ライフサイエンスコーパス: immune tolerance

1 lator (Aire), a critical mediator of central immune tolerance.

2 cids, and particularly butyrate, can promote immune tolerance.

3 urenine pathway which augments tumor-induced immune tolerance.

4 in HM is able to modulate the mechanisms of immune tolerance.

5 3, and can suppress inflammation and promote immune tolerance.

6 f the present understanding of fetus-induced immune tolerance.

7 direct targeting of immune cells to generate immune tolerance.

8 ion phase and their ability to persist under immune tolerance.

9 ed on activated T cells for the induction of immune tolerance.

10 mediated gene induction to establish central immune tolerance.

11 le to regulate adaptive immunity and promote immune tolerance.

12 for mature Treg identity and maintenance of immune tolerance.

13 fibrotic liver was tightly related to innate immune tolerance.

14 d function but is dispensable for peripheral immune tolerance.

15 s that regulate mucosal barrier function and immune tolerance.

16 n in vivo role for granzyme A in maintaining immune tolerance.

17 f T cell function contributing to peripheral immune tolerance.

18 cal modulators of both thymic and peripheral immune tolerance.

19 l population capable of facilitating durable immune tolerance.

20 n of DC maturation is a central mechanism of immune tolerance.

21 ating DCs as key mediators of organ-specific immune tolerance.

22 vity of this enzyme has been associated with immune tolerance.

23 -10(+) regulatory T cells, which may promote immune tolerance.

24 atory T (Treg) cells, a lineage critical for immune tolerance.

25 been recognized as an important mechanism in immune tolerance.

26 an attractive way to induce antigen-specific immune tolerance.

27 NS) resulting from a breakdown in peripheral immune tolerance.

28 Tregs) are critical regulators of peripheral immune tolerance.

29 a process critical for establishing central immune tolerance.

30 regulated to balance immune activation with immune tolerance.

31 ectly to T cells, resulting in a bias toward immune tolerance.

32 ll immunity, whereas immature DCs can induce immune tolerance.

33 reducing osteoclast precursors and promoting immune tolerance.

34 ng miR-155 have an impaired ability to break immune tolerance.

35 which drives regulatory T-cell responses and immune tolerance.

36 ells via the receptor MerTK is important for immune tolerance.

37 of this regulatory DNA element in promoting immune tolerance.

38 esolution of organ damage and maintenance of immune tolerance.

39 e T-regulatory cells in tumor tissue promote immune tolerance.

40 ve processes to promote Treg homeostasis and immune tolerance.

41 age mouse blastocysts, which induces central immune tolerance.

42 is immune-mediated and adaptation represents immune tolerance.

43 umans, and it was accomplished by inhibiting immune tolerance.

44 diated DNA demethylation of Foxp3 to promote immune tolerance.

45 ing the oral mucosa to antigen may stimulate immune tolerance.

46 commensal microbiota and its contribution to immune tolerance.

47 nt a suitable approach to induce Ag-specific immune tolerance.

48 tolerance and ultimately in the breakdown of immune tolerance.

49 s being developed with the goal of restoring immune tolerance.

50 have potential as powerful tools to mediate immune tolerance.

51 through the PD-1/PD-L1 pathway is central to immune tolerance.

52 s through which ATRA may contribute to liver immune tolerance.

53 tion of environmental factors that influence immune tolerance.

54 are each independently required to maintain immune tolerance.

55 f which may promote the development of fetal immune tolerance.

56 at it may be a therapeutic target to promote immune tolerance.

57 ed neoantigen expression, and tumor-specific immune tolerance.

58 se activities may be titrated to break tumor immune tolerance.

59 ddition, at steady-state, cDCs help maintain immune tolerance.

60 prevents excessive inflammation and supports immune tolerance.

61 t plays a recognized role in promoting tumor immune tolerance.

62 ation of immune responses and maintenance of immune tolerance.

63 e essential for establishing and maintaining immune tolerance.

64 tion in recipient lymphoid organs to acquire immune tolerance.

