ライフサイエンスコーパス: immunological synapse

1 es relevant to T cells, and translocation to immunological synapse).

2 g domain and thus no longer localizes at the immunological synapse.

3 membrane remodelling during formation of the immunological synapse.

4 freely mobile ligands, a key feature of the immunological synapse.

5 tionality of filamentous-actin at the T cell immunological synapse.

6 ound within CD8(+) T cell lipid rafts at the immunological synapse.

7 ting cytotoxic granules for secretion at the immunological synapse.

8 r-target cell interface of the CD16-mediated immunological synapse.

9 olecules including the CD8 coreceptor to the immunological synapse.

10 f these phosphatases with ligated TCR at the immunological synapse.

11 to phosphorylate stathmin molecules near the immunological synapse.

12 get cells contacted by the T cell through an immunological synapse.

13 ll and an antigen-presenting cell termed the immunological synapse.

14 ters directly, that is, as they occur in the immunological synapse.

15 he transpresentation of IL-15 as part of the immunological synapse.

16 avidity of the beta(2) integrin LFA-1 in the immunological synapse.

17 ately drive receptor cluster dynamics at the immunological synapse.

18 required to efficiently recruit CD28 to the immunological synapse.

19 lasma membrane directs lytic granules to the immunological synapse.

20 ese interactions promote the formation of an immunological synapse.

21 ules at the T cell-APC interface to form the immunological synapse.

22 rin and granzymes at the NK cell-target cell immunological synapse.

23 n of signaling molecules PKC- and lck at the immunological synapse.

24 PKC-theta was sequestered away from the Treg immunological synapse.

25 osphate (PI(4,5)P(2)) at the APC side of the immunological synapse.

26 the APC or activating surface, i.e., at the immunological synapse.

27 and delayed CD3 epsilon localization to the immunological synapse.

28 tivation and signal transduction through the immunological synapse.

29 stalk region mediating the formation of the immunological synapse.

30 ough localization to the cSMAC region of the immunological synapse.

31 reaction-diffusion process in an established immunological synapse.

32 cruited to the central region (cSMAC) of the immunological synapse.

33 s in the rapid displacement of CD28 from the immunological synapse.

34 ing receptor turnover and maintenance of the immunological synapse.

35 of cytotoxic substances from granules at the immunological synapse.

36 istance that facilitates localization to the immunological synapse.

37 t and force dynamics in the cytotoxic T-cell immunological synapse.

38 ellular localization and its delivery to the immunological synapse.

39 e T cell receptor (TCR) at the center of the immunological synapse.

40 ell activation process through the so-called immunological synapse.

41 and the formation of LAT nanoclusters at the immunological synapse.

42 g as well as more efficient formation of the immunological synapse.

43 l forces that regulate LFA-1 activity at the immunological synapse.

44 ake is shaped locally by the geometry of the immunological synapse.

45 keleton regulates receptor activation at the immunological synapse.

46 gen 1 (LFA-1) form a concentric array at the immunological synapse.

47 on, leading to impaired formation of NK-cell immunological synapses.

48 oskeleton as well as in the formation of the immunological synapses.

49 various morphologies, including Kupfer-type immunological synapses.

50 s in the formation or composition of anergic immunological synapses.

51 longed contacts from stable junctions called immunological synapses.

52 in information transfer at both neuronal and immunological synapses.

53 ing the formation of KIR2DS2 ligand-specific immunological synapses.

54 n and recruitment of cytosolic organelles to immunological synapses.

55 nd CD45 exclusion from the signaling foci of immunological synapses.

56 ally regulates the formation and function of immunological synapses.

57 and the adaptor PAG in primary human T cell immunological synapses.

