ライフサイエンスコーパス: immunologic

1 treatment failure events (161 virologic, 128 immunologic, 11 clinical) at a rate of 3.78 per 100 pers

2 This neurocognitive and immunologic ability for humans to symbolically represent

3 uses neither expansion of HIV reservoirs nor immunologic abnormalities following reinitiation of ART.

4 rmal tight junctions and did not exhibit any immunologic abnormalities, indicating that interactions

5 erstitial lung disease (ILD) and may reflect immunologic activation and subsequent cytokine-mediated

6 timal balance between leukemia abundance and immunologic activation was achieved before treatment ces

7 tion with MITF was measured before and after immunologic activation.

8 rging data tying circadian clock function to immunologic activities within the respiratory system.

9 istinct T cell subsets are tailored to their immunologic activities.

10 to assess the pharmacokinetics and in vitro immunologic activity of the different dosing regimens.

11 ed biomaterial implants and their associated immunologic activity to develop a "metastasis sensor" fo

12 ndary objectives were to assess efficacy and immunologic activity.

13 The use of an immunologic adjuvant to augment the immune response is e

14 mune response to vaccine and functions as an immunologic adjuvant.

15 ill review the most prominent phenotypes and immunologic advances that suggest these disease subtypes

16 ata suggests that recurrent NPC may had more immunologic advantage than primary NPC, especially the G

17 as the rat, which offers some technical and immunologic advantages over mice.

18 Clinical and immunologic analysis of patients was also performed and

19 A and protein expression, SOCE measurements, immunologic analysis of peripheral blood lymphocyte popu

20 the bronchial microbiome are associated with immunologic and clinical features of the disease.

21 ice displayed features that recapitulate the immunologic and clinical phenotype of CAPS.

22 associated with distinct early and sustained immunologic and endothelial biomarker signatures and dec

23 timing and frequency of AD-MSC treatment on immunologic and graft survival as well as graft vasculop

24 pondylometaphyseal dysplasia with or without immunologic and hematologic abnormalities, but no defini

25 ed from gram-negative bacteria causes strong immunologic and inflammatory effects and, when airborne,

26 effects of H pylori on allergy severity and immunologic and microbiome correlates thereof.

27 e by interaction with multiple cell types of immunologic and nonimmunologic origin.

28 ude combinations with a wide variety of both immunologic and nonimmunologic therapies.

29 ogic aspects and roles of these receptors in immunologic and oncogenic processes are discussed.

30 ated changes in the microbiota contribute to immunologic and physiologic decline.

31 sus to initiate ATT was reached only if both immunologic and radiologic test results were positive.

32 culosis, provided by several combinations of immunologic and radiologic test results.

33 s enabling tumors to grow, spread, and avoid immunologic and therapeutic destruction.

34 The immunologic and therapeutic effects of intratumoral (IT)

35 treatment controller phenotype and performed immunologic and virologic analysis of blood, lymph node,

36 Here, we investigated the immunologic and virologic efficacy of baricitinib in a r

37 We characterized immunologic and virologic features associated with post-

38 l treatment interruption (ATI); however, the immunologic and virologic impact of ATI in individuals w

39 ch within 6 months, which resulted in better immunologic and virologic outcomes compared to those who

40 In this study, we characterized the immunologic and virologic status of BM-derived CD4(+) T

41 ent transplantation and to determine whether immunologic and/or clinical parameters may be predictive

42 loration of molecular, physiologic, genetic, immunologic, and biochemical events at microscopic to ma

43 lure (ALF) is life threatening with genetic, immunologic, and environmental etiologies.

44 Using a combination of biochemical, immunologic, and ex vivo cell metabolic studies, we repo

45 and midadulthood and to examine demographic, immunologic, and genetic factors associated with period

46 Knowing which metabolic, immunologic, and genetic features are unique to individu

47 etypes characterized by distinct functional, immunologic, and histologic features and associated caus

48 rting at day 0 combined with close clinical, immunologic, and histologic monitoring.

