ライフサイエンスコーパス: immune response(|s) (to|against)

1 knowledge particularly with regards to host immune response against A. invadans infection in a susce

2 chanistic insight and a paradigm into how an immune response to a respiratory virus, such as IAV, is

3 pulmonary EGPA immune response resembles the immune response to a tissue-invasive parasite infection.

4 lization breadth involves vaccine priming of immune responses against a target site of vulnerability,

5 etic variation may help to explain different immune responses to a virus across a population.

6 nous Myd88 can effectively modulate the host immune response against AAV-mediated gene therapy and in

7 Our results suggest that the innate immune response to an obligate cytosolic bacterial patho

8 Tet2 loss also attenuates transcriptional immune responses to an inflammatory trigger.

9 We sought to assess in vivo immune responses to an innate stimulus and compare respo

10 uction of the earliest aspects of the innate immune response to Aspergillus fumigatus.

11 cells (DCs) play a central role in the early immune response against B. burgdorferi We investigated t

12 this study that DCs respond to and mount an immune response against B. miyamotoi that is similar to

13 Dysregulation of the immune response to bacterial infection can lead to sepsi

14 Lyz1-deficiency diminished intestinal immune responses to bacterial molecular patterns and res

15 ly hard-wiring the first steps of an induced immune response to become constitutive.

16 ll types that are involved in mounting rapid immune responses against blood-borne pathogens, includin

17 administered to mice and generated a humoral immune response against both peptide antigen, and the pa

18 sculature can be manipulated to mount better immune responses against brain tumours.

19 The initial degree of the host immune response to C difficile and its pathogenic toxins

20 ith the development of a protective Th1/Th17 immune response to C. immitis at the site of infection.

21 study by Bruno et al. delineates innate host immune responses against C. auris and identifies critica

22 ll molecule kinase inhibitor to modulate the immune response against cancer.

23 ements of the diverse cells that comprise an immune response to cancer offers an opportunity to selec

24 K) cells are important effector cells in the immune response to cancer.

25 IL-17D can promote immune responses to cancer and viruses in part by induci

26 h might contribute to an exaggerated vaginal immune response to Candida hyphae.

27 refines the understanding of the integrated immune response to Cb vaccine and challenge, which can i

28 ch stronger predictors of melanoma patients' immune response to checkpoint inhibitors than the tumors

29 pathoadaptation that dampens the host innate immune response to Chlamydia infection.

30 ires more comprehensive understanding of the immune response to chronic allogeneic stimulation.

31 Antigen (Ag)-specific immune responses to chronic infections, such as herpes s

32 , and ways to therapeutically manipulate the immune response to combat disease were, in large part, d

33 unotherapies and vaccines to engage the host immune response to combat these antibiotic-resistant str

34 Our work suggests that immune responses to common coinfections, such as herpesv

35 m a positive feedback loop to amplify innate immune responses to control viral infections by activati

36 Also, the role of innate immune response to coronavirus infection and the related

37 cs (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinica

38 Single-cell analysis sheds light on immune response to COVID-19 infection, enables the rapid

39 There is paucity of evidence assessing immune responses to COVID-19 in severe asthmatics treate

40 Host immune responses to CoVs are complex and regulated in pa

41 t that diet and microbiota influence mucosal immune responses to CT vaccination and identify a candid

42 t only necroptotic CT26 cells would mount an immune response against CT26-specific neoepitopes.

43 Immune responses to current vaccines focus on the haemag

44 STING) protein-a key regulator of the innate immune response to cytosolic DNA.

45 (cGAMP) synthase (cGAS) triggers host innate immune responses against cytosolic double-stranded (ds)D

46 To induce a reproducible, strong immune response against difficult pathogens, sophisticat

47 members, suggesting an adaptive host social immune response to diminish transmission.

48 owever, how bacterial diversity orchestrates immune responses to direct distinct TB severities is unk

49 is providing unprecedented insights into the immune response to disease and into the development of i

50 the subsequent contribution of dysfunctional immune responses to disease progression.

