ライフサイエンスコーパス: immunoglobulin gene

1 receptor beta chain gene and the heavy chain immunoglobulin gene.

2 le exception of somatic hypermutation in the immunoglobulin gene.

3 zing radiation or V(D)J recombination of the immunoglobulin genes.

4 tor for OCT factors during the activation of immunoglobulin genes.

5 biochemical mechanisms of diversification of immunoglobulin genes.

6 some cases carrying functionally inactivated immunoglobulin genes.

7 with increasing rates of somatic mutation in immunoglobulin genes.

8 SHM) and class-switch recombination (CSR) of immunoglobulin genes.

9 ellular genes, including proto-oncogenes and immunoglobulin genes.

10 h recombination and somatic hypermutation in immunoglobulin genes.

11 tion (SHM) and class switch recombination of immunoglobulin genes.

12 tation and class switch recombination of the immunoglobulin genes.

13 se in mutations of C during hypermutation of immunoglobulin genes.

14 ion by PCR of a single or limited numbers of immunoglobulin genes.

15 on that links one c-myc allele to one of the immunoglobulin genes.

16 d induction of somatic cell hypermutation of immunoglobulin genes.

17 may participate in somatic hypermutation of immunoglobulin genes.

18 (OCA-B, OBF-1) to stimulate transcription of immunoglobulin genes.

19 issue- and stage-restricted transcription of immunoglobulin genes.

20 f polymerase chain reaction amplification of immunoglobulin genes.

21 primarily by rearrangement and expression of immunoglobulin genes.

22 ns result from the same process that targets immunoglobulin genes.

23 and undergo secondary V(D)J recombination of immunoglobulin genes.

24 may play a role in somatic hypermutation of immunoglobulin genes.

25 se that direct transcription from rearranged immunoglobulin genes.

26 ber tandem repeats and switch regions of the immunoglobulin genes.

27 ally regulated transcriptional activation of immunoglobulin genes.

28 mers for highly conserved regions of TCR and immunoglobulin genes.

29 amplifies the variable region repertoire of immunoglobulin genes.

30 ection from a phage display library of mouse immunoglobulin genes.

31 hallmarks of somatic mutation of endogenous immunoglobulin genes.

32 crophages, in addition to an upregulation of immunoglobulin genes.

33 ic processes during somatic hypermutation of immunoglobulin genes.

34 ermutation and class switch recombination of immunoglobulin genes.

35 s (GCs) to proliferate and hypermutate their immunoglobulin genes.

36 rocesses by deaminating cytosine residues in immunoglobulin genes.

37 quired affinity-enhancing mutations in their immunoglobulin genes.

38 inase (AID) deaminates cytosine to uracil in immunoglobulin genes.

39 s no physical evidence of uracil residues in immunoglobulin genes.

40 A (RPA), an AID cofactor, was restricted to immunoglobulin genes.

41 cholera vaccine were compared by analysis of immunoglobulin genes.

42 switch recombination, and gene conversion of immunoglobulin genes.

43 nd perhaps in somatic hypermutation (SHM) of immunoglobulin genes.

44 so far aimed at revealing how variations in immunoglobulin genes affect a vaccine response.

45 II pauses or stalls during transcription of immunoglobulin gene, AID is likely to promote MCMs.

46 Though largely specific for immunoglobulin genes, AID also acts on a limited set of

47 R and Sanger sequencing-based techniques for immunoglobulin gene analysis are labor-intensive and rel

48 Immunoglobulin gene analysis provides fundamental insigh

49 Immunoglobulin gene analysis was unique and demonstrated

50 Transcription of the rearranged immunoglobulin gene and expression of the enzyme activat

51 Antibodies are encoded by the immunoglobulin genes and AID acts as a transcription-dep

52 switch recombination within their rearranged immunoglobulin genes and also participate in a number of

53 We sequenced the VH immunoglobulin genes and germline progenitors of two rat

54 6 patients with somatically mutated CLL-cell immunoglobulin genes and identified 2 patients with mult

55 on, including appropriate expression of both immunoglobulin genes and other early B-cell-restricted g

56 V antibodies are encoded by a diverse set of immunoglobulin genes and recognize various conformationa

57 in loci; it can instigate DNA lesions in non-immunoglobulin genes and thus stringent checks are in pl

58 lated to ensure ordered recombination of the immunoglobulin genes and to avoid genomic instability.

