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1 d unfolding of a small protein with only one immunoglobulin domain.
2 ins resides within an homologous, C-terminal immunoglobulin domain.
3 cause of specific substitutions in the first immunoglobulin domain.
4 s, each encoding half or a complete variable immunoglobulin domain.
5 polysialylation of N-glycans on the adjacent immunoglobulin domain.
6 polysialylation of N-glycans on the adjacent immunoglobulin domain.
7 ound to IL-23 exclusively via its N-terminal immunoglobulin domain.
8 o 104 of the N-terminal variable domain-like immunoglobulin domain.
9 interaction, predominantly through the first immunoglobulin domain.
10 aspase prodomains contain a death domain and immunoglobulin domains.
11 h structure of FN3 closely resembles that of immunoglobulin domains.
12 pre-TCR that lacked all of its extracellular immunoglobulin domains.
13 , a 45-55-kDa transmembrane protein with two immunoglobulin domains.
14 acellular portions of which consist of seven immunoglobulin domains.
15 yl hydrolase, leucine-rich repeat and hybrid immunoglobulin domains.
16 the Z-disk of the sarcomere, is composed of immunoglobulin domains.
17 ne-bound gene containing three extracellular immunoglobulin domains.
18 soforms differing at any one of the variable immunoglobulin domains.
19 ing different combinations of three variable immunoglobulin domains.
20 diverse group of proteins composed solely of immunoglobulin domains.
21 e vertebrate protein composed solely of four immunoglobulin domains.
22 n such muscle, and contains tandem arrays of immunoglobulin domains.
23 om lepidopteran insects, is composed of four immunoglobulin domains.
24 and bioengineering of isolated antibody and immunoglobulin domains.
25 st in the PEVK-region and then in individual immunoglobulin domains.
27 nce tags in zebrafish we identified secreted immunoglobulin domain 4 (sid4), a gene encoding a solubl
28 This isoform consists of two extracellular immunoglobulin domains, a transmembrane domain and a cyt
30 omains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V dom
32 dependent unfolding and refolding of a titin immunoglobulin domain and alpha-actinin spectrin repeats
33 ragments, these knobs are not reliant on the immunoglobulin domain and have potential as a new class
34 expression of the inhibitory receptor T cell immunoglobulin domain and mucin domain 3 (Tim-3) after s
35 at 20 weeks posttransplant revealed T cell, immunoglobulin domain and mucin domain-1(+) B cells, pot
36 tolimab is an immunotherapy targeting T-cell immunoglobulin domain and mucin domain-3 (TIM-3), an imm
38 ucine-rich repeats, a fibronectin domain, an immunoglobulin domain and short intracellular tails capa
39 resists forces much higher than the typical immunoglobulin domain and that the force distribution is
41 lular domain of TMIGD1 contains two putative immunoglobulin domains and mediates self-dimerization.
42 immunoglobulin superfamily containing three immunoglobulin domains and one fibronectin type III repe
43 t that N-CAM-N-CAM binding involves all five immunoglobulin domains and prompt the hypothesis that in
44 n cell-adhesion molecule (CAM) that contains immunoglobulin domains and regulates the EGFR signaling
45 inetics of multidomain protein constructs of immunoglobulin domains and the ability of different homo
46 eins corresponding to each of the individual immunoglobulin domains and the combined FnIII 1-2 and pr
47 a predicted transmembrane protein with five immunoglobulin domains and three fibronectin type III re
48 g of an extracellular region containing five immunoglobulin domains and two fibronectin type III (FnI
49 ar basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are m
51 f 282 amino acids with a signal sequence, an immunoglobulin domain, and a COOH-terminal hydrophobic t
52 een two cysteine residues resembling a V-set immunoglobulin domain, and another region containing a m
53 estral genes into those specifying bona fide immunoglobulin domains, and the generation of multiple c
54 erall fold and disposition of the two C2-set immunoglobulin domains are similar to the D1D2 domains o
55 y cDNA clones consists of V-type and C2-type immunoglobulin domains as well as a hydrophobic signal s
56 x with CAR (2.8 angstroms) reveal an unusual immunoglobulin-domain assembly for JAML and a charged in
58 d in the conformation of the four N-terminal immunoglobulin domains, because x-ray diffraction showed
60 ll rearrangement require its fifth and sixth immunoglobulin domains, but not the first four, although
61 bled with a TCRalpha mutant that lacked both immunoglobulin domains, but shortening of the TCRalpha c
62 like receptors (PIR), contain two additional immunoglobulin domains, but show strong sequence and fun
63 that is joined to N- and C-terminal flanking immunoglobulin domains by long, flexible linkers with pa
64 e limited to the relative disposition of the immunoglobulin domains C epsilon 3 and C epsilon 4 in Ig
65 The N-terminal binding site, consisting of immunoglobulin domains C1 and C2 connected by a flexible
66 ditions indicates that the unfolding of each immunoglobulin domain can be explained by a simple two-s
67 sequence alone, in the absence of any other immunoglobulin domains, can mediate cardiolipin binding,
69 Because of its structural homology to the immunoglobulin domain, combinatorial libraries of FN3 de
70 hat cell adhesion molecule transmembrane and immunoglobulin domain containing 1 (TMIGD1) are highly e
72 on of CD27 or Fc receptor-like 4 (FCRL4), an immunoglobulin domain containing a receptor with strong
74 we examined the importance of the conserved immunoglobulin domain, containing the homophilic binding
76 ing evidence suggests that transmembrane and immunoglobulin domain-containing 1 (TMIGD1) protects tub
78 the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two i
79 o their structural features: TIGIRR-1 (three immunoglobulin domain-containing IL-1 receptor-related)