51 i.e., how the host's diet improves the host immune response to drive down the parasite population an

52 alter Mtb physiology and differences in the immune response to drug-resistant Mtb provides significa

53 ive was to test whether goat's mammary gland immune response to E. coli lipopolysaccharide (LPS) coul

54 to broaden and potentially extend protective immune responses against Ebola viruses.

55 inding, neutralizing antibodies and cellular immune responses to Ebolavirus (EBOV) glycoprotein.

56 EVD outbreak in Liberia and evaluated their immune responses to EBOV.

57 Methods of augmenting the immune response to EBV in low-grade LYG include treatmen

58 y of urogenital schistosomiasis is caused by immune responses to eggs deposited in the bladder wall.

59 ght for strategies aimed at manipulating the immune response to enhance therapeutic efficacy in TNBC.

60 The orchestration of host immune responses to enteric bacterial pathogens is a com

61 ibody glycosylation plays a critical role in immune responses to enveloped viruses, including COVID-1

62 way disease driven predominantly by a T(H) 2 immune response to environmental allergens.

63 tes neurodevelopment, synaptic function, and immune response to environmental stimuli.

64 n receptors that enhance the skin's adaptive immune response to epicutaneous antigens.

65 owever, given that HSV-1 can overcome innate immune responses to establish lifelong latency throughou

66 ally uses fatty acids associated with innate immune response to esterify cholesterol, weakening the p

67 in the small intestine sense and direct the immune response against eukaryotic parasites.

68 he actions of its oncogenes, HPV evades host immune responses to facilitate its productive life cycle

69 is surprising finding of an inflammation and immune response to FL not only holds for direct light re

70 is an essential component of the protective immune response to flavivirus infection.

71 the intestine coordinates physiological and immune responses to food consumption to optimize nutrien

72 to explain alternate B cell recruitment into immune response to foreign antigens vs. induction of tol

73 ripherally induced regulatory T cells during immune responses against foreign antigen.

74 s cerevisiae antibodies (ASCA) as a systemic immune response to fungal products or fungi.

75 ase inhibitor abrogated refractory B-1b cell immune responses against Gal-glycan Ags.

76 induced a remarkable increase of functional immune responses against GBS compared to the simple co-a

77 All infected subjects developed strong immune responses to GI.1 with a 30-fold (geometric mean

78 can be manipulated with VEGF-C to promote an immune response to glioblastoma.

79 Here, we investigate how excessive innate immune responses to H5N1 impair subsequent adaptive T ce

80 We describe host immune response to hCoV infections derived from studies

81 r knowledge about virus replication and host immune responses to hCoV infection in young and aged ind

82 es self-peptides as foreign and activates an immune response against healthy cells.

83 4(+) T cells is the hallmark of a protective immune response against hepatitis C virus (HCV), associa

84 n of a heroin hapten and its impact upon the immune response against heroin and its psychoactive meta

85 Pre-existing humoral immunity can impact immune responses to heterologous infections.

86 required FcRn to induce innate and adaptive immune responses to hIgG1 ICs, which were augmented in t

87 c insights into the differential host innate immune responses to highly pathogenic arenavirus infecti

88 cal first step in understanding the earliest immune response to HIV-1 and suggest that changes in blo

89 d MHC-I down-regulation restore the adaptive immune response to HIV-infected cells in vitro and have

90 at elicit strong and long-lasting protective immune responses against HIV-1 infection.

91 Immunometabolism also shapes immune responses against HIV-1, and cell metabolic produ

92 T cell receptor signaling in the context of immune responses to HIV-1 infection.

93 ignificantly contribute to the host adaptive immune response to HSV-1 challenge following vaccination

94 adjuvant Nano-11 significantly enhanced the immune response to ID-injected vaccines in mice and pigs

95 mmunotherapeutic target to improve antitumor immune responses to immune checkpoint therapy in gliobla

96 The protective immune response against inactive TcdB involves developme

97 ost environment occur over the course of the immune response to infection and can result in exposure

98 lexes that play key roles in the host innate immune response to infection and sterile insults.