49 ing method integrating clinical, functional, immunologic, and histologic parameters revealed five tra

50 Physical, immunologic, and microbiologic (bacterial, fungal, archa

51 mprehensive pathology findings and clinical, immunologic, and outcome data to identify distinct group

52 ow similar these models are at the cellular, immunologic, and transcriptome levels.

53 elial cells using genetic, pharmacologic, or immunologic approaches abolished intestinal T84 cell rad

54 In this Review, we discuss immunologic approaches that directly target the malignan

55 Most of the immunologic assays confirmed a protective effect of H. p

56 ogenic 'hits', of which most had no previous immunologic association.

57 thelium provides a physical, functional, and immunologic barrier to protect the host from the potenti

58 in the lung, functioning as a mechanical and immunologic barrier.

59 immunologic data summarized here suggest an immunologic basis for these coallergies that is based on

60 ality control, and may exhibit a distinctive immunologic behavior.

61 Finally, PTCs showed immunologic benefits of viral control after ATI, includi

62 ese anti-leukocyte antibodies to initiate an immunologic cascade resulting in lung injury.

63 ed with HLA mismatches and may be due to non-immunologic causes (hypertension, obesity, etc.) suggest

64 ect in these patients and characterize their immunologic cellular abnormalities.

65 e pulmonary clock and circadian responses to immunologic challenges.

66 ered by autologous transplantation, avoiding immunologic challenges.

67 acterized by profound systemic metabolic and immunologic changes and are cancer risk factors.

68 Data support the similarity of efficacy and immunologic changes between children and adults treated

69 We aimed to determine the immunologic changes caused by peanut OIT in preschool ag

70 xamine in the GRASS trial the time course of immunologic changes during 2 years of sublingual and sub

71 of NAMPT inhibitor GMX1778 induces specific immunologic changes in the tumor microenvironment of mur

72 Central to the mechanical and immunologic changes induced by air pollution are activat

73 the intestine is emerging as a new site for immunologic changes that affect whole-body metabolism.

74 gate the safety, clinical effectiveness, and immunologic changes with long-term SLIT in children with

75 BACKGROUNDUnderstanding outcomes and immunologic characteristics of cellular therapy recipien

76 uvant within a fusion protein determines its immunologic characteristics.

77 The clinical and immunologic characterization, as well as current pathoph

78 pies, particularly with agents targeting the immunologic checkpoints PD-1 and CTLA-4.

79 reover, we summarize current knowledge about immunologic, clinical, and histologic features of virus-

80 Thus, the presence of allergic immunologic comorbidities may be advantageous for patien

81 likely influenced by the host's preexisting immunologic comorbidities.

82 Expanding donor organ availability and immunologic compatibility is a priority to help meet the

83 neic cell therapy is limited by host patient immunologic competence and inconsistent performance due

84 ity of suitable matched donors and potential immunologic complications.

85 Patients with PHTS were assessed for immunologic conditions, lymphocyte subsets, forkhead box

86 This inference of individual immunologic configurations based on treatment alteration

87 oach provides strong evidence that different immunologic configurations in patients with CML determin

88 There are different immunologic consequences depending on whether cells die

89 suppression of antigen presentation may have immunologic consequences that hamper innate and adaptive

90 ically important and can result in different immunologic consequences.

91 n class I (HLA-I) genes underlies successful immunologic control of both infectious disease and cance

92 Immunologic control was conceptually necessary to explai

93 ge suggested that protection was mediated by immunologic control.

94 erns of antiretroviral therapy (ART) use and immunologic correlates vary globally, and contemporary t

95 pecified secondary end points, and potential immunologic correlates.

96 Immunologic cross-reactivity may explain disparate outco

97 The clinical and immunologic data summarized here suggest an immunologic

98 es the first line of physical, chemical, and immunologic defenses and provides a protective wall agai

99 cell death and survival, cell signaling, and immunologic disease pathways.

100 ted in the pathobiology of many allergic and immunologic diseases, as well as host defense mechanisms

101 , autoimmune disease, and other allergic and immunologic diseases.