59 sively differentiating cells, an analysis of immunoglobulin genes and transcripts indicated that pro-

60 is necessary for production of a functional immunoglobulin gene, and renders the cells highly sensit

61 cesses such as class-switch recombination of immunoglobulin genes, and its dysfunction is implicated

62 Immunoglobulin genes are assembled during lymphoid devel

63 among which expressions of mitochondria and immunoglobulin genes are differentially perturbed in ped

64 Immunoglobulin genes are formed through V(D)J recombinat

65 f AID's promiscuity and its predilection for immunoglobulin genes are unknown.

66 opriate reference DNA enabled us to identify immunoglobulin genes as novel cancer targets playing a r

67 l division is accompanied by mutation of the immunoglobulin genes, at what is believed to be a fixed

68 B lymphopoiesis requires that immunoglobulin genes be accessible to RAG1-RAG2 recombin

69 The cytidine deaminase AID hypermutates immunoglobulin genes but can also target oncogenes, lead

70 Rearrangement of T-cell receptor (TCR) and immunoglobulin genes by a common V(D)J recombination mac

71 c hypermutation (SHM) in variable regions of immunoglobulin genes by activation-induced deaminase (AI

72 Blimp-1 induced the transcription of immunoglobulin genes by controlling the 3' enhancers of

73 relies on the somatic diversification of the immunoglobulin genes by V(D)J recombination, somatic hyp

74 Somatic mutations of immunoglobulin genes characterize mature memory B cells,

75 iously known to be involved in mRNA editing, immunoglobulin gene class switching, and immunoglobulin

76 d that HGAL is dispensable for GC formation, immunoglobulin gene class-switch recombination, and soma

77 ranscription polymerase chain reaction-based immunoglobulin gene cloning and recombinant expression a

78 we have previously shown to hypermutate its immunoglobulin genes constitutively.

79 and this report addresses the nature of the immunoglobulin genes controlling the host antibody respo

80 damage induced sister chromatid exchange and immunoglobulin gene conversion are unaffected.

81 n by disruption of XRCC3 not only suppresses immunoglobulin gene conversion but also prevents the abe

82 t induce DSBs, (ii) defective in HR-mediated immunoglobulin gene conversion, and (iii) exhibit an inc

83 e (AID) converts DNA cytosines to uracils in immunoglobulin genes, creating antibody diversification.

84 unable to generate somatic hypermutations of immunoglobulin genes) displayed anti-nontypeable H influ

85 iters, but the role of ATM in antigen-driven immunoglobulin gene diversification has not been defined

86 AID is required for immunoglobulin gene diversification in B lymphocytes, bu

87 cific factor that deaminates DNA to initiate immunoglobulin gene diversification.

88 d deaminase, acting in the shared pathway of immunoglobulin gene diversification.

89 rporation of dUTP in DNA, and for increasing immunoglobulin gene diversity during the acquired immune

90 ns as the frequency of mutation in noncoding immunoglobulin gene DNA is the same in high- and low- af

91 function is to potentiate diversification of immunoglobulin gene DNA.

92 as the rearrangement of T-cell receptor and immunoglobulin genes during lymphoid development or the

93 beyond about 1 to 2 kb from the promoter of immunoglobulin genes during SHM must be due to special c

94 which leads to mutations at C:G basepairs in immunoglobulin genes during somatic hypermutation.

95 s of these xenoantibodies were compared with immunoglobulin genes encoding antibodies that react with

96 hat overexpress TCL1 under control of the mu immunoglobulin gene enhancer, develop a CD5+ B cell lymp

97 Allelic exclusion of immunoglobulin genes ensures the expression of a single

98 of B cells with a diverse representation of immunoglobulin genes, exhibiting antigen-driven positive

99 present an IFN response, cell proliferation, immunoglobulin gene expression, viral dose-dependent gen

100 Together, these data add to the selectin and immunoglobulin gene families a new inducible endothelial

101 tebrate major histocompatibility complex and immunoglobulin gene families.

102 s of evolution, involving random mutation of immunoglobulin genes followed by natural selection by T

103 may expand B cells carrying largely distinct immunoglobulin genes following antigenic challenge.