58 As previously reported in immunological synapses, a significant nonrecoverable fra

59 of the HIV envelope (Env) in the CD4 T cell immunological synapse affects synapse formation and intr

60 venting the recruitment of active Lck to the immunological synapse after TCR engagement and limiting

61 Prior to transfer, bacteria localize to the immunological synapse, an intimate DC/T cell contact str

62 amin A and impaired the assembly of a mature immunological synapse and central co-accumulation of PKC

63 FA-1 is to enhance TCR signaling through the immunological synapse and deliver distinct signals in CD

64 the stabilization of F-actin and Vav1 at the immunological synapse and for efficient calcium response

65 ression of V3 sequestered PKC-theta from the immunological synapse and interfered with its functions.

66 lls because it initiates the assembly of the immunological synapse and mediates firm adhesion to the

67 ired for F-actin accumulation at the NK cell immunological synapse and NK cell cytotoxicity ex vivo.

68 ected secretion requires the formation of an immunological synapse and occurs stepwise with actin reo

69 amolecular activation cluster (cSMAC) of the immunological synapse and optimal TCR/costimulatory rece

70 In T lymphocytes, MAL is found at the immunological synapse and plays a crucial role in exosom

71 ngagement, beginning with an overview of the immunological synapse and progressing to regulators of T

72 addition, GAKIN dynamically localizes to the immunological synapse and regulates the redistribution o

73 as an important functional component of the immunological synapse and reveal a crucial role for GJs

74 e architectural and dynamic diversity of the immunological synapse and state-of-the-art methodologies

75 s evidence of the exploitation of the normal immunological synapse and T cell activation process by H

76 a is essential for the formation of a mature immunological synapse and T cell activation.

77 ew focuses on recent work characterizing the immunological synapse and the signaling pathways involve

78 okine signaling at two successive scales: in immunological synapses and in dense multicellular enviro

79 ify the requirement of RIAM for formation of immunological synapses and in resulting T cell functions

80 he formation of T cell and NK cell cytotoxic immunological synapses and in target cell killing.

81 e micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses de

82 erable fractions of interacting molecules in immunological synapses and other stable cell-bilayer jun

83 on target cells, effector T cells establish immunological synapses and secrete cytokines.

84 tes the formation of lamellipodia and normal immunological synapses and thereby enables T cell activa

85 Mitochondria accumulate at neuronal and immunological synapses and yeast bud tips and associate

86 on in narrow junctions between immune cells (immunological synapses) and global signaling throughout

87 KIR3DL1, increases KIR3DL1 clustering at the immunological synapse, and augments KIR3DL1-mediated inh

88 cts with multiple signaling molecules at the immunological synapse, and characterizing these interact

89 d antigen-presenting cells, formation of the immunological synapse, and other immune cell interaction

90 This interface has become known as the immunological synapse, and this review examines some of

91 ncreasing valency by recruiting LFA-1 to the immunological synapse, and ultimately for promoting intr

92 unoregulatory molecules participating in the immunological synapse are stored in secretory lysosomes.

93 Immunological synapses are a key feature of the system i

94 or signaling and the subsequent formation of immunological synapses are active processes dependent on

95 Immunological synapses are initiated by signaling in dis

96 n effector and target cell) and formation of immunological synapses are required.

97 Immunological synapses are specialized intercellular con

98 These results suggest that HIV uses the immunological synapse as a conduit not only for selectiv

99 study, we assessed the role of Tim-3 at the immunological synapse as well as its interaction with pr

100 T cell to an APC induces the formation of an immunological synapse as well as reorientation of the mi

101 not sufficient for CD28 localization to the immunological synapse, as truncation of the cytosolic ta

102 ed that surface-anchored N protein prevented immunological synapse assembly by naive CD4(+) T cells a

103 volved in the formation and signaling of the immunological synapse at the dendritic cell side.

104 In this respect, formation of the immunological synapse bears striking similarities to cil

105 horylation and transient localization to the immunological synapse before movement to the DPC.

