ライフサイエンスコーパス: immune system

1 sults, including other bacteria and the host immune system.

2 clude a dysregulation and dysfunction of the immune system.

3 nmental and host factors, including the host immune system.

4 f the full differentiative complexity of the immune system.

5 the chitin and beta-1,3-glucans to the host immune system.

6 ile domains, presents a moving target to the immune system.

7 ls and protects the bacteria from the innate immune system.

8 ger inflammatory processes and sensitise the immune system.

9 probably via cross talk with the developing immune system.

10 ical role of viral DNA sensing in the innate immune system.

11 cells are a critical component of the innate immune system.

12 or many forms of cancer and disorders of the immune system.

13 e adjuvant in addition stimulates the innate immune system.

14 n to enhance the exposure of E dimers to the immune system.

15 as fundamental recognition elements for the immune system.

16 ghout the body, including in the CNS and the immune system.

17 otoxin in conjunction with activation of the immune system.

18 able approach to study how a TME affects the immune system.

19 ctor BHLHE40 is an emerging regulator of the immune system.

20 with induction of autoimmunity in the human immune system.

21 ent of the intestinal microbiota and mucosal immune system.

22 al mechanisms to evade clearance by the host immune system.

23 cancer cell survival and the function of the immune system.

24 on in shaping the molecular evolution of the immune system.

25 ium and further perpetuated by a predisposed immune system.

26 tic susceptibility and interactions with the immune system.

27 gration of hemocytes generated by the innate immune system.

28 ith genotoxic stresses generated by the host immune system.

29 e strategies tumors employ to circumvent the immune system.

30 a feasible approach to bolster dairy calves' immune system.

31 ven in the conventionally memory-less innate immune system.

32 ture vaccines to optimally interact with the immune system.

33 pand antigens presented by beta cells to the immune system.

34 macronutrients and their metabolism with the immune system.

35 nvolve complex interactions with the mucosal immune system.

36 widely used to suppress inflammation or the immune system.

37 ions suggest altered responses of the innate immune system.

38 ocytes are important players of the adaptive immune system.

39 with class switch recombination (CSR) in the immune system.

40 valuable template for boosting the antitumor immune system.

41 mic interaction between tumour cells and the immune system.

42 hat target specific components of the innate immune system.

43 nfluence bacterial interaction with the host immune system.

44 se and may be rapidly eliminated by the host immune system.

45 tic approaches that target components of the immune system.

46 sential component of the innate and adaptive immune system.

47 en reservoirs of HIV-1 to elimination by the immune system.

48 gical applications and also by the mammalian immune system.

49 D) is a way of reengaging the tumor-specific immune system.

50 ilized by phages to suppress CRISPR-mediated immune systems.

51 by interacting with the innate and adaptive immune systems.

52 organs, including the nervous, skeletal, and immune systems.

53 iated molecular pattern recognized by innate immune systems.

54 mitochondrial metabolism in the nervous and immune systems.

55 study and characterize the hematopoietic and immune systems.

56 normal aerobic metabolism and by the innate immune systems.

57 ct of oil and hypoxia exposure on developing immune systems.

58 ins secreted by cells in innate and adaptive immune systems.

59 l as other types of bacterial and eukaryotic immune systems.

60 ation by pathogens, and train the developing immune system.(1)(,)(2) However, humans are unique among

61 ther(1), including marked changes within the immune system(2).

62 d comorbidities, with diseases affecting the immune system accounting for 26% of all cases.

63 ause unintended biological responses such as immune system activation and prolongation of the blood c

64 heart that may occur because of infections, immune system activation, or exposure to drugs.

65 as a self-renewing population that regulates immune system activation.

66 on the surface of cells, where they regulate immune system activation.

67 Regulatory T cells (T(reg) cells) restrict immune system activity, such as in response to self-anti

68 The innate immune system acts as the first line of defense against

69 y among vertebrates, knowledge of associated immune system adjustments is restricted to mammals.

70 we discuss potential mechanisms by which the immune system affects the central nervous system after s

71 te balance between the activity of the donor immune system against malignant and nonmalignant cells o

72 However, the role of sex in immune system aging is not well understood.

73 we describe a mechanism by which the innate immune system allows rapid quality check of absorbed flu

74 A prenatally stress-exposed immune system alone did not suffice to increase the seve

75 er by-products can be used to boost the fish immune system and also as drug delivery agents.