104 tion and the DNA cleavage events involved in immunoglobulin gene formation, and because Tn5-derived t

105 blood from the same patient showed that the immunoglobulin genes from both compartments had dominant

106 further tested these programs using 30 human immunoglobulin genes from Genbank and here highlight ins

107 Cloning of immunoglobulin genes from HA-specific B cells isolated f

108 By expressing immunoglobulin genes from individual cells, we identifie

109 Immunoglobulin genes from single Api m 1-specific Bmem w

110 rainbow' cell-fate mapping and sequencing of immunoglobulin genes from single cells, we find that 5-1

111 We sought to sequence immunoglobulin genes from single-cell clones of dominant

112 gate revealed that they all used heavy-chain immunoglobulin genes from the V(H)3 family, two expresse

113 NK cells do not rearrange T-cell receptor or immunoglobulin genes from their germline configuration.

114 and insertion of DNA that encodes LAIR1 into immunoglobulin genes generates RIFIN-specific antibodies

115 Evidence for somatic hypermutation of immunoglobulin genes has been observed in all of the spe

116 ell diversification in patients with mutated immunoglobulin genes has not been previously presented.

117 Molecular analyses of immunoglobulin genes have delineated two or more subgrou

118 ures in HCL were examined in a series of 130 immunoglobulin gene heavy chain rearrangements, includin

119 L) with unmutated (U-CLL) or mutated (M-CLL) immunoglobulin gene heavy-chain variable region (IGHV) d

120 n-activated B-cell clones expand and undergo immunoglobulin gene hypermutation and selection.

121 particularly useful for analysing endogenous immunoglobulin gene hypermutation in several mouse strai

122 To test the hypothesis that immunoglobulin gene hypermutation in vivo employs a path

123 ng, immunoglobulin gene class switching, and immunoglobulin gene hypermutation.

124 ed apoptosis and suggest that members of the immunoglobulin gene (Ig) superfamily, like cell surface

125 h recombination and somatic hypermutation of immunoglobulin genes (Ig) in B lymphocytes.

126 ained from high-throughput DNA sequencing of immunoglobulin genes (Ig-seq) can be applied to detect B

127 on (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igkappa, and Iglambda).

128 ations in the heavy-chain variable region of immunoglobulin genes (IGHV).

129 rmutations (SHM) into the variable region of immunoglobulin genes (IgVs).

130 se by activation of AID and hypermutation of immunoglobulin gene in B cells, leading to HCV-associate

131 The collection of immunoglobulin genes in an individual's germline, which

132 S does not impact on the rate of mutation of immunoglobulin genes in B lymphocytes, suggesting that t

133 The c-myc gene is translocated to one of the immunoglobulin genes in Burkitt's lymphoma resulting in

134 in T-helper lymphocytes, and suppression of immunoglobulin genes in early stages of disease.

135 ypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during a

136 d undergo secondary diversification of their immunoglobulin genes in germinal centres (GCs).

137 ymphomagenesis has been inferred by studying immunoglobulin genes in human lymphomas and by engineeri

138 These genes catalyze the rearrangement of immunoglobulin genes in immature B lymphocytes and of T

139 e inferred to be copied by pol during SHM of immunoglobulin genes in mice.

140 argeted hypermutation of variable regions of immunoglobulin genes in response to stimulation by antig

141 Analysis of the repertoire of rearranged immunoglobulin genes in the B cells of microdissected fo

142 ductive V gene rearrangement, the functional immunoglobulin genes in the B lymphocytes of man and mou

143 in prokaryotes and by V(D)J recombination of immunoglobulin genes in vertebrates.

144 It has been postulated that certain immunoglobulin genes (including 2a2) are rearranged pref

145 ) MCLs carry CCND2/CCND3 rearrangements with immunoglobulin genes, including a novel IGK/L enhancer h

146 Hypermutation of immunoglobulin genes is a key process in antibody divers

147 The expression of immunoglobulin genes is controlled in part by the DNA-bi

148 e of variations in the genomic loci encoding immunoglobulin genes is incomplete, resulting in conflic

149 B-cell-specific transcription of immunoglobulin genes is mediated by the interaction of a

150 ypermutation mechanism is targeted solely to immunoglobulin genes is no longer tenable.

151 Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antib

152 tic hypermutation in the variable regions of immunoglobulin genes is required to produce high affinit

153 e propose that diversification of functional immunoglobulin genes is triggered by AID-mediated deamin

154 ion (CSR) and somatic hypermutation (SHM) of immunoglobulin genes, is essential for the removal of de

155 onstrated with antibody-deficient muMT mice (immunoglobulin-gene knockout mice), and CD4(+) spleen T

156 cells, AID deaminates cytosine in the DNA of immunoglobulin genes, leading to the accumulation of mut

157 ased on the insertion of host receptors into immunoglobulin genes, leading to the production of recep

158 cells and correlates with the expression of immunoglobulin genes located in its genomic vicinity.