106 tem, we developed a biophysical model of the immunological synapse between a cytotoxic lymphocyte and

107 of T-cell recognition is the formation of an immunological synapse between a T cell and a cell that i

108 er-side protein density patterns in a hybrid immunological synapse between a T-cell and a supported b

109 A distinct immunological synapse between Ag-stimulated NK cells and

110 y donor DCs contributes to generation of the immunological synapse between DCs and CD4 T cells, and t

111 ow that STIM1 and Orai1 are recruited to the immunological synapse between primary human T cells and

112 rogen peroxide from the neutrophils into the immunological synapse between the neutrophils and T cell

113 east in part by structurally undermining the immunological synapse between the NK cell and its target

114 These microclusters coalesced within the immunological synapse between the NK cell and its target

115 ptor molecules that mediate formation of the immunological synapse between the target cancer cell and

116 in which this is done is by the formation of immunological synapses between cells.

117 Nef disturbs the organization of immunological synapses between infected CD4(+) T lymphoc

118 G was associated with an increased number of immunological synapses between memory CD4(+) T cells and

119 ent on an increased frequency of Kupfer-type immunological synapses between T cells and tumor cells.

120 synthesized perforin rapidly appears at the immunological synapse, both in association with and inde

121 to translocate around the nucleus toward the immunological synapse but is unable to dock at the plasm

122 PKC-theta) translocates to the center of the immunological synapse, but the underlying mechanism and

123 CD22 and Siglec-G are recruited to the immunological synapse by sialic acid ligands on the Ag-b

124 Although accumulation of TCRs at the immunological synapse centre correlates with T-cell func

125 extracellular microvesicles that bud at the immunological synapse centre.

126 n disrupts the NK cell's ability to organize immunological synapse components including decreases in

127 ight on signaling pathways downstream of the immunological synapse critical for T-cell activation and

128 de actin flow in lamellipodia, growth cones, immunological synapses, dendritic spines, and filopodia

129 failed to detect an increased proportion of immunological synapses displaying the characteristic Kup

130 contributes to the reverse signaling in the immunological synapse, downstream of MHCII glycoproteins

131 coalescing key signaling molecules into the immunological synapse during T cell activation, thereby

132 n in the immune system, was recruited to the immunological synapse during T cell priming as both GJs

133 endritic cells (DCs) and is recruited to the immunological synapse during T cell priming.

134 invariant chain to accumulate stably at the immunological synapse during T cell-APC interactions.

135 studies showed that KSR1 is recruited to the immunological synapse during T-cell activation and that

136 As mitochondria translocate to the immunological synapse during TCR activation, we hypothes

137 the secretory lysosomes and polarizes toward immunological synapse during the process of target cell

138 ze the in vivo structure of antigen-specific immunological synapses during an effective immune respon

139 microtubule-organizing center (MTOC) to the immunological synapse enables the directional secretion

140 act, the CTL centrosome rapidly moves to the immunological synapse, focusing microtubule-directed rel

141 ated Erk1/2 signal pathway in the context of immunological synapse for recruitment and amplification

142 ter et al. (2015) define the early events of immunological synapse formation and granule release.

143 show that UNC-45A is disposable for NK cell immunological synapse formation and lytic granules reori

144 he Unc119-regulated pathway is essential for immunological synapse formation and T cell activation.

145 odeling, and T cells exhibited dysfunctional immunological synapse formation and T-cell signaling, wh

146 Immunological synapse formation between cytotoxic T lymp

147 nteracts with LFA-1, a critical molecule for immunological synapse formation between T cells and APCs

148 Immunological synapse formation between T cells and targ

149 an important role in leukocyte trafficking, immunological synapse formation, and numerous cellular i

150 t of T cell receptor (TCR) microclusters and immunological synapse formation, but no study has integr

151 artment of human CD4(+) T cells, and, during immunological synapse formation, it transiently redistri

152 ng demonstrates that at the initial stage of immunological synapse formation, LZTFL1 is concentrated

153 is not required for microcluster formation, immunological synapse formation, nor actin remodeling fo

154 dual receptor systems that play key roles in immunological synapse formation, shear-dependent thrombu

155 CD8(+) T cell motility, and promotes stable immunological synapse formation.

156 ies involved in TCR signaling, as well as on immunological synapse formation.

157 ment of VAV1, which are important for stable immunological synapse formation.

