ライフサイエンスコーパス: immune reconstitution

1 nt as adjunctive therapy with ART to improve immune reconstitution.

2 orrelation between the course of viremia and immune reconstitution.

3 ore reduce treatment duration and facilitate immune reconstitution.

4 ded engraftment, acute and chronic GVHD, and immune reconstitution.

5 he mechanism of Treg-dependent regulation of immune reconstitution.

6 may be related to T-cell repopulation and/or immune reconstitution.

7 w-level viral replication to thereby improve immune reconstitution.

8 luence the survival of T cells during normal immune reconstitution.

9 hemistry were used to assess engraftment and immune reconstitution.

10 perienced immune system may affect antiviral immune reconstitution.

11 ery of thymic activity in adults, leading to immune reconstitution.

12 ttle is known about these populations during immune reconstitution.

13 graft-versus-host reactions permits superior immune reconstitution.

14 ghly active antiretroviral therapy following immune reconstitution.

15 are generated after infection, also promote immune reconstitution.

16 tion has been reported to result in enhanced immune reconstitution.

17 d thus may be a determinant of the extent of immune reconstitution.

18 active or recently treated PCP subjected to immune reconstitution.

19 e, such as in the fetus and neonate or after immune reconstitution.

20 V-infected patients on ART with insufficient immune reconstitution.

21 suppression and the risk of infection before immune reconstitution.

22 w the progression of the disease and improve immune reconstitution.

23 monitored for safety, clinical symptoms, and immune reconstitution.

24 ol immune activation that could affect their immune reconstitution.

25 WAS has shown promising results in terms of immune reconstitution.

26 r many disorders, is intertwined with T cell immune reconstitution.

27 val after RCI by regulating myelopoiesis and immune reconstitution.

28 ation, innate immune activation, and reduced immune reconstitution.

29 recovery or worsen outcomes associated with immune reconstitution.

30 m/progenitor cells, ADA gene expression, and immune reconstitution.

31 ixed chimerism result in clinically relevant immune reconstitution.

32 y immunodeficiency that is caused by delayed immune reconstitution.

33 ents in those who have achieved CMV-specific immune reconstitution.

34 m followed by graft reinfusion for blood and immune reconstitution.

35 lead to resolution of viremia without T-cell immune-reconstitution.

36 In patients with HIV, immune reconstitution after antiretroviral therapy (ART)

37 pair the survival of naive T cells and limit immune reconstitution after antiretroviral therapy.

38 humans, rhesus macaques, and mice, and with immune reconstitution after chemotherapy and autologous

39 y a disease flare and HBV DNA clearance with immune reconstitution after chemotherapy is stopped.

40 -IL-22-TEC axis may be useful for augmenting immune reconstitution after clinical hematopoietic trans

41 Immune reconstitution after HAART initiation did not res

42 g the beneficial effects of this approach to immune reconstitution after haplo-HSCT.

43 nitoring of lymphoid malignancies, assessing immune reconstitution after hematopoietic cell transplan

44 red DC provides a novel strategy for de novo immune reconstitution after human HCT and a practical an

45 valuate the incidence of late infections and immune reconstitution after preemptive R treatment of EB

46 -versus-host disease (GVHD), GVL effect, and immune reconstitution after transplant.

47 Immune-reconstitution after highly active antiretroviral

48 d before HIV infection did not recover after immune reconstitution and a previously unrealized declin

49 It is associated with better immune reconstitution and a quite powerful graft-versus-

50 ory T (T(SCM)) cells, which possess superior immune reconstitution and antitumor response capabilitie

51 However, delayed immune reconstitution and associated infectious morbidit

52 Detailed analysis of T- and B-cell immune reconstitution and donor chimerism was compared b

53 0, 1.08], respectively) after accounting for immune reconstitution and graft-versus-host disease.

54 IT and reduced GvHD severity independent of immune reconstitution and graft-versus-tumor effects.

55 Secondary outcomes included measures of immune reconstitution and HIV resistance.

56 determined whether the iC9-T cells produced immune reconstitution and if any resultant graft-versus-

57 These data suggest that immune reconstitution and immunocompetence are maintaine

58 We prospectively evaluated immune reconstitution and immunocompetence.

59 late, and no antithymocyte globulin (ATG) on immune reconstitution and outcome.

