ライフサイエンスコーパス: immune memory

1 y to reinfection, a phenomenon called innate immune memory.

2 germinal centre (GC) response and diminished immune memory.

3 pite having reduced fitness due to long-term immune memory.

4 nefits of Rapa treatment as means to improve immune memory.

5 ector functions and limits the generation of immune memory.

6 to secondary stimulation, and form long-term immune memory.

7 nd, consequently, impairs the development of immune memory.

8 xcessive) pathology and that elicit specific immune memory.

9 as necessary and sufficient to confer innate immune memory.

10 itumor response but still preserve antitumor immune memory.

11 sponse to PnCRM7 but does not interfere with immune memory.

12 wever, suggest an essential role for IL-2 in immune memory.

13 ve immunity in malaria may be dependent upon immune memory.

14 acity of knockout mice to develop protective immune memory.

15 evelopment of both humoral and cell-mediated immune memory.

16 nteractions in primary T cell activation and immune memory.

17 in newborns and elicits protective antiviral immune memory.

18 es and its effect on vaccine efficacy and on immune memory.

19 ersus therapeutic vaccination in maintaining immune memory.

20 umor elimination and generation of antitumor immune memory.

21 nstrated the presence of vaccination-induced immune memory.

22 n as a key mechanism for establishing innate immune memory.

23 leading to tumour rejection and induction of immune memory.

24 ies, and mediate distinct aspects of humoral immune memory.

25 e B(+) T cell infiltration, and formation of immune memory.

26 t modifications that define bona fide innate immune memory.

27 as a cell-autonomous regulator of microglial immune memory.

28 gainst COVID-19, with particular interest in immune memory.

29 g tumour relapse and inducing development of immune memory.

30 and consistent activation of tumor-specific immune memory.

31 g with data that suggest a possible cellular immune memory.

32 Cs) serve as a cellular reservoir for innate immune memory.

33 etection of pathogens, immune responses, and immune memory.

34 ns which helps promote immune protection and immune memory.

35 s, which helps promote immune protection and immune memory.

36 end unwanted immune responses or to promote immune memory.

37 been exposed to and retain in their specific immune memory.

38 ation yearly, promoting the establishment of immune memory.

39 ting epithelial progenitor cells or adaptive immune memory.

40 dered to be essential for the maintenance of immune memory.

41 ity maturation and the generation of humoral immune memory.

42 termed 'trained immunity', a de facto innate immune memory.

43 cells, tolerance and the training of innate immune memory.

44 sponse patterns has been described as innate immune memory.

45 ine type/composition and presence/absence of immune memory.

46 or pathogen exposure, and thus the extent of immune memory.

47 eased tumoral CD8(+) T cells and established immune memory.

48 mor regression, and tumor-specific antitumor immune memory.

49 ng antiviral immunity and the development of immune memory.

50 but not GII.4c displayed characteristics of immune memory.

51 ghly immunogenic in girls, suggesting a high immune memory.

52 e adaptive immune responses and long-lasting immune memory.

53 umor growth, and the cured mice developed an immune memory.

54 ibodies to encountered antigens and generate immune memory.

55 adapted (ca) backbone that induced long-term immune memory.

56 effector cells and long-lived sentinels for immune memory.

57 DNA methylation, we propose an analogy with immune memory.

58 ned fashion but eventually inducing systemic immune memory.

59 establishment of tumor-specific and durable immune memory.

60 nal characteristics, including properties of immune memory.

61 sessed the ability of 1 or 2 doses to induce immune memory.

62 orous restimulation potential, a hallmark of immune memory.

63 us non-self recognition when acquiring novel immune memories.

64 past infections and a reservoir of potential immune memory [5].

65 nal profile of COVID-19 mRNA vaccine-induced immune memory across blood, lymphoid organs, and lungs o

66 mphasize the lung as a complex repository of immune memory after local infection.

67 The reduction in humoral immune memory after measles infection generates potentia

68 ween previously vaccinated girls, indicating immune memory after one dose.

69 Immune memory after smallpox vaccination (DryVax) is a v

70 Ruxolitinib also enhanced immune memory after the second infection, with elevated

71 marker for predicting reduced virus-specific immune memory after transcutaneous infection with a live

72 r, this involves the risk of autoimmunity if immune memory against host DNA is mistakenly acquired.

73 nt challenge, indicating the induction of an immune memory against the tumor.

74 odeficient athymic mice, leading to specific immune memory against the tumor.

