ライフサイエンスコーパス: immune-privileged

1 volve anatomic sites that are not considered immune privileged.

2 r MSCs suggest that MSCs may not actually be immune privileged.

3 protective effects, and are considered to be immune privileged.

4 brain parenchyma, a site that is considered immune privileged.

5 cells derived from autologous iPSCs will be immune-privileged.

6 Fetal tissue is considered to be immune privileged and is under extensive investigation a

7 oscientists, we are taught that the brain is immune privileged and thus unlikely to be affected by th

8 a tripartite neuroprotective barrier between immune-privileged and extra-neural environments after SC

9 d type-H vessels(2-10) co-localize with less immune-privileged and less potent NO(low) HSCs.

10 topically, forms the anterior surface of the immune privileged anterior chamber.

11 t immune cells can take up residence in more immune-privileged areas of the CNS during inflammation w

12 The cornea is an immune privileged barrier tissue that relies primarily o

13 neurons in the healthy brain were considered immune-privileged because they did not appear to express

14 their multipotent differentiation, and their immune-privileged behavior, reveals, at least in part, t

15 Neonates are not immune privileged but generate TH2 or TH1 responses, dep

16 of Fas ligand (FasL) renders certain tissues immune privileged, but its expression in other tissues c

17 Neonatal porcine Sertoli cells (NPSC) are immune privileged cells showing innate phagocytic and an

18 PI-9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protects these c

19 plore the tumor-specific CTL response in the immune-privileged central nervous system using P511 mast

20 Vigorous immune responses are induced in the immune privileged CNS by injury and disease, but the mol

21 d function of NK cells in the traditionally "immune-privileged" CNS is controversial.

22 As the CNS is an immune-privileged compartment, inducible innate defense

23 In the immune-privileged cornea, epithelial wounds heal rapidly

24 transient progeny virion replication in the immune-privileged cornea.

25 LX are highly expressed in the avascular and immune-privileged cornea.

26 ese data refute the tenet that the cornea is immune privileged due to lack of resident lymphoreticula

27 adjacent" regions in the CNS are in fact not immune privileged during the steady state, and that immu

28 d for latent pathogens and persistence in an immune-privileged enteric niche.

29 al cells contributes to the generation of an immune-privileged environment at the maternal-fetal inte

30 d SCID mice, could survive in the relatively immune-privileged environment of dialysis membrane chamb

31 Our data demonstrate that the immune-privileged environment within the eye induces a t

32 Although intraocular tumors reside in an immune-privileged environment, T cells can circumvent im

33 The CNS is an immune-privileged environment, yet the local control of

34 ocorticoid-induced ocular hypertension in an immune-privileged environment.

35 tion that guide migration of T cells in this immune-privileged environment.

36 ve expression of FasL and hence maintain an "immune privileged" environment within the testicle.

37 vironment of TP53 mutant MDS and sAML has an immune-privileged, evasive phenotype that may be a prima

38 ta2-treated Ag-pulsed APC mimic APC from the immune privileged eye, and provide signals that generate

39 required to initiate inflammation within the immune privileged eye, as compared with nonprivileged si

40 al melanoma, a rare variant arising from the immune privileged eye.

41 The ability of ADCC to protect the immune-privileged eye, however, may differ from skin or

42 om primary uveal melanomas that arise in the immune-privileged eye, prime and boost IFNgamma-secretin

43 We previously showed that, within the immune-privileged eye, tumors expressing high levels of

44 cognate antigens are sequestered within the immune-privileged eye.

45 However, GCs are considered to be immune privileged for antiviral CD8 T cells.

46 until recently the brain was thought to be "immune privileged." However, it is now known that the im

47 ervous system (CNS) is classically viewed as immune-privileged; however, recent advances highlight in

48 cluding immune-isolating islets, engineering immune-privileged islet implantation sites, rendering is

49 Together, we identify highly immune-privileged, late-rising primitive HSCs and charac

50 ration of tumor antigens within a relatively immune privileged location present serious problems for

51 wn that it is very difficult to abrogate the immune privileged mechanism called anterior chamber-asso

52 ery few events are capable of overcoming the immune-privileged mechanisms in the eye.

53 g molecules to immune cells, resulting in an immune privileged microenvironment.

54 ventional therapeutics is a product of their immune-privileged milieu behind the blood-brain barrier,

55 nt, as well as potentially contribute to the immune-privileged nature of the brain.

56 ring maturation that could contribute to the immune-privileged nature of the CNS or potentially influ

57 rowth, played a key role in formation of the immune-privileged niche, and predicted poor prognosis in

58 enitor cells that encounter cell death in an immune-privileged niche.

59 Human uveal melanoma arises in an immune privileged ocular environment in which both adapt

60 fective immune modulation in the classically immune-privileged ocular haven.

