ライフサイエンスコーパス: immunoglobulin heavy chain

1 re-B cells that have successfully rearranged immunoglobulin heavy chain.

2 omain of gp130 fused to the Fc region of the immunoglobulin heavy chain.

3 s with completed V(D)J rearrangements of the immunoglobulin heavy chain.

4 y the loss of individual contacts across the immunoglobulin heavy chain.

5 ciated with unassembled, incompletely folded immunoglobulin heavy chains.

6 e sequenced gene rearrangements encoding the immunoglobulin heavy chain, a major determinant of epito

7 a (CLL) samples that expressed more than one immunoglobulin heavy-chain allele and five samples that

8 er they did or did not express more than one immunoglobulin heavy-chain allele.

9 ection of class switch recombination in both immunoglobulin-heavy chain alleles in single cells from

10 pro-B- to pre-B-cell transition and impairs immunoglobulin heavy chain allelic exclusion, hallmarks

11 iants were not restricted to samples lacking immunoglobulin heavy-chain allelic exclusion and most li

12 V-DJ recombination in a transgenic model of immunoglobulin heavy-chain allelic exclusion.

13 hain allele and five samples that had normal immunoglobulin heavy-chain allelic exclusion.

14 highest levels detected in plants expressing immunoglobulin heavy chain alone.

15 pt were found in those plants that expressed immunoglobulin heavy chain alone.

16 DnaJ family member that binds to unassembled immunoglobulin heavy chains along with the BiP chaperone

17 s of the VRC01-class derive from the IGHV1-2 immunoglobulin heavy chain and neutralize a wide spectru

18 To determine the localization of immunoglobulin heavy chains and complement activation in

19 and the lysis of B cells in preparation for immunoglobulin heavy-chain and light-chain amplification

20 ination (CSR) and accumulation of unresolved immunoglobulin heavy chain-associated DSBs.

21 Immunoglobulin heavy chain binding protein (BiP) and two

22 inding protein homologous protein (chop) and immunoglobulin heavy chain binding protein (bip) levels.

23 te binding protein with sequence identity to immunoglobulin heavy chain binding protein (BiP).

24 Whereas immunoglobulin heavy chain binding protein mRNA was sign

25 ancer-binding protein homologous protein and immunoglobulin heavy chain binding protein UPR-response

26 induce expression of the molecular chaperone immunoglobulin heavy chain binding protein.

27 Here, we show that loss of the BiP (immunoglobulin heavy-chain binding protein) co-chaperone

28 BiP (immunoglobulin heavy-chain binding protein) is the endop

29 pical UPR target, the Caenorhabditis elegans immunoglobulin heavy chain-binding protein (BiP) homolog

30 bAB favors cleavage of the newly synthesized immunoglobulin heavy chain-binding protein (BiP) to yiel

31 d, as was the endoplasmic reticulum protein, immunoglobulin heavy chain-binding protein, that co-immu

32 ed expression of UPR target genes, including immunoglobulin heavy chain-binding protein/glucose-regul

33 nd identified ER lumenal molecular chaperone immunoglobulin heavy-chain-binding protein (BiP) as limi

34 complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3), the center of the c

35 recursor B cells (PreB cells) is dictated by immunoglobulin heavy chain checkpoint (IgHCC), where the

36 Immunoglobulin heavy chain class switch recombination (C

37 Immunoglobulin heavy chain class switch recombination (C

38 regulate the Iepsilon promoter that controls immunoglobulin heavy chain class switching to IgE.

39 mature B cells are moderately defective for immunoglobulin heavy-chain class switch recombination.

40 ps in vitro, a potential intermediate during immunoglobulin heavy-chain class switch recombination.

