ライフサイエンスコーパス: immune regulation

1 ation, smooth muscle cell proliferation, and immune regulation.

2 g light on unappreciated mechanisms of neuro-immune regulation.

3 genetic diseases that reveal new concepts of immune regulation.

4 pies for MS patients that promote heightened immune regulation.

5 ed, which participates in several aspects of immune regulation.

6 s a cell surface death receptor critical for immune regulation.

7 ed for the gas exchange and is important for immune regulation.

8 n immunity, ranging from pathogen killing to immune regulation.

9 infection, underscoring their importance in immune regulation.

10 is due to the absence of negative control by immune regulation.

11 ative contribution of these two cytokines in immune regulation.

12 ve on the discovery of DCs and their role in immune regulation.

13 1 and promote antibody-mediated immunity and immune regulation.

14 m for autoimmune progression and escape from immune regulation.

15 ) have been recognized as central players in immune regulation.

16 IL-18 axis is critical to H. pylori-specific immune regulation.

17 ning targets downstream of mTOR that promote immune regulation.

18 n molecules (SLAMs) play an integral role in immune regulation.

19 inflammatory equilibrium critical to innate immune regulation.

20 tance of TDP-43-mediated InSAC biogenesis in immune regulation.

21 on, contributing to failure of Treg-mediated immune regulation.

22 lation may impact multiple players in innate immune regulation.

23 l barrier function, nutrient absorption, and immune regulation.

24 as butyrate, which affect DNA integrity and immune regulation.

25 mplicated in both apoptotic cell removal and immune regulation.

26 c oxide synthase (iNOS) produced by MDSCs in immune regulation.

27 t understanding of the functions of GATA3 in immune regulation.

28 was shifted toward immune activation versus immune regulation.

29 gly shown that the lungs are a major site of immune regulation.

30 on, and plays roles in tissue remodeling and immune regulation.

31 iR-155) one of the first to be implicated in immune regulation.

32 function activities reveal an active role in immune regulation.

33 heralded a major shift in T-cell biology and immune regulation.

34 ubjects them to prolonged states of negative immune regulation.

35 phasis on recent developments in the area of immune regulation.

36 helial barrier disruption and alterations in immune regulation.

37 and MMPs/TIMPs may be involved in the local immune regulation.

38 ritic cells (DCs) are important mediators in immune regulation.

39 as enhanced in the absence of IL-10-mediated immune regulation.

40 and intermittent diarrhea suggested impaired immune regulation.

41 indicating the significant role of Tregs in immune regulation.

42 , thus revealing a novel mechanism for local immune regulation.

43 to LC motility/migration and LC migration to immune regulation.

44 me with previously defined roles in adaptive immune regulation.

45 eptibility genes that control key aspects of immune regulation.

46 s an important role in bacterial killing and immune regulation.

47 ession may be attributable to dysfunction of immune regulation.

48 ouse bacterial load, suggesting some role in immune regulation.

49 as a mechanism of regulatory T cell-mediated immune regulation.

50 icating a potential role for this pathway in immune regulation.

51 by epithelial barrier disruption and altered immune regulation.

52 se that is also linked to both metabolic and immune regulation.

53 sis, tissue development, carcinogenesis, and immune regulation.

54 mmensal microbiota, the IL-23/Th17 axis, and immune regulation.

55 metabolic physiological processes, including immune regulation.

56 lays an important role in several aspects of immune regulation.

57 sm, play a significant role in hAEC-mediated immune regulation.

58 stone 3 lysine 27 (H3K27Me3) is critical for immune regulation.

59 agocytic receptor "colocalization" in innate immune regulation.

60 uction, metabolism, transport, signaling and immune regulation.

61 s is critical for diagnosing and deciphering immune regulation.

62 changes in islet autoimmunity, with signs of immune regulation.

63 rominent changes in outcomes associated with immune regulation.

64 due to its roles in neuronal development and immune regulation.

65 monstrating a mechanism for C5orf30-mediated immune regulation.

66 as helped to shape population differences in immune regulation.

67 derstanding of the gene networks involved in immune regulation.

68 calcium-dependent protein kinase (PKC), and immune regulation.

69 ast (OC) cell fusion, as well as DC-mediated immune regulation.

70 re responsible for various aspects of T-cell immune regulation.

71 s therefore identified as a major new hub of immune regulation.

72 e expression, protection from apoptosis, and immune regulation.

73 in lipid metabolism, cellular signaling and immune regulation.

74 he beta-lactam hapten and/or an imbalance in immune regulation.

75 oxidase plays a key role in host defense and immune regulation.

