ライフサイエンスコーパス: immunological

1 ress provides insights into the cellular and immunological abnormalities observed in patients and sug

2 olipterins are antioxidants, harbour diverse immunological activities in primary human tissues, activ

3 to render them non-viable, but retain their immunological activities.

4 response include high levels of intratumour immunological activity, a high tumour mutational burden

5 Moreover, a "young immunological age" as determined by numbers of CD3(+) CD

6 The integration of immunological agents might afford new opportunities to d

7 1+ T cells could contribute to the premature immunological aging phenotype observed in these patients

8 e most human studies have been restricted to immunological analyses of blood and various tissues.

9 Detailed immunological analysis was performed on 9 adult patients

10 group), not included in the main safety and immunological analysis, received HD-MAPs delivering 15 m

11 Variance for immunological analytes was estimated using each individu

12 nd plasma processing impact commonly studied immunological analytes.

13 Here, we reflect on the immunological and epidemiological aspects and implicatio

14 iated this study by performing an exhaustive immunological and functional characterization of adult n

15 urance races have substantial physiological, immunological and metabolic effects on these athletes.

16 nnected dynamic between the evolution of the immunological and neurological systems.

17 This study examines the early immunological and pathological consequences of rectal an

18 -On-VascularNet model will permit metabolic, immunological and physiochemical studies and screens to

19 Thus, coordinated immunological and physiological responses mediate exerci

20 We performed virologic, immunological, and pathogenic characterization of wild-t

21 study was conducted to assess the clinical, immunological, and patient-centered outcomes of microcur

22 rovided the basis for targeted therapies and immunological approaches that underlie individual tumour

23 o DiNP dysregulates cellular, endocrine, and immunological aspects in the colon of adult female mice.

24 0 (HBs(lo)) or >50,000 IU/ml (HBs(hi)) using immunological assays (flow cytometry, ICS, ELISPOT).

25 esent, there are no known clinical findings, immunological assays or biomarkers that can differentiat

26 omics, proteomics, metabolomics, lipidomics, immunological assays, and flux balance analysis.

27 Here, we have used a combination of immunological assays, structural biology, and cheminform

28 nsight into the contribution of IL-10 to the immunological balance necessary for granulomas to contro

29 The intestine is an essential physical and immunological barrier comprised of a monolayer of divers

30 These results add to the evidence of immunological benefits of CPT among HIV-infected populat

31 eriodontal debridement provides clinical and immunological benefits to the treatment of periodontitis

32 nfection, is the main source of exposure and immunological boosting in children and adults.

33 detection using magnetic beads as support of immunological chain and secondary antibody with alkaline

34 Although these immunological changes did not affect the overall disease

35 Here, we aimed to evaluate the immunological changes in global and HCV-specific CD4 + C

36 ed control nonhuman primates, but there were immunological changes in granulomas and lymph nodes from

37 Furthermore, we correlated immunological changes with clinical and demographic para

38 Here, we studied clinical and immunological characteristics of the cohort of NS patien

39 -19 dynamics and highlight the importance of immunological characterization beyond the measurement of

40 Immunological characterization showed that Pten mutants

41 Due to immunological checkpoints, to achieve major cancer thera

42 erpret interactions, a curated compendium of immunological combination treatment datasets, and their

43 nine human transgenes that enhance the pigs' immunological compatibility and blood-coagulation compat

44 ronal accumulation of Abeta as a significant immunological component in the AD pathogenesis.

45 e study results support the hypothesis of an immunological component to psychosis.

46 which the various contributions of different immunological components can be probed in an integrated

47 The purpose of the study was to explore the immunological components that are responsible for the pr

48 Our results provide insight into the immunological components that connect immune-mediated sk

49 oad scientific audience about the underlying immunological concepts.

50 been shown to worsen autoimmune disease, the immunological consequences of clinical salt depletion ar

51 n infected tissues during resolution and the immunological consequences of in situ efferocytosis.

52 ighting the complexity of these systems, the immunological consequences of sensory neuron activation

53 Here, we discuss the immunological considerations relating to each side of th

54 Coupled with feature engineering and immunological context, researchers can immediately extra

55 marker to quantify Notch signals in multiple immunological contexts.

56 correlated with AgeAccelGrim, suggesting an immunological contribution to the accelerated biological

57 We define a cascade of events that lead to immunological control of ZIKV, with previous exposure to

58 he viral load in saliva, suggesting separate immunological controls within each compartment.

