parasitic

53 clear to what extent genetic defects control immune mechanisms and confer resistance to T-cell-based

54 ing field of cutaneous immunity is revealing immune mechanisms and functions that can be harnessed to

55 e regulation of hematopoiesis through innate immune mechanisms and illustrate the expansive cell-cell

56 However, the underlying immune mechanisms and interaction between rhinovirus and

57 sclerosis seems to result more from diffuse immune mechanisms and neurodegeneration.

58 range of functions that may drive unexpected immune mechanisms and provide new tools for immunotherap

59 ction, HIV-1 must counteract cellular innate immune mechanisms and redirect cellular processes toward

60 t decades, and several studies on underlying immune mechanisms and risk factors for formation of thes

61 highlights our current state of knowledge of immune mechanisms and targeted immunomodulatory treatmen

62 However, its underlying immune mechanisms and the genetic etiology for differenc

63 ch provide a measure of a range of different immune mechanisms and their interactions.

64 quence of insults, and allow deciphering the immune mechanisms and their relation with microorganisms

65 mmation mediated by both innate and adaptive immune mechanisms and where the inflammatory response in

66 ns that thwart individual innate or adaptive immune mechanisms, and an overall replication strategy t

67 des allow us to target selectively different immune mechanisms, and certain of those show features th

68 ning insight into our basic understanding of immune mechanisms, and extensions of these findings have

69 ata suggest that many such reactions involve immune mechanisms, and genetic association studies have

70 T3SS effectors target host innate immune mechanisms, and T3SS-defective mutants are cleare

71 We investigated the immune mechanisms (antibody and T-cell responses) of lon

72 Our results show that innate immune mechanisms are activated immediately after influe

73 Conversely, innate immune mechanisms are also central to noninflammatory cl

74 Negative feedback immune mechanisms are essential for maintenance of hepat

75 m genome-wide studies, showing that not only immune mechanisms are important determinants of host res

76 Innate immune mechanisms are not so effective against biofilms

77 inflammatory phase, both innate and adaptive immune mechanisms are operative.

78 cted transcriptomics responses, particularly immune mechanisms are shared across disease etiologies.

79 Multiple immune mechanisms are therefore in place to maintain tis

80 ng is not well understood, although adaptive immune mechanisms are thought to play a central role.

81 remodeling and reveal that context-dependent immune mechanisms are utilized to remodel synapses in th

82 Determining the functional immune mechanisms associated with parasite clearance wil

83 esist bubonic plague and used it to identify immune mechanisms associated with resistance.

84 ool for analysis of vaccine efficacy and the immune mechanisms associated with vaccination in the org

85 Insights into the immune mechanisms at play in skin diseases including acn

86 can further improve our understanding of the immune mechanisms behind allergic sensitization.

87 Bacteria have evolved numerous immune mechanisms, both innate and adaptive, to cope wit

88 ibit components of both, innate and adaptive immune mechanisms but to a lesser extent compared to CD.

89 MicroRNAs (miRNAs) regulate specific immune mechanisms, but their genome-wide regulation of T

90 This study defines an immune mechanism by which DENV can induce vascular patho

91 These studies define an innate immune mechanism by which pathogenic fungi regulate host

92 n of CXCR4-regulated tumoral, stem cell, and immune mechanisms by adjunctive CXCR4 antagonists may he

93 contribute to a better understanding of the immune mechanisms by which the hygiene hypothesis operat

94 The data also delineate innate immune mechanisms by which TLI/ATS/CTX conditioning may

95 ies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis

96 erspective on how understanding tissue-based immune mechanisms can be used to guide therapeutic appro

97 Thus, delineating the disease-promoting immune mechanisms can facilitate development of immunoth

98 Although immune mechanisms can suppress tumour growth, tumours es

99 ipheral immune response or by endogenous CNS immune mechanisms, can affect CNS neurodegeneration.