76 es for high- and low-affinity iNKT clones in immune regulation.

77 function of B7-H3, B7x, HHLA2, and TMIGD2 in immune regulation.

78 e in axon guidance, vascular patterning, and immune regulation.

79 iology, host defense against infections, and immune regulation.

80 ing evidence supports a role for exosomes in immune regulation.

81 substantial barrier to the understanding of immune regulation.

82 y infection affects the long-term quality of immune regulation.

83 (androgen/AR) play significant roles in both immune regulations.

84 PTDM is associated with altered immune regulation after HSCT and could represent a targe

85 idermal growth factor receptor signaling and immune regulation, among others, also displayed associat

86 (MSCs) have been suggested to participate in immune regulation and airway repair/remodeling.

87 beta-galactoside-binding lectin involved in immune regulation and antimicrobial defense, is a target

88 is study was to better understand the innate immune regulation and associated IFN- and transforming g

89 of circRNAs and their emerging functions in immune regulation and autoimmune disorders, and discuss

90 ations for neurogenesis, dopamine signaling, immune regulation and behavior.

91 y cells provides an avenue for understanding immune regulation and biologic processes linked to intes

92 hat TLR9 and MyD88 play central roles in the immune regulation and development of protective immunity

93 o address the contributions of RRV vCD200 to immune regulation and disease in vivo, we generated a fo

94 Monocytes have been implicated in immune regulation and disease progression in patients wi

95 ing several cellular processes, most notably immune regulation and DNA repair, but also cellular prol

96 ature and provide examples of the nuances of immune regulation and dysregulation that can be targeted

97 L21R have revealed diverse roles of IL-21 in immune regulation and effector function.

98 ts with CD40L and plays an essential role in immune regulation and homeostasis.

99 dge could reveal novel mechanisms underlying immune regulation and identify new therapeutic approache

100 gest a role for STAT6 polymorphisms in early immune regulation and implications on early atopic disea

101 types and the mechanisms by which they drive immune regulation and inflammation remain unclear.

102 -lived Klrg1(+) suppressor cells to optimize immune regulation and maintain homeostasis of the Treg c

103 I3K/AKT/mTOR pathways, and genes involved in immune regulation and metabolism) for single nucleotide

104 The microbiome is increasingly implicated in immune regulation and mortality from sepsis.

105 ulatory factors (IRFs) have crucial roles in immune regulation and oncogenesis.

106 nes provide new reagents to study flavivirus immune regulation and pathogenesis.

107 Immune regulation and phagocytosis are mechanisms for CD

108 udy reveals a new mechanism for HSC-mediated immune regulation and potentially for other conditions,

109 cells may be a biomarker for fading regional immune regulation and progression to overt diabetes.

110 nd previously unknown mechanism of antitumor immune regulation and provide new insights into our unde

111 nd previously unknown mechanism of antitumor immune regulation and provide new insights into our unde

112 s unfolds previously unidentified details of immune regulation and provides new insight into homeosta

113 ed important insights into the mechanisms of immune regulation and served as a proof-of-concept for p

114 Understanding the pivotal role of RLRs in immune regulation and signaling crosstalk in antiviral i

115 ant roles for the matrix microenvironment in immune regulation and suggest unique strategies for immu

116 (HK) BF to prediabetic mice caused enhanced immune regulation and suppression of autoimmunity, resul

117 cated that microbiome composition influences immune regulation and that multiple health care factors

118 lammatory responses and participate in local immune regulation and the tissue remodeling/repair event

119 on and maturation, and a potential target of immune regulation and therapy.

120 acute or chronic inflammation to deficits in immune regulation and tissue repair.

121 ing system fulfilling important functions in immune regulation and tumor surveillance.

122 oding RNAs involved in telomere maintenance, immune regulation and tumour progression, providing deep

123 n and related genes lead to a loss of normal immune regulation and underlie hemophagocytic lymphohist

124 function of the oncogenic pathway in innate immune regulation and unexpectedly connect HER2-AKT1 sig

125 revealed a signature of active inflammation, immune regulation, and cell trafficking.

126 number of pathways, including inflammation, immune regulation, and cell-cycle control.

127 hich polymorphisms in the IL-2RA gene affect immune regulation, and consequently upon susceptibility

128 vation in vasculogenesis during development, immune regulation, and endothelial/epithelial-mesenchyma

129 These nucleases are involved in DNA repair, immune regulation, and have been associated with various

130 idate their role in innate immune responses, immune regulation, and inflammatory diseases.

