ライフサイエンスコーパス: immune privilege

1 uced in certain organs, a phenomenon called 'immune privilege'.

2 common, despite its perception as a site of immune privilege.

3 echanisms that together contribute to ocular immune privilege.

4 the eye plays a dual role: in vision and in immune privilege.

5 represent a newly recognized form of ocular immune privilege.

6 as been demonstrated to play a vital role in immune privilege.

7 ic system plays a role in maintaining ocular immune privilege.

8 Hence, the liver shows features of immune privilege.

9 helial (RPE) cells may contribute to retinal immune privilege.

10 may underlie the contribution of the RPE to immune privilege.

11 and function, and may play a role in ocular immune privilege.

12 -/-) mice, an area typically associated with immune privilege.

13 ting the secretion of proteins that modulate immune privilege.

14 nflammation in uveitis implies compromise of immune privilege.

15 sents a mechanism by which tumors may foster immune privilege.

16 e factors in aqueous humor contribute to the immune privilege.

17 and have a role in the maintenance of ocular immune privilege.

18 ociated immune deviation, and loss of ocular immune privilege.

19 d implies that NNR tissue possesses inherent immune privilege.

20 ponse but may be involved with the spleen in immune privilege.

21 mber of the eye is endowed with a remarkable immune privilege.

22 ctions in the brain and can readily overcome immune privilege.

23 r, and may play a role in the acquisition of immune privilege.

24 6 may reduce inflammation and restore ocular immune privilege.

25 ation being the primary mechanism of retinal immune privilege.

26 remodels the metabolic landscape to support immune privilege.

27 s gained, we have reevaluated the concept of immune privilege.

28 es support RS cell survival and foster their immune privilege.

29 on, and immunotherapy approaches to overcome immune privilege.

30 of T cells into PDAC and establish a site of immune privilege.

31 dysregulation of molecular components of CNS immune privilege.

32 ibiting an intrinsic degree of MC-maintained immune privilege.

33 orting the role of IL-4 in the abrogation of immune privilege.

34 ch commensal bacteria and pathogens maintain immune privilege.

35 The brain is a site of relative immune privilege.

36 brain parenchyma, a site that is considered immune privileged.

37 r MSCs suggest that MSCs may not actually be immune privileged.

38 protective effects, and are considered to be immune privileged.

39 cells derived from autologous iPSCs will be immune-privileged.

40 following: 1) IL-17A is necessary for ocular immune privilege; 2) IL-17A is not required for the indu

41 etinal laser burn (RLB) to one eye abrogated immune privilege (ACAID) bilaterally for an extended per

42 Immune privilege allows for the immune protection of the

43 This breach in CNS immune privilege allows undeterred trafficking of myelin

44 r understanding of mechanisms underlying CNS immune privilege and CNS drainage.

45 an important role in maintaining testicular immune privilege and display reduced proinflammatory cap

46 -deficient IPCC allografts exhibited certain immune privilege and enjoyed long-term survival in diabe

47 ine essential for the maintenance of corneal immune privilege and establish a new paradigm whereby in

48 for sustaining at least one aspect of ocular immune privilege and for promoting corneal allograft sur

49 ontralateral eye to induce changes to ocular immune privilege and has a central role in the bilateral

50 ine orthotopic corneal allografts experience immune privilege and have good survival as compared with

51 Allergic diseases rob corneal allografts of immune privilege and increase immune rejection.

52 e minor H alloantigens that terminate ocular immune privilege and initiate corneal allograft rejectio

53 However, mechanisms underlying testicular immune privilege and intratesticular allograft survival

54 an important mechanism underlying testicular immune privilege and long-term survival of intratesticul

55 esults indicate that CD8+ T cells circumvent immune privilege and mediate intraocular tumor rejection

56 ivileged environment, T cells can circumvent immune privilege and mediate tumor rejection without ind

57 findings shed new light on the phenomenon of immune privilege and on its role, as well as its limitat

58 These findings reveal novel mechanisms of immune privilege and provide direct evidence that testic

59 nd assessed their role in developing RS cell immune privilege and survival.