159 ies hyperdiploidy or translocations into the immunoglobulin gene loci are considered as initiating ev

160 inging c-MYC into the vicinity of one of the immunoglobulin gene loci.

161 Thus, AID is required for all three immunoglobulin gene modification programs (gene conversi

162 namic programming method that uses conserved immunoglobulin gene motifs to improve performance of ali

163 with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T ba

164 ow a markedly reduced level of non-templated immunoglobulin gene mutation, indicating a defect in tra

165 notype and a post-germinal center pattern of immunoglobulin gene mutation.

166 status and presence of specific somatic and immunoglobulin gene mutations have been shown to be reli

167 h respect to clinical course and presence of immunoglobulin gene mutations in the CLL cells.

168 sive accumulation of somatic mutation in the immunoglobulin genes of antigen-specific memory B cells

169 alter genomic sequence and structure at the immunoglobulin genes of B lymphocytes: gene conversion,

170 Subsequent sequencing of immunoglobulin genes of individual IgA + PCs present wit

171 The characteristics of their immunoglobulin genes offer insights into the underlying

172 ell markers, such as expression of unmutated immunoglobulin genes or the zeta-associated protein of 7

173 liest jawed vertebrates possess a primordial immunoglobulin gene organization where each gene cluster

174 ion, class switching, and gene conversion in immunoglobulin genes, possibly via the spliceosome trans

175 Changes in signal transduction and immunoglobulin genes predicted peak hemagglutinin inhibi

176 Hypermutation in immunoglobulin genes produces a high frequency of substi

177 l as a reduction in mRNA levels of secretory immunoglobulin gene products such as mu(s) and J chain a

178 tions showed the highest frequency of clonal immunoglobulin gene products.

179 arget the somatic hypermutation process, the immunoglobulin gene promoter located upstream of the var

180 The B-cell lymphoma is monoclonal for immunoglobulin gene rearrangement and is phenotypically

181 for DNA double-strand break (DSB) repair and immunoglobulin gene rearrangement and may play a role in

182 nal center B cells creates the potential for immunoglobulin gene rearrangement and the generation of

183 Functional immunoglobulin gene rearrangement is a sine qua non for

184 This analysis also demonstrated that immunoglobulin gene rearrangement is less precise than p

185 machinery that is responsible for secondary immunoglobulin gene rearrangement, we examined the expre

186 cked at the progenitor B cell stage prior to immunoglobulin gene rearrangement.

187 on from B-0 (also known as B-2) occurs after immunoglobulin gene rearrangement.

188 mammalian DNA double-strand break repair and immunoglobulin gene rearrangement.

189 ssociated antigens (11/15), exhibited clonal immunoglobulin gene rearrangements (13/13), contained Ep

190 Both neoplasms contained clonal immunoglobulin gene rearrangements and clonal EBV genome

191 Hairy cells possess clonal immunoglobulin gene rearrangements and express monoclona

192 Molecular analysis detecting immunoglobulin gene rearrangements and ocular cytokine l

193 t microbes can induce specific signatures of immunoglobulin gene rearrangements and that pathogen exp

194 Analysis of immunoglobulin gene rearrangements and viral terminal re

195 ne conversion but also prevents the aberrant immunoglobulin gene rearrangements associated with RAD18

196 Immunoglobulin gene rearrangements document the monoclon

197 prepared libraries from T-cell receptor and immunoglobulin gene rearrangements in context of lymphop

198 ents occur in developing macronuclei, as for immunoglobulin gene rearrangements in mammals, but not d

199 Analysis of immunoglobulin gene rearrangements indicated that the ly

200 Clonal CD27(+)ALDH(high) B cells, sharing immunoglobulin gene rearrangements with lymph node HRS c

201 ll antigen receptor through nested secondary immunoglobulin gene rearrangements, a process termed rec

202 nt is a highly ordered process that involves immunoglobulin gene rearrangements, antigen receptor exp

203 cillary testing included PCR for heavy chain immunoglobulin gene rearrangements, immunohistochemistry

204 Southern blot analysis for immunoglobulin gene rearrangements, terminal repeat anal

205 nds, and Rag1 is a transposase that mediates immunoglobulin gene rearrangements.