61 AP-1 in the recruitment of leukocytes to the immune-privileged ocular tissues during acute inflammati

62 We now know that the brain is not an immune privileged organ.

63 chanisms may include loss of tolerance in an immune-privileged organ and subsequent development of T-

64 re highly vulnerable to rejection even in an immune-privileged organ like the brain.

65 the widely accepted dogma that the eye is an immune-privileged organ that can suppress antigen immuno

66 The liver is considered to be an immune-privileged organ that favors the induction of tol

67 The brain, previously thought of as an immune-privileged organ, is now known to communicate ext

68 As an immune-privileged organ, the placenta can tolerate the i

69 Although the inner ear has been known as an immune-privileged organ, there is emerging evidence indi

70 Despite being considered an immune-privileged organ, we detect a mycobacteria-specif

71 nfected macrophages or if ranavirus exploits immune privileged organs, such as the brain, in order to

72 s ligand (CD95L) inhibits T cell function in immune-privileged organs such as the eye and testis, yet

73 clear placental viral infections within the immune-privileged placenta.

74 Such highly immune-privileged, primitive NO(hi) HSCs co-localize wit

75 wo factors, their low immunogenicity and the immune-privileged properties of the eye.

76 controversy remains as to whether hESCs have immune-privileged properties.

77 e photoreceptors and synaptic regions of the immune-privileged retina implies a role in visual transm

78 The brain was once believed to be immune privileged, sequestered from peripheral inflammat

79 The CNS is considered an immune privileged site because its repertoire of highly

80 One clinical example of the function of an immune privileged site is the success of human corneal t

81 The lens has been considered to be an immune privileged site not susceptible to the immune pro

82 detection of virus in the vitreous fluid, an immune privileged site that has been proposed as a viral

83 The eye is an immune privileged site that is styled to maintain the vi

84 esence of parenchymal cells from the eye (an immune privileged site) express B7-2 in a manner that eq

85 Although once believed to be an immune privileged site, it is now known that antimicrobi

86 While the eye is considered an immune privileged site, its privilege is abrogated when

87 Although intraocular tumors reside in an immune privileged site, some tumors are rejected nonethe

88 or this molecule in tumor surveillance in an immune privileged site.

89 sult implies that the subretinal space is an immune-privileged site and a favorable site for gene tra

90 notherapy because primary tumors arise in an immune-privileged site and may express antigens to which

91 Immune-privileged site DLBCL (IP-DLBCL) patients reporte

92 e barriers in the mammalian body, creates an immune-privileged site for postmeiotic spermatid develop

93 ted cells that line the subretinal space, an immune-privileged site in the eye.

94 nt infection in the seminiferous tubules, an immune-privileged site in the testis protected by the bl

95 ined the fate of such grafts placed in a non-immune-privileged site of adult recipient mice.

96 ent of systemic tolerance associated with an immune-privileged site suggests a mechanism involving NK

97 cades the brain has been considered to be an immune-privileged site that excludes circulating cells f

98 Although intraocular tumors reside in an immune-privileged site where immune responses are suppre

99 The central nervous system (CNS) is an immune-privileged site where the role of immune cells an

100 tudy documents that tumors growing within an immune-privileged site within the eye develop a tumor es

101 The eye is an immune-privileged site, and FasL expression is a major p

102 us system has historically been viewed as an immune-privileged site, but recent data have shown that

103 Although the CNS has been regarded as an immune-privileged site, recent studies demonstrate the c

104 n be elicited by introducing antigen into an immune-privileged site, such as the eye, or directly int

105 As an immune-privileged site, the eye, and particularly the ou

106 primary DLBCL samples, including 44 primary immune-privileged site-associated DLBCL (IP-DLBCL) sampl

107 Therefore, this model for immune-privileged site-mediated tolerance provided us wi

108 challenging because the eye is a relatively immune-privileged site.

109 tissue as to the qualities of the eye as an immune-privileged site.

110 s lining the anterior chamber of the eye, an immune-privileged site.

111 across the BTB to exert their effects at the immune-privileged site.

112 duced by the introduction of antigen into an immune-privileged site.

113 body PE, and retina PE of the inner eye, an immune-privileged site.

114 f the PD-1:PD-L1 interaction in creating an "immune-privileged" site for initial viral infection and

115 It is expressed in immune privileged sites and is implicated in establishin

116 ter the hypothesis that B cell follicles are immune privileged sites and suggest that strategies to a

117 ions, carrying infectious virus particles to immune privileged sites and/or to sites protected by phy

118 s required for dissemination of the virus to immune privileged sites has not been definitively shown.

119 rticipation in inflammatory responses within immune privileged sites such as the brain and eye is les

120 The induction of peripheral tolerance via immune privileged sites such as the eye requires splenic

121 In immune privileged sites such as the eye, CD95 ligand (Fa

122 sion helps control inflammatory reactions in immune privileged sites such as the eye.