102 ll (MC) activation are linked with important immunologic disorders, including allergy, anaphylaxis, a

103 This observed immunologic distinction between mothers of children with

104 L, which explicitly includes an antileukemic immunologic effect, and applied it to 21 patients with C

105 We previously reported the safety and immunologic effects of a DNA vaccine (pTVG-HP [MVI-816])

106 es known measures of immune function and the immunologic effects of common immunosuppressive drugs an

107 sought to evaluate the clinical, safety, and immunologic effects of EPIT for the treatment of peanut

108 Immunologic effects of PD-L2 overexpression were evaluat

109 Furthermore, the immunologic effects of the CCR5 inhibitor maraviroc (MVC

110 r, RAS activation in hematopoietic cells has immunologic effects that diverge from those of RAS stimu

111 d points were median MFS, changes in PSA DT, immunologic effects, and changes in quantitative (18)F-s

112 , whereas vasopressin does not have untoward immunologic effects.

113 solution of select AEs (those with potential immunologic etiology), and impact of select AEs and supp

114 nduction of bnAbs is to define the viral and immunologic events that occur during HIV-1 infection, an

115 o the Mtb-specific proteins ESAT6 and CFP10, immunologic evidence of exposure to Mtb.

116 spite the fully aquatic habits of cetaceans, immunologic exposure to arboviruses including West Nile

117 This study evaluated clinical and immunologic factors associated with impending flare in t

118 ved understanding of the complex genetic and immunologic factors that permit progression from the abe

119 t is essential that we understand better the immunologic factors underlying both original antigenic s

120 ent knowledge on BIA-ALCL cell of origin and immunologic factors underlying its pathogenesis.

121 ression, adjusting for donor, recipient, and immunologic factors.

122 oral microbiota relationships to clinical or immunologic features in mild atopic asthma and the impac

123 This review will highlight the clinical and immunologic features of these entities to define common

124 We compared their clinical, virologic, and immunologic features vs 20 patients with HIV-associated

125 ontrast, the mechanistic contribution of the immunologic features was reversed, with no role for IFN-

126 Associations with clinical and immunologic features were examined, including markers of

127 ssociations of sputum and oral microbiota to immunologic features were observed in this cohort of sub

128 Many patients remain asymptomatic despite immunologic findings mirroring those of immunosenescence

129 T cells (Treg) have proven to be a powerful immunologic force in nearly every organ system and hold

130 Immunologic function in innate and adaptive immunity cha

131 GG analysis indicated that 225 unigenes with immunologic function were mapped into immune-related pat

132 an liver is an organ with a diverse array of immunologic functions.

133 production or CD25 expression and assess the immunologic, hematologic, and physiologic disease measur

134 ic immune response can lead to disruption of immunologic hemostasis in healthy tissues, causing adver

135 allude to the possibility of restoration of immunologic homeostasis and thus a state of tolerance as

136 nadequate vascular remodeling, and a loss of immunologic homeostasis are associated with pregnancy co

137 ith donor-modified immune cells and achieved immunologic hyporesponsiveness.

138 We highlight the immunologic implications of these errors.

139 riving pyroptotic rupture, and highlight the immunologic importance of this event.

140 n is characterized by rapid viral seeding of immunologic inductive sites in the gut followed by the s

141 Anti-donor antibodies cause immunologic injury in transplantation.

142 ntenance immunosuppression and prevention of immunologic injury to the renal allograft, yet there rem

143 ells, and summarize the clinical results and immunologic insights from studies that are testing the l

144 Here we discuss emerging views on immunologic interactions occurring in the lungs for M. t

145 Hence it has been proposed to anticipate immunologic intervention at disease onset (early allerge

146 when compared to previous regimens and that immunologic interventions may be necessary to achieve AR

147 In the search for effective immunologic interventions to prevent and treat HIV-1 inf

148 otential for causing harmful postvaccination immunologic (Koch-type) reactions.