60 expressing either H3a or H3a+H3b experienced immune privilege and survived longer than skin allograft

61 ndings provide fundamental new insights into immune privilege and the molecular mechanisms underlying

62 id organ transplants because of the inherent immune privilege and tolerogenic mechanisms associated w

63 We took the advantages of immune privilege and transparent nature of developing ze

64 Fetal tissue is considered to be immune privileged and is under extensive investigation a

65 oscientists, we are taught that the brain is immune privileged and thus unlikely to be affected by th

66 trophil-mediated inflammation, 2) terminated immune privilege, and 3) were completely rejected.

67 xpressed in corneal tissue, terminate ocular immune privilege, and initiate corneal allograft rejecti

68 in sustaining tumor cell growth, cultivating immune privilege, and promoting transformation.

69 demonstrate that Flt3L overcomes the brain's immune privilege, and supports the clinical development

70 topically, forms the anterior surface of the immune privileged anterior chamber.

71 Mechanisms underlying immune privilege are also not well understood.

72 l nervous system (CNS) and disruption of its immune privilege are major contributors to the pathogene

73 ocal adaptations of the immune system coined immune privilege are required to confer protection from

74 n its epithelial and stromal layers, whereas immune privilege arises from the endothelium.

75 w evidence for the collapse of hair follicle immune privilege as a key step in the pathogenesis of al

76 presents a pathogen strategy to create local immune privilege at epithelial surfaces, attenuating inn

77 a novel structural mechanism for conferring immune privilege at the level of quaternary structure.

78 Likewise, loss of immune privilege at the maternal-fetal interface culmina

79 The cornea is an immune privileged barrier tissue that relies primarily o

80 neurons in the healthy brain were considered immune-privileged because they did not appear to express

81 their multipotent differentiation, and their immune-privileged behavior, reveals, at least in part, t

82 nsplanted directly to the liver do not enjoy immune privilege but rather require immunosuppression to

83 of Fas ligand (FasL) renders certain tissues immune privileged, but its expression in other tissues c

84 expression of Fas-ligand (Fas-L) can provide immune privilege by inducing apoptosis of "invading" lym

85 results suggest that TM maintain testicular immune privilege by inhibiting NF-kappaB signaling throu

86 s humor (AqH) are thought to preserve ocular immune privilege by inhibiting proinflammatory NO produc

87 elanoma cells maintain a microenvironment of immune privilege by secreting active MIF that protects a

88 Ocular pigment epithelia contribute to immune privilege by suppressing T cell activation and co

89 is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmu

90 Neonatal porcine Sertoli cells (NPSC) are immune privileged cells showing innate phagocytic and an

91 PI-9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protects these c

92 Vigorous immune responses are induced in the immune privileged CNS by injury and disease, but the mol

93 d function of NK cells in the traditionally "immune-privileged" CNS is controversial.

94 rodent studies suggests that a breakdown in immune privilege contributes to multiple sclerosis, uvei

95 In the immune-privileged cornea, epithelial wounds heal rapidly

96 LX are highly expressed in the avascular and immune-privileged cornea.

97 Immune privilege describes how the immune system respond

98 ese data refute the tenet that the cornea is immune privileged due to lack of resident lymphoreticula

99 cell-derived IL-1beta contributes to loss of immune privilege during CNS autoimmunity via pathologic

100 potent inflammatory response that terminates immune privilege, eliminates ocular tumors, and prevents

101 d for latent pathogens and persistence in an immune-privileged enteric niche.

102 al cells contributes to the generation of an immune-privileged environment at the maternal-fetal inte

103 d SCID mice, could survive in the relatively immune-privileged environment of dialysis membrane chamb

104 Our data demonstrate that the immune-privileged environment within the eye induces a t

105 Although intraocular tumors reside in an immune-privileged environment, T cells can circumvent im

106 The CNS is an immune-privileged environment, yet the local control of

107 tion that guide migration of T cells in this immune-privileged environment.