76 higher titer viral type suppresses the host-immune system and an increased virulence compared to the

77 Macrophages are part of the innate immune system and are present in every organ of the body

78 bolic branches of the enteroendocrine innate immune system and argue that this response may play a ro

79 Viruses potently activate the immune system and can damage beta cells by either direct

80 estore the balance between the brain and the immune system and can rewire their communication to modi

81 was to investigate the interplay between the immune system and circulating exosomes in metastatic bre

82 tural killer (NK) cells belong to the innate immune system and contribute to protecting the host thro

83 es of Lifestyle-Related Factors on the Human Immune System and Development of Allergies in Childhood

84 al insights into the biology of the adaptive immune system and empower diagnostics and therapeutics.

85 to play an important role in "educating" the immune system and facilitating competitive exclusion of

86 acute elevation of transcripts in the innate immune system and growth factor signaling.

87 severe COVID-19 infection due to a depressed immune system and high-risk underlying comorbidities, th

88 vated, how infection is sensed by the innate immune system and how intracellular signalling systems a

89 eckpoint inhibitors, an immature or impaired immune system and inhibitory tumor microenvironment can

90 is a key effector protein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes

91 ystems-level mapping of the developing human immune system and its emergent properties.

92 barrier that K. pneumoniae uses to avoid the immune system and last-resort antibiotics.

93 Emergence of an adaptive immune system and more complex neural systems presented

94 Further, an intact immune system and natural co-evolution of tumour and mic

95 can still be recognised by the host's innate immune system and persistent BDG antigenaemia, in the ab

96 on the majority of white blood cells of the immune system and play critical roles in immune cell sig

97 system is an intricate cascade of the innate immune system and plays a key role in microbial defense,

98 lysis highlighted the potential roles of the immune system and polycomb repressive complex 2 in patho

99 he increased visibility of beta-cells to the immune system and position the IRE1alpha/miR-17 pathway

100 n driving phenotype variation in the mucosal immune system and provide a strategy to robustly modify

101 Opioids modulate the immune system and suppress antiviral gene responses, whi

102 s, the inter-relationship between the innate immune system and the central nervous system (CNS) has m

103 uring their coevolution have shaped both the immune system and the countermeasures used by pathogens.

104 iple diseases, interactions between the host immune system and the gut microbiota are now attracting

105 eutrophils are important cells of the innate immune system and the major leukocyte subpopulation in b

106 IGNIFICANCE STATEMENT The interaction of the immune system and the nervous system is known to play an

107 the interplay between different arms of the immune system and the role of ectoparasites in the devel

108 cribe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunc

109 conserved during evolution of the vertebrate immune system and widely studied in contexts of infectio

110 mor, protecting cancer cells from the host's immune system and/or exogenous immunotherapies.

111 ng drug target for modulating the intestinal immune systems and regulating the inflammatory microenvi

112 nterplay between genetic susceptibility, the immune system, and commensal intestinal microbiota.

113 elf from several aspects of the human innate immune system, and control its iron homeostasis.

114 effects in xenobiotic metabolism, the innate immune system, and glutamate-associated proteins while s

115 h the human microbiota may be regulating the immune system, and how sudden changes in the composition

116 robiota can affect development of the brain, immune system, and lungs, as well as body growth.

117 al tissue-specific function to rpl10a in the immune system, and thus exemplify the advantages of the

118 natural environments and the presence of an immune system are difficult to simulate in vitro.

119 these results show that contributions of the immune system are integral for NMJ reinnervation and fun

120 quences of decreased parasite exposure on an immune system are not well understood.

121 ulation is the fact that the human brain and immune system are principally designed to keep the body

122 ta suggest that, in this context, CRISPR-Cas immune systems are maladaptive to the host, owing to the

123 f diet composition on wild adult birds whose immune systems are presumably fully developed and adapte

124 CRISPR-Cas adaptive immune systems are used by prokaryotes to defend against

125 However, they must face the immune system as a natural protection mechanism against

126 derived peptides that are recognized by the immune system as tumor-associated Ags.

127 IV-1 in >50% mice reconstituted with a human immune system, as demonstrated by the lack of viral rebo

128 dvances have made it possible to profile the immune system at high resolution, translating high-throu

129 ntibody titers and altered expression of the immune system, autophagy, and apoptosis pathway transcri

130 dest jawed vertebrates that have an adaptive immune system based on the MHC and Ig superfamily-based

131 These observations suggest that the immune system behaves differently in children than adult

132 Autoimmune diseases are a result of the immune system being misdirected toward its host and have

133 (PLC) is a cornerstone of the human adaptive immune system, being responsible for processing antigens

134 potential mechanism of escape from the host immune system by the expression of immunologically privi

135 he evolutionary trajectory of the vertebrate immune system, by comparing river with cave morphotypes.