41 e activation-induced deaminase (AID) acts at immunoglobulin heavy-chain class switch regions during m

42 The only immunoglobulin heavy-chain classes known so far in teleo

43 cogenic chromosomal abnormalities as well as immunoglobulin heavy chain complementarity region 3 area

44 and exon skipping with the gene encoding the immunoglobulin heavy-chain complex (Igh) and reporter co

45 re of signals that govern the development of immunoglobulin heavy chain-dependent B cells is largely

46 sed CSR and substantial levels of IgH locus (immunoglobulin heavy chain, encoded by Igh) chromosomal

47 ement of genomic DNA that occurs to form the immunoglobulin heavy-chain-encoding sequence in developi

48 ession in B lymphocytes by incorporating the immunoglobulin heavy chain enhancer (E micro ) with and

49 SREBP-1, the transcription factor binding to immunoglobulin heavy chain enhancer 3', and the aryl hyd

50 ell survival to regions juxtaposed to active immunoglobulin heavy chain enhancer elements, chromosoma

51 appaB and Sp1 transcription factors with the immunoglobulin heavy chain enhancer region are important

52 ich CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associa

53 The immunoglobulin heavy chain enhancer, or mu enhancer, is

54 placing an oncogene under the control of the immunoglobulin heavy chain enhancer.

55 ed by means of next-generation sequencing of immunoglobulin heavy chains from circulating memory B ce

56 Chromosomal rearrangements involving the immunoglobulin heavy chain gene (IGH) at 14q32 are obser

57 that establishes the structure of the 2.8-Mb immunoglobulin heavy chain gene (IgH) locus in pro-B cel

58 B cell development and rearrangement of the immunoglobulin heavy chain gene (Igh).

59 0 years, and in prognostic groups defined by immunoglobulin heavy chain gene (V(H)) mutation status a

60 efect in the VH to DJH rearrangement step of immunoglobulin heavy chain gene assembly even though the

61 interaction of these factors with the human immunoglobulin heavy chain gene enhancer regions in t(14

62 In a cell-free system based on the immunoglobulin heavy chain gene enhancer, we show that T

63 required for the complete activation by the immunoglobulin heavy chain gene enhancer.

64 activation of c-myc promoter activity by the immunoglobulin heavy chain gene enhancer.

65 n a loss of promoter activity induced by the immunoglobulin heavy chain gene enhancer.

66 within the bcl-2 5' flanking region and the immunoglobulin heavy chain gene enhancers.

67 2: 18 of 29 (62%) had a translocation of the immunoglobulin heavy chain gene IGH@ on 14q32 to CRLF2 i

68 rimers to amplify the CDR3 VDJ region of the immunoglobulin heavy chain gene in combination with an i

69 Regulation of the immunoglobulin heavy chain gene is controlled in part by

70 Translocation of the bcl-2 gene to the immunoglobulin heavy chain gene is the most common alter

71 It positively induces gene rearrangements at immunoglobulin heavy chain gene loci by transcriptionall

72 t role in the lineage-specific regulation of immunoglobulin heavy chain gene rearrangement.

73 ndergo clonal expansion following successful immunoglobulin heavy chain gene rearrangement.

74 was used to confirm amplification of clonal immunoglobulin heavy chain gene rearrangements and to es

75 on initiation factor-I (TFII-I), to activate immunoglobulin heavy chain gene transcription in the nuc

76 gene driven by the powerful enhancer of the immunoglobulin heavy chain gene, leading to uncontrolled

77 onal machinery to the variable region of the immunoglobulin heavy chain gene.

78 nd the mechanisms underlying the role of the immunoglobulin heavy-chain gene (IgH) 3' enhancers on bc

79 visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B ce

80 neration sequencing approach to characterize immunoglobulin heavy-chain gene (IGH) repertoires in pat

81 14;18) lymphomas, bcl-2 is juxtaposed to the immunoglobulin heavy-chain gene (IgH), resulting in incr

82 within the bcl-2 5' flanking region and the immunoglobulin heavy-chain gene enhancers.

83 tic factors such as interphase cytogenetics, immunoglobulin heavy-chain gene mutational analysis, and

84 rs (interphase cytogenetics) but not others (immunoglobulin heavy-chain gene mutational status, zeta-

85 D45, CD19, CD5, CD10, kappa, and lambda) and immunoglobulin heavy-chain gene rearrangement by reverse

86 ion on a polymerase chain reaction (PCR) for immunoglobulin heavy-chain gene rearrangements in the fi

87 rk that regulates B cell fate commitment and immunoglobulin heavy-chain gene recombination.