65 (Tregs) contribute to maintaining mammalian immune tolerance.

66 lecules of attention as targets for inducing immune tolerance.

67 mmation and contribute to the maintenance of immune tolerance.

68 liver regulates innate immunity and adaptive immune tolerance.

69 rgan graft survival and that they can induce immune tolerance, accelerate recovery from AKI, and prom

70 The development and maintenance of immune tolerance after allogeneic hematopoietic stem cel

71 of antithymocyte globulin [ATG]) facilitates immune tolerance after bone marrow transplantation (BMT)

72 sible pathogenic TCRs that can cause loss of immune tolerance against elastin.

73 The mechanistic insights into UVR-induced immune tolerance against skin cancers, particularly cuta

74 a maternal T1D environment improves neonatal immune tolerance against the autoantigen (pro)insulin.

75 godendrocyte glycoprotein-loaded DCs carried immune tolerance against the subsequent development of M

76 Immune tolerance and active immune suppression results i

77 rrant tryptophan catabolism reduces maternal immune tolerance and adversely impacts pregnancy outcome

78 ential of 1,25D3-mDCs to restore Ag-specific immune tolerance and arrest autoimmune disease progressi

79 the general principles, such as breaches in immune tolerance and barriers, leading to the promotion

80 eplication but is implicated in establishing immune tolerance and chronic infection.

81 ullination have been linked to the breach of immune tolerance and clinical autoimmunity.

82 r, which has a critical role in establishing immune tolerance and determining the fate of tumors.

83 ls (MDSCs) play a critical role in promoting immune tolerance and disease growth.

84 Prostaglandin E2 promotes not only immune tolerance and epithelial homeostasis but also the

85 is continuously required for maintenance of immune tolerance and for a major part of their character

86 onal fitness of Treg cells in the control of immune tolerance and homeostasis.

87 h17) and regulatory T (Treg) cells maintains immune tolerance and host defense.

88 tes asthma by modulating the balance between immune tolerance and inflammation.

89 observed for higher FOXP3(+) T-cell-mediated immune tolerance and lower CD8(+) T-cell-mediated cytoto

90 elevated 12,13-diHOME concentrations impede immune tolerance and may be produced by bacterial EHs in

91 Foxp3(+) regulatory T cells (Tregs) maintain immune tolerance and play an important role in immunolog

92 Epitope-optimization is required to break immune tolerance and potently activate AFP-specific CD8

93 es as a homeostatic rheostat that safeguards immune tolerance and prevents age-dependent development

94 pTregs, but not tTregs, mediates the loss of immune tolerance and promotes allograft rejection.

95 hronic inactivation of pickle causes loss of immune tolerance and shortened lifespan.

96 mmune reconstitution and re-establishment of immune tolerance and their therapeutic potential followi

97 With our growing knowledge of immune tolerance and ways to overcome it, combination tr

98 ked in human PDA where it is associated with immune-tolerance and diminished patient survival.

99 pharmacologically reduce serum HBsAg, break immune tolerance, and increase functional cure rates.

100 phages (MZMs) are important for establishing immune tolerance, and loss of their number or function c

101 f the immune system but also for maintaining immune tolerance, and more recent work has begun to iden

102 cell function and maintenance of peripheral immune tolerance, and mutations in its coding gene cause

103 ease in these cells implies the induction of immune tolerance, and the alanine aminotransferase (ALT)

104 role in the establishment and maintenance of immune tolerance, and this role is disrupted in diabetes

105 To protect mucosal tissues and maintain immune tolerance, animal hosts actively sequester bacter

106 stion will provide fundamental insights into immune tolerance, antiviral signaling, and complex autoi

107 olecular mechanisms underlying tumor-induced immune tolerance are largely unknown.