80 nhibited in a dominant-negative manner by an immunoglobulin domain-containing palladin fragment lacki
81 alladin (MYPN) is a striated muscle-specific immunoglobulin domain-containing protein located in the
82 We now show that SynCAM is a brain-specific, immunoglobulin domain-containing protein that binds to i
83 urther demonstrate that PMP22 interacts with immunoglobulin domain-containing proteins known to regul
84 ut not neurotrophin-3, selectively regulated immunoglobulin domain-containing splice variants of NRG,
85 expressed on activated T lymphocytes, V-type immunoglobulin domain-containing suppressor of T cell ac
87 trained conformation of the second and third immunoglobulin domains creates a binding site that is co
88 X-ray structures of the amino-terminal four immunoglobulin domains (D1-D4) of two distinct Dscam iso
89 alpha indicates that the mouse CD8alphaalpha immunoglobulin-domain dimer does not undergo significant
90 nteraction between SpA and the Fab-region of immunoglobulin domains encoded by the V(H)3 gene family
91 n of intimin comprises an articulated rod of immunoglobulin domains extending from the bacterium surf
92 The overall fold places it within the V-type immunoglobulin domain family and reveals close homology
93 rofascin molecules, all of which contain six immunoglobulin domains, five fibronectin repeats, a tran
95 dicating that the secondary structure of the immunoglobulin domain folds are preserved on complex for
96 ition states for folding of TI I27, the 27th immunoglobulin domain from human cardiac titin, and that
98 s, which resembles the N-terminal half of an immunoglobulin domain from the immense skeletal muscle p
99 nd quantify rare misfolding events in tandem immunoglobulin domains from the I band of titin under na
100 icity, by determining the properties of five immunoglobulin domains from the I-band in three differen
101 r dynamics simulation of force-induced titin immunoglobulin domain I27 unfolding led to the discovery
102 eplicated in BioVU, rs993312 in Sema domain, immunoglobulin domain (Ig), short basic domain, secreted
103 r homodimers mediated by the four N-terminal immunoglobulin domains (Ig1-4), arranged in a horseshoe
104 lation of two N-glycans located on the fifth immunoglobulin domain (Ig5) of NCAM requires the presenc
105 ymer that is added to N-glycans on the fifth immunoglobulin domain (Ig5) of the neural cell adhesion
107 REM-1) signaling (eg, CCL2, CCL3, and single immunoglobulin domain IL1R1 related [SIGIRR]) and IL-36
109 erefore illustrates the critical role of the immunoglobulin domain in regulation of the localization
111 able mechanical strength, similar to that of immunoglobulin domains in the giant muscle protein titin
113 s bound to N-CAM, and in solution all of the immunoglobulin domains inhibited the aggregation of N-CA
116 mutations in the Sns fibronectin-binding or immunoglobulin domains lead to morphologically abnormal
117 c cell surface molecule called Tim-3 (T cell immunoglobulin domain, mucin domain) has been identified
118 e T(H) type 1 (T(H)1)-specific Tim-3 (T cell immunoglobulin domain, mucin domain) protein functions t
119 ino terminus, a long stretch (>40) of tandem immunoglobulin domains, multiple tandem epidermal growth
120 ial N-linked glycosylation site in the first immunoglobulin domain of CD22 completely abrogates ligan
121 on motif Asp-Gly-Glu-Ala (DGEA) in the sixth immunoglobulin domain of CHL1, suggesting that CHL1 func
122 amer through direct interactions between the immunoglobulin domain of gp130 and site III of viral IL-
124 ion of purified N-CAM, the recombinant third immunoglobulin domain of N-CAM, or N-CAM antibodies eith
125 rystal structure of TIGIT bound to the first immunoglobulin domain of nectin-2 indicated that the rec
128 lular portion of PECAM, or of only the first immunoglobulin domain of PECAM, fused to the Fc portion
129 f the huntingtin exon-1 protein fused to the immunoglobulin domain of protein G, both of which exist
131 We also report the crystal structure of the immunoglobulin domain of TLT-1 determined at the resolut
133 r between the second and third extracellular immunoglobulin domains of fibroblast growth factor recep
135 Previously, we demonstrated that one of the immunoglobulin domains of palladin (Ig3) is both necessa
136 ave similar architectures, with the variable immunoglobulin domains of the heavy and light chain each
137 studied the unfolding by force of one of the immunoglobulin domains of the muscle protein titin using
139 long term evolution of these characteristic immunoglobulin domains over the 450 million years since
140 in conjunction with mechanical loading, that immunoglobulin domains preferentially from the distal ti
142 hrough junctional localization of the Alcama immunoglobulin-domain protein, which functions to restab
143 the zig gene family, which code for secreted immunoglobulin domain proteins required for maintaining
144 ide analysis of members of a small family of immunoglobulin domain proteins, we found that OIG-8, a p
146 nclude semaphorins of Ctenophora with tandem immunoglobulin domains (Sema-IG) and secreted semaphorin
147 This may be due to the loss of its native immunoglobulin domain structure or to the requirement fo
148 ng variants known to affect the stability of immunoglobulin domains, such as different N-glycoforms,
149 ution solution structure, which comprises an immunoglobulin domain that is intimately coupled to a no
150 ructure reveals a highly bent arrangement of immunoglobulin domains that form an extended convex surf
151 f the immunoglobulin superfamily, having six immunoglobulin domains, thirteen fibronectin repeats and
154 would be predicted to encode for at least 68 immunoglobulin domains, two fibronectin domains, one cal
156 exceptional preservation of their N-terminal immunoglobulin domains, which results in maintenance of
158 wo (D1-D2) or three (D0-D1-D2) extracellular immunoglobulin domains, with the D1 and D2 domain recogn
159 at both antibodies interacted with the third immunoglobulin domain within the extracellular region of