88 and relevant secondary surrogate markers of immunoglobulin heavy-chain gene, including methylation o

89 Sequence analysis of the immunoglobulin heavy chain genes (IgH) has demonstrated

90 region-binding transcriptional regulator of immunoglobulin heavy chain genes and of E2F1-dependent c

91 ed as at least 1 of the following: unmutated immunoglobulin heavy chain genes, deletion 17p or 11q, o

92 M variable genes are most similar to that of immunoglobulin heavy chain genes.

93 ve variant of CLL characterized by unmutated immunoglobulin heavy-chain genes and with a single nucle

94 tion, or both and in patients with unmutated immunoglobulin heavy-chain genes.

95 ses the interaction of p/CIP with the murine immunoglobulin heavy chain germ line epsilon promoter in

96 at in all donors a heavily biased use of two immunoglobulin heavy chain germlines generated high affi

97 amorphous deposits of a truncated monoclonal immunoglobulin heavy chain (HC) bearing a deletion of th

98 rd complementarity determining region of the immunoglobulin heavy chain (HCDR3).

99 The immunoglobulin heavy chain (IgH) 3' regulatory region mo

100 ulated contraction of the locus encoding the immunoglobulin heavy chain (Igh) and controlled expressi

101 g (V(D)J) recombination at loci encoding the immunoglobulin heavy chain (Igh) and immunoglobulin ligh

102 ng the 3' enhancers of the loci encoding the immunoglobulin heavy chain (Igh) and kappa-light chain (

103 ceptor spectratyping, and deep sequencing of immunoglobulin heavy chain (IGH) and T-cell receptor del

104 Immunoglobulin heavy chain (IgH) class switch recombinat

105 tes DNA double-strand break (DSB) repair and immunoglobulin heavy chain (IgH) class switch recombinat

106 Immunoglobulin heavy chain (IgH) class switch recombinat

107 ifferent effector functions, B cells undergo Immunoglobulin Heavy Chain (IgH) class switch recombinat

108 Immunoglobulin heavy chain (IgH) class-switch recombinat

109 ks (DSBs) into switch (S) regions that flank immunoglobulin heavy chain (IgH) constant region exons.

110 ty of 0.8 and sensitivity of 0.65 to 0.95 by immunoglobulin heavy chain (IGH) gene arrangement testin

111 comprehensive view of DNA methylation at the immunoglobulin heavy chain (IgH) gene locus prior to and

112 The immunoglobulin heavy chain (IgH) gene locus spans severa

113 lated recombination and transcription of the immunoglobulin heavy chain (IgH) gene locus.

114 A clonal rearrangement of the immunoglobulin heavy chain (IgH) gene was identified in

115 Immunoglobulin heavy chain (IgH) genes are formed, teste

116 monstrated in knock-in mouse models carrying immunoglobulin heavy chain (IgH) genes encoding self-rea

117 In particular, the rearrangement of immunoglobulin heavy chain (IgH) genes in murine PDCs an

118 B cell-specific expression of immunoglobulin heavy chain (IgH) genes utilizes two cis

119 merase chain reaction (PCR) amplification of immunoglobulin heavy chain (IgH) genes.

120 which we determined the progenitor B cell by immunoglobulin heavy chain (IgH) genotyping.

121 hieved on tissue-specific genes, such as the immunoglobulin heavy chain (IgH) in B cells remains uncl

122 romatin remodeling constraints as endogenous immunoglobulin heavy chain (IgH) loci and examined the r

123 terized by complicon formation involving the immunoglobulin heavy chain (Igh) locus and the c-myc onc

124 determine the exact breakpoints in both the immunoglobulin heavy chain (IGH) locus and the partner c

125 ch depends on contraction of the 2.8-Mb-long immunoglobulin heavy chain (Igh) locus by Pax5(17,18).