75 to enhance adaptive immunity and protective immune memory against viral infection.

76 However, it is unknown if innate immune memory also protects against M. tuberculosis In t

77 o be mediated by mechanisms including innate immune memory (also known as "trained immunity") and cro

78 o modulate immune response and induce innate immune memory (also termed trained immunity).

79 BACKGROUNDInduction of innate immune memory, also termed trained immunity, by the anti

80 Induction of innate immune memory, also termed trained immunity, contributes

81 esponse, a finding that has implications for immune memory and autoimmunity.

82 unds can improve our understanding of innate immune memory and broaden the scope of its clinical appl

83 secondary antibody responses associated with immune memory and composed of IgG, IgA, and IgE.

84 ted robust serum antibody and CD4 Th1-biased immune memory and conferred protection against pneumococ

85 e markers closely associated with protective immune memory and could help to define a rational strate

86 low potency, inability to generate long-term immune memory and decreased activities against tumour-ce

87 h SARS-CoV-2 spike glycoprotein DNA enhances immune memory and durability in vivo.

88 a fundamental tradeoff between the amount of immune memory and effectiveness of response to a given t

89 ints the fetal immune system with the needed immune memory and epigenetic marks to navigate a far les

90 accine also demonstrated robust formation of immune memory and exhibited a favorable biosafety profil

91 ice and humans, at the dose shown to improve immune memory and extend lifespan.

92 + T cells helps to explain the phenomenon of immune memory and facilitates the design of effective th

93 r (HVR), to test for vaccine antigen-induced immune memory and for antigen-presenting cell (APC) func

94 improved understanding of pregnancy-induced immune memory and foster the identification of immune ta

95 onstrate the functionality of vaccine-primed immune memory and highlight memory T cells as rapid resp

96 We hypothesize that preexisting immune memory and innate immune interference contribute

97 osomal HAV vaccine is sufficient to activate immune memory and may provide long-term protection.

98 in control of tumor growth, establishment of immune memory and protection against tumors bearing anti

99 ations for vaccination and the durability of immune memory and protection.

100 vaccines, and of antimicrobial therapies on immune memory and reconstitution after lymphocyte deplet

101 esponses to the combined treatment displayed immune memory and rejected tumours upon re-challenge.

102 nt an overview of documented cases of insect immune memory and summarize the experimental evidence in

103 Moreover, because we capture adaptive immune memory and the impact of transplantation, this mo

104 the rate of cell turnover on the duration of immune memory and the maintenance of the immune repertoi

105 evealed functions for NK cells in long-lived immune memory and the regulation of adaptive immune resp

106 infections often fail to produce long-lived immune memory and the underlying mechanism(s) for this a

107 titumor immune activity as well as antitumor immune memory and therefore might have an impact against

108 he mechanisms involved in the development of immune memory and those conditioning Type I and CTL resp

109 tization through the generation of effective immune memory, and 2) severe antigen challenges represen

110 election theory, antigen receptor diversity, immune memory, and innate control of adaptive immunity.

111 sights into the dynamics of tissue-localized immune memory, and is a novel basis for interpreting tim

112 during clonal contraction, establishment of immune memory, and preservation of peripheral tolerance.

113 imizing CD8(+) T-cell immunity, facilitating immune memory, and preventing tolerance.

114 Immune memories are stored in the form of 'spacers' whic

115 Indeed, reports showing alternative forms of immune memory are accumulating in invertebrates.

116 t infection but the underlying mechanisms of immune memory are unclear.

117 Our findings identify astrocytic immune memory as a modulator of microglial function and

118 ibody levels, and hepatitis B virus-specific immune memory, as evaluated with T-cell proliferation as

119 l receptor expression selectively influenced immune memory, as postinfection memory CD4(+) population

120 tep in the generation of long-lived adaptive immune memory at body surfaces.

121 ications for our understanding of protective immune memory at epithelial interfaces with the environm

122 The presence of immune memory at pathogen-entry sites is a prerequisite

123 ates acquisition to quickly expand the small immune memory banks.

124 Trained immunity is a form of innate immune memory best described in mice and humans.

125 at HA head immunodominance is independent of immune memory bias.

126 riming in invertebrates, which lack adaptive immune memory but demonstrate enhanced responses to re-i

127 olic reprogramming are key drivers of innate immune memory, but it is important to distinguish betwee

128 vaccination induce multifaceted, functional immune memory, but together, they engender improved prot

129 Prokaryotes create adaptive immune memories by acquiring foreign DNA snippets, known

130 of an ancestral principle regulating innate immune memory by controlling cellular metabolism.