60 y T cells (Tregs) have been shown to enhance immune reconstitution and prevent graft-versus-host dise

61 Therefore, we investigated their role during immune reconstitution and re-establishment of immune tol

62 invasive CMV disease in its relationship to immune reconstitution and viral dynamics.

63 The 2 groups had comparable immune-reconstitution and viral burden.

64 d before HIV infection did not recover after immune reconstitution, and a previously unrealized decli

65 T cells resulted in consistent engraftment, immune reconstitution, and acceptable rates of GVHD.

66 pairment of MMUD RIC HSCT, can enhance early immune reconstitution, and appears to be suitable for pr

67 to engraftment, lineage-specific chimerism, immune reconstitution, and discontinuation of immunoglob

68 K cells influenced donor T-cell engraftment, immune reconstitution, and long-term outcomes in childre

69 T-cell dosing as it relates to engraftment, immune reconstitution, and relapse.

70 on, ganciclovir resistance, quality of life, immune reconstitution, and safety.

71 ic in vitro derived effector CD8 T cells for immune reconstitution approaches, which would be amenabl

72 on or through improvements in the quality of immune reconstitution are required.

73 decreased GVHD, but hematologic recovery and immune reconstitution are slow.

74 r extreme longevity and robust potential for immune reconstitution, are central players in many physi

75 e instrumental in guiding the optimal use of immune reconstitution as a durable therapeutic strategy.

76 findings suggest T-cell repopulation and/or immune reconstitution as putative mechanisms for bone lo

77 Patients with superior immune reconstitution, as defined by an increase in seru

78 long-term follow-up and detailed analysis of immune reconstitution associated with a different suicid

79 rms of stem cell transduction and subsequent immune reconstitution, but have also highlighted the pot

80 a (GVL) effect, as well as the impairment of immune reconstitution by immunomodulatory drugs leading

81 treatment preserved long-term posttransplant immune reconstitution characterized by more donor thymic

82 nticipated by CMV viremia, and (3) no T-cell immune reconstitution despite previous viremia episodes.

83 the majority of T cells supporting long-term immune reconstitution did not carry the suicide gene and

84 ce injected with CD4 T cells also develop an immune reconstitution disease (IRD) manifesting as weigh

85 Immune reconstitution disease (IRD) represents a syndrom

86 Long-term immune reconstitution does not explain this event, which

87 t decade, most likely the result of improved immune reconstitution due to better HIV care and managem

88 hes to moderate T cell depletion and improve immune reconstitution during HIV-1 infection.

89 patterns and kinetics of CMV-specific T-cell immune reconstitution: during the early time-points, pat

90 ificant differences in the profile of T-cell immune reconstitution emerged between D+ and D-.

91 In this study, early immune reconstitution, especially of T and NK cell compa

92 Antiretroviral therapy (ART)-mediated immune reconstitution fails to restore the capacity of t

93 filgrastim) is used clinically to accelerate immune reconstitution following chemotherapy and is bein

94 n African setting, and how this changes with immune reconstitution following HAART is unknown.

95 fected Malawian adults and then investigated immune reconstitution following HAART.

96 This case demonstrates successful immune reconstitution following hematopoietic stem cell

97 ed HIV load prior to HAART (P=.005) and poor immune reconstitution following initiation of HAART (P=.

98 ic variability of immune response to HIV and immune reconstitution following initiation of highly act

99 However, delayed immune reconstitution following rATG treatment, partly c

100 that are key for the antiviral response and immune reconstitution.FUNDINGNIH grant P01 CA23766 and N

101 Efforts to augment GVL and immune reconstitution have been limited by GVHD, the att

102 n, but a high risk of graft failure and poor immune reconstitution have been observed in the absence

103 Attempts to improve immune reconstitution have until now been unsuccessful,

104 Following immune reconstitution, hematopoietic stem cell transplan

105 Even with suppression of viral loads and immune reconstitution, HIV-positive individuals exhibit

106 of JCV VP1-specific T-cell responses during immune reconstitution in 1 of the patients.