131 plicate loci involved in cancer development, immune regulation, and keratinocyte differentiation in S

132 anisms involving FSTL-1 in lung homeostasis, immune regulation, and NF-kappaB signaling may provide a

133 , likely reflecting tradeoffs in metabolism, immune regulation, and other functions of mitochondria.

134 tor 2 (FPR2) play key roles in host defense, immune regulation, and resolution of inflammation.

135 size that this is a physiological process in immune regulation, and that it occurs within lymph nodes

136 -derived AAM have properties associated with immune regulation, and the different physiological prope

137 unctions such as host-pathogen interactions, immune regulation, and tumor evasion.

138 cells) are innate-like T cells important in immune regulation, antimicrobial protection, and anti-tu

139 Age-related changes in immune regulation are likely to account for the age-asso

140 ptor colocalization and the role it plays in immune regulation are unclear, due to the inaccessibilit

141 to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout

142 Review will focus on the different modes of immune regulation, both direct and indirect, by EVs.

143 only point to a fundamental role for GBA in immune regulation but also suggest that GBA mutations in

144 coprotein folding, cellular homeostasis, and immune regulation but are involved in multiple disease c

145 s and their ligands play a prominent role in immune regulation but many have also been implicated in

146 any seminal insights about the mechanisms of immune regulation, but their relevance to humans has bee

147 iNKT cells play important roles in immune regulation by bridging the innate and acquired im

148 Immune regulation by CD4+CD25+FoxP3+ regulatory T-cells

149 In this study, mechanisms of immune regulation by MAT vaccines in vitro and in allerg

150 (HSCs) may play an important role in hepatic immune regulation by producing numerous cytokines/chemok

151 shing DNA damage as a downstream mediator of immune regulation by reactive oxygen species.

152 targeting Stat3 that may underlie selective immune regulation by the AAR.

153 which suggests a role for CD8(+) T cells in immune regulation by the ICOS-B7h pathway.

154 munologists and dermatologists to understand immune regulation by UV radiation affected immunology in

155 her necessary for induction of this systemic immune regulation by UVB radiation, because ablation of

156 primary site where T and B cell priming and immune regulation can occur, but also introduces the mou

157 Mendelian analysis of disorders of immune regulation can provide insight into molecular pat

158 osis (FHL) is a life-threatening disorder of immune regulation caused by defects in lymphocyte cytoto

159 histiocytosis (HLH) is an inborn disorder of immune regulation caused by mutations affecting perforin

160 Diet also impacted immune regulation, cell cycle control/gene expression, c

161 support for the concept that alterations in immune regulation contribute to idiosyncratic DILI.

162 This new method of peripheral immune regulation could potentially contribute to develo

163 infection, environmental toxins, or impaired immune regulation, create a microenvironment that foster

164 cycle progression, glycogen metabolism, and immune regulation; deregulation is associated with disea

165 revealed a complex mechanism of Ag-specific immune regulation driven by CT25, in which both Tregs an

166 e that STIM1 is required for T cell-mediated immune regulation during chronic Mtb infection.

167 ook at the interplay of lipid metabolism and immune regulation during host infection.

168 ittle is known about how Tregs contribute to immune regulation during memory responses to previously

169 Hippo signaling plays a key role in adaptive immune regulation during the post-MI recovery phase.

170 i et al. (2013) expose a unique mechanism of immune regulation during viral infection, which is media

171 l and mechanistic studies of SAMHD1-mediated immune regulation during viral infections.

172 resentation (e.g., CD83, CD86 and CD209) and immune regulation (e.g., CD101) on circulating APCs.

173 To understand the mechanisms of immune regulation employed by the host to control this i

174 arks of PDA including the fibrotic reaction, immune regulation, energy metabolism and is a novel ther

175 Because PI3K/AKT signaling is critical for immune regulation, Ezrin-deficient MPhis are hyperinflam

176 However, immune regulation fails to control the underlying tissue

177 thogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtype

178 inflammatory diseases, yet no direct link to immune regulation had been shown.

179 -derived macrophages, suggesting that global immune regulation has a significant impact on nanopartic

180 The role of prostaglandin E2 in immune regulation has been better defined.

181 ritical role of suppressive myeloid cells in immune regulation has come to the forefront in cancer re

182 physiological mechanism of perforin-mediated immune regulation has never been demonstrated in a disea

183 The biological relevance of this feature in immune regulation has not been evaluated.

184 ype 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of m

185 pproaches using nanoparticles engineered for immune regulation have yielded promising results in prec

186 E3 ubiquitin ligase, Roquin, is involved in immune regulation; however, its role in immunity to M. t

187 onjugation system plays an important role in immune regulation; however, the ubiquitin-specific prote

188 expression profiles that highlight cues for immune regulation in a major pest.