100 immunopathology, mediated through different immune mechanisms, can influence parasite fitness and ho

101 To dissect the difference in protective immune mechanisms conferred by these two vaccine strains

102 Evidence suggests that immune mechanisms contribute to myocardial injury and fi

103 Thus, unique immune mechanisms contribute to the differential respons

104 lped characterize the cellular and molecular immune mechanisms contributing to cardiovascular complic

105 rkers that reflect inflammatory or cytotoxic immune mechanisms contributing to its onset.

106 However, the innate immune mechanisms controlling sunburn development are no

107 ation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or pr

108 rtant first step to identifying dysregulated immune mechanisms driving adverse maternal or neonatal o

109 estigate the maturation of pulmonary mucosal immune mechanisms during early life because they are mos

110 llance providing molecular insights into the immune mechanisms during tumor progression.

111 Currently, the immune mechanisms elicited during biofilm growth and the

112 course will improve our understanding of how immune mechanisms evolve and guide the introduction of n

113 h a granzyme- and granulysin-mediated innate immune mechanism exerted by gammadelta T cells to kill l

114 lunteers, demonstrating that impaired innate immune mechanisms following DEP exposure are also at pla

115 In this article, we describe an immune mechanism for inflammatory activation of human br

116 emonstrated a chlamydial antigen-independent immune mechanism for regulating chlamydial pathogenicity

117 tive neutrophil function are critical innate immune mechanisms for bacterial clearance.

118 s-tumor responses and dissect the underlying immune mechanisms for this, we compared the ability of H

119 While many studies have focused on immune mechanisms for trachoma during chronic stages of

120 Because of this long history, innate immune mechanisms found in modern eukaryotic organisms t

121 Here, we report a novel innate immune mechanism functioning against respiratory syncyti

122 To understand the underlying immune mechanisms, graft infiltrating and peripheral blo

123 ating high-throughput data into knowledge of immune mechanisms has been challenged by the complexity

124 Genes involved in both adaptive and innate immune mechanisms have been identified, notably includin

125 Immune mechanisms have been recognized to have a role in

126 ver 30 years, and both melanocyte stress and immune mechanisms have been thought to be mutually exclu

127 mental, genetic, and epidemiologic evidence, immune mechanisms have entered the central stage and are

128 ounteract these elements, a number of innate immune mechanisms have evolved that can lead to lung inf

129 Immune mechanisms have evolved to cope with local entry

130 Studies of plant immune mechanisms have led to strategies of engineering

131 Immune mechanisms important in asthma such as Th2 cells

132 results suggest that ADCC might be an active immune mechanism in EC that helps to maintain durable su

133 alloantibodies cannot solely account for the immune mechanism in platelet refractoriness.

134 These findings support an immune mechanism in the etiology of childhood ALL involv

135 nity for harnessing an endogenous protective immune mechanism in the treatment of sepsis.

136 Here, we investigated peripheral and central immune mechanisms in a translational passive transfer tr

137 with controls, implicating astrocytes in DG, immune mechanisms in CA3, and synaptic scaling in CA1.

138 ovel role for Th1 and Th17-mediated adaptive immune mechanisms in chronic pelvic pain.

139 us spread or the appearance of RABV-specific immune mechanisms in CNS tissues.

140 We assessed the roles of CXCR6-dependent immune mechanisms in hepatocarcinogenesis.

141 c diseases, identification of new allergens, immune mechanisms in host defense, factors involved in a

142 characterization of the innate and adaptive immune mechanisms in human iPSC lines derived from perip

143 An involvement of immune mechanisms in its pathophysiology has been propos

144 Immune mechanisms in MS are thus highly compartmentalize

145 Fungal phytopathogens can suppress plant immune mechanisms in order to colonize living host cells

146 ges of infection, less research has targeted immune mechanisms in primary ocular infections, events t

147 sociation studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclero

148 Mucosal immune mechanisms in the upper and lower respiratory tra

149 poptosis of tumor cells and triggers several immune mechanisms, including a T-helper type 1 (T(H)1) r

150 remaining question is whether virus-specific immune mechanisms, including cytotoxic T lymphocytes (CT

151 study presents new insight into fundamental immune mechanisms, including the chemotactic recruitment

152 ion pressure, which is likely independent of immune mechanisms, induces the infiltration of immune ce

153 t it is currently unknown how cutaneous host immune mechanisms influence the composition, diversity,

154 The pathogenetic immune mechanisms involved (cell-mediated versus humoral

155 ghts into the comprehensive understanding of immune mechanisms involved during primary HCMV infection

156 proaches to T1D, and how these relate to the immune mechanisms involved in disease development.