108 vironment of TP53 mutant MDS and sAML has an immune-privileged, evasive phenotype that may be a prima

109 ta2-treated Ag-pulsed APC mimic APC from the immune privileged eye, and provide signals that generate

110 required to initiate inflammation within the immune privileged eye, as compared with nonprivileged si

111 The ability of ADCC to protect the immune-privileged eye, however, may differ from skin or

112 om primary uveal melanomas that arise in the immune-privileged eye, prime and boost IFNgamma-secretin

113 We previously showed that, within the immune-privileged eye, tumors expressing high levels of

114 cognate antigens are sequestered within the immune-privileged eye.

115 However, GCs are considered to be immune privileged for antiviral CD8 T cells.

116 and provide direct evidence that testicular immune privilege fosters the induction of transplantatio

117 This phenomenon, called 'immune privilege', has been linked to the existence of m

118 he CNS selectively or whether these sites of immune privilege have limited capacity to eradicate the

119 neurons and limits inflammation, designated "immune privilege." However, there is not an absolute lac

120 until recently the brain was thought to be "immune privileged." However, it is now known that the im

121 ervous system (CNS) is classically viewed as immune-privileged; however, recent advances highlight in

122 port that retinal laser burn (RLB) abrogates immune privilege in both the burned and nonburned eye.

123 ts covered with syngeneic epithelium display immune privilege in orthotopic transplantation and wheth

124 lammation stimulates immunity but can create immune privilege in some settings.

125 Together, these data indicate that immune privilege in the brain is actively maintained and

126 ude by proposing a revised interpretation of immune privilege in the brain, which takes beneficial ne

127 Immune privilege in the CNS is often mis-attributed whol

128 Although CD95L contributes to immune privilege in the cornea and testis, the functions

129 This form of immune privilege in the eye is mediated through Tregs an

130 A fundamental mechanism of immune privilege in the eye is the induction of T lympho

131 itical for the generation and maintenance of immune privilege in the eye through the facilitation of

132 This role might be of specific relevance for immune privilege in the eye, where, sporadically, patien

133 esent an important mechanism for maintaining immune privilege in the eye.

134 e, we address these issues and re-define CNS immune privilege in the light of recent data.

135 les for bone marrow-derived cells and ocular immune privilege in the pathogenesis of PG.

136 essential to the creation and maintenance of immune privilege in the subretinal space and that the im

137 y play a significant role in maintaining the immune privilege in the subretinal space.

138 ithelium may play a role in the induction of immune privilege in the subretinal space.

139 s concerning their potential contribution to immune privilege in this space and to the fate of retina

140 opose that mechanisms associated with ocular immune privilege, in combination with paucity of age-rel

141 on of Fas ligand (FasL) in the eye maintains immune privilege, in part through inducing apoptosis of

142 es that tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protect

143 ane-only form of Fas ligand (FasL) terminate immune privilege, induce vigorous inflammation, undergo

144 The immune privilege (IP) of hair follicles (HFs) has been w

145 ls, in maintaining physiologic hair follicle immune privilege (IP); the extent to which these functio

146 This loss of immune privilege is accompanied by a decrease in the con

147 Thus, ocular immune privilege is achieved in part by subversion of mo

148 Immune privilege is afforded to xenografts of guinea pig

149 We believe this immune privilege is caused by the absence of antigen pre

150 Corneal immune privilege is integral in maintaining the clear av

151 These results suggest that immune privilege is lost in the absence of a functional

152 It is now increasingly recognized how immune privilege is maintained actively as a result of t

153 Ocular immune privilege is the result of several unique feature

154 us, uncommitted T cells can be disarmed, but immune privilege is unable to protect from uveitogenic T