99 en the temperature trajectories and the host immune response to infection could allow us to immunophe

100 could provide a means of studying the human immune response to infection in the human skin.

101 an underutilized opportunity to moderate the immune response to infection to promote an improved outc

102 out the nature and durability of the humoral immune response to infection with severe acute respirato

103 oreign or damaged DNA to activate the innate immune response to infection, inflammatory diseases, and

104 viral factors known to limit the host innate immune response to infection.

105 programmed cell death pathways as an innate immune response to infection.

106 e: Sepsis is characterized by a dysregulated immune response to infection.

107 coccus aureus (MRSA) and bolsters the innate immune response to infection.

108 s that cholesterol metabolism impacts innate immune responses against infection.

109 Innovative insights into the immune responses to infection by Bordetella resulted in

110 h regulate physiological processes including immune responses to infection, and there is an emerging

111 of ZIKV infection and the subsequent mucosal immune responses to infection, and we demonstrate the pr

112 While our examples focus on immune responses to infection, the overall ideas and des

113 its complete deletion results in more potent immune responses to infection.

114 the diseases they cause and underlying host immune responses to infection.

115 ell-matrix interactions can drive the innate immune responses to infection; however, the molecular un

116 ctor that plays a key role in regulating the immune response to infections.

117 ptors (TCR) plays a key role in the adaptive immune response to infections.

118 Metabolic fitness of T cells is crucial for immune responses against infections and tumorigenesis.

119 ed that this enzyme can substantially impact immune responses to infectious agents and their products

120 fail to make a universally protective memory immune response to influenza A.

121 enza infection, which has lasting impacts on immune responses to influenza and protection against new

122 Humoral immune responses to influenza virus vaccines in elderly

123 sensing plays a critical role in shaping the immune response to intestinal antigens by promoting a to

124 Chloroquine can impair the immune responses to intradermal rabies vaccination.

125 while preserving its ability to mount robust immune responses to invading pathogens.

126 accine-based approach, to enhance the body's immune response against invasive candida infections.

127 ols to understand and monitor its spread and immune responses to it.

128 eed, and it requires an antigen that elicits immune responses to key conserved epitopes.

129 test the ability of each to regulate various immune responses to live Mycoplasma pneumoniae in SP-A k

130 The skin microbiota interacts with the host immune response to maintain the homeostasis.

131 a challenge to our understanding of the host immune response against malaria.

132 However, the infant immune response to malaria may be influenced by events t

133 Our understanding of the human immune response to malaria remains incomplete.

134 sights into the biologic basis of the global immune response to maximize potential therapeutic benefi

135 AhR is important for modulation of the host immune response to MHV and plays a role in the expressio

136 sensing cytosolic DNA and initiating innate immune responses against microbial infection and tumors.

137 d invariant T (MAIT) cells are important for immune responses against microbial infections.

138 considered to represent mal-directed type 2 immune responses against mostly innocuous exogenous comp

139 lonotypes not previously associated with the immune response to Mtb and demonstrates the power of hig

140 The proinflammatory immune response to Mtb infection in untreated guinea pig

141 tolerance against these Ags while initiating immune responses against mucosal pathogens.

142 , play an important role in the early innate immune response to Mycobacterium tuberculosis infection

143 host-directed therapies aimed at optimizing immune responses to Mycobacterium tuberculosis (Mtb), as

144 Vitamin D metabolites support innate immune responses to Mycobacterium tuberculosis.

145 nto the spinal cord and completely abrogates immune responses to myelin antigen in the spleen.

146 in both the inflammatory and the reparatory immune responses to myocardial infarction.