206 is that should occur following nonproductive immunoglobulin gene rearrangements.

207 ressed the transgene and excluded endogenous immunoglobulin gene rearrangements.

208 reaction for clone-specific T-cell receptor/immunoglobulin gene rearrangements.

209 We propose that secondary immunoglobulin-gene rearrangements outside organized lym

210 om HIV-1-infected individuals are encoded by immunoglobulin gene rearrangments with infrequent naive

211 The data further suggest that selected immunoglobulin genes recognize specific protein structur

212 Immunoglobulin gene recombination can result in the asse

213 kage promotes interactions between c-myc and immunoglobulin gene regulatory elements that affect c-my

214 t tolerant of the DNA breaks associated with immunoglobulin gene remodeling mechanisms involved in th

215 , presumably due to bystander effects of the immunoglobulin gene remodeling that takes place at these

216 MBL and subsequent CLL and characterized the immunoglobulin gene repertoire of the prediagnostic B-ce

217 of the breast, but little is known about the immunoglobulin gene repertoire of these tumor-infiltrati

218 ic hypermutation and switch recombination of immunoglobulin genes require the activity of the activat

219 The establishment of allelic exclusion in immunoglobulin genes requires differential treatment of

220 re used to clone, sequence, and identify the immunoglobulin genes responsible for encoding rat xenoan

221 Single-cell immunoglobulin gene retrieval analysis shows that these

222 bodies revealed the versatility of the human immunoglobulin gene segment D3-3 (IGHD-3-3) in recognizi

223 results may help explain the GC-richness of immunoglobulin gene segment joins (N regions) and the lo

224 mal cell and cytokine dependency, functional immunoglobulin gene segment rearrangement, and subsequen

225 arantee high coverage of even highly mutated immunoglobulin gene segments as well as on optimized ant

226 nhairpin coding ends associated with various immunoglobulin gene segments in cells undergoing V(D)J r

227 R modules in agnathans (jawless fish) and of immunoglobulin gene segments in gnathostomes (jawed vert

228 e antibodies combining the IGHV3-15/IGLV1-40 immunoglobulin gene segments that were identified in all

229 mbination of extrachromosomal and endogenous immunoglobulin gene segments.

230 eudogenes, and, additionally, 70 pseudogenic immunoglobulin gene segments.

231 r circulating tumour DNA encoding the clonal immunoglobulin gene sequence could be detected in the se

232 Previous studies of immunoglobulin gene sequences in patients with allergic

233 metimes oncogenic) mutations at numerous non-immunoglobulin gene sequences.

234 Immunoglobulin gene sequencing confirmed that several of

235 Given these findings, vaccines driving immunoglobulin gene somatic hypermutation should be a pr

236 tic reduction in the accumulation of de novo immunoglobulin gene somatic mutations upon vaccination.

237 ytes that infiltrate the kidneys express the immunoglobulin gene somatic recombination machinery usua

238 mode of action is probably a combination of immunoglobulin gene specific activation of AID and a per

239 ne deaminase (AID), that is required for all immunoglobulin gene-specific modification reactions (som

240 HIV have aberrant and unstable expression of immunoglobulin genes suggestive of a high degree humoral

241 ecule-1 (PECAM-1) is a 130-kDa member of the immunoglobulin gene superfamily (IgSF) that is present o

242 nt of mouse 5A11/Basigin, is a member of the immunoglobulin gene superfamily and has been named 5A11/

243 ciated glycoprotein (MAG) is a member of the immunoglobulin gene superfamily and is thought to play a

244 1 (PECAM-1, CD31) is a 130-kDa member of the immunoglobulin gene superfamily expressed on endothelial

245 ial cell adhesion molecule-1 (PECAM-1) is an immunoglobulin gene superfamily member expressed constit

246 at mediate compaction: protein zero (P0), an immunoglobulin gene superfamily member, or proteolipid p

247 Structurally, KIM-1 is a member of the immunoglobulin gene superfamily most reminiscent of muco

248 -1 (PECAM-1, CD31) is a 130-kd member of the immunoglobulin gene superfamily that is expressed on the

249 olecule-1 (PECAM-1) is 130-kDa member of the immunoglobulin gene superfamily that localizes to cell-c

250 Myelin protein zero (MPZ) is a member of the immunoglobulin gene superfamily with single extracellula

251 of huMUC18, a cell adhesion molecule in the immunoglobulin gene superfamily, causes a non-metastatic

252 a cell adhesion/recognition molecule of the immunoglobulin gene superfamily, regulates axon growth a

253 n kinase (MLCK) gene, a muscle member of the immunoglobulin gene superfamily, yields both smooth musc

254 B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily.

255 at, and murine genes that are members of the immunoglobulin gene superfamily.