107 ly analyze and compare clinical outcomes and immune reconstitution in 13 consecutive SCID-X1 patients

108 tus, mechanism, and clinical implications of immune reconstitution in adults with hematologic maligna

109 herapeutic thymus restoration and peripheral immune reconstitution in adults.

110 with hematopoietic engraftment and improved immune reconstitution in allo-HSCT recipients with aGVHD

111 nst malaria and non-malaria infections after immune reconstitution in ART-treated individuals in sub-

112 une dysfunction play a role for insufficient immune reconstitution in HIV infection independently of

113 of adjunctive antifibrotic agents to improve immune reconstitution in HIV infection.

114 the gut that could prevent efficient mucosal immune reconstitution in HIV-infected individuals despit

115 populations, cellular immune activation, and immune reconstitution in HIV-infected individuals receiv

116 Influenza-specific CD4(+) T-cell immune reconstitution in HIV-infected patients on HAART

117 ontribution of this subset to posttransplant immune reconstitution in humans.

118 ffective therapy for selective CD4(+) T-cell immune reconstitution in hypoleptinemic states such as t

119 P allows multilineage engraftment and robust immune reconstitution in mice with either null or hypomo

120 cytes expressing a safety switch may promote immune reconstitution in patients undergoing haploidenti

121 HIV-1-infected subjects generally allows for immune reconstitution in peripheral blood, reconstitutio

122 the gene into donor T cells given to enhance immune reconstitution in recipients of haploidentical st

123 n the decision to stop CTX after ART-induced immune reconstitution in regions with high infectious di

124 on of inflammation and facilitation of rapid immune reconstitution in those with only a limited respo

125 uman hematopoietic progenitors and performed immune reconstitutions in NOD/LtSz-scid IL2Rgamma(null)

126 Therefore, partial immune-reconstitution in AIDS, attributable to reduced t

127 Furthermore, immune reconstitution included both adoptively transferr

128 gmented and accelerated cellular and humoral immune reconstitution, including antitumor immunity, aft

129 Cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) may

130 ioration, known as cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS), up

131 sed by paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS).

132 ces them at risk for Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS).

133 Adverse events, including CM immune reconstitution inflammatory syndrome (CM-IRIS), a

134 Central nervous system-immune reconstitution inflammatory syndrome (CNS-IRIS) i

135 The immunopathogenesis of CM immune reconstitution inflammatory syndrome (IRIS) after

136 velop active cytomegalovirus retinitis as an immune reconstitution inflammatory syndrome (IRIS) after

137 thogens in HIV-infected patients who develop immune reconstitution inflammatory syndrome (IRIS) after

138 losis are at risk of tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) and d

139 etroviral therapy (ART) are at high risk for immune reconstitution inflammatory syndrome (IRIS) and d

140 WH) with low CD4 counts are at high risk for immune reconstitution inflammatory syndrome (IRIS) and d

141 Cryptococcal meningitis (CM)-related immune reconstitution inflammatory syndrome (IRIS) compl

142 Patients who experienced immune reconstitution inflammatory syndrome (IRIS) event

143 fficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) follo

144 deficiency virus (HIV) is the development of immune reconstitution inflammatory syndrome (IRIS) in ap

145 Immune reconstitution inflammatory syndrome (IRIS) in hu

146 arly detection of MRI findings suggestive of immune reconstitution inflammatory syndrome (IRIS) in na

147 The immunopathogenesis of immune reconstitution inflammatory syndrome (IRIS) in pa

148 ring the HIV epidemic and the development of immune reconstitution inflammatory syndrome (IRIS) in pa

149 wide distribution, histoplasmosis-associated immune reconstitution inflammatory syndrome (IRIS) in pe

150 or HIV infection and can cause a devastating immune reconstitution inflammatory syndrome (IRIS) in th