147 We compared mouse innate immune responses to N. caninum and T. gondii and found m

148 otective and are broadly cross-reactive, the immune response to NA during infection is poorly underst

149 The primary humoral immune response to natural infection is neutralizing ant

150 Little is known about cell-mediated immune responses to natural influenza infection in solid

151 Limitations in immune responses to natural T. cruzi infection usually r

152 Understanding the immune response to neurotrauma is an urgent priority, ye

153 unity can be informed by previous studies of immune responses to non-human coronaviruses, common cold

154 We analyzed humoral immune responses to nonhuman leukocyte antigen (HLA) aft

155 To study the mucosal and systemic immune response against norovirus, 43 long-term care fac

156 Most information on mucosal and systemic immune response to norovirus infection is derived from h

157 However, few data are available on immune responses to norovirus in the elderly.

158 immunodominance plays a role in the humoral immune response to NoV infections.

159 ient sera to facilitate investigation of the immune response to NoV.IMPORTANCE NoV infections are a l

160 cobacter pylori gastric infection influences immune responses to oral enteric vaccines.

161 from 2 different trials, the lack of data on immune responses to other non-vaccine-matched antigens,

162 ulting from the inappropriate development of immune responses to otherwise innocuous aeroallergens an

163 nces of dysregulated PAD enzyme activity and immune responses against PAD enzymes will be important t

164 has been extensively studied as a model for immune responses to parasites.

165 OS) is critical for successful activation of immune responses against pathogen infection.

166 vaccine elicits strong humoral and cellular immune responses against pathogenic Ebola viruses and su

167 ll death mechanism that underpins the innate immune response against pathogens and is dysregulated in

168 sms and serve as key receptors in the innate immune response to pathogens.

169 ginine is an important modulator of the host immune response to pathogens.

170 an homeostasis, repair following injury, and immune response to pathogens.

171 a prerequisite for the induction of adaptive immune responses against pathogens and cancer.

172 tegies for depleting i35-Bregs that suppress immune responses against pathogens and tumor cells.

173 he initial step for the activation of innate immune responses against pathogens in the airways.

174 e important effectors of innate and adaptive immune responses to pathogens and NK cell function is al

175 ncert with IL-10 are essential for balancing immune responses to pathogens and suppressing inflammati

176 T cells are critical for protective immune responses to pathogens and tumors.

177 rtoire across humans, ultimately influencing immune responses to pathogens and vaccines.

178 elper (T(FH)) cells are critical in adaptive immune responses to pathogens and vaccines; however, wha

179 including monocytes, play a crucial role in immune responses to pathogens.

180 innate immune proteins known to generate an immune response to PG.

181 Immune responses against polyethylene glycol (PEG) can l

182 production and how IFN-gamma enhances local immune responses to prevent Bp-mediated disease.

183 We find that variations in the immune response to primary SARS-CoV-2 infections and a p

184 Eliciting immune responses against primary tumours is hampered by

185 gastric cancer derived exosomes modulate the immune response to promote lung tumor metastasis.

186 pment of diagnostics and removal of unwanted immune responses against protein therapeutics.

187 Since the potential of HIV-specific immune responses to provide protection against HIV is a

188 terial infection and NF-kappaB-driven innate immune responses to R-loop-dependent replication stress

189 s have revealed that TLR7 is involved in the immune response to RABV.

190 hronic disease, based on a persistent type 2 immune response to respiratory infection with a natural

191 heterologous prime-boost strategy.IMPORTANCE Immune responses to RSV in infants can be reduced due to

192 uman neutrophils are critical for the innate immune response to S. aureus infection.

193 ble TRIM21 as a negative regulator of innate immune responses to S Typhimurium and a previously unrec

194 e role played by gammadelta T cells in human immune responses to S. aureus is almost entirely unknown

195 sand fly bites develop humoral and cellular immune responses to sand fly salivary proteins.