149 Here we establish that the immunologic landscape and tumor microenvironments (TME)

150 We sought to construct the immunologic landscape in the airways of children with se

151 heir predicted immune system configuration ("immunologic landscapes").

152 cle of EBV can be triggered by chemicals and immunologic ligands, the lytic cascade is activated only

153 Immunologic markers based on resection cavity analysis c

154 Data integration of key immunologic measures identified a subset of non-protecte

155 utcomes were tolerability, inflammatory, and immunologic measures, and the intestinal microbiome.

156 hite individuals highlight the importance of immunologic mechanism in the disease etiology.

157 To investigate the immunologic mechanism responsible for uterine tropism, w

158 To investigate the underlying immunologic mechanism, we analyzed the B and T periphera

159 e.g., PTEN loss or PIK3CA mutation), and 5) immunologic mechanisms (such as FcR polymorphisms).

160 cted in more precise ways to target specific immunologic mechanisms and pathways.

161 r oropharyngeal cancer risk, suggesting that immunologic mechanisms are implicated in the etiology of

162 ortality after lung transplantation, but the immunologic mechanisms are poorly understood.

163 une dysregulation, and describe the possible immunologic mechanisms behind causes and consequences of

164 Understanding the genetic risks and immunologic mechanisms driving ICI-mediated inflammatory

165 As a result, the precise immunologic mechanisms mediating ACD are more complex th

166 teractions and, as well, led to insight into immunologic mechanisms of control of bnAb development.

167 For the first time, we demonstrate that the immunologic mechanisms of LPP immunotherapy are undersco

168 We sought to investigate immunologic mechanisms of LPP immunotherapy in a subset

169 The immunologic mechanisms promoting eosinophilic granulomat

170 Understanding the immunologic mechanisms that provide durable protection a

171 te GABA and glutamate dysfunction as well as immunologic mechanisms.

172 e complete tumor regression and long-lasting immunologic memory in pre-clinical models of aggressive

173 Immunologic memory is the ability of adaptive immune sys

174 ment and molecular signals that underlie the immunologic memory of IgE responses remain unclear.

175 in the first year suggesting no evidence for immunologic memory response.

176 ADCs also induced immunologic memory.

177 We used radiometric, immunologic, metabolomic, and biochemical assays to meas

178 These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbi

179 This study aims to model genetic, immunologic, metabolomics, and proteomic biomarkers for

180 of youthful gut microbiome via modulation of immunologic, microbial, and metabolomic profiles in the

181 The immunologic microenvironment might have prognostic/predi

182 This immunologic mismatch can also lead to lethal graft-versu

183 This immunologic mode of multi-generational transmission may

184 Immunologic monitoring to tailor immunosuppressive drugs

185 nt strategies to overcome the limitations of immunologic monotherapy.

186 ase of global travel, and societal dynamics, immunologic naivete of the host population, and muted in

187 been implemented to monitor TMA exposure and immunologic outcomes.

188 to compare the physical characteristics and immunologic output of GC responses in patients with CVID

189 Morphologic immunologic parameters (inflammatory infiltrate, stromal

190 Though immunologic parameters are drastically altered with ATG

191 We report on unique hematologic and immunologic parameters that distinguish between COVID-19

192 In summary, immunologic parameters were closely intertwined.

193 points included quality-of-life assessments, immunologic parameters, and safety.

194 c assessments of clinical, histological, and immunologic parameters.

195 ersistent symptoms that may be the result of immunologic pathophysiology.

196 s in itch biology and highlight how distinct immunologic pathways integrate with recently identified

197 Dysfunction in immunologic pathways, reduced cellular signaling, and in

198 ucosa and to identify potentially implicated immunologic pathways.

199 Advances in our understanding of the diverse immunologic perturbations that drive airway inflammation

200 imaging performance of a novel pretargeting immunologic PET (immuno-PET) method in patients with hum

201 se data demonstrate successful CD38-targeted immunologic PET imaging of multiple myeloma in a murine

202 xamine (DFO), or (89)Zr-DFO-daratumumab, for immunologic PET imaging of multiple myeloma.