59 However, the longitudinal immunological correlates of disease outcome remain uncle

60 homology to Dengue virus (DENV), the role of immunological cross-reactivity in ZIKV and DENV infectio

61 sely related flavivirus strain can result in immunological cross-reactivity; however, the consequence

62 e provide detailed clinical, virological and immunological data of a B-cell depleted patient treated

63 skin provides the first line of physical and immunological defense against environmental insults.

64 l contaminants and provides a first layer of immunological defense within the abdomen.

65 fection, and neoplasia) is a complex primary immunological deficiency caused by mutations in MAGT1, a

66 In accordance with clinical and immunological deterioration in the HLA-B*57:01 group, th

67 asymptomatic infections, but the underlying immunological differences remain unclear.

68 enomic instability in cancer cells to enable immunological disease control.

69 acrophage homeostasis, lung inflammation and immunological disease.

70 immune expressed SPs associate with numerous immunological diseases including Crohn's disease, multip

71 serve as an important resource for studying immunological diseases.

72 ospects for treating congenital and acquired immunological diseases.

73 ntal therapeutics for cancer, metabolic, and immunological disorders.

74 They also highlight an unexpected immunological divergence of Qa-1(b)/HLA-E function, indi

75 d trial aimed to investigate the nonspecific immunological effects of BCG and DTP-containing vaccines

76 Our data provide evidence for immunological effects of SLIT on B-cell memory.

77 ertain clinical significance of the observed immunological effects.

78 Atopic dermatitis in infancy comprises three immunological endotypes.

79 e hypothesized that Mtb infection creates an immunological environment that influences the course of

80 Pre-existing Mtb infection creates an immunological environment that reflects Mtb infection st

81 The uterus constitutes a unique immunological environment with specific features of tiss

82 The immunological evaluation analyzed the proinflammatory cy

83 epeating units, which are valuable tools for immunological evaluation and vaccine development.

84 Immunological evaluations of these analogues in BALB/c m

85 Adding this knowledge to pharmacological and immunological explorations will expand our understanding

86 vide an overview of key cellular and soluble immunological factors mediating irAEs and propose a mode

87 Here, we describe the virological and immunological factors that play a role in the establishm

88 scle, muscular pathology is mediated by host immunological factors.

89 ntral nervous system glia, indicating common immunological features across different parts of the ner

90 ding investigations into genetic, viral, and immunological features of affected patients, host-virus

91 humans and to define the microbiological and immunological features of presymptomatic infection.

92 A and correlate positively with clinical and immunological features of the disease.

93 In this study, we characterized the immunological features of the malignant clone and altera

94 basis of the parallel pathophysiological and immunological features of the other human coronaviruses

95 ib had improvements in variable clinical and immunological features, and a favorable risk-benefit pro

96 the value of integrating microbiological and immunological findings to unravel complex and dynamic ho

97 ive immune defense suggests a high degree of immunological flexibility among vertebrates, which may a

98 ts deepen our understanding of the degree of immunological flexibility wild animals present, informat

99 B lymphocytes have immunological functions beyond Ab production and may pro

100 ficant increase in studies investigating the immunological functions of microbial-induced host cell d

101 genitor differentiation and impairs the core immunological functions of the thymus.

102 cellular subsets and those with specialized immunological functions such as cytokines and chemokines

103 ose-resident leukocytes have non-traditional immunological functions that regulate organismal metabol

104 essed on immune cells, which promote various immunological functions.

105 Endothelial failure and immunological graft rejection remain long-term complicat

106 ed B cells as a subset with pivotal roles in immunological health, disease, and aging.

107 reserve immune homeostasis in the context of immunological history.

108 rstanding of how these integrate to maintain immunological homeostasis is incomplete.

109 d their bacterial symbionts can control host immunological homeostasis via the resulting metabolites.

110 rging and highlight the critical role of the immunological hyper-response - characterized by widespre

111 nses to RSV in infants can be reduced due to immunological immaturity and immunosuppression by RSV-sp

112 is study was to investigate the clinical and immunological impact of orally administered omega-3 PUFA

113 In this Comment, we discuss the immunological impacts of glucocorticoid therapy for COVI

114 are insufficient with increasing age due to immunological impediments, including defects in T follic

115 Other efforts have shed light on the immunological implications of canonical cancer signallin

116 naturally infected humans establish strong "immunological imprints" against HA stalk antigens first

117 s a scalable synthesis required for accurate immunological, including vaccination, studies.