136 Bacteria have evolved sophisticated adaptive immune systems, called CRISPR-Cas, that provide sequence

137 In sum, the peripheral immune system can be conceptualized as a dynamic, interc

138 lying conditions, and those with compromised immune systems can develop severe disseminated disease.

139 ich can become lysogenic), type I CRISPR-Cas immune systems cannot eliminate the phages from the bact

140 brain regions that may be relevant for brain-immune system communication, our goal being to introduce

141 understanding how almost every aspect of the immune system contributes to the expression of systemic

142 Together, the immune system critically acts as a rheostat that fine-tu

143 n LL-37 serves a critical role in the innate immune system defending bacterial infections.

144 causality and establish a role for systemic immune system-dependent factors and pro-inflammatory pro

145 stigate the impacts of multiple stressors on immune system development in early life stage fishes.

146 e in multiple aspects of immunity, including immune system development, regulation of innate and adap

147 The evolution of the immune system, diet, and the microbiome are interconnect

148 It is clear that the bat immune system differs when compared with other mammals,

149 containing glycans as ligands, they help the immune system distinguish between self and nonself.

150 Chronic activation of the innate immune system drives inflammation and contributes direct

151 a key role as a recognition molecule in the immune system, driving autocatalytic complement cascade

152 activation (MIA) disrupts the central innate immune system during a critical neurodevelopmental perio

153 sociation between activation of the maternal immune system during pregnancy and increased risk of neu

154 s what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest direc

155 tion is a commonly reported manifestation of immune system dysregulation during spaceflight.

156 ecule that variably affects all cells of the immune system either directly or after hydrolysis to ade

157 wastes, have proven their potential as plant immune-system elicitors.

158 e is known to be sensitive to changes in the immune system, especially during autoimmune diseases suc

159 confer adaptive advantages on the mammalian immune system, especially during coinfection and during

160 omain (MLD) of the EBOV GP may enhance virus immune system evasion.

161 s genomic signatures of host association and immune system evasion.

162 In this study, we investigated why the immune system fails to effectively control a modified fo

163 nal and internal signals can prime the plant immune system for a faster and/or stronger response to p

164 onally designed in order be delivered to the immune system for maximizing induction of dynamic immune

165 is, underscoring the importance of an intact immune system for parasite control.

166 effective because it uses the patient's own immune system for protection and potentially can be used

167 e impact of CNS-resident cells of the innate immune system for the development of neurodegenerative d

168 novel immunotherapies, which recalibrate the immune system for tumor recognition and destruction, hav

169 ndividuals with KS, but the role of KMT2D in immune system function has not been identified.

170 Leukocyte telomere length, a marker of immune system function, is sensitive to exposures such a

171 s including the heart, liver, kidney, lungs, immune system, gastro-intestinal system, skin as well as

172 ive dissonance is part of the "psychological immune system" (Gilbert 2006; Mandelbaum 2019) and funct

173 both the intestinal mucosa and the systemic immune system, given that these networks have a common i

174 How the planarian immune system has evolved to cope with these potential p

175 reakdown of the multiple strategies that the immune system has evolved to promote the separation betw

176 The immune system has long been recognised important in pain

177 Yet, the role of GABA in the immune system has remained elusive.

178 es, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool

179 ctivates the innate and adaptive arms of the immune system; however, the administration of IL-12 has

180 Humanized immune system immunodeficient mice have been extremely u

181 onstrating the possibility of harnessing the immune system in a well-controlled manner for the treatm

182 ion of neutrophils) imprints in the cellular immune system in addition to induction of specific antib

183 ssection of their interactions with the host immune system in allo-SCT and posttransplant complicatio

184 cts have shown that the dysregulation of the immune system in autoimmune diseases is associated with

185 Redirecting the immune system in cancer treatment has led to remarkable

186 nmental factors and their interplay with the immune system in disease pathogenesis.

187 t different clonal expansion of the adaptive immune system in distant regions of the same tumor.

188 Poly-N-acetyl-lactosamine is involved in the immune system in many ways.

189 ermal Langerhans cell components of the skin immune system in our porcine model of VCA tolerance, and

190 mmune cell repertoires and rebuild a healthy immune system in people with MS is variable.