189 ents on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune disease

190 tial progress in understanding mechanisms of immune regulation in allergy, asthma, autoimmune disease

191 layed type hypersensitivity assay to measure immune regulation in both the recipient antidonor and do

192 ne bound receptor (CD40) that is critical to immune regulation in colon biopsies collected from monke

193 We examined TIGIT-mediated immune regulation in different murine cancer models and

194 mechanisms of inflammatory infiltration and immune regulation in DMD.

195 derscore the roles of HCV proteins in innate immune regulation in establishing a chronic infection.

196 has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many di

197 mechanisms of immune activation or negative immune regulation in human skin.

198 rovides a model to investigate mechanisms of immune regulation in humans, given that the disease form

199 f the current understanding of signaling and immune regulation in melanoma and implications for respo

200 Mechanistic insights into gene and immune regulation in melanoma have led to the developmen

201 We also emphasize how defining the immune regulation in metabolic tissues has broadened the

202 odulation of IL-2 receptor restores impaired immune regulation in MS by increasing the proportion of

203 Defective NK-mediated immune regulation in MS is mainly attributable to a CD4(

204 T(reg) cells as the underlying mechanism of immune regulation in MSC-mediated allograft survival.

205 This apparent loss of immune regulation in obese adipose tissue contributes to

206 e known mechanisms that underlie the loss of immune regulation in obesity-associated adipose tissue i

207 relationship between small RNA pathways and immune regulation in other organisms.

208 receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma an

209 -cell compartment as an additional defect in immune regulation in patients with chronic ITP that may

210 ection to investigate different scenarios of immune regulation in rabbits infected with one or two he

211 urther investigate the role of granzyme B in immune regulation in response to viral infections, we ch

212 To assess the immune regulation in subTCMR grafts, gene expression of

213 new mechanism of alpha4 nAChR signaling and immune regulation in T cells, possibly accounting for th

214 ght have therapeutic potential for promoting immune regulation in the context of autoimmune disease.

215 une activation, we studied perforin-mediated immune regulation in the context of mixed chimerism usin

216 of cytotoxic immune dysfunction and aberrant immune regulation in the COPD lung that may explain both

217 ings identify a pathway of estrogen-mediated immune regulation in the intestine, whereby homeostatic

218 e production of IL-2 by ILC3s to orchestrate immune regulation in the intestine.

219 The precise mechanism of hydrocortisone immune regulation in the management of colitis is poorly

220 r the role of neuroinflammation and aberrant immune regulation in the pathophysiology of AD.

221 f local Treg cell populations, also to local immune regulation in the skin.

222 Thus, immune regulation in the tumor landscape may often be dr

223 a deeper understanding of the complexity of immune regulation in the tumor microenvironment, has pro

224 to target RMC in situ to promote Ag-specific immune regulation in transplantation and to usher in a n

225 mic relationship between innate and adaptive immune regulation in tumours and support further investi

226 herapeutic targets that could restore proper immune regulation in type 1 diabetes by augmenting the I

227 e the same phenotype, confirming its role in immune regulation in vitro.

228 These data reveal a mechanism of immune regulation in which CTLA-4 acts as an effector mo

229 cognition is innate and linked to a profound immune regulation (innate apoptotic immunity [IAI]) invo

230 Immune regulation is a finely balanced process of positi

231 these results indicate that B cell-mediated immune regulation is best characterized by the cytokine

232 The impact of LAP to immune regulation is best characterized in professional

233 Immune regulation is critical for the maintenance of per

234 a variety of lymphoid cells, and its role in immune regulation is just beginning to be elucidated.

235 on of the complexity of post-transcriptional immune regulation is needed.

236 , the role of TNFRp75-dependent signaling in immune regulation is poorly defined.

237 however, their role in local versus systemic immune regulation is unknown.

238 lectively, our results show that CpG-induced immune regulation leads to a dampening of the host immun

239 This defect in immune regulation led to a nonspecific upregulation of e

240 These studies have revealed a new immune regulation loop consisting of T cell-derived IFN-

241 ental data in relation to the role of LAIR-1 immune regulation may be overestimated when applied to a

242 We propose that immune regulation may prolong pneumococcal colonization

243 ts correlates with carcinogen resistance and immune regulation mediated by tumour-associated immune c

244 e intersection of two key pathways of innate immune regulation, NLR and STING, to fine tune host resp

245 OR) signaling pathway has been implicated in immune regulation, not only by suppressing T cell respon

246 se needs to be proinflammatory; and finally, immune regulation of autoreactive responses must fail.