118 mplicated postoperative course with numerous immunological, infectious, cardiorespiratory, and psycho

119 f Spike mutations to aid with development of immunological interventions.

120 corded with a standardised questionnaire and immunological investigations of IL-17 responsiveness und

121 ondary antibody with alkaline phosphatase as immunological label.

122 This approach has revealed that the immunological landscape is diverse, with numerous immune

123 of COVID-19 and consider the virological and immunological lessons, animal models, and tools develope

124 These results highlight key immunological leukocyte subsets as well as associated pa

125 eity of malignant gliomas at the genetic and immunological levels remains a profound challenge.

126 ons (DST) has previously required additional immunological manipulation.

127 ing to dominant tolerance without additional immunological manipulation.

128 links its associated metabolites to a major immunological marker of IBD.

129 rio of the main phenotypical, molecular, and immunological markers related to MF pathogenesis and dis

130 Finally, 10 of the host immunological markers were significantly elevated in the

131 At all time points, immunological measures were statistically higher in the

132 ctional evidence for disease tolerance as an immunological mechanism by which the bat reservoir asymp

133 entify the specific elements involved in the immunological mechanism necessary to produce robust HIV-

134 concern; however, little is known about the immunological mechanism(s) that initiate the disease pro

135 tments provide support for the molecular and immunological mechanism-based approach to cancer immunot

136 n with HLA variants are characteristic of an immunological mechanism.

137 esults indicate that complex and significant immunological mechanisms are associated with the pathoge

138 tion of the CNS.IMPORTANCE Understanding the immunological mechanisms contributing to both host defen

139 r gaps in our knowledge, we investigated the immunological mechanisms involved in peanut allergen sen

140 The immunological mechanisms of cancer cell destruction are

141 pathogen-specific antibodies often point to immunological mechanisms of protection.

142 However, the immunological mechanisms responsible for severe inflamma

143 w potential molecular approaches to identify immunological mechanisms that control disease susceptibi

144 Although the immunological mechanisms that underlie different clinica

145 A complex interplay of metabolic and immunological mechanisms underlies many diseases that re

146 ort a beneficial role for, and elucidate the immunological mechanisms underlying, the use of bariciti

147 on, and selective reactions, associated with immunological mechanisms.

148 apse, which was probably caused by different immunological mechanisms.

149 dy-binding epitopes is crucial to understand immunological mechanisms.

150 trigger the mechanisms necessary to generate immunological memory able to induce long-term protection

151 te a novel mechanism by which IFN-I regulate immunological memory and provide insights for rational v

152 uced systemic cytotoxic T-cell responses and immunological memory associated with tumour regression a

153 NLRC4 negatively regulates immunological memory by preventing delayed activation of

154 ous antitumor immunity with the formation of immunological memory in murine tumor models and robust a

155 These data indicate a potential role for immunological memory in the dynamics of HA and NA antibo

156 Immunological memory is required for protection against

157 curs, and what processes are involved in the immunological memory of allergen-specific IgE responses.

158 CD8(+) T cell immunological memory of past antigen exposure can confer

159 Immunological memory specific to previously encountered

160 ection induced a long-lasting enhancement of immunological memory that conferred improved protection

161 ans and dogs residing in Tbilisi have little immunological memory to saliva of P. kandelakii, the pri

162 Immunological memory was rapidly recalled by booster vac

163 and sustain multifaceted SARS-CoV-2-specific immunological memory.

164 D-L1 therapy, and establishes tumor-specific immunological memory.

165 tion, cytokine production, and generation of immunological memory.

166 he foundation for T cell differentiation and immunological memory.

167 prime the immune system to develop anti-GBM immunological memory.

168 d dogmas: (1) only adaptive immunity confers immunological memory; and, (2) innate immunity lacks spe

169 Using biochemical and immunological methods, we show that beta cells selective

170 replacing traditional antibodies in various immunological methods.

171 a carrier of the virus, but also provides an immunological milieu that affects HIV transmission.

172 nobiology can be incorporated into canonical immunological models to improve how these models explain

173 tial relationships between microbes and host immunological molecules.

174 In more northerly latitudes, where immunological naivety is most likely, we demonstrated th

175 We additionally evaluate the likely immunological, neuronal, and metabolic mechanisms for ho

176 ribe the use of engineered biomaterial-based immunological niches amenable to biopsy to provide insig

177 observed in antibodies isolated from various immunological niches, the biophysical properties that al

178 HIV-infected immunological non-responders (INR) fail to reconstitute

179 We propose that a Global Immunological Observatory and associated developments in

180 ived B types, pointing to founder effects or immunological or environmental resistance against this t

181 Bone marrow (BM) is the central immunological organ and the origin of hematological dise

182 e immune cell function and therefore dictate immunological outcomes during health and disease.