126 dentify a novel susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a hap

127 e 3' regulatory region (3' RR) of the murine immunoglobulin heavy chain (IgH) locus contains multiple

128 Chromosomal translocations involving the immunoglobulin heavy chain (IGH) locus define common sub

129 V(D)J recombination at the immunoglobulin heavy chain (IgH) locus follows the 12/23

130 ncoded by a gene found to translocate to the immunoglobulin heavy chain (IgH) locus in some mucosa-as

131 VDJ rearrangement in the mouse immunoglobulin heavy chain (Igh) locus involves a combin

132 ns based on the sequence of their rearranged immunoglobulin heavy chain (IgH) locus is an important t

133 The intronic enhancer (E mu) of the immunoglobulin heavy chain (IgH) locus is critical for V

134 double-strand breaks (DSBs) within two large immunoglobulin heavy chain (IgH) locus switch (S) region

135 Transcription at the immunoglobulin heavy chain (Igh) locus targets CSR-assoc

136 We identify the immunoglobulin heavy chain (IGH) locus to be associated

137 about the role of CTCF binding at the murine immunoglobulin heavy chain (IgH) locus, we utilized a co

138 We identified a TTR in the mouse immunoglobulin heavy chain (Igh) locus, which contains r

139 d by chromosome translocations involving the immunoglobulin heavy chain (IgH) locus.

140 to analyze rearrangements at the endogenous immunoglobulin heavy chain (Igh) locus.

141 ype switching to IgE in human subjects using immunoglobulin heavy chain (IGH) mutational lineage data

142 Production of immunoglobulin heavy chain (IgH) protein feeds back to t

143 The production of immunoglobulin heavy chain (IgH) protein in pro-B cells

144 We studied the molecular features of the immunoglobulin heavy chain (IGH) rearrangements in 165 p

145 In plasma cells, immunoglobulin heavy chain (IgH) secretory-specific mRNA

146 nslocations, which are mediated by errors in immunoglobulin heavy chain (IgH) switch recombination or

147 Chromosomal translocations involving immunoglobulin heavy chain (Igh) switch regions and an o

148 as and frequently have chromosomal breaks in immunoglobulin heavy chain (IgH) switch regions, suggest

149 uid specimens and more recently by molecular-immunoglobulin heavy chain (IGH) translocation or cytoki

150 The characterization of immunoglobulin heavy chain (IGH) translocations provides

151 severely defective for recombination of all immunoglobulin heavy chain (IgH) V gene segments, but th

152 B-cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segmen

153 in most cases and typically carry rearranged immunoglobulin heavy chain (IGH) variable (V) region gen

154 Immunoglobulin heavy chain (IgH) variable region exons a

155 pre- and post-HCT relapse risk, we performed immunoglobulin heavy chain (IgH) variable, diversity, an

156 and survival impact of del(6)(q22) and BCL6, immunoglobulin heavy chain (IGH), and MYC gene rearrange

157 Of 51 MBL samples in which immunoglobulin heavy chain (IGH)V-D-J genotypes could be

158 Genes encoding immunoglobulin heavy chains (Igh) are assembled by rearr

159 The immunoglobulin heavy-chain (IgH) gene locus undergoes ra

160 The first steps of murine immunoglobulin heavy-chain (IgH) gene recombination take

161 - and growth factor-induced up-regulation of immunoglobulin heavy-chain (IgH) genes and in E2F1-depen

162 sed a defect in somatic rearrangement in the immunoglobulin heavy-chain (IgH) locus and a block in th

163 FISH-based techniques, rearrangements of the immunoglobulin heavy-chain (IgH) locus at 14q32 have bee

164 Large-scale contraction of the immunoglobulin heavy-chain (Igh) locus facilitates rearr

165 The immunoglobulin heavy-chain (Igh) locus is organized into

166 The murine immunoglobulin heavy-chain (Igh) locus provides an impor

167 The immunoglobulin heavy-chain (IgH) locus undergoes large-s

168 Translocations at the immunoglobulin heavy-chain (IgH) locus, 14q32, are likel

169 itiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, leading to defec

170 Tumor-related immunoglobulin heavy-chain (IgH) rearrangements are mark

171 Immunoglobulin heavy-chain (IgH) translocations are seen

172 All identified SNPs are clustered around the immunoglobulin heavy chain (IGHC) locus on chromosome 14

173 The pre-BCR constitutes an immunoglobulin heavy chain (Igmu) and a surrogate light

174 )-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific

175 ion strongly reduces the ability of a distal immunoglobulin heavy chain intronic enhancer to stimulat

176 lear matrix attachment regions (MARs) of the immunoglobulin heavy chain intronic enhancer.