158 In contrast, there was a large impairment in immunological synapse formation.

159 ults showed that the HIV Env did not disrupt immunological synapse formation.

160 osome regulation during fever contributes to immunological synapse formation.

161 The immunological synapse formed between a cytotoxic T lymph

162 dent exocytosis of cytolytic granules at the immunological synapse formed between the two cells.

163 The immunological synapse formed by a T lymphocyte on the su

164 Priming of T cells takes place via an immunological synapse formed with an antigen-presenting

165 It is postulated that HIV exploits immunological synapses formed between CD4 T cells and an

166 Confocal imaging of immunological synapses formed between primary T lymphocy

167 l previous studies have looked at aspects of immunological synapses formed by anergic T cells, but it

168 heir NK cells and the F-actin content at the immunological synapses formed by their NK cells.

169 nd exclude protein kinase C (PKC)-theta from immunological synapses formed on supported lipid bilayer

170 ation of both membranes and receptors as the immunological synapse forms.

171 into the area of cellular contact to form an immunological synapse from where T cell signaling is ini

172 ion, ciliogenesis, membrane trafficking, and immunological synapse function.

173 l protease genes and depressed expression of immunological synapse genes.

174 ultiple antigen receptor microclusters by an immunological synapse has parallels to bundling of multi

175 N3, MPO) and also of 5 genes involved in the immunological synapse (HLA-DRA, CD40LG, CD3E, CD28, ICOS

176 ntigen presenting cell junction, known as an immunological synapse if symmetric and stable and as a k

177 adhesion and costimulatory molecules in the immunological synapse impact upon the overall force of t

178 ytic compartments, which are released at the immunological synapse in a differentially regulated mann

179 ring Ag presentation, CD6 is targeted to the immunological synapse in a ligand binding-dependent mann

180 -bound molecules from APCs directly from the immunological synapse in a process termed trogocytosis.

181 trating the recruitment of LAT to the T-cell immunological synapse in data acquired by iPALM providin

182 highlights the importance of DNAM-1 and the immunological synapse in T cell-mediated antitumor immun

183 R-T cells through the selective formation of immunological synapses, in which the sCAR-T cell, switch

184 domain mutant, HS1 failed to localize to the immunological synapse, indicating that Itk serves to rec

185 so found that a single pMHC localized to the immunological synapse induced the slow formation of a lo

186 is was dependent on the formation of compact immunological synapses, interaction of the adaptor Vav1

187 tion that is similar in some respects to the immunological synapse involved in T-cell activation and

188 While immune cells lack a cilium, the immunological synapse is a surrogate cilium as it utiliz

189 tribution of the beta2 integrin LFA-1 to the immunological synapse is compromised in Cav1-knockout T

190 The immunological synapse is part of the immune response, wh

191 inase C-theta (PKC-theta) recruitment to the immunological synapse is required for full Teff activati

192 The immunological synapse is the location of sustained TCR s

193 s that one of the principal functions of the immunological synapse is to facilitate cytokine secretio

194 hesis predicts that formation of Kupfer-type immunological synapses is necessary for polarized distri

195 proper accumulation of K(+) channels at the immunological synapse (IS) a signaling zone that forms b

196 NDE1 and dynein failed to accumulate at the immunological synapse (IS) and MTOC translocation was in

197 ected secretion of cytolytic granules at the immunological synapse (IS) and requires dynamic rearrang

198 The formation of a dynamic, actin-rich immunological synapse (IS) and the polarization of cytol

199 ular contact through the establishment of an immunological synapse (IS) between the NK cell and the t

200 ion of B cell adhesion, thereby facilitating immunological synapse (IS) formation and B cell activati

201 reover, modulating CD3 ubiquitylation alters immunological synapse (IS) formation and Erk phosphoryla

202 -knockout (KO) cells fail to polarize during immunological synapse (IS) formation and have severely i

203 ells and live images of T-cell migration and immunological synapse (IS) formation revealed that funct

204 The immunological synapse (IS) formed between immune cells a

205 was recruited to the cytoplasmic side of the immunological synapse (IS) in activated T cells.