123 Zika virus (ZIKV) can establish infection in immune privileged sites such as the testes, eye, and pla

124 ic infections in humans, mainly localized in immune privileged sites, such as the brain and the eye.

125 Because synovial joints include immune privileged sites, these findings are significant

126 sponse in controlling lymphocyte function in immune privileged sites.

127 IFN-dependent MHC regulation, as evident in immune privileged sites.

128 Diffuse large B-cell lymphoma arising in immune-privileged sites (eg, the central nervous system)

129 brella term primary large B-cell lymphoma of immune-privileged sites (IP-LBCL) was proposed.

130 Large B-cell lymphoma of immune-privileged sites (LBCL-IP) arise in immune sanctu

131 nance of tolerance, as Fas ligand can create immune-privileged sites and prevent graft rejection by i

132 if somatic stem-cell niches more broadly are immune-privileged sites by examining the haematopoietic

133 rulence factor-based strategies and invading immune-privileged sites enables persistent infection in

134 h long-term sequelae and persistent virus in immune-privileged sites for many years.

135 ultiple organs of infected people, including immune-privileged sites like the brain, eyes, and reprod

136 Thus, dysregulated innate immunity at immune-privileged sites may be an essential mechanism tr

137 , suggesting that tumor cells originating in immune-privileged sites may have enhanced capacity for i

138 Implantation of RPE cells in immune-privileged sites of the eye induces a deviant imm

139 Among these, DLBCLs from immune-privileged sites showed abundant T cell infiltrat

140 Tissues derived from immune-privileged sites sometimes possess special charac

141 in view of the immune deviation existing in immune-privileged sites such as the brain and eye, where

142 g how EBOV disseminates into and persists in immune-privileged sites was impossible due to the absenc

143 rogram tolerance in the gut and the eye, two immune-privileged sites where immunosuppressive response

144 nous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and muri

145 t Zika virus uniquely utilizes AXL, found in immune-privileged sites, such as the brain and placenta,

146 se the brain and testis are considered to be immune-privileged sites, the expression pattern of cdr2

147 are immune-suppressive environments, called immune-privileged sites, where multiple mechanisms coope

148 n the development of peripheral tolerance in immune-privileged sites.

149 n almost 50% of patients, typically at other immune-privileged sites.

150 issue-specific virus diversity, including in immune-privileged sites.

151 mph nodes or extranodal locations, including immune-privileged sites.

152 event or treat long-term EBOV persistence in immune-privileged sites.

153 ion and promoted the establishment of cancer immune-privileged sites.

154 e highlight a dilemma that is central to all immune-privileged sites.

155 d, suggesting that lymphoid follicles may be immune-privileged sites.

156 virus can persist in survivors for months in immune-privileged sites; however, viral relapse causing

157 ccommodate and even differentiate in the non-immune-privileged space beneath the kidney capsule.

158 he accessibility for routine surgery and its immune privileged state make the eye an ideal target for

159 l inflammation that subvert the normal eye's immune privileged state.

160 especially TGF-beta2, that contribute to the immune privileged status of the anterior chamber.

161 tures of the corneal graft contribute to its immune privileged status: (a) absence of donor-derived,

162 this class Ib protein may contribute to the immune-privileged status of the anterior chamber.

163 ged self during healing and suggest that the immune-privileged status of the CNS may contribute to fa

164 n (IRBP) in the periphery, thus revoking its immune-privileged status.

165 t even though the retina is often considered immune-privileged, suppression of host immune-mediated c

166 long been reported to be hypoimmunogenic or 'immune privileged'; this property is thought to enable M

167 The cornea is an immune privileged tissue that, when grafted orthotopical

168 While the brain is an immune privileged tissue, robust immune responses are mo

169 as much to the qualities of the graft as an immune-privileged tissue as to the qualities of the eye

170 e bulge region of the hair follicle (HF), an immune-privileged tissue niche with impaired tumor immun

171 tinal pigment epithelium (RPE) behaves as an immune-privileged tissue when transplanted extraocularly

172 endritic cells (DC) reside in the cornea, an immune-privileged tissue, is unknown.

173 sed on the cell surface of many tumor cells, immune-privileged tissues and activated lymphocytes.

174 ession and otherwise localized expression to immune-privileged tissues with no (testis-restricted) or

175 pplicability following tumor resection or in immune-privileged tissues.

176 ain species of bacteria selectively colonize immune-privileged tumor cores and can be engineered as a

177 rate that i.t. 2141-V11 is safe and promotes immune-privileged tumor microenvironments that promote s

178 er, CX3CR1(hi) patrolling monocytes serve as immune-privileged vehicles to transport MCMV via the blo

179 rast to the notion that ES-derived cells are immune-privileged, we show in this study that NK cells f