157 his study provide more details on the innate immune mechanisms involved in DNA vaccination and furthe

158 current understanding of the cell types and immune mechanisms involved in each of these steps leadin

159 of this study was to identify the underlying immune mechanisms involved in formation of inflammatory

160 to the interplay between adaptive and innate immune mechanisms involved in HIV-1 immunity and unveil

161 erapy (SLIT) and to begin to investigate the immune mechanisms involved in successful immunotherapy w

162 We investigate here the immune mechanisms involved in the development of CLAD af

163 nism can lead to better understanding of the immune mechanisms involved in these liver pathologies, w

164 do not use injection drugs suggests that the immune mechanisms involved with a successful response to

165 evelop or be greatly enhanced through innate immune mechanisms involving IL-33, natural helper cells,

166 ritical to the role of CRISPR as an adaptive immune mechanism is its capacity for self versus non-sel

167 balance between positive and negative innate immune mechanisms is crucial for maintaining homeostasis

168 nts for infection and further elucidation of immune mechanisms is needed.

169 HER3 signaling in tumors influences cellular immune mechanisms is therefore warranted.

170 ulative effect of these eosinophil-dependent immune mechanisms is to promote the Th2 polarization cha

171 velopment of novel radioligands for specific immune-mechanisms is needed for further clarification.

172 olled drug-resistant disease through a novel immune mechanism, it may offer a fine strategy for salva

173 The immune mechanism leading to the generation of protective

174 Immune mechanisms leading to aSS could be initiated in t

175 Innate immune mechanisms leading to liver injury subsequent to

176 ity and mortality, yet little is known about immune mechanisms leading to NV control.

177 a mouse model that allows deciphering of the immune mechanisms leading to orexin(+) neuron loss and n

178 Elucidating basic immune mechanisms likely requires both in vivo and in vi

179 t Tim-3 expression might represent a natural immune mechanism limiting viral spread.IMPORTANCE HIV in

180 To evade host immune mechanisms, many bacteria secrete immunomodulator

181 ria and cardiovascular risk, suggesting that immune mechanisms may contribute to the development of d

182 oocysts, without considering that different immune mechanisms may target different developmental sta

183 stulates that CS therapy, by reducing innate immune mechanisms, may promote C. albicans colonization

184 t the patients' tumor and suggesting that an immune mechanism mediating the observed antitumor effect

185 Viral interference and innate antiviral immune mechanisms might be more important determinants o

186 this novel concept of modulating endogenous immune mechanisms might be translated to a broad spectru

187 gh increased antigen penetration, additional immune mechanisms might explain the increased susceptibi

188 a knockin approach can provide insight into immune mechanisms not possible using conventional geneti

189 The findings establish a candidate innate immune mechanism of action for a human autoimmunity "ris

190 The immune mechanism of ALP-induced severe cutaneous adverse

191 , revealing a previously unrecognized innate immune mechanism of intestinal tissue protection.

192 r and humoral immune responses; however, the immune mechanism of protection remains unknown.

193 This neuro-immune mechanism of selective NK cell-mediated degenerat

194 We sought to study the immune mechanism of TH2/TH17-predominant and TH2/TH17-lo

195 as identify gaps in our knowledge about the immune mechanisms of allergy and tolerance to foods.

196 recent developments in our understanding of immune mechanisms of clinical manifestations of food all

197 As such, a deeper understanding of the immune mechanisms of conventional and targeted cancer th

198 Abundance in research on the immune mechanisms of CRS has revealed various new endoty

199 The innate immune mechanisms of host cells are diverse in nature an

200 s lagged far behind our understanding of the immune mechanisms of IgE-mediated food allergy.