155 Immune privilege is used by the eye, brain, reproductive

156 Immune privilege is well developed in three regions of t

157 On the one hand, immune privilege limits inflammation to prevent bystande

158 ivilege in the subretinal space and that the immune privilege limits the severity and duration of ret

159 ration of tumor antigens within a relatively immune privileged location present serious problems for

160 We further discuss how mimicking the bulge immune privilege may be an effective melanoma prevention

161 ause our findings on molecular mechanisms of immune privilege may be responsible for the failure of i

162 wn that it is very difficult to abrogate the immune privileged mechanism called anterior chamber-asso

163 ery few events are capable of overcoming the immune-privileged mechanisms in the eye.

164 g molecules to immune cells, resulting in an immune privileged microenvironment.

165 undertaken to test the idea that modulating immune privilege might be an effective therapeutic appro

166 nt, as well as potentially contribute to the immune-privileged nature of the brain.

167 ring maturation that could contribute to the immune-privileged nature of the CNS or potentially influ

168 rowth, played a key role in formation of the immune-privileged niche, and predicted poor prognosis in

169 Human uveal melanoma arises in an immune privileged ocular environment in which both adapt

170 fective immune modulation in the classically immune-privileged ocular haven.

171 AP-1 in the recruitment of leukocytes to the immune-privileged ocular tissues during acute inflammati

172 administration of anti-IL-17A abolished the immune privilege of corneal allografts but had no effect

173 ed the expression of ACAID and abolished the immune privilege of corneal allografts.

174 rejection and may instead contribute to the immune privilege of corneal allografts.

175 le roles of corneal endothelium in promoting immune privilege of corneal xenografts are discussed.

176 erived DCp may contribute to the comparative immune privilege of hepatic allografts.

177 ursor/immature stage, may play a role in the immune privilege of liver allografts.

178 nolaminylation of lipid A contributes to the immune privilege of most commensal Neisseria strains by

179 Strategies to reverse the immune privilege of PDAC, which is regulated by extratum

180 as challenged the traditional view about the immune privilege of the brain, but the precise roles of

181 The concept of immune privilege of the central nervous system (CNS) has

182 We examine the notion of immune privilege of the CNS in light of both earlier fin

183 implications of a revised perspective on the immune privilege of the CNS on the etiology and patholog

184 eview emphasizes the fact that understanding immune privilege of the CNS requires intimate knowledge

185 tedly provoked dismissal of the existence of immune privilege of the CNS.

186 Thus, immune privilege of the eye regulates inflammation secon

187 roducing PEDF, the RPE contributes to innate immune privilege of the eye.

188 poptosis is crucially important in mediating immune privilege of the fetus during pregnancy.

189 disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent aut

190 se of the CNS remains speculative, given the immune privilege of this organ.

191 The 'immune privilege' of the central nervous system (CNS) is

192 We now know that the brain is not an immune privileged organ.

193 chanisms may include loss of tolerance in an immune-privileged organ and subsequent development of T-

194 The liver is considered to be an immune-privileged organ that favors the induction of tol

195 The brain, previously thought of as an immune-privileged organ, is now known to communicate ext

196 As an immune-privileged organ, the placenta can tolerate the i

197 Although the inner ear has been known as an immune-privileged organ, there is emerging evidence indi

198 Despite being considered an immune-privileged organ, we detect a mycobacteria-specif

199 nfected macrophages or if ranavirus exploits immune privileged organs, such as the brain, in order to

200 ent genomic rearrangement events underlie an immune privilege phenotype in a subset of B-cell lymphom

201 clear placental viral infections within the immune-privileged placenta.

202 nt corneal neovascularization, which revokes immune privilege, prevents corneal allograft rejection.

203 deviation (ACAID), a manifestation of ocular immune privilege, prevents Th1-dependent delayed hyperse

204 However, it is unknown whether testicular immune privilege promotes transplantation tolerance.

205 Ocular immune privilege promotes tumor growth by hindering the

206 wo factors, their low immunogenicity and the immune-privileged properties of the eye.