203 o a new perspective on the complexity of the immunologic phenotype found in CVID syndrome.

204 We evaluated the functional consequence and immunologic phenotype of a novel NFKB2 loss of function

205 The patient had an immunologic phenotype of B-cell dysregulation with decre

206 The K171R mouse immunologic phenotype parallels human, suggesting IKBKB

207 esults with the severity of the clinical and immunologic phenotype.

208 ssociated with a broad range of clinical and immunologic phenotypes in human subjects.

209 ns that extend beyond atopy to include other immunologic phenotypes not previously associated with CA

210 and indel mutations in CARD11 presented with immunologic phenotypes similar to those observed in sign

211 ia FcepsilonRI, we identified three distinct immunologic phenotypes.

212 ng identified in patients with heterogeneous immunologic phenotypes.

213 based approach to understand the genetic and immunologic processes controlling the development of HIV

214 ealed Kdm6a involvement with a collection of immunologic processes having the potential to skew immun

215 macrophages is crucial for a broad array of immunologic processes that regulate inflammation, neopla

216 kappaB) signaling system, a key regulator of immunologic processes, also affects a plethora of metabo

217 ical dystrophin deficiency, with a favorable immunologic profile and preserved function in the face o

218 COVID-19 ARDS exhibits a distinct immunologic profile in the lungs, with a depleted and ex

219 SC (AdMSC) display and induce a differential immunologic profile, upon ongoing AdMSC suppressive acti

220 y was to characterize age-related changes in immunologic profiles according to CRS subtypes.

221 ntification of HIV-1-controllers at risk for immunologic progression, and provide avenues for persona

222 we summarize the current information on the immunologic properties of this tumor, its potential immu

223 ast, convalescence may be prolonged by other immunologic reactions to infection, even after fungal re

224 r the use of preparative chemotherapy, other immunologic reconstitution parameters were not affected,

225 LV-mediated GT allowed immunologic reconstitution, although it was suboptimal c

226 sorder (PTSD), there are no studies of brain immunologic regulation in individuals with PTSD.

227 integral role in developing the concepts of immunologic rejection and tolerance, which led to him re

228 10 years after surgery with minimal risk of immunologic rejection, herpetic recurrence and graft fai

229 The 10-year cumulative risk for immunologic rejection, herpetic recurrence, and graft fa

230 astigmatism (RA), endothelial cell density, immunologic rejection, herpetic recurrence, and graft fa

231 a T2-low subgroup with a distinct microbiota-immunologic relationship.

232 riginally hypothesized to function solely as immunologic responders within the central nervous system

233 d and vaginal washes were collected for host immunologic response assessments.

234 To investigate whether immunologic response to HPV16 is associated with patient

235 story of DCM, provides insight into the host immunologic response, and has direct clinical implicatio

236 atic formation, and modulators for improving immunologic response, for all of which oxygen is a major

237 n a mouse model and discuss the cellular and immunologic response.

238 Cancer and sepsis have surprisingly similar immunologic responses and equally dismal long term conse

239 sights into observed clinical differences in immunologic responses between different age and sex grou

240 (UVR) impacts various cellular, genetic, and immunologic responses governing biological and pathophys

241 ate the mechanisms of TOL, we compared local immunologic responses in renal allografts with those in

242 Immunologic responses to anti-PD-1 therapy in melanoma p

243 We sought to compare clinical and immunologic responses to cat allergen in NAC versus EEC.

244 sting immunity when evaluating virologic and immunologic responses to LAIVs.

245 eliciting NA immunity.IMPORTANCE Data on the immunologic responses to neuraminidase (NA) is lacking c

246 ly different and nonequivalent in magnitude, immunologic responses were similar.

247 vivo-adapted H. pylori, we investigated host immunologic responses.

248 d 17 helper T cells, that have more tailored immunologic responses.