196 ely characterized at baseline for endogenous immune response against SARS-CoV-2 (serum antibody-posit

197 Thus, understanding the immune response to SARS-CoV-2 is of the utmost importanc

198 failed to properly convey likelihoods of the immune response to SARS-CoV-2 to the public and the medi

199 A better understanding of the immune response to SARS-CoV-2 will be critical for the a

200 ese data indicate that children can mount an immune response to SARS-CoV-2 without virological confir

201 on what we do and do not know regarding our immune response to SARS-CoV-2, and provide a number of s

202 ective efficacy and duration of the adaptive immune response to SARS-CoV-2, as well as its interactio

203 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing

204 Although studies analyzing humoral immune responses against SARS-CoV-2 were available rathe

205 lls in cancer patients for studying cellular immune responses against SARS-CoV-2.

206 s for clinical use, and provide insight into immune responses against SARS-CoV-2.

207 e, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of dis

208 d Ab responses, and describes tools to study immune responses to SARS-CoV-2 infection and vaccination

209 stochemical analyses, we delineated cellular immune responses to SARS-CoV-2 infection in macaque and

210 f CD4(+) T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown

211 However, the understanding of immune responses to SARS-CoV-2 is still limited, and it

212 esting close connections between ineffective immune responses to SARS-CoV-2, severe pneumonia and lif

213 echanisms of viral pathogenesis and the host immune responses to SARS-CoV-2.

214 nnection between aging and impaired adaptive immune responses to SARS-CoV-2.

215 nformation is available about the targets of immune responses to SARS-CoV-2.

216 eckpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the developme

217 erve as early rapid responders in the innate immune response to self-derived autoantigens and pathoge

218 t is attributed as a sign of the body's host immune response to sepsis.

219 COVID-19) requires understanding the natural immune response to severe acute respiratory syndrome cor

220 An unbridled host immune response to severe acute respiratory syndrome cor

221 y, we provide a cell atlas of the peripheral immune response to severe COVID-19.

222 However, whether immune responses against severe acute respiratory syndro

223 Characterization of virus-specific immune responses to severe acute respiratory coronavirus

224 Understanding immune responses to severe acute respiratory syndrome co

225 icated that heat stress affected the mammary immune response to simulated infection, which could make

226 ) as markers of gastric inflammation and the immune response to single-dose live oral cholera vaccine

227 strains, we ask whether CPSs can modify the immune responses to specific bacterial Ags.

228 We discovered that the adaptive immune response against Staphylococcus aureus (SA) skin

229 1 cells play a role in the protective innate immune response against symptomatic ocular herpes.IMPORT

230 n schizophrenia (DISC1), is involved in host immune responses against T. gondii infection.

231 at the injection site, and leads to a potent immune response against the antigen.

232 cells is central to the understanding of the immune response against the parasite and its implication

233 facilitate our understanding of the complex immune response to the highly dynamic malaria parasite.

234 infections and can influence the downstream immune response to the host's benefit or detriment.

235 diseases that can associate with an altered immune response to the infecting virus.

236 lications caused by the pathogen or the host immune response to the invading microbe.

237 d model, we investigated whether there is an immune response to the lens following cornea injury invo

238 as a virulence factor alternating the host's immune response to the parasite.

239 Eye disease is the result of a prolonged immune response to the replicating virus.

240 tentially modulating the innate and adaptive immune response to the SARS-CoV-2 virus or to a related

241 hes to optimize both the innate and adaptive immune response to the tumor.

242 t for RABV requires understanding the innate immune response to the virus because early virus clearan

243 n regulating coronavirus replication and the immune response to the virus.

244 volve as we gain increasing insight into our immune response to the virus.

245 ther with CNI abrogated refractory B-1b cell immune responses against the ABO-blood group Ags, while

246 similarities between the model and real-life immune responses to the 2009 vaccine.

247 ming immunization provides a method to focus immune responses to the desired target region, in the ab

248 To attempt to model human immune responses to the eOD-GT8 60mer, we tested each au

249 nd the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is

250 Many unknowns exist about human immune responses to the severe acute respiratory syndrom

251 the B cell compartment, and elicited strong immune responses to the SIV Gag antigen.