256 haring sequence homology with members of the immunoglobulin gene superfamily.

257 noma-associated antigen pE4, a member of the immunoglobulin gene superfamily.

258 s encoding antigen receptors on lymphocytes (immunoglobulin genes, T cell receptor genes and NK recep

259 Despite its nonproductive immunoglobulin genes, the Reed-Sternberg cell avoids the

260 Immunoglobulin genes then experience further diversifica

261 otic gene BCL2 to the regulatory elements of immunoglobulin genes, thereby disrupting 1 heavy-chain a

262 duced deaminase (AID) initiates diversity of immunoglobulin genes through deamination of cytosine to

263 ion of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and

264 ID) is a B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombinat

265 uction of deoxyuridine (dU) mutations within immunoglobulin genes to initiate somatic hypermutation (

266 Because of the extreme diversity in immunoglobulin genes, tolerance mechanisms are necessary

267 iption factor that activates B-cell-specific immunoglobulin gene transcription and is required for ea

268 Immunoglobulin gene transcription was enhanced when Brig

269 ncing the generation of genetic lesions (c- :immunoglobulin gene translocation, -6 overexpression) as

270 l of human Burkitt's lymphoma that bears MYC/Immunoglobulin gene translocations.

271 e (AID) deaminates deoxycytidine residues in immunoglobulin genes, triggering antibody diversificatio

272 DMPA associated with mucosal-wide immunoglobulin gene upregulation, verified by CD20(+) B-

273 During somatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-i

274 sporadic B-CLL display a similar pattern of immunoglobulin gene usage and frequency of somatic mutat

275 ith no apparent tendency for conservation of immunoglobulin gene usage between individuals.

276 s unique and demonstrated a clonal bias; the immunoglobulin gene usage was considerably different fro

277 s exhibited close similarities in phenotype, immunoglobulin gene usage, and mutation status, and expr

278 velopment, low B- and T-cell numbers, normal immunoglobulin gene use, limited B- and T-cell repertoir

279 tic similarity between the human and macaque immunoglobulin genes used to encode some V3-directed MAb

280 (RT-PCR) amplified variable regions of mouse immunoglobulin genes using a strong anion exchange (AEX)

281 in the context of developmentally regulated immunoglobulin gene V(D)J recombination, somatic hypermu

282 tation, switch recombination, and reactivate immunoglobulin gene V(D)J recombination.

283 lineage-specific gene expression program and immunoglobulin gene V(H) to DJ(H) recombination.

284 Immunoglobulin gene variable domains encoding the antibo

285 rom nonautoreactive B cells that diversified immunoglobulin genes via SHM.

286 fied, indicating that machinery to rearrange immunoglobulin genes was intact.

287 PCR for immunoglobulin genes was polyclonal in reactive lymphoid

288 By following the rapidly mutating tumor immunoglobulin genes, we discovered that BCR subclones w

289 lonality by PCR of T-cell receptor gamma and immunoglobulin genes were categorized in 122 EBV(+) lesi

290 Mice transgenic for human immunoglobulin genes were immunized with OspA from B. bu

291 Transgenic mice with human immunoglobulin genes were immunized with the recombinant

292 Transgenic mice carrying human immunoglobulin genes were used to isolate HuMAbs that ne

293 The detected variants of the cattle immunoglobulin genes, which are implicated in the succes

294 echnique to amplify clonospecific rearranged immunoglobulin genes, which have applications as markers

295 ned by assembly and sequential expression of immunoglobulin genes, which in turn are regulated by the

296 mples include the somatic diversification of immunoglobulin genes, which is the foundation of the ver

297 s commonly bear chromosome translocations to immunoglobulin genes, which points to a role for antibod

298 n of the ALAS2 and downregulation of several immunoglobulin genes, while the good prognosis subgroup

299 ee novel genes: IGHG3 (p = 9.8 x 10(-7)), an immunoglobulin gene whose antibodies interact with beta-

300 ions/deletions led to a rapid birth/death of immunoglobulin genes within the human population and lar