151 Immune reconstitution inflammatory syndrome (IRIS) is a

152 Immune Reconstitution Inflammatory Syndrome (IRIS) is a

153 Immune reconstitution inflammatory syndrome (IRIS) is a

154 Tuberculosis immune reconstitution inflammatory syndrome (IRIS) is a

155 Immune reconstitution inflammatory syndrome (IRIS) is a

156 Immune reconstitution inflammatory syndrome (IRIS) is a

157 Immune reconstitution inflammatory syndrome (IRIS) is a

158 The management of corticosteroid refractory immune reconstitution inflammatory syndrome (IRIS) is cu

159 Furthermore, the role of unmasking immune reconstitution inflammatory syndrome (IRIS) is un

160 Immune reconstitution inflammatory syndrome (IRIS) occur

161 Immune reconstitution inflammatory syndrome (IRIS) refle

162 mmunopathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome (IRIS) remai

163 Concerns about the immune reconstitution inflammatory syndrome (IRIS) remai

164 Immune reconstitution inflammatory syndrome (IRIS) repre

165 Immune reconstitution inflammatory syndrome (IRIS) was r

166 with raised intracranial pressure (ICP) and immune reconstitution inflammatory syndrome (IRIS) were

167 The incidence of immune reconstitution inflammatory syndrome (IRIS) when

168 the CSF even though all patients experienced immune reconstitution inflammatory syndrome (IRIS), 11 p

169 relapse of talaromycosis, development of the immune reconstitution inflammatory syndrome (IRIS), and

170 hen administered postinfection in a model of immune reconstitution inflammatory syndrome (IRIS), both

171 these patients is neurological tuberculosis-immune reconstitution inflammatory syndrome (IRIS), but

172 All of them experienced immune reconstitution inflammatory syndrome (IRIS), but

173 systemic infection with Tropheryma whipplei, immune reconstitution inflammatory syndrome (IRIS), is a

174 cal outcome of PML and PML in the setting of immune reconstitution inflammatory syndrome (IRIS), we t

175 cult to interpret secondary to KS-associated immune reconstitution inflammatory syndrome (IRIS).

176 elerates fungal clearance during PcP-related immune reconstitution inflammatory syndrome (IRIS).

177 iral therapy (ART), perhaps due to unmasking immune reconstitution inflammatory syndrome (IRIS).

178 ug interactions, overlapping toxicities, and immune reconstitution inflammatory syndrome (IRIS).

179 tory symptoms that are collectively known as immune reconstitution inflammatory syndrome (IRIS).

180 oorly understood inflammatory disease termed immune reconstitution inflammatory syndrome (IRIS).

181 ays to a few weeks after PLEX, indicative of immune reconstitution inflammatory syndrome (IRIS).

182 mary outcomes: mortality, drug toxicity, and immune reconstitution inflammatory syndrome (IRIS).

183 ial translocation for their association with immune reconstitution inflammatory syndrome (IRIS).

184 isk factors for tuberculosis (TB)-associated immune reconstitution inflammatory syndrome (IRS) in sol

185 87 (10%) of 834 versus 84 (10%) of 841 had immune reconstitution inflammatory syndrome (p=0.56).

186 cal leukoencephalopathy (PML) and full-blown immune reconstitution inflammatory syndrome (PML-IRIS).

187 sis ('inflammatory PML'), reminiscent of PML-immune reconstitution inflammatory syndrome (PML-IRIS).

188 Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) co

189 Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) fr

190 Tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in

191 HIV-tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is

192 nesis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) re

193 are at risk of the paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) wh

194 of HIV-1-infected TB patients at risk of TB immune reconstitution inflammatory syndrome (TB-IRIS), i

195 as a possible manifestation of tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).

196 re all-cause mortality and the TB-associated immune reconstitution inflammatory syndrome (TB-IRIS).

197 ing antiretroviral therapy (ART) may develop immune reconstitution inflammatory syndrome (TB-IRIS).