201 the pathophysiology of food allergy and the immune mechanisms of oral tolerance.

202 The immune mechanisms of protection against recurrent genita

203 inical results provide new insights into the immune mechanisms of protection against recurrent genita

204 scientific information available concerning immune mechanisms of protection allow protection in the

205 However, the immune mechanisms of protection conferred by this vaccin

206 aternal antibodies may provide insights into immune mechanisms of protection.

207 e earlier and stronger effects than top-down immune mechanisms on within-host community dynamics.

208 opulations, passively and naturally acquired immune mechanisms operating faster than pitting may exis

209 cterial resistance to an IFN-gamma-dependent immune mechanism other than NOS2.

210 ate that flagellin induces additional innate immune mechanisms over those induced by VSV alone.

211 tivities of other essential type-2-dependent immune mechanisms, Pla2g1b(-/-) mice failed to expel the

212 r of activated B cells (NF-kappaB)-dependent immune mechanisms plays a major role in the pathogenesis

213 Immune mechanisms preventing inappropriate immune reacti

214 ins cause damaging colonic inflammation, the immune mechanisms protecting from tissue damage require

215 dels for this disease; therefore, underlying immune mechanisms regulating GM-CSF-specific IgG in aPAP

216 odium immunity is multimodal, with different immune mechanisms regulating ookinete and oocyst surviva

217 allows the investigation of T cell-mediated immune mechanisms relevant to vaccine design.

218 orms of DHR were discriminated: the allergic-immune mechanism relies on the covalent binding of drugs

219 rgeted by peroral arsenic and the associated immune mechanisms remain poorly defined.

220 Evaluation of immune mechanisms required for bacterial containment and

221 Identifying immune mechanisms responsible for antibody-mediated reje

222 e we review our current understanding of the immune mechanisms responsible for oral tolerance and how

223 Immune mechanisms responsible for pathogen clearance fro

224 here is little knowledge about the long-term immune mechanisms responsible for sustained allergen tol

225 experimental and clinical studies; however, immune mechanisms responsible for this sex-based dispari

226 teractions between the microbiota and innate immune mechanisms, such as the inflammasome-mediated res

227 ngs reveal that RegIIIgamma is a fundamental immune mechanism that promotes host-bacterial mutualism

228 y unknown.Objectives: To identify the innate immune mechanism that promotes platelet-neutrophil aggre

229 cells is emerging as the key maternal-fetal immune mechanism that regulates placentation.

230 This study provides evidence for specific immune mechanisms that are associated with a model of op

231 e present therapies that target inflammatory/immune mechanisms that are currently enrolling patients,

232 provide a new understanding of the intrinsic immune mechanisms that can contribute to the onset of ir

233 however, whether host species possess innate immune mechanisms that can neutralize pore-forming toxin

234 The immune mechanisms that cause tissue injury in lupus neph

235 Many of the details of immune mechanisms that change with age are currently not

236 in PBMC.IMPORTANCE The detailed knowledge of immune mechanisms that contribute to HIV control is a pr

237 The immune mechanisms that contribute to the efficacy of tre

238 Imbalance in the regulatory immune mechanisms that control intestinal cellular and b

239 ver an intricate relationship between innate immune mechanisms that control response to self and to r

240 ulosis infection and to ascertain protective immune mechanisms that could be exploited to develop mor

241 raft survival, and ignore specific risks and immune mechanisms that differentially contribute to allo

242 The precise immune mechanisms that drive the progression from benign

243 As such, understanding the innate immune mechanisms that enable this T cell response has i

244 poietin 2 (Ang2/ANGPT2), induces pleiotropic immune mechanisms that facilitate tumor rejection in sev

245 een monkey (AGM) model was used to elucidate immune mechanisms that facilitate viral clearance but ma

246 The immune mechanisms that govern progression from latent (L

247 In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid

248 not known whether these alterations reflect immune mechanisms that initiate islet autoimmunity, prom

249 ells and allergic effector cells by adaptive immune mechanisms that involve allergen-specific IgG1 an

250 e its host, balanced with sophisticated host immune mechanisms that maintain viral latency.