247 As TLR2 has been implicated in immune regulation of helminth infections and as alternat

248 istic evidence supporting its role in innate immune regulation of islet-directed autoimmunity.

249 ed it as a powerful system to study adaptive immune regulation of organogenesis.

250 g metastatic spread, including evidence that immune regulation of primary tumors may be distinct from

251 These data demonstrate that the immune regulation of SerpinB2 expression plays a critica

252 schaemia; however, their contribution to the immune regulation of Th2-skewed allergic rhinitis (AR) a

253 nuclear cell subsets in parasite control and immune regulation of the CNS.

254 y intake, energy utilization, and storage to immune regulation of tissue function and is therefore es

255 ated with stemness has implications for both immune regulation of tumor growth as well as regenerativ

256 TGF-beta1 is a master cytokine in immune regulation, orchestrating both pro- and anti-infl

257 /beta-catenin/Foxo1 signaling in TLR4 innate immune regulation, our study provides a rationale for th

258 pecific CD8 T cell activation, but efficient immune regulation, partially mediated by IL-10R-signalin

259 rombin-PAR-1 signaling significantly altered immune regulation pathways.

260 Defective immune regulation plays a permissive role enabling effec

261 or HC, suggests a possible role of HLA-G in immune regulation possibly mediated by enhanced host Tre

262 Transplacental immune regulation refers to the concept that during preg

263 mitochondrion-dependent cell death of DCs in immune regulation remain to be elucidated.

264 rin in the maintenance of DC homeostasis for immune regulation remains to be determined.

265 The in vivo role of JKAP in immune regulation remains unclear.

266 T cells assist in viral clearance, but immune regulation serves to limit these responses and to

267 onses, and nearly all the miRNAs involved in immune regulation show modulation during aging.

268 number of these genes are in interferon and immune regulation signaling networks, but surprisingly,

269 Immune regulation status may indicate immunological remi

270 s related to airway epithelial integrity and immune regulation, such as FBXL7, NTRK1, and SLC9A3.

271 On the other hand, miRNAs are involved in immune regulation, such as regulatory T (Treg) cell diff

272 -dimensional definition of the mechanisms of immune regulation that chronic viruses implement to expl

273 sion, we demonstrate a novel role for GP2 in immune regulation that could provide a platform for new

274 cancer immunotherapy, as well as settings of immune regulation that include autoimmunity and transpla

275 appaB activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiqui

276 y plays a critical role in the lung-specific immune regulation that prevents spontaneous inflammation

277 to elucidate the role of SlpA in protective immune regulation, the NCK2187 strain, which solely expr

278 Besides having implications for immune regulation, the results may explain how persisten

279 tory B cells (Bregs) play important roles in immune regulation, their surface phenotypes and function

280 on, differentiation, plastic adaptation, and immune regulation, thereby mediating tumorigenesis, meta

281 list of cell cycle proteins that impinge on immune regulation, these results support the value of ag

282 in intercellular communication pathways and immune regulation, they may impact the likelihood of HIV

283 y showing the importance of inflammation and immune regulation through the IL18-IL18RAP axis and anti

284 lysulfides as important signaling factors in immune regulation through the kynurenine pathway.

285 infection by secreting cytokines crucial for immune regulation, tissue homeostasis, and repair.

286 he maintenance of an organism's health, from immune regulation to fat metabolism.

287 controls multiple aspects of T cell-mediated immune regulation to limit injurious inflammation during

288 nessing these reciprocal mechanisms of sleep-immune regulation to mitigate the risk of inflammatory a

289 me B in the regulatory T cell compartment in immune regulation to viral infections.

290 selective role for opioids in CD8(+) T cell immune regulation via their ability to modulate cell res

291 transcripts for graft injury, tolerance, and immune regulation was analyzed in 77 biopsies with "no h

292 etic or CD8(+) T cell chimerism, above which immune regulation was reestablished.

293 Although first implicated in immune regulation, we propose that NLRX1 function extend

294 en T cells unresponsive to TGF-beta-mediated immune regulation were used as donor T lymphocytes.

295 merges as a factor with diverse functions in immune regulation, which are in some cases cell-type spe

296 disease at 1 year, and genes associated with immune regulation, which showed increased levels in pati

297 (T1D) is thought to be caused by a defective immune regulation with regulatory T (Treg) cells playing

298 e of infection depends on multiple layers of immune regulation, with innate immunity playing a decisi

299 t cellular proliferation, communication, and immune regulation within the cutaneous microenvironment.

300 tenance of antihypergesia can be achieved by immune regulation without actual engraftment of BMSCs.