198 orted in treated HIV patients, including CNS immune reconstitution inflammatory syndrome and neurosym

199 occal CSF clearance and a lower incidence of immune reconstitution inflammatory syndrome and relapse

200 that PML can present during the course of an immune reconstitution inflammatory syndrome and that it

201 n was inversely related to the occurrence of immune reconstitution inflammatory syndrome at the time

202 The incidence of recognized cryptococcal immune reconstitution inflammatory syndrome did not diff

203 e factors associated with the development of immune reconstitution inflammatory syndrome in HIV patie

204 Immune reconstitution inflammatory syndrome occurred in

205 ptoms, 2 patients presented criteria for the immune reconstitution inflammatory syndrome of the CNS,

206 L based on lesion evolution and signs of PML-immune reconstitution inflammatory syndrome on MRI, and

207 Incidence of paradoxical immune reconstitution inflammatory syndrome was 5% (two

208 The presence of immune reconstitution inflammatory syndrome was determin

209 Tuberculosis-associated immune reconstitution inflammatory syndrome was more com

210 Therefore, a murine model of PcP-related immune reconstitution inflammatory syndrome was used to

211 ed, of whom 22 (10 with clinically diagnosed immune reconstitution inflammatory syndrome) fulfilled t

212 ng to acute inflammatory responses (known as immune reconstitution inflammatory syndrome) shortly aft

213 e but caution is needed in the management of immune reconstitution inflammatory syndrome, an exuberan

214 maging and to analyse their association with immune reconstitution inflammatory syndrome, and surviva

215 elected serious infections, serious non-ADE, immune reconstitution inflammatory syndrome, or death).

216 e been most extensively updated are those on immune reconstitution inflammatory syndrome, tuberculosi

217 une pathology, without clinically recognized immune reconstitution inflammatory syndrome.

218 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome.

219 treated rabies, indicative of a neurological immune reconstitution inflammatory syndrome.

220 itive predictive value of 88% for absence of immune reconstitution inflammatory syndrome.

221 ly after ART initiation, possibly because of immune reconstitution inflammatory syndrome.

222 nitiation and the clinical predictors of TBM immune reconstitution inflammatory syndrome.

223 nce for Kaposi sarcoma as a manifestation of immune reconstitution inflammatory syndrome.

224 and NfL continued to increase until onset of immune reconstitution inflammatory syndrome.

225 ting the paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome.

226 s to the broad spectrum of fungal-associated immune reconstitution inflammatory syndromes.

227 the compartmentalisation (or CSF escape) and immune reconstitution inflammatory syndromes.

228 T-cell immune reconstitution (IR) after allogeneic hematopoieti

229 Successful immune reconstitution (IR) is associated with improved o

230 Timely immune reconstitution (IR) is suggested to prevent VR.

231 We present the outcomes, safety and immune reconstitution (IR) of patients with active, trea

232 The pulmonary host response during immune reconstitution (IR)-mediated clearance of PcP in

233 onclude that the evaluation of the antiviral immune reconstitution is a promising and appealing syste

234 tation are also at risk during the time when immune reconstitution is incomplete or while they are re

235 tion antiretroviral therapy, suggesting that immune reconstitution is not complete until the CD4 incr

236 However, it also delays immune reconstitution, leading to frequent infections an

237 of disease, control of GVHD, enhancement of immune reconstitution, less toxic regimens, and preventi

238 vasculopathy may manifest as a result of an immune reconstitution-like syndrome after starting ART.

239 antiretroviral therapy (ART), suggesting an immune reconstitution-like syndrome.

240 Peripheral blood chimerism, recipient immune reconstitution, liver function tests, and graft s

241 In an immune reconstitution model, adoptive transfer of Gr-1+C

242 ll depletion might contribute to the delayed immune reconstitution observed after unrelated umbilical

243 Immune reconstitution occurred equivalently in chimeras

244 could be involved in the incomplete mucosal immune reconstitution of cART-treated HIV-infected indiv

245 Immune reconstitution of CD4Treg, CD4Tcon, and CD8 T cel

246 Immune reconstitution of CMV-specific CTLs (CMV-CTLs) is

247 lymphoid hosts, an approach that allowed the immune reconstitution of nonpermissive mice following in

248 Following immune reconstitution of this novel strain with HSCs fro

249 We have studied the immune reconstitution of Vdelta2negative (Vdelta2neg) ga

250 Long-term immune reconstitution on antiretroviral therapy (ART) ha

251 s, emphasizing the critical impact of robust immune reconstitution on efficient control of viral infe

252 in peripheral blood without impairing early immune reconstitution or increasing risk for infections.