108 However, the drivers of intratumoral immune tolerance are uncertain.

109 ory T cells (Treg) are essential to maintain immune tolerance, as their loss leads to a fatal autoimm

110 naturally formed nanoparticles expressed the immune tolerance-associated molecule 'programmed death-l

111 ce instead of having the normal TH1 bias and immune tolerance because of repeated exposure to pathoge

112 nism, which can contribute to maintenance of immune tolerance, becomes insufficient in allergic disea

113 Immune tolerance between the fetus and mother represents

114 esents a new type of immune cell involved in immune tolerance, but it also is a potential candidate f

115 LSECs are involved in induction of immune tolerance, but little is known about their functi

116 Dietary proteins usually induce immune tolerance, but may trigger life-threatening immun

117 bypasses many of the mechanisms involved in immune tolerance by allowing for expansion of tumor-spec

118 Induction of immune tolerance by an increase in regulatory T (Treg) c

119 er tyrosine kinase (Mer) signaling maintains immune tolerance by clearing apoptotic cells (ACs) and i

120 hat GARP exerts oncogenic effects, promoting immune tolerance by enriching and activating latent TGFb

121 Thus, Aire enforces immune tolerance by ensuring that distinct autoreactive

122 ells (mTECs) play a critical role in central immune tolerance by mediating negative selection of auto

123 Thus, PPARgamma favors immune tolerance by promoting regulatory T cell generati

124 ays a key role in the development of central immune tolerance by promoting thymic presentation of tis

125 l repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of a

126 We provide evidence that immune tolerance can be overcome in a murine model of ha

127 at cancer immunotherapy designed to overcome immune tolerance can be useful for a growing number of p

128 tumor inflammatory response, which increases immune tolerance, cell survival, and proliferation.

129 Immune tolerance checkpoint inhibition has been transfor

130 we supply a comprehensive overview of human immune tolerance checkpoints with associated mechanisms

131 has opposing effects on pre-immune and post-immune tolerance checkpoints, and suggest that B cell to

132 Moreover, immune tolerance could be induced that precluded inducti

133 ent mechanisms involved in the regulation of immune tolerance could lead to new strategies to enhance

134 questions with regard to the role of DCs in immune tolerance could lead to the development of novel

135 es, these three Ags exert major functions in immune tolerance, defense against infections, and antica

136 n this position paper, we review insights on immune tolerance derived from allergy and from cancer in

137 th food allergy who were not able to acquire immune tolerance during childhood.

138 Immune tolerance during human pregnancy is maintained by

139 of a state of operationally defined clinical immune tolerance during peanut OIT.

140 nta, is a central component of fetus-induced immune tolerance during pregnancy.

141 ycin, to induce durable and antigen-specific immune tolerance, even in the presence of potent Toll-li

142 ing stem cell-derived islets while fostering immune tolerance, exemplified in Yoshihara et al., holds

143 (Treg) are critical elements for maintaining immune tolerance, for instance to exogenous antigens tha

144 ious mechanisms that have been described for immune tolerance govern our ability to control self-reac

145 A growing understanding of immune tolerance has been the foundation for new approac

146 ivo at the start or stop of therapy impaired immune tolerance, highlighting the dependence of the the

147 wild-type (WT) mice, which induced dominant immune tolerance, identical treatment of DAF(-/-) mice o

148 lar type-II (AT-II) cells is associated with immune tolerance in an inflammatory microenvironment.

149 laboratory changes associated with clinical immune tolerance in antigen-induced T cells, basophils,

150 tion while concurrently restoring peripheral immune tolerance in autoimmune disease.

151 boost regulatory T cells (Tregs) and promote immune tolerance in autoimmune patients.

152 s were required for long-term maintenance of immune tolerance in both the CD4+ and CD8+ T cell compar

153 This suggests that the presumed immune tolerance in chronic HBV infections needs to be r

154 mplete characterization of the mechanisms of immune tolerance in hematological malignancies is critic

155 deficient emphysema implicates regulation of immune tolerance in lung macrophages through Nr4a1.

156 d function in inhibiting aTreg-cell-mediated immune tolerance in mice.

157 mmune surveillance in MGUS and to break down immune tolerance in MM.

158 provide critical insight into how to achieve immune tolerance in organ transplantation.