249 ce to investigate age-related differences in immunologic responses; juvenile mice displayed a sustain

250 of primed subjects following this prolonged immunologic rest period, and CD4+ T-cell responses were

251 gle booster dose of protein following a long immunologic rest period.

252 cascade family screening followed, blind to immunologic results.

253 These data suggest previously reported immunologic risk associated with high TAC intra-patient

254 These data suggest that previously reported immunologic risk associated with high TAC intrapatient v

255 candidates include patients who are at high immunologic risk because of sensitization to alloantigen

256 r receptor (suPAR) has been identified as an immunologic risk factor for AKI.

257 belatacept should be done cautiously in high immunologic risk patients.

258 We sought to determine the immunologic rules that govern skin inflammation in early

259 Notably, a specular immunologic scenario was seen in benign MS.

260 The immunologic significance and long-term health consequenc

261 EBV infection resulted into a pronounced immunologic skewing regarding the expansion of CD8(+) T

262 The clinical and immunologic spectrum of MIS-C and its relationship to ot

263 potential and caution and reflection of the immunologic state at the time of conversion.

264 el of SIV infection and ART, we examined the immunologic status of the BM and its role as a potential

265 se clinical trials offer renewed promise for immunologic strategies for blocking acquisition of HIV-1

266 Here we review current immunologic strategies for HIV-1 prevention, with a focu

267 ers, thereby imposing genetically regulated 'immunologic structures', the integrity of which was asso

268 The immunologic study revealed high titers of IgG autoantibo

269 tients with CU can be categorized into three immunologic subgroups based on their basophil reactivity

270 Purpose Immunologic surveillance of minimal residual disease in

271 describe two brothers with hematopoietic and immunologic symptoms reminiscent of Wiskott-Aldrich synd

272 ing effectors to the target cell to build an immunologic synapse and induce tumor cell killing.

273 This formation of an immunologic synapse between the CAR T cell and cancer ce

274 ocompatibility complex class II (MHC II)-CD4 immunologic synapse is classically described between the

275 s by CD4-positive lymphocytes, which form an immunologic synapse with the hepatocyte.

276 phosphatase network that is polarized at the immunologic synapse.

277 nalysis identified abundant inflammatory and immunologic targets for miR-17 and miR-548b that are kno

278 uloma, positive results from even 1 positive immunologic test were considered sufficient to recommend

279 However, comprehensive immunologic testing showed exaggerated production of int

280 resence of positive results for any 1 of the immunologic tests along with radiologic features suggest

281 f positive results for any 1 of the positive immunologic tests along with radiologic features suggest

282 cytes with cell lines prior to molecular and immunologic tests.

283 condition and its impact on the discovery of immunologic tolerance and the field of transplant surger

284 condition and its impact on the discovery of immunologic tolerance and the field of transplant surger

285 aluable therapeutic target for MS to achieve immunologic tolerance in the intestine and suppress CNS

286 to investigate how IL-33 affects established immunologic tolerance in vivo.

287 underlying the induction and maintenance of immunologic tolerance induced by IL-35 and iT(R)35 cells

288 Induction of longstanding immunologic tolerance is essential for survival of trans

289 that in utero exposure to malaria may induce immunologic tolerance that interferes with the developme

290 33 dysregulated lung Treg cells and impaired immunologic tolerance to inhaled antigens.

291 e Nobel Prize "for the discovery of acquired immunologic tolerance" and eventually made organ transpl

292 ally, common elements include a breakdown of immunologic tolerance, a biased type 2 immune response,

293 tients(6) should protect utrophin by central immunologic tolerance.

294 d in affecting previously established airway immunologic tolerance.

295 modality is attenuated by the occurrence of immunologic toxicity syndromes that occur upon CAR T-cel

296 and the increasing success of strategies in immunologic tumor therapy, which include checkpoint inhi

297 Here, we review the immunologic underpinnings of Treg therapy and technical

298 ed to identify the clinical, pathologic, and immunologic variables associated with the presence of AL

299 Results did not vary based on demographic or immunologic variables.

300 This "organ" contains immunologic, vascular, and neural connections to its hos