207 controversy remains as to whether hESCs have immune-privileged properties.

208 However, the role of FasL in immune privilege remains controversial due to studies th

209 e photoreceptors and synaptic regions of the immune-privileged retina implies a role in visual transm

210 Importantly, testicular immune privilege significantly suppressed the generation

211 The CNS is considered an immune privileged site because its repertoire of highly

212 The lens has been considered to be an immune privileged site not susceptible to the immune pro

213 The eye is an immune privileged site that is styled to maintain the vi

214 esence of parenchymal cells from the eye (an immune privileged site) express B7-2 in a manner that eq

215 Although once believed to be an immune privileged site, it is now known that antimicrobi

216 Although intraocular tumors reside in an immune privileged site, some tumors are rejected nonethe

217 or this molecule in tumor surveillance in an immune privileged site.

218 notherapy because primary tumors arise in an immune-privileged site and may express antigens to which

219 Immune-privileged site DLBCL (IP-DLBCL) patients reporte

220 e barriers in the mammalian body, creates an immune-privileged site for postmeiotic spermatid develop

221 ted cells that line the subretinal space, an immune-privileged site in the eye.

222 nt infection in the seminiferous tubules, an immune-privileged site in the testis protected by the bl

223 ined the fate of such grafts placed in a non-immune-privileged site of adult recipient mice.

224 Although intraocular tumors reside in an immune-privileged site where immune responses are suppre

225 The central nervous system (CNS) is an immune-privileged site where the role of immune cells an

226 tudy documents that tumors growing within an immune-privileged site within the eye develop a tumor es

227 The eye is an immune-privileged site, and FasL expression is a major p

228 us system has historically been viewed as an immune-privileged site, but recent data have shown that

229 As an immune-privileged site, the eye, and particularly the ou

230 primary DLBCL samples, including 44 primary immune-privileged site-associated DLBCL (IP-DLBCL) sampl

231 Therefore, this model for immune-privileged site-mediated tolerance provided us wi

232 across the BTB to exert their effects at the immune-privileged site.

233 challenging because the eye is a relatively immune-privileged site.

234 duced by the introduction of antigen into an immune-privileged site.

235 body PE, and retina PE of the inner eye, an immune-privileged site.

236 tissue as to the qualities of the eye as an immune-privileged site.

237 f the PD-1:PD-L1 interaction in creating an "immune-privileged" site for initial viral infection and

238 It is expressed in immune privileged sites and is implicated in establishin

239 ter the hypothesis that B cell follicles are immune privileged sites and suggest that strategies to a

240 ions, carrying infectious virus particles to immune privileged sites and/or to sites protected by phy

241 s required for dissemination of the virus to immune privileged sites has not been definitively shown.

242 rticipation in inflammatory responses within immune privileged sites such as the brain and eye is les

243 The induction of peripheral tolerance via immune privileged sites such as the eye requires splenic

244 sion helps control inflammatory reactions in immune privileged sites such as the eye.

245 Zika virus (ZIKV) can establish infection in immune privileged sites such as the testes, eye, and pla

246 ic infections in humans, mainly localized in immune privileged sites, such as the brain and the eye.

247 Because synovial joints include immune privileged sites, these findings are significant

248 IFN-dependent MHC regulation, as evident in immune privileged sites.

249 sponse in controlling lymphocyte function in immune privileged sites.

250 Diffuse large B-cell lymphoma arising in immune-privileged sites (eg, the central nervous system)

251 if somatic stem-cell niches more broadly are immune-privileged sites by examining the haematopoietic

252 Thus, dysregulated innate immunity at immune-privileged sites may be an essential mechanism tr

253 , suggesting that tumor cells originating in immune-privileged sites may have enhanced capacity for i

254 Tissues derived from immune-privileged sites sometimes possess special charac

255 in view of the immune deviation existing in immune-privileged sites such as the brain and eye, where

256 g how EBOV disseminates into and persists in immune-privileged sites was impossible due to the absenc

257 rogram tolerance in the gut and the eye, two immune-privileged sites where immunosuppressive response

258 nous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and muri

259 are immune-suppressive environments, called immune-privileged sites, where multiple mechanisms coope

260 e highlight a dilemma that is central to all immune-privileged sites.