159 antigen-presenting cells was shown to induce immune tolerance in other animal models of autoimmune di

160 are a subset of CD4(+) T cells that maintain immune tolerance in part by their ability to inhibit the

161 ch to regulate immune homeostasis to promote immune tolerance in patients with autoimmune diseases, i

162 ng cells might enable therapies that promote immune tolerance in patients with autoimmune diseases.

163 uman cartilage proteoglycan (PG) can promote immune tolerance in PG-induced arthritis (PGIA).

164 lar aspects of immune dynamics: breakdown of immune tolerance in response to an infection with a path

165 r low-dose IL-2 therapy to enhance Tregs for immune tolerance in T1D.

166 ism to allergic sensitization and disrupting immune tolerance in the airways of patients with asthma

167 inoid receptor 2 (CB2), in the regulation of immune tolerance in the gut and the pancreas.

168 ne diseases but may come at risk for reduced immune tolerance in the intestinal tract.

169 the regulatory T cells (Tregs) and maintains immune tolerance in the pancreas.

170 al period is a critical time for shaping the immune tolerance in the progeny, influencing development

171 ne-two punch injury that profoundly disrupts immune tolerance in this devastating disease.

172 ing the immune response to establish durable immune tolerance in type 1 diabetes remains a substantia

173 nt of iNKT-based therapies aiming to restore immune tolerance in type 1 diabetes.

174 ammatory potential and the ability to induce immune tolerance in vitro.

175 icity of RLN2 and highlight the weak central immune tolerance induced against this self-hormone.

176 These observations suggest that immune tolerance induced by peptide immunotherapy can be

177 f tolerogenic therapies, other than standard immune tolerance induction (ITI), is an unmet goal.

178 ggest that the approach can also be used for immune tolerance induction to prevent or eliminate inhib

179 herapy; thus, developing strategies to break immune tolerance is a high priority.

180 e an active autoimmune reaction, wherein the immune tolerance is already broken.

181 DC-mediated T cell immune tolerance is an active process that is influenced

182 ciphering cellular and molecular pathways of immune tolerance is an important goal, with the expectat

183 utologous cells as antigen carriers inducing immune tolerance is appreciated.

184 ls targeting hybrid peptides may explain how immune tolerance is broken in T1D.

185 more efficient methods to induce Ag-specific immune tolerance is critical to advancing allergy treatm

186 Immune tolerance is critical to the avoidance of unwarra

187 n this study, we demonstrate that peripheral immune tolerance is critically dependent on posttranscri

188 Immune tolerance is executed partly by Foxp3(+)regulator

189 These data may explain how peripheral immune tolerance is impaired in tissues under autoimmune

190 ource of antigenic peptides to which central immune tolerance is lacking.

191 for tissue-restricted self antigens, or how immune tolerance is maintained for self-antigen-specific

192 How immune tolerance is maintained in the skin remains uncle

193 ffective immune responses to pathogens while immune tolerance is maintained to protect the host.

194 Immune tolerance is necessary to prevent the immune syst

195 contribution to either immune activation or immune tolerance is still not entirely understood.

196 A major contributor to immune tolerance is the tumor physiologic microenvironme

197 reactive cells are silenced by mechanisms of immune tolerance, islet antigen-reactive B lymphocytes a

198 e a mechanism by which loss of AIRE-mediated immune tolerance leads to intestinal disorders in patien

199 sts an interplay of macrophages with IgG4 in immune tolerance, likely relevant in allergen immunother

200 osition as a key determinant of immunity and immune tolerance, linked to the risk for the development

201 This study is the first to show that immune tolerance may be impaired in spaceflight, leading

202 rus (AAV) gene therapy, exploiting a natural immune tolerance mechanism induced by human leukocyte an

203 erapy approach was used to exploit a natural immune tolerance mechanism induced by the human leukocyt

204 e findings implicate the PSGs in a potential immune tolerance mechanism of cancers.