183 tutes a detailed description of clinical and immunological parameters in 20 COVID-19 patients, with a

184 Here, we performed a phenotypic analysis of immunological parameters in laboratory mice carrying sus

185 nct material properties, allows isolation of immunological parameters or processes in a way that is c

186 Safety, immunological parameters, and viral loads were monitored

187 derated by specific behavioral, cellular and immunological parameters.

188 Model selection suggests that the immunological pathways activated against Trichostrongylu

189 ellular compositional changes and associated immunological pathways are partly resolved in humans; th

190 ses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease

191 ar ribosomes are probably not silent from an immunological perspective and could possibly be decoded

192 Immunological perspective: A high level of IgE cross-rea

193 host-parasite interactions and possible new immunological/pharmacological interventions in the areas

194 totype of the broad spectrum of clinical and immunological phenotypes associated with CID.

195 To decipher involved immunological players and pathways, human skin biopsies

196 to quantify interventions by considering the immunological potential of dd-cfDNA.

197 individual glycan compositions but also the immunological pressure across the protein surface.

198 Furthermore, immunological priming through the rectal mucosa with an

199 ontribute to and result from the fundamental immunological process of clonal expansion, highlighting

200 nity but rather is associated with an active immunological process.

201 n factor that modulates several cellular and immunological processes following activation by pathogen

202 Circulating 25HC modulates essential immunological processes including antiviral immunity, in

203 The implications of immunological processes on other aspects of SARS-CoV-2 e

204 erstanding the fundamental physiological and immunological processes underlying the clinical manifest

205 Indeed, IEL are involved in many different immunological processes, ranging from pathogen control t

206 the networks are enriched for cell cycle and immunological processes.

207 ciency host-mice revealed a global change in immunological profile and impaired recruitment and activ

208 avioral, transcriptional, brain network, and immunological profiles even under conditions of genetic

209 We aimed to identify immunological profiles that were most predictive of inci

210 ause of their favourable pharmacokinetic and immunological properties and their ability to penetrate

211 We posit that understanding the distinct immunological properties at the interface of the transpl

212 es were monitored for eleven days, while the immunological properties of kombucha polysaccharide extr

213 However, little is known about their immunological properties.

214 ise the possibility that dengue might induce immunological protection against SARS COV-2.

215 an skin provides both physical integrity and immunological protection from the external environment u

216 erent ways one can use such models to answer immunological questions.

217 ely maintain parasitemias below clinical and immunological radar.

218 graft survival is mediated by the variety of immunological reactions and wound healing process.

219 h transgenic, knockout, xenotransplantation, immunological reconstitution, drug-induced, or spontaneo

220 ow humanized organs with lower potential for immunological rejection after transplantation in humans.

221 that ripasudil may be useful for suppressing immunological rejection in corneal transplantation.

222 odel to show good histocompatibility with no immunological rejection, support vascularized tissue ing

223 ained without invoking special ecological or immunological relationships between hosts and viruses, p

224 It modulates the immunological repertoire of sebocytes, notably by upregu

225 esents a viewpoint from which to restore the immunological reputation of the allergic phenotype.

226 ars of preclinical and clinical studies, the immunological requirements necessary to achieve GvT effe

227 This area of immunological research has been highly active for the pa

228 ctive for diagnosis, disease monitoring, and immunological research.

229 rapy, and their prognosis is inferior to the immunological responders (IR).

230 nts (AEs), adverse drug reactions (ADRs) and immunological response (IgE, IgG4) were evaluated post h

231 high-altitude treatment on the clinical and immunological response in asthma.

232 allogenic AT-MSCs did not induce clinical or immunological response in healthy cows.

233 ces of body weight for efficacy, safety, and immunological response in treatment with SQ HDM SLIT-tab

234 We investigated the efficacy, safety and immunological response of SQ house dust mite (HDM) SLIT-

235 tinctive trend of increasing virological and immunological response rates through 96 weeks; these fin

236 a series of clinical syndromes caused by the immunological response to infection.

237 ancer surgery may influence tumour cells and immunological response.