177 rs, interleukin-10, chemokine receptors, and immunoglobulin heavy-chain isotypes, was measured.

178 ulin heavy chain gene in combination with an immunoglobulin heavy chain joining region consensus prim

179 obulin heavy chain transcription) binding to immunoglobulin heavy chain loci after B-cell activation

180 boundaries of R-loops are well-documented at immunoglobulin heavy chain loci in mammalian B cells.

181 ecombination (CSR) in B lymphocytes replaces immunoglobulin heavy chain locus (Igh) Cmu constant regi

182 include, among others, translocations of the immunoglobulin heavy chain locus (IgH).

183 d by the spatio-temporal organization of the immunoglobulin heavy chain locus (Igh).

184 t link c-myc or other proto-oncogenes to the immunoglobulin heavy chain locus (IgH, encoded by Igh).

185 Translocations into the immunoglobulin heavy chain locus and aneuploidy are near

186 and antisense strand DNA mutagenesis at the immunoglobulin heavy chain locus and some other regions

187 The human immunoglobulin heavy chain locus contains 39 functional

188 presence of one of the translocations in the immunoglobulin heavy chain locus influenced the expressi

189 In this report, we have used the immunoglobulin heavy chain locus to address the role of

190 The previously reported association of the immunoglobulin heavy chain locus with immunoglobulin G i

191 initiated by deamination of C-->U within the immunoglobulin heavy chain locus, catalyzed by activatio

192 he HLA-DQA1 to HLA-DQB1 region, but also the immunoglobulin heavy chain locus, including the IGHV4-61

193 pairs at the region downstream of JH4 in the immunoglobulin heavy chain locus.

194 erted into its physiological position in the immunoglobulin heavy chain locus.

195 c, occurs extensively in the V region of the immunoglobulin heavy chain locus.

196 d acquired a translocation of c-myc into the immunoglobulin heavy chain locus.

197 lities and recurrent translocations into the immunoglobulin heavy chain locus.

198 enic translocations juxtaposes c-myc and the immunoglobulin heavy-chain locus (IgH) and is found in B

199 ently generated at switch (S) regions in the immunoglobulin heavy-chain locus (Igh), consistent with

200 00 kb apart within switch (S) regions in the immunoglobulin heavy-chain locus (IgH).

201 The profiling of S(mu) and immunoglobulin heavy-chain locus (IgH-VH) mutations in f

202 The break at the immunoglobulin heavy-chain locus on chromosome 14 is an

203 Productive rearrangement of the immunoglobulin heavy-chain locus triggers a major develo

204 Immunoglobulin heavy-chain locus V(D)J recombination req

205 ble, diversity, joining rearrangement at the immunoglobulin heavy-chain locus, a permanent genetic ch

206 cDNA, Myc(His), head to head into the mouse immunoglobulin heavy-chain locus, Igh, just 5' of the in

207 ad to head into different sites of the mouse immunoglobulin heavy-chain locus, Igh, mimic the chromos

208 variable gene segments and compaction of the immunoglobulin heavy-chain locus.

209 d to recombine variable gene segments at the immunoglobulin heavy-chain locus.

210 se, which expressed a Pax5 minigene from the immunoglobulin heavy-chain locus.

211 e nuclear repositioning or compaction of the immunoglobulin heavy-chain locus.

212 s revealed that translocations involving the immunoglobulin-heavy chain locus occurred exclusively in

213 Locus B of immunoglobulin heavy chain mapped to an area containing

214 induce a DNase I-hypersensitive site at the immunoglobulin heavy chain micro enhancer in vitro.

215 wer abundance of secretory-specific forms of immunoglobulin heavy-chain mRNA.