191 g evidence suggesting the involvement of the immune system in regulating brain function, the specific

192 lows unprecedented profiling of the adaptive immune system in submucosal and mucosal isolated lymphoi

193 minent role of the cellular component of the immune system in the development and perpetuation of AF.

194 has become a central focus for engaging the immune system in the fight against cancer.

195 has highlighted the power of leveraging the immune system in the fight against cancer.

196 crosstalk between metabolic tissues and the immune system in the inception and progression of obesit

197 rom patients support a role for the adaptive immune system in the pathogenesis of IADRs.

198 onal excitability, synaptic function and the immune system in the pathogenesis of schizophrenia.

199 nding of the role of the innate and adaptive immune systems in the pathogenesis of heart failure, and

200 ation, progression, manifestation, and tumor-immune-system interactions in an animal model system.

201 The organizational integrity of the adaptive immune system is determined by functionally discrete sub

202 An individual's immune system is driven by both genetic and environmenta

203 As the immune system is inextricably linked to wound healing/re

204 However, how opioid impacts the immune system is still barely characterized systematical

205 etus to malaria antigens in utero, while the immune system is still developing.

206 sent in lymphoma have effector function, the immune system is unable to eradicate the malignant clone

207 st in utero and interact with the intestinal immune system is unknown.

208 The development of the zebrafish immune system is well understood, thereby use of larvae

209 or known how they contribute to wider AI and immune system issues.

210 ractions with the cells and molecules of the immune system just recently began to be extensively stud

211 nly occurs due to aberrant regulation of the immune system leading to abnormal proliferation of skin

212 is characterized by aberrant activity of the immune system, leading to variable clinical symptoms.

213 ts provide mechanistic insights into how the immune system may interact with the brain to affect MDD

214 sensing is a critical mechanism by which the immune system monitors for pathogen invasion.

215 ts associate an important part of the innate immune system, namely complement receptors, with the cen

216 o a decision-making problem in the mammalian immune system, namely effector choice among CD4+ T helpe

217 lexity and functional diversity of the human immune system necessitate the use of high-dimensional si

218 stablished role as a potent activator of the immune system, NKG2D-driven regulation of CD4+ T helper

219 The adaptive immune system of all jawed vertebrates relies on the pre

220 have highlighted how the naive, neonate-like immune system of specific pathogen-free mice differs dra

221 nmunoneuroendocrine interplay, impacting the immune system of the challenged individuals, and potenti

222 aherpesvirus infection.IMPORTANCE The innate immune system of the host is critical for the restrictio

223 d by molecular incompatibilities between the immune systems of pigs and humans as well as by the risk

224 can be poorly effective some years, and the immune systems of the most susceptible populations are o

225 The immune system operates at the scale of the whole organis

226 ions of viral molecules with the host innate immune system play a pivotal role in determining virus h

227 sue-specific genes for asthma shows that the immune system plays an essential function for asthma dev

228 The immune system plays critical roles in promoting tissue r

229 hese molecules into potential targets of the immune system, presumably triggering the production of a

230 CRISPR-Cas adaptive immune systems protect bacteria and archaea against thei

231 There is much interest in the role of innate immune system proteins (antimicrobial peptides) in the i

232 Type III CRISPR-Cas prokaryotic immune systems provide anti-viral and anti-plasmid immun

233 CRISPR-Cas adaptive immune systems provide prokaryotes with defense against

234 f the brain is dependent on support from the immune system, provided that this immune response is tig

235 The human immune system recognizes chitin as one of the major cell

236 iators of antiviral immunity and homeostatic immune system regulation.

237 ring DST shift, enriched with infections and immune system-related maladies.

238 The human immune system relies on highly complex and diverse trans

239 autoimmune liver disease, and the peripheral immune system remains to be fully understood.

240 nction of Treg cells in the adult peripheral immune system remains unclear.

241 The adaptive immune system responds to pathogens by selecting clones

242 ed a downregulation in genes associated with immune system response, relative to control calls of a s

243 etory immunoglobulin A (sIgA) represents the immune system's first line of defense against mucosal pa

244 ammation, telomere dysfunction, and adaptive immune system senescence may also contribute to frailty.