131 lity arises from destruction of pre-existing immune memory by measles virus (MeV), a paramyxovirus of

132 administration in young adults and explored immune memory by measuring antibody avidity.

133 IL-15 thus seems to contribute to enhanced immune memory by selectively propagating memory T cells

134 Innate immune memory can be induced centrally, through systemic

135 Depending on the context, immune memory can increase or decrease the total neutral

136 Immune memory cells are poised to rapidly expand and ela

137 ng a repeat infection, dengue virus-specific immune memory cells are reactivated and large amounts of

138 y responses, but formation and durability of immune memory cells following vaccination are associated

139 chanisms governing the long-term survival of immune memory cells remain to be elucidated.

140 Adoptive transfer of TLR7(+/+) LCMV immune memory cells that enhanced clearance of persisten

141 ta indicate that blockade of NRP1, a unique 'immune memory checkpoint', may promote the development o

142 Immune memory - comprising T cells, B cells and plasma c

143 combination induces long-lasting antitumour immune memory, conferring 100% protection against tumour

144 We hypothesized that innate immune memory contributes to the protective host defense

145 However, differential mucosal and systemic immune memory could be difficult to induce because of re

146 these various processes to the longevity of immune memory (defined as the rate of decline of the pop

147 g by host cells-rather than cancer cells-and immune memory depends on the spleen.

148 Therapies targeted at reversing this immune memory depletion warrant further investigation.

149 Immune memory determines infection risk and responses to

150 to this, we sought to understand the role of immune memory during bacterial superinfections.

151 Innate immune memory endows innate immune cells with antigen in

152 e observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.

153 ted changes and it is becoming apparent that immune memory exhibits significant defects as a result o

154 , there was an urgent need to rapidly assess immune memory following infection or vaccination.

155 ed robust antitumor activity and evidence of immune memory following rechallenge of cured mice with f

156 ween multiple vaccines, the understanding of immune memory for 1 year to SARS-CoV-2 infection and vac

157 s specific to S. aureus are common, implying immune memory formation and suggesting a large pool of S

158 cell metabolic pathways in microglia innate immune memory formation, focusing on glucose, glutamine,

159 stages of disease resolution, recovery, and immune memory formation.

160 bolism may be a common denominator of innate immune memory from lower animals to mammals.

161 Although immune memory generated during youth functions well into

162 Innate immune memory has been shown to last for months to years

163 Immune memory has traditionally been the domain of the a

164 ovide greater solid tumor control and robust immune memory, highlighting advancement in the field of

165 ections; yet, the role of dietary protein in immune memory homeostasis remains poorly understood.

166 off-target metal accumulation, and improved immune memory in a tumor challenge study compared to a 1

167 enograft and induces tumor-specific adaptive immune memory in an immunocompetent mouse cancer model,

168 e, suggesting the potential establishment of immune memory in animals treated with niraparib monother

169 r, we address the significance of microglial immune memory in disease pathology and discuss the poten

170 A new study demonstrates that innate immune memory in Drosophila embryonic macrophages can al

171 robust antigen-specific, long-lived humoral immune memory in humans.

172 cell biology to explore the key features of immune memory in innate lymphocytes, including quantity,

173 the mechanism of antiviral and antibacterial immune memory in insects.

174 provides a baseline to gauge the efficacy of immune memory in light of an organism's coevolutionary h

175 athway may play a role in the development of immune memory in lung to certain allergens.

176 nt aging, is critical for the maintenance of immune memory in mice.

177 onses and promote epigenetic changes shaping immune memory in microglia.

178 de and promoted the development of long-term immune memory in mouse models of melanoma and hepatocell

179 and lymph nodes, but recently the concept of immune memory in peripheral tissues mediated by resident

180 This could pose a risk to the development of immune memory in persons previously infected with or vac

181 ents investigating the possible existence of immune memory in sponges indicate that faster second set

182 dings provide insights into antiviral innate immune memory in the airway that may facilitate the deve

183 Here, we examined innate immune memory in the context of commonly circulating res

184 g pathogen diversity and associated specific immune memory in the population dynamics of hyperdiverse

185 nce, IL-4/IL13-targeting therapies prime the immune memory in therapy success-favoring manner.

186 e study of innate allorecognition and innate immune memory in transplantation.