216 (A) site and was necessary for processing of immunoglobulin heavy-chain mRNA.

217 atifying by biologically related biomarkers, immunoglobulin heavy chain mutational status, and ZAP70

218 Furthermore, immunoglobulin heavy chain ongoing mutation status, whic

219 by the presence of clonal rearrangements of immunoglobulin heavy chain or T-cell receptor gamma chai

220 esenting increased PC differentiation and no immunoglobulin heavy chain production.

221 fluorescent protein under the control of an immunoglobulin heavy chain promoter and selected for hig

222 ane protein 1 (LMP1) under the control of an immunoglobulin heavy-chain promoter and enhancer develop

223 nsensus MORE (ATGCATATGCAT) or on MOREs from immunoglobulin heavy chain promoters (AT[G/A][C/A]ATATGC

224 as the heptamer/octamer motif) are found in immunoglobulin heavy chain promoters.

225 Immunoglobulin heavy chain rearrangement (V(H)-to-DJ(H))

226 BLIN-4E and BLIN-4L have the identical immunoglobulin heavy chain rearrangement and a CD10(+)/C

227 rogenase isozyme 5, beta2-microglobulin, and immunoglobulin heavy chain rearrangement studies have im

228 r immunoglobulin lambda chain 5, and contain immunoglobulin heavy-chain rearrangements, suggesting th

229 oth the major histocompatibility complex and immunoglobulin heavy chain region as major determinants.

230 trated both at the cyclin D1 promoter and 3' immunoglobulin heavy-chain regulatory regions only in ma

231 The immunoglobulin heavy chain repertoire is generated by so

232 ss 6.5 years to show that the BM plasma cell immunoglobulin heavy chain repertoire is remarkably stab

233 continues to contract while the diversity of immunoglobulin heavy chain repertoire recovers.

234 y, common restrictions were not found in the immunoglobulin heavy chain repertoire.

235 sfected with Bright and/or Btk along with an immunoglobulin heavy chain reporter construct.

236 The highly repetitive human immunoglobulin heavy chain sequence was analyzed using w

237 Younger age and mutated immunoglobulin heavy chain status were significant risk

238 ng subsets defined by expression of distinct immunoglobulin heavy chain subclasses.

239 fic model system, it was determined that the immunoglobulin heavy chain subunit of the IgM BCR of nor

240 mice) that often have canonical CDR3s in the immunoglobulin heavy chain that, owing to junctional bia

241 myeloid genes in vitro, including gp91-phox, immunoglobulin heavy chain, the T-cell receptor beta and

242 n switch from the membrane-bound form of the immunoglobulin heavy chain to its secreted form by activ

243 Bright (B-cell regulator of immunoglobulin heavy chain transcription) binding to imm

244 Bright, for B cell regulator of immunoglobulin heavy chain transcription, binds A+T-rich

245 s been characterized both as an activator of immunoglobulin heavy-chain transcription and as a proto-

246 apsulated bacteria and molecular analysis of immunoglobulin heavy chain transcripts were studied for

247 m these B cells lack functionally rearranged immunoglobulin heavy-chain transcripts, as shown by PCR-

248 year PFS was 53.9% for patients with mutated immunoglobulin heavy chain variable (IGHV) gene (IGHV-M)

249 sex, Rai stage, CD38 status, ZAP-70 status, immunoglobulin heavy chain variable (IGHV) gene mutation

250 in of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each h

251 nd that these changes are more pronounced in immunoglobulin heavy chain variable (IGHV)-unmutated CLL

252 Multivariate modeling revealed immunoglobulin heavy chain variable gene (IGHV) mutation

253 This effect was independent of treatment, immunoglobulin heavy chain variable gene (IGHV) status,

254 be predicted by analysis of mutations in the immunoglobulin heavy chain variable gene (IGHV).

255 A mutated immunoglobulin heavy chain variable gene and trisomy 12

256 s had high-risk features: 94% with unmutated immunoglobulin heavy chain variable gene rearrangement,

257 ulation of poor prognostic markers-unmutated immunoglobulin heavy chain variable genes, ZAP-70/CD38 p

258 ressing unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain variable genes.