261 d, suggesting that lymphoid follicles may be immune-privileged sites.

262 n the development of peripheral tolerance in immune-privileged sites.

263 ion and promoted the establishment of cancer immune-privileged sites.

264 virus can persist in survivors for months in immune-privileged sites; however, viral relapse causing

265 gh the anterior chamber of the eye expresses immune privilege, some ocular tumors succumb to immune r

266 ccommodate and even differentiate in the non-immune-privileged space beneath the kidney capsule.

267 he accessibility for routine surgery and its immune privileged state make the eye an ideal target for

268 Here we show that Del-1 contributes to the immune privilege status of the CNS.

269 gen-presenting cells that contributes to the immune privilege status of the eye is dependent on their

270 an important role in the establishment of an immune privilege status of the tumor by inducing Fas-med

271 nvironment within the CNS contributes to the immune privilege status of this tissue.

272 especially TGF-beta2, that contribute to the immune privileged status of the anterior chamber.

273 this class Ib protein may contribute to the immune-privileged status of the anterior chamber.

274 ged self during healing and suggest that the immune-privileged status of the CNS may contribute to fa

275 n (IRBP) in the periphery, thus revoking its immune-privileged status.

276 t even though the retina is often considered immune-privileged, suppression of host immune-mediated c

277 ) pDCs elicited by PMA exposure create local immune privilege that favors tumor development, IDO-defi

278 ed corneas from normal mice possess inherent immune privilege that protects them from alloimmune reje

279 Immune privilege, therefore, provides unwanted refuge fo

280 long been reported to be hypoimmunogenic or 'immune privileged'; this property is thought to enable M

281 rived epithelial cells participate in ocular immune privilege through poorly defined molecular mechan

282 hese results suggest that Tregs preserve CNS immune privilege through selective control of CNS-specif

283 owever, an indiscriminate maintenance of CNS immune privilege through Treg-mediated negative regulati

284 The cornea is an immune privileged tissue that, when grafted orthotopical

285 as much to the qualities of the graft as an immune-privileged tissue as to the qualities of the eye

286 e bulge region of the hair follicle (HF), an immune-privileged tissue niche with impaired tumor immun

287 tinal pigment epithelium (RPE) behaves as an immune-privileged tissue when transplanted extraocularly

288 endritic cells (DC) reside in the cornea, an immune-privileged tissue, is unknown.

289 e blood-brain barrier (BBB) provides limited immune privilege to brain parenchyma, and the immune res

290 Thus, although Fas-L can lend some immune privilege to islet cells, local virus-induced inf

291 s and innate-like B-1 B cells, which provide immune privilege to malignant cell foci.

292 nt within seminiferous tubules and providing immune privilege to meiotic and postmeiotic cells.

293 Thus, neonatal RPE tissue owes its immune privilege to the capacity to prevent immune rejec

294 ast cells seem to confer a certain degree of immune privilege to tissues in concert with T-regulatory

295 Targeting immune privilege using cytotoxic molecules or by increas

296 er, CX3CR1(hi) patrolling monocytes serve as immune-privileged vehicles to transport MCMV via the blo

297 s, and whether this tissue displays inherent immune privilege, we have examined the fate of such graf

298 ate the mechanism(s) by which FasL regulates immune privilege, we used an ocular tumor model and exam

299 rast to the notion that ES-derived cells are immune-privileged, we show in this study that NK cells f

300 f Fas+ inflammatory cells contributes to the immune privilege within the anterior chamber and provide