238 om cellular activation to drug combinations, immunological responses are shaped by the action of mult

239 to investigate the mechanisms behind complex immunological responses because of their genetic similar

240 Patients with H3.3K27M-specific CD8+ immunological responses demonstrated prolonged OS compar

241 rgetically expensive vital functions such as immunological responses might have thus evolved to respo

242 endosomes that are critical for CCL5-induced immunological responses that include Akt activation and

243 l cytoreduction and the potentially systemic immunological responses to radiotherapy and ablative the

244 Immunological responses were assessed in PBMCs using mas

245 Immunological responses were measured.

246 s vesicle fast recycling to promote PI3K-Akt immunological responses.

247 ical outcomes in elderly recipients with low immunological risk according to their induction therapy.

248 nhibitors (mTORi) should not be used in high-immunological risk kidney transplant recipients due to a

249 Demographic and immunological risk profiles were similar, and almost 90%

250 tive crossmatch is associated with increased immunological risk remains an area of uncertainty.

251 Given this immunological role of Cx43, we hypothesized that gap jun

252 , which are devoid of bioactive factors with immunological roles.

253 Stable versus dynamic immunological signatures were identified and linked to t

254 the president of the International Union of Immunological Societies and the presidents of 15 other n

255 es, as defined by the International Union of Immunological Societies.

256 ional Uveitis Study Group, and Foster Ocular Immunological Society, set up an international, expert-l

257 PIR was associated with older age and worse immunological stage at ART start, hepatitis B coinfectio

258 how these metabolic activities reprogram the immunological state of target cells remains poorly under

259 ontributing to the establishment of specific immunological states in disease.

260 Despite these opposing immunological states, the metabolic states in the tissue

261 the ability to reactivate when triggered by immunological stress.

262 late immune cells is important to both basic immunological studies and therapeutic applications.

263 ent microbiological, structural, genetic and immunological studies have expanded our understanding of

264 f Ig and TCR repertoires is a focal point of immunological studies.

265 role in vaccine development and fundamental immunological studies.

266 A comprehensive clinical, virological, and immunological study was performed.

267 ntation model can be used to further analyze immunological subjects for MHC homo-to-hetero iPSC-based

268 -knockout (KO) cells fail to polarize during immunological synapse (IS) formation and have severely i

269 cell conjugate formation, and stabilized the immunological synapse (IS).

270 et cell, they form a tight contact zone, the immunological synapse (IS).

271 ll rosetting are important components of the immunological synapse (IS).

272 In T lymphocytes, MAL is found at the immunological synapse and plays a crucial role in exosom

273 Immunological synapse formation between cytotoxic T lymp

274 is not required for microcluster formation, immunological synapse formation, nor actin remodeling fo

275 cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation

276 D2 localized to the outer edge of the mature immunological synapse, with cellular or artificial APC,

277 t and force dynamics in the cytotoxic T-cell immunological synapse.

278 etric, stable intercellular junctions termed immunological synapses which facilitate exchange of cruc

279 and the adaptor PAG in primary human T cell immunological synapses.

280 cell terminal maturation and acquisition of immunological system function.

281 hat are associated with the phenotype though immunological systems, brain function, metabolic pathway

282 tion as well as screening techniques against immunological targets have led to more effective peptide

283 based methods, including electrophoretic and immunological techniques, are at times unsuitable for di

284 Using molecular and immunological techniques, we assessed the potential of E

285 g options consisting of either undergoing an immunological test for fecal occult blood or colonoscopy

286 Subsequently, basic genetic and immunological tests were performed in primary immune cel

287 ur findings suggest that a trade-off between immunological tolerance and embryo rejection accompanied

288 Mammals achieve immunological tolerance by down-regulating both major hi

289 on of Tregs and a host response outcome with immunological tolerance features.

290 We assess how immunological tolerance is achieved by reconstruction of

291 ied a new B-cell subset that is critical for immunological tolerance through interactions with Treg.

292 Immunological tolerance was studied by measuring Cyp c 1

293 l traits, females were much more variable in immunological traits.

294 Together, these data describe immunological trends in two NHP species during acute ZIK

295 ion in specific cell populations reshape the immunological tumor microenvironment.

296 (SARS-CoV-2) COVID-19 pandemic, although the immunological underpinnings of diverse disease outcomes

297 genetic markers known to be associated with immunological variability or disease resistance.

298 No associations were found for any immunological variables after 1 year of ART.

299 t the associations between environmental and immunological variation.

300 ed an open nonrandomized study comparing the immunological, virological, and clinical responses to cA