205 asion is achieved through multiple layers of immune tolerance mechanisms including immune editing, re

206 This approach has allowed immune tolerance mechanisms limiting bnAb production to

207 iduals with autoimmune disease and defective immune tolerance mechanisms may produce BnAbs more readi

208 nization initiates CD4bs-bnAb responses, but immune tolerance mechanisms restrict their development,

209 Discovery of immune tolerance mechanisms, which inhibit pre-existing

210 cell receptor axis that can be targeted for immune tolerance modulation.

211 response, the National Institutes of Health Immune Tolerance Network and JDRF established a multicen

212 liver transplant recipients enrolled in the Immune Tolerance Network immunosuppression withdrawal (I

213 MIC-treated patients showed the Immune Tolerance Network operational tolerance signature

214 Longitudinal specimens from the Immune Tolerance Network's A Cooperative Clinical Study

215 tion approach with the potential to overcome immune tolerance observed in pregnancy, and lower vaccin

216 esponsible IgG receptors for the breaking of immune tolerance of microglia.

217 ngeneic bile duct antigens efficiently break immune tolerance of recipient mice, capturing several ke

218 Specific immune tolerance of transplanted organs in association w

219 taneous, or intramuscular), and induction of immune tolerance or encapsulation of islets.

220 s B virus exploits these naturally occurring immune tolerance pathways to establish persistent postna

221 ensal Staphylococcus epidermidis facilitates immune tolerance preferentially in neonates via inductio

222 n Treg cells can be titrated to break tumour immune tolerance preferentially.

223 m implies the concept of naturally occurring immune tolerance, presumably activated by overloading of

224 an and mouse, results in compromised central immune tolerance processes that may significantly impact

225 re), a transcription coordinator involved in immune tolerance processes, is a critical spindle-associ

226 presence of tumor cells in the ALN causes an immune tolerance profile that contrasts with that of the

227 ce, and may inform the development of future immune tolerance protocols.

228 nts respond to microorganisms through biased immune tolerance rather than resistance strategies.

229 tion-induced cell death (AICD) essential for immune tolerance regulation.

230 opment of therapeutic interventions in other immune tolerance-related diseases.

231 Therapeutic approaches for the induction of immune tolerance remain an unmet clinical need for the t

232 Maintaining immune tolerance requires the production of Foxp3-expres

233 r, characterized by impaired, or exaggerated immune tolerance, respectively.

234 -/-) and PD-1(-/-) mice, which have impaired immune tolerance, resulted in a slightly greater injury.

235 gulatory cells, consistent with induction of immune tolerance, resulting in decreased inflammatory re

236 nduce transplantation tolerance in neonates, immune tolerance strategies have been actively pursued.

237 n the context of the clinical translation of immune tolerance strategies, we discuss the significant

238 Our studies thus identify Notch4-mediated immune tolerance subversion as a fundamental mechanism t

239 higher concentrations of markers related to immune tolerance than luminal A.

240 cells (Tregs) are non-redundant mediators of immune tolerance that are critical to prevent autoimmune

241 rt-term costimulation blockade led to robust immune tolerance that could be transferred independently

242 une system immaturity by inducing a state of immune tolerance that facilitates HBV persistence.

243 Dendritic cells (DCs) can induce peripheral immune tolerance that prevents autoimmune responses.

244 autoimmune regulator (AIRE, which regulates immune tolerance) that allow self-reactive T cells to en

245 that APCs have a crucial role in maintaining immune tolerance, the underlying mechanisms are poorly u

246 esponse to inflammatory stimuli and promotes immune tolerance through effector T-cell anergy and enha

247 oenvironment of established tumours promotes immune tolerance through poorly understood mechanisms.