252 9) is currently a global pandemic, but human immune responses to the virus remain poorly understood.

253 acks by pathogens or herbivores and activate immune responses against them.

254 Immune response to therapeutic enzymes poses a detriment

255 s into the mechanism for the distinct innate immune response to these highly pathogenic arenaviruses

256 ebrain might similarly regulate inflammatory immune responses to these pathologies in the aging brain

257 hese pathogens are closely related, the host immune responses to these virus infections differ remark

258 How the immune response to this collateral damage influences bra

259 The immune response to this disease is thought to lead to an

260 genetic variabilities play in the individual immune response to this viral infection.

261 unogen and provides a basis for interpreting immune responses to this multivalent nanoparticle immuno

262 rophages play an essential role in the early immune response against Toxoplasma and are the cell type

263 rms for vaccine delivery that produce strong immune responses against Toxoplasma gondii in HLA superm

264 T-cell receptor clonotypes, T-cell function, immune responses to transgenes and autoantibodies, vecto

265 ed NK and memory phenotype T cells, enhanced immune responses against transplanted tumors, and augmen

266 s suggest that assessing the proinflammatory immune response to trauma exposure immediately after tra

267 herapy for GVHD will not affect alloreactive immune responses against tumor cells.

268 r masses, (ii) time, the temporal dynamic of immune response against tumors, and (iii) activity, the

269 gamma) pathway play an important role in the immune response to tumors.

270 ion therapy is capable of directing adaptive immune responses against tumors by stimulating the relea

271 ts of BCG and DTP-containing vaccines on the immune response to unrelated pathogens.

272 1V2 scaffold alters the hierarchy of humoral immune responses to V2 region epitopes, providing a meth

273 diately prior to vaccination may predict the immune response to vaccination.

274 ence of antigen presentation geometry on the immune response to vaccination.

275 y role for the gut microbiome in controlling immune responses to vaccination.

276 parameter, namely laser light, augments the immune response to vaccine and functions as an immunolog

277 earch is needed to understand how to monitor immune response to vaccines in immunosuppressed patients

278 d adults typically generate more efficacious immune responses to vaccines and infections than age-mat

279 ory function, CD40L has been used to enhance immune responses to vaccines, including candidate vaccin

280 T cells are central to the immune response against various pathogens and cancer cel

281 own to play a critical role in orchestrating immune responses to various pathogens through sensing cy

282 IFN-beta is a key component of the innate immune response to viral infection.

283 mportant and multifaceted role in the innate immune response to viral infection.

284 SAMHD1 suppresses innate immune responses to viral infection and inflammatory sti

285 e proteins that regulate innate and adaptive immune responses to viral infection by engaging with rec

286 ulating host intrinsic, innate, and adaptive immune responses to viral infections in the respiratory

287 ns, and how the viral genome influences host immune responses to viral infections.

288 tivating the TLR3 or TLR4 subtypes, to mimic immune responses to viral or bacterial infections, respe

289 e immune genes are useful tools for studying immune responses to viral or microbial pathogens.

290 tigen-specific humoral and cellular-mediated immune responses to virtually any infectious disease.

291 y proteins play integral roles in the innate immune response to virus infection.

292 on of multiple genes important in the innate immune response to viruses.

293 Killer (NK) cells have an important role in immune responses to viruses and tumours.

294 ion as adjuvants for the augmentation of the immune response to weak vaccines.

295 Analyses of the human immune response to ZIKV are lacking(21-28), but the rece

296 However, the long-term immune response to ZIKV following an outbreak remains po

297 nsively assess the acute innate and adaptive immune response to ZIKV infection in ten women who were

298 nancy results in altered innate and adaptive immune responses to ZIKV infection in the reproductive t

299 ut integrative function of pDCs in the human immune responses to ZIKV infection.

300 To characterize immune responses to ZIKV, here we examine transcriptiona