187 However, the potential regulation of "immune memory" in nonclassic immune cells, such as MSCs,

188 ough previous studies have shown that innate immune memory induced by beta-glucan confers protection

189 uggest that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurre

190 cines that would combine innate and adaptive immune memory induction.

191 Immune memory is a central feature of the mammalian adap

192 Immune memory is a defining feature of the acquired immu

193 s context, durable and cross-reactive T cell immune memory is critical for continued protection again

194 Innate immune memory is currently being defined and is transfor

195 eview, we summarize the evidence that innate immune memory is epigenetically encoded in HSPCs, and we

196 nomenon challenges the traditional view that immune memory is exclusive to the adaptive immune system

197 he factors contributing to the generation of immune memory is important for rational vaccine design.

198 Innate immune memory is induced via activation of pattern recog

199 with concurrent inhibition of donor-specific immune memory is likely to be involved.

200 rrent understanding of the cellular basis of immune memory is reviewed and the relative contributions

201 Immune memory is tailored by cues that lymphocytes perce

202 Innate immune memory is the phenomenon whereby innate immune ce

203 cell response nor the diversity of resulting immune memory is well understood.

204 erologous infections, by induction of innate immune memory, is increasingly recognized.

205 High neutralizing titers and robust B cell immune memory likely explain the more durable protection

206 While infection is associated with immune memory, little is known regarding the role of the

207 By preventing measles-associated immune memory loss, vaccination protects polymicrobial h

208 Alternatively, innate immune memory may contribute to the pathogenesis of chro

209 These findings suggest that innate immune memory, mediated by specific cellular and molecul

210 Antiviral innate immune memory mounted by airway-resident macrophages pos

211 imultaneously inducing a long-lasting innate immune memory named trained immunity.

212 prompted a reevaluation of what delineates "immune memory." Natural killer (NK) cells of the innate

213 Immune memory of a first infection with influenza virus

214 The extent to which this is a consequence of immune memory of infection history or prevalent diversit

215 ve to be optimised to boost the efficacy and immune memory of protection against HIV-1 in the clinica

216 f vaccination is that it functions to induce immune memory of the specific pathogen components of the

217 ults indicate that the various components of immune memory operate together to provide optimal protec

218 einfection by these viruses is due to waning immune memory or antigenic drift of the viruses.

219 A similar phenomenon, named innate immune memory or trained immunity, has been reported wit

220 ild nonspecific memory, also known as innate immune memory or trained immunity.

221 exhibit memory, a phenomenon called 'innate immune memory' or 'trained immunity'.

222 Innate immune memory, or trained innate immunity (TII), represe

223 e, our results help explain the longevity of immune memory phenomenologically.

224 BCG- but not LCMV-immune memory phenotype CD4 T cells preferentially produ

225 iate myeloid progenitors to produce opposing immune memory phenotypes.

226 Antitumor immune memory plays a critical role in preventing melano

227 Broad immune memory pools were narrowed postinfection but NP(1

228 scovery of innate allorecognition and innate immune memory presents novel targets in transplantation

229 Each cluster had immune memory profiles that differed in magnitude and qu

230 rotection to barrier tissues via circulating immune memory provides an unexpected opportunity for vac

231 due to faster viral clearance facilitated by immune memory recall.

232 Effective immune memory relies, in part, on the maintenance of the

233 isms underlying the development of efficient immune memory remain incompletely understood.

234 Immune memory represents the most efficient defense agai

235 demonstrate that beta-glucan-induced innate immune memory represses IL-1beta-mediated inflammation a

236 induced tumor elimination and tumor-specific immune memory require tumor cell expression of the IFN-g

237 that the persistence of an immune response (immune memory) requires the density of persistent antige

238 Recent developments in the field of immune memory research and the accumulating literature o

239 implicated in the generation of a protective immune memory response following priming by the injectio

240 overexpressing tumors, eliciting an adaptive immune memory response that protects mice from future tu

241 ey innate mechanism in the regulation of the immune memory response to allergens.

242 his was not solely the result of a classical immune memory response, but rather involved local persis

243 hile primary infection generates an adaptive immune memory response, stem cell transplantation disrup

244 ss and-through challenge vaccination-humoral immune memory response.