253 Maternal immune reconstitution or lowering breast milk CMV levels

254 blood transplantation (UCBT) is the delay in immune reconstitution, placing patients at increased ris

255 During immune reconstitution post-transplantation we observed s

256 V) specific cytotoxic T lymphocytes (CTL) as immune reconstitution postallogeneic transplant in a pha

257 atic profiling could serve as a biomarker of immune reconstitution, predict clinical events after HCT

258 , the presence of Tregs during the period of immune reconstitution preserves optimal TCR diversity an

259 Despite the immune reconstitution promoted by combined antiretrovira

260 The mechanism of immune reconstitution reactions is complex and variable,

261 However, delayed immune reconstitution remains a great challenge.

262 er, how these genetic variants impact T cell immune reconstitution remains poorly understood.

263 pulated grafts, but its effect on subsequent immune reconstitution remains undetermined.

264 are consistent with delayed and insufficient immune reconstitution resulting in high infection-relate

265 sence of Foxp3(+) Tregs during the period of immune reconstitution results in the development of TCR

266 on-free survival, overall survival (OS), and immune reconstitution.RESULTSNo participants showed evid

267 After immune reconstitution, some of these cases may show long

268 patient outcomes are linked to the degree of immune reconstitution, specifically of T cells.

269 mmunosuppression influence the occurrence of immune reconstitution syndrome (IRS) in solid organ tran

270 Because immune reconstitution syndrome may occur in HIV-infected

271 Two possible mechanisms include (1) an immune reconstitution syndrome, supported by stereotypic

272 ation, 52% met the criteria for tuberculosis immune reconstitution syndrome.

273 cribed in tuberculosis (TB) pathology and TB-immune reconstitution syndrome.

274 ion and treatment of Cryptococcus-associated immune reconstitution syndrome.

275 ion and treatment of tuberculosis-associated immune reconstitution syndrome.

276 ntuberculous mycobacteria, old PTB scar, and immune reconstitution syndrome.

277 atients fulfilling criteria for tuberculosis immune reconstitution syndrome; liver biopsy remains a u

278 New so-called immune reconstitution therapies (IRTs) have the potentia

279 , once considered fatal, is now managed with immune reconstitution therapy; however, surviving patien

280 The goal of this study was to understand how immune reconstitution through antiretroviral therapy (AR

281 blishing a molecular diagnosis enables early immune reconstitution through prompt therapeutic interve

282 affected infants through their diagnosis and immune reconstitution was 87% (45/52), 92% (45/49) for i

283 This poor immune reconstitution was characterised by a low influen

284 The pattern of immune reconstitution was characterized by heterogeneous

285 Immune reconstitution was comparable in both groups, how

286 Immune reconstitution was demonstrated by normalization

287 Enhanced functional immune reconstitution was demonstrated in CD62L(-) T-cel

288 Immune reconstitution was monitored through flow cytomet

289 T-cell immune reconstitution was robust among CB transplants, a

290 To elucidate mechanisms involved in immune reconstitution, we studied immune activation, imm

291 xicity, activity and the impact of rhIL-7 on immune reconstitution were monitored.

292 ufficiently diverse TCR repertoire to permit immune reconstitution with antiretroviral therapy alone,

293 both of which deplete naive T cells to limit immune reconstitution with antiretroviral treatment.

294 idal amphotericin-based regimens, and prompt immune reconstitution with ART are priorities for improv

295 Despite immune reconstitution with combination antiretroviral th

296 -infected children against measles following immune reconstitution with combination antiretroviral th

297 apidly converted, and there was preferential immune reconstitution with donor CD4(+) Th2 and Th1 cell

298 rst-line treatment regimens results in rapid immune reconstitution with residual low-level microbial

299 Despite the immune-reconstitution with antiretroviral therapy (ART),

300 establish a strategy for augmenting GVL and immune reconstitution without elaborate T-cell manipulat