251 review, we discuss some of the bat-specific immune mechanisms that may have resulted in a virus-tole

252 field, and on consideration of the allergic immune mechanisms that may influence positive or negativ

253 GS-9688 treatment provides insights into the immune mechanisms that mediate this antiviral effect.

254 fe origins of allergic disorders, as well as immune mechanisms that might suggest novel disease preve

255 Understanding the early innate immune mechanisms that participate in the development of

256 olve within the context of self-tissues, the immune mechanisms that prevent the autoimmune attack of

257 Our results identify specific immune mechanisms that promote fibrosis and suggest a th

258 However, the innate immune mechanisms that promote natural antitumor T cell

259 our understanding of the innate and adaptive immune mechanisms that protect against ubiquitous fungal

260 This study details enhancement of numerous immune mechanisms that provide an explanation for the im

261 lar watershed following activation of innate immune mechanisms that provoke hypoxia, and superoxide a

262 Defining immune mechanisms that suppress the underlying Th2-drive

263 We show that the two immune mechanisms that target ookinetes-epithelial nitra

264 Immune mechanisms that terminate acute HAV infection, an

265 in a subset of kidney transplant recipients, immune mechanisms that underlie successful vs unsuccessf

266 To determine an underlying immune mechanism, the murine B16 melanoma model and the

267 significantly to our understanding of basic immune mechanisms, the involvement of cytokines in sever

268 essential determinants of the circadian and immune mechanisms, the transcription factors CLOCK and N

269 As with many immune mechanisms, there is a degree of functional overl

270 ic and clinical research examining potential immune mechanisms thought to contribute to stress suscep

271 o find empirical support for behavioural and immune mechanisms through which human-provided resources

272 TING pathway constitutes a widespread innate immune mechanism to monitor cellular damage and microbia

273 s) act in an evolutionarily conserved innate immune mechanism to provide essential protection for ger

274 rscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

275 efense that includes physical, chemical, and immune mechanisms to combat environmental stress.

276 Resisters may use immune mechanisms to control aerosolized M.tb that diffe

277 gical organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens

278 d that PSA requires both innate and adaptive immune mechanisms to generate protection.

279 system integrates with more primitive innate immune mechanisms to maintain immune homeostasis, holds

280 ases, suggesting that there exist regulatory immune mechanisms to prevent aberrant inflammation.

281 results suggest that tadpoles use different immune mechanisms to resist different stages of trematod

282 ntal factors could foster the involvement of immune mechanisms to the abnormal developmental trajecto

283 is of the transition from reliance on innate immune mechanisms to the appearance of adaptive immunity

284 mental evidence supporting a contribution of immune mechanisms to the development of hypertension.

285 murine leukemia virus (MuLV) via an adaptive immune mechanism, to assess the contribution of cellular

286 noted in clinical outcomes and modulation of immune mechanisms toward effective therapy.

287 ew recently published data that suggest that immune mechanisms underlie most of these observed epidem

288 A key immune mechanism underlying the safety of VSVDeltaG-CHIK

289 provide an overview of the atopic march and immune mechanism underlying the sensitization and effect

290 This study provides insights into the immune mechanisms underlying the protective role of GBV-

291 risk in developing egg allergy; however, the immune mechanisms underlying this protection remain uncl

292 will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

293 The elucidation of immune mechanisms underpinning the parasitic infections,

294 rains that control retroviruses via adaptive immune mechanisms, we found that of all steps in viral r

295 ance when given intranasally and induce both immune mechanisms when injected.

296 Rather, HD6 possesses a unique innate immune mechanism whereby it self-assembles into oligomer

297 These results identify a cellular immune mechanism whereby TGF-beta signaling blockade lic

298 Some approaches suppress CNS immune mechanisms, while others harness the immune syste

299 es of genetic-environmental interactions and immune mechanisms will lead to better therapeutics.

300 of the intestinal microbiota in shaping host immune mechanisms, with particular emphasis on allergic