245 mechanisms of B-cell function and reproduced immune memory responses across a range of different anti

246 and second transplant may be a stimulus for immune memory responses and increased risk of alloimmune

247 These data raise questions about immune memory responses in an acute superficial respirat

248 ldhood VZV vaccination can elicit long-lived immune memory responses in the bone marrow.IMPORTANCE Ch

249 n this review, we discuss the dual nature of immune memory responses of gammadelta T cells and provid

250 ella-zoster virus (VZV) immunization induces immune memory responses that protect against primary VZV

251 Cross-reactive immune memory responses to orthopoxviruses in humans rem

252 ons with most other viruses, indicating that immune memory responses to RSV are defective.

253 ance and the formation of protective humoral immune memory responses.

254 an initiate and propagate rapid and vigorous immune memory responses.

255 ly ART initiation to maintain polyfunctional immune memory responses.

256 vaccinated individuals develop and that this immune memory signature is different from that seen in s

257 ignificant toxicity and 83% of survivors had immune memory specific for E0771 cells.

258 dent memory CD8 T (T(RM)) cells are a unique immune memory subset that develops and remains in periph

259 ate immune systems can also provide forms of immune memory, such as immune priming in invertebrates a

260 persisted for at least 6 years, and induced immune memory, suggesting possible protection against HP

261 type 2 innate lymphoid cells (ILC2s) exhibit immune memory, termed "trained immunity," which enhances

262 specific CD8(+) cytotoxic T lymphocytes with immune memory than IFA-emulsifying vaccines.

263 The A(H7N9) pLAIV induces strong immune memory that can be demonstrated by exposure to su

264 s are able to help the immune system develop immune memory that can have long-lasting, tumor-specific

265 s unknown whether this can induce persistent immune memory that could contribute to immunity.

266 infection or vaccination, a de facto innate immune memory that is also termed trained immunity.

267 d by original antigenic sin, an attribute of immune memory that leads to greater induction of antibod

268 ablished tumors, but also induced protective immune memory that prevented the growth of rechallenged

269 ng to the recently emerged concept of innate immune memory, the functions of neutrophils can be enhan

270 CD8+ T lymphocytes confers a key feature of immune memory: the capacity for autonomous secondary exp

271 propriate effector functions and maintaining immune memory, they also can cause autoimmunity or neopl

272 ope M1(58-66) can be an instructive model of immune memory to a nonevolving epitope of a frequently e

273 ether and how (sub)clinical infections shape immune memory to Bp, particularly in populations primed

274 int blockers, and thus activates anti-tumour immune memory to effectively inhibit tumour recurrence a

275 e needed to redirect antibody responses from immune memory to egg-adapted epitopes and re-focus the i

276 nd may be the result of a failure to develop immune memory to infection, pointing to actionable targe

277 Vaccines are powerful tools to develop immune memory to infectious diseases and prevent excess

278 d qualitative approach to comparing adaptive immune memory to influenza 1 year after mild or severe i

279 murine models, achieving long-term antitumor immune memory to inhibit tumor recurrence and metastasis

280 these cells in a range of processes linking immune memory to metabolic regulation.

281 duce the expected appropriate development of immune memory to mild antigen exposure, as well as the i

282 it the stem cell characteristics of cellular immune memory to promote long-term viral persistence.

283 are active and dynamic, capable of inducing immune memory to propagate a successful rebalancing of t

284 hood are critical life stages for generating immune memory to protect against pathogens; however, the

285 implications of pre-existing cross-reactive immune memory to SARS-CoV-2, which largely originates fr

286 ed target cells, and may be involved in host immune memory to this parasite.

287 ection, yet their contributions to long-term immune memory to viruses are unclear.

288 ized mechanisms that bias the acquisition of immune memory towards non-self targets.

289 nomenon termed "trained immunity" or "innate immune memory." Trained immunity is orchestrated by epig

290 Immune memory was considered for decades an exclusive ha

291 reports of Thy1(+) NK cells contributing to immune memory, we analyzed their role in secondary prote

292 inst HIV-1 acquisition, but the efficacy and immune memory were inadequate.

293 with 6TG and ICI treatment exhibited lasting immune memory, which effectively suppressed tumor growth

294 This de facto innate immune memory, which has been termed 'trained immunity',

295 cts can develop long-term, pathogen-specific immune memory, which in some cases can be transmitted to

296 ride, contributes to the induction of innate immune memory, which is associated with long-term epigen

297 rs and development of long-lasting antitumor immune memory, which was primarily attributed to the act

298 cells, then, for a wide range of parameters, immune memory will be long-lived in the absence of persi

299 e) is greater than this threshold value then immune memory will be relatively short lived.

300 s the only innate correlate of CD8(+) T cell immune memory yet to be identified.