245 rgarita genome reveals the importance of its immune system, shedding light on the evolutionary pathwa

246 etabolites, and both the innate and adaptive immune system show evidence of admixture-enabled polygen

247 g1-/- mice, which lack a functional adaptive immune system, showed improvement in cardiovascular feat

248 e, including the nervous, cardiovascular and immune systems, skeletal muscle and metabolic regulation

249 ciated pQTMs implicating key proteins of the immune system, such as CD48, CD163, CXCL10, CXCL11, LAG3

250 o other cancer types in which the endogenous immune system supports maintenance therapy, long-term di

251 xt of airway mucus obstruction, the adaptive immune system suppresses antibacterial macrophage activa

252 The dance between microbes and the immune system takes place in all biological systems, inc

253 , and cellular changes in the aging lung and immune system that facilitate the development and progre

254 masome is a critical component of the innate immune system that leads to release of IL-1beta.

255 mes are multiprotein complexes of the innate immune system that orchestrate development of inflammati

256 ement system is an ancient arm of the innate immune system that plays important roles in pathogen rec

257 Antibodies are vital proteins of the immune system that recognize potentially harmful molecul

258 ollowing emergence into secondary hosts with immune systems that diverge from those unique to bats.

259 gh ERs are broadly expressed by cells of the immune system, the mechanisms by which they modulate imm

260 These areas include the immune system, the tumor microenvironment, the fibrotic

261 between cells of the innate and the adaptive immune systems, the role of resident cells as well as ne

262 r pylori colonization may affect the mucosal immune system through modification of microbiota composi

263 Our results demonstrate the capacity of the immune system to affinity-mature large numbers of Env-sp

264 s is illuminating how they interact with the immune system to cause disease and how interrelations be

265 To unravel the contribution of the immune system to CDC pathogenesis, we undertook a prospe

266 amples of the possibilities of targeting the immune system to combat disease.

267 l in 87.5% of GBM-bearing mice and prime the immune system to develop anti-GBM immunological memory.

268 m to kill tumor cells directly or engage the immune system to fight malignancy.

269 rug discovery, cow immunisations harness the immune system to generate knob domains with affinities i

270 how metabolic intervention can act upon the immune system to modify the process of aging.

271 elanoma is how malignant cells can shift the immune system to pro-tumorigenic functions.

272 y to immunotherapies that stimulate the host immune system to recognize and kill cancer cells.

273 e immune system with the aim of allowing the immune system to renew itself.

274 microbiota, the barrier surfaces or the host immune system to restore tolerance and homeostasis will

275 tion optimally increases the pressure on the immune system to target conserved antigenic sites, thus

276 colitis-caused by untoward reactivity of the immune system to the components of the intestinal microb

277 ectrum of receptors on discrete cells of the immune system to trigger the clearance of viruses and su

278 allows the bacterium to manipulate the human immune system, tolerate antibiotic treatment and adapt t

279 the Treg compartment can skew the patient's immune system toward an anti-inflammatory phenotype and

280 ion of influenza A virus (IAV) by the innate immune system triggers pathways that restrict viral repl

281 The studies presented suggest that the immune system, upon detecting the first signs of a poten

282 The innate immune system uses pattern recognition receptors to surv

283 ging of cell-specific lineage markers of the immune system using biomolecules.

284 sed GVHD treatment regimens target the donor immune system, we explored here an approach that aims at

285 Because of its impact in the immune system, we investigated the role of osteopontin i

286 ent concepts relating the microbiome and the immune system, we predict that dietary measures might pr

287 tistimulatory CPS blocked Ag delivery to the immune system, which could be rescued by Fc receptor-dep

288 tinuously monitored by effector cells of the immune system, which police the peptide status presented

289 controlled proteolytic cascade in the innate immune system, which tags intruding pathogens and dying

290 nsmitting viruses that have evolved with bat immune systems will likely cause enhanced virulence foll

291 nally, our study suggests that targeting the immune system with anti-inflammatory medication holds th

292 However, the mechanisms that link the immune system with PD remain unclear, and the temporal r

293 These therapies deplete components of the immune system with the aim of allowing the immune system

294 uch specificities are lacking, providing the immune system with tumor antigen material for processing

295 w the brain communicates with the peripheral immune system, with a focus on the endocrine, sympatheti

296 circulating and tissue-resident arms of the immune system, with emphasis on recent work on the regul

297 tivation of cells of the innate and adaptive immune systems, with pivotal roles for pro-inflammatory

298 ed the anatomy, genetics and function of the immune system within the central nervous system (CNS) an

299 xplain the patchy distribution of CRISPR-Cas immune systems within and between bacterial species, and

300 MicroRNAs (miRNAs) are key regulators of the immune system, yet their variation and contribution to i