248 Regulatory T (Treg) cells maintain immune tolerance through the master transcription factor

249 ignificant impact on subsequent immunity and immune tolerance, thus placing them in a unique position

250 disease, as well as the processes that drive immune tolerance to allergens, will be instrumental in d

251 T (Treg) cells play a key role in sustaining immune tolerance to allergens, yet mechanisms by which T

252 Immune tolerance to allografts has been pursued for deca

253 Immune tolerance to alpha-Gal in blood type B individual

254 Immune tolerance to avoid chronic immunosuppression is a

255 Finally, we suggest a unified model in which immune tolerance to beta cells can be broken by several

256 underlying immune dysregulation that impairs immune tolerance to both food allergens and autoantigens

257 Immune tolerance to both self-antigens and innocuous non

258 pecific T cell response because of a lack of immune tolerance to C-terminal epitopes as a consequence

259 S) mainly in young adults, and a breakage of immune tolerance to CNS self-antigens has been suggested

260 we sought to determine whether induction of immune tolerance to col(V) might ameliorate atherosclero

261 Mucosal inoculation successfully induced immune tolerance to col(V) with an accompanying reductio

262 on and anti-T-cell antibodies safely induces immune tolerance to combined hematopoietic cell and orga

263 ry T cells (Tregs) are required to establish immune tolerance to commensal microbes.

264 neonatal life was required for establishing immune tolerance to commensal microbes.

265 V) vector-mediated gene therapy that induced immune tolerance to factor IX (FIX) in a hemophilia B (H

266 Loss of immune tolerance to gut microflora is inextricably linke

267 will guide future studies into induction of immune tolerance to intervene in the initiation and prog

268 It is assumed that newborns may develop immune tolerance to milk-transmitted pathogens similarly

269 that maternal microchimerism induces stable immune tolerance to non-inherited maternal antigens in o

270 autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens.

271 ing pathways would make blocking of neonatal immune tolerance to retroviruses an achievable goal.IMPO

272 controller 2 (vic2), that abrogates neonatal immune tolerance to retroviruses.

273 Regulatory T cells (Tregs) mediate immune tolerance to self and depend on IL-2 for homeosta

274 Loss of immune tolerance to self-antigens can promote chronic in

275 oimmune disease that results from a break in immune tolerance to self-antigens, leading to multi-orga

276 overcoming multiple mechanisms that mediate immune tolerance to self-antigens.

277 Cs) is recognized as a critical mechanism of immune tolerance to self-antigens.

278 n has been associated with a break in innate immune tolerance to self-DNA.

279 P3 play a pivotal role in the maintenance of immune tolerance to self.

280 e immunological factors that promote loss of immune tolerance to self.

281 y known therapy that provides long-term host immune tolerance to the allergen, but is time-consuming

282 At this age, neonates acquire immune tolerance to the conditionally responsive lucifer

283 cating the importance of LRP5/6 in mediating immune tolerance to the gut flora.

284 In contrast, END showed strong evidence for immune tolerance to the parasite, with high levels of ci

285 Therapeutic vaccines might be used to end immune tolerance to the virus in patients with chronic i

286 al epitopes in humans results in the loss of immune tolerance to this epitope and production of abund

287 erapy and the vital protagonists that shape 'immune tolerance' to allergens.

288 Tregs play a fundamental role in immune tolerance via control of self-reactive effector T

289 The immune tolerance was confirmed by marked reduction in ai

290 Immune tolerance was confirmed in all dogs after challen

291 (+) T regulatory cells (Treg), essential for immune tolerance, was significantly reduced.

292 A majority of tumors exist in a state of immune tolerance where the patient's immune system has b

293 Pregnancy induces a state of immune tolerance, which can result in spontaneous improv

294 tal adenocarcinoma (PDA) is characterized by immune tolerance, which enables disease to progress unab

295 ory T (Treg) cells are critical mediators of immune tolerance whose activity depends upon T cell rece

296 In this review, we describe principles of immune tolerance with a focus on its breakdown during pa

297 The induction of immune tolerance with HSCs has led to isolation of other

298 e liver appears to be privileged in terms of immune tolerance, with a low incidence of antibody-media

299 insights on the failure of the mechanisms of immune tolerance, with potential implications in designi

300 ry T (T reg) cells are pivotal regulators of immune tolerance, with T cell receptor (TCR)-driven acti