259 ct relative to CD38 and ZAP-70 expression or immunoglobulin heavy chain variable region (IGHV) status

260 Such enhanced expression was more evident in immunoglobulin heavy chain variable region (IGHV)-mutate

261 < .001), and the absence of mutation in the immunoglobulin heavy chain variable region (IgV(H)) (P <

262 by the identification of a single rearranged immunoglobulin heavy chain variable region (VH) sequence

263 carrying CHD2 mutations also present mutated immunoglobulin heavy chain variable region genes (IGHVs)

264 ell expression of ZAP-70, CD38, or unmutated immunoglobulin heavy chain variable region genes (U-IGHV

265 revealed that CL1/CL2 combination score and immunoglobulin heavy chain variable region mutation stat

266 tment, whereas CL1/CL3 combination score and immunoglobulin heavy chain variable region mutation stat

267 ltivariable models of PFS and OS showed that immunoglobulin heavy chain variable region mutational st

268 induction of Noxa and Puma, independently of immunoglobulin heavy chain variable region mutational st

269 Next-generation sequencing of an immunoglobulin heavy chain variable region repertoire be

270 Using deep sequencing, we analyzed the immunoglobulin heavy chain variable region repertoire in

271 The tumor immunoglobulin heavy chain variable region was more freq

272 onic lymphocytic leukemia (CLL), analysis of immunoglobulin heavy chain variable regions for somatic

273 s also showed activation of their endogenous immunoglobulin heavy chain variable regions.

274 Chromosomal abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene m

275 3 as well as established prognostic markers (immunoglobulin heavy chain variable-region mutation stat

276 undance of RNA polymerase II (Pol II) at the immunoglobulin heavy-chain variable (Igh-V) region compa

277 Of the immunoglobulin heavy-chain variable (IGHV) genes express

278 The presence of immunoglobulin heavy-chain variable (IGHV) genes was det

279 In chronic lymphocytic leukemia (CLL), the immunoglobulin heavy-chain variable (IgVH) region may be

280 Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments

281 ter memory B cells that usually have mutated immunoglobulin heavy-chain variable (VH) genes.

282 During B lymphocyte development, immunoglobulin heavy-chain variable (VH), diversity (DH)

283 some 17p13.1 deletion, and 75% had unmutated immunoglobulin heavy-chain variable genes.

284 asculitis by analysing BCR clonality, use of immunoglobulin heavy-chain variable region (IGHV) genes

285 subgroup analysis involving patients without immunoglobulin heavy-chain variable region (IGHV) mutati

286 ecting TP53 and the mutational status of the immunoglobulin heavy-chain variable region are important

287 s systematic review, we examined the role of immunoglobulin heavy-chain variable region gene (IGHV) m

288 Use of immunoglobulin heavy-chain variable region gene families

289 positive results (P = .0002) and had mutated immunoglobulin heavy-chain variable region gene status (

290 e high Rai risk, 71% were nonmutated for the immunoglobulin heavy-chain variable region gene, 34% wer

291 eukemia (CLL) B cells that express unmutated immunoglobulin heavy-chain variable region genes (IgV(H)

292 espect to the somatic mutation status of the immunoglobulin heavy-chain variable region genes.

293 70), the mutational status of the rearranged immunoglobulin heavy-chain variable-region (IgV(H) ) gen

294 time to first treatment irrespective of the immunoglobulin heavy-chain variable-region gene (IGHV) m

295 , the CLL cells usually express an unmutated immunoglobulin heavy-chain variable-region gene (IgV(H))

296 , we performed high-throughput sequencing of immunoglobulin heavy chain VDJ rearrangements of naive,

297 stinct RNA transcriptome signature and human immunoglobulin heavy chain (VH) repertoire that was rela

298 whose population is dramatically expanded in immunoglobulin heavy chain Vh11 knock-in mice.

299 The monoclonal immunoglobulin heavy chains were also classified into sp

300 hains only, without expression of the normal immunoglobulin heavy chain, which constitutes light-chai