206 d the role of cytoskeleton remodeling at the immunological synapse (IS) in cytokine secretion.

207 The immunological synapse (IS) is a superstructure formed du

208 The immunological synapse (IS) is one of the most pivotal co

209 The Treg immunological synapse (IS) recruited fourfold more Dlgh1

210 Agonist MHC-peptide complexes in the immunological synapse (IS) signal through T cell recepto

211 ficiency on NK cell activation and cytotoxic immunological synapse (IS) structure and function.

212 T cells form an immunological synapse (IS) that sustains and regulates s

213 vation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven p

214 sition their centrosome to the center of the immunological synapse (IS) to drive polarized secretion

215 city requires the formation of an actin-rich immunological synapse (IS) with a target cell and the po

216 mune homeostasis and self-tolerance, form an immunological synapse (IS) with antigen-presenting cells

217 e, we discuss the flexibility of the primary immunological synapse (IS) with respect to motility.

218 CRAC) channels and the formation of a stable immunological synapse (IS) with the antigen-presenting c

219 The immunological synapse (IS), a highly organized structure

220 to the recruitment of the centrosome to the immunological synapse (IS), a specialized cell-cell junc

221 cells (APCs) results in the formation of an immunological synapse (IS), assembly of a signaling scaf

222 omplexes is a defining characteristic of the immunological synapse (IS), but its impact on cell commu

223 antigen-presenting cells (APCs), called the immunological synapse (IS), includes receptors and signa

224 lation, PKCtheta is rapidly recruited to the immunological synapse (IS), the region of contact betwee

225 basis of membrane protein patterning in the immunological synapse (IS), which encompass membrane mec

226 et cell, they form a tight contact zone, the immunological synapse (IS).

227 ll rosetting are important components of the immunological synapse (IS).

228 n the antigen-presenting cells (APCs) at the immunological synapse (IS).

229 l role in modulating signaling events at the immunological synapse (IS).

230 hin a specialized membrane domain termed the immunological synapse (IS).

231 highly organized contact zone denoted as the immunological synapse (IS).

232 l, and negatively regulates stability of the immunological synapse (IS).

233 accumulation of diacylglycerol (DAG) at the immunological synapse (IS).

234 These are collectively known as the immunological synapse (IS).

235 ace between T cells and APCs is known as the immunological synapse (IS).

236 T cell and antigen-presenting cell, i.e. the immunological synapse (IS).

237 cell conjugate formation, and stabilized the immunological synapse (IS).

238 We analyzed formation of immunological synapses (IS) in self-reactive T cell clon

239 id bilayers (BSLB) to capture SE from single immunological synapses (IS), determined SE composition b

240 n cluster (cSMAC) have been defined in model immunological synapses (IS).

241 We highlight the T cell immunological synapse, junctions formed between EphA2- a

242 igible effect on actin polymerization at the immunological synapse, leading to gaps in our understand

243 gnaling, establish a molecular basis for the immunological synapse localization of PKC-theta and indi

244 in V3 required for association with CD28 and immunological synapse localization.

245 Centrosome reorientation to the immunological synapse maintains the specificity of T-cel

246 naling plays a role in CTL function, and the immunological synapse may represent a modified cilium.

247 amolecular activation cluster (pSMAC) of the immunological synapse mediate formation of a tight adhes

248 ssary and sufficient for localization to the immunological synapse mediated by association with the c

249 mic instability of mitotic microtubules, the immunological synapse, neutrophil motility in a 3D matri

250 an NK cells, UNC-45A localize at the NK cell immunological synapse of activated NK cells and is part

251 OGT) isoforms and accumulation of OGT at the immunological synapse of murine T cells.

252 ity, both RIFIN and MHC are recruited to the immunological synapse of NK cells and reduce the activat

253 mplicated in centrosome reorientation to the immunological synapse of T lymphocytes.

254 e addition of zinc, at functional inhibitory immunological synapses of NK cells with HLA-C(+) cells.

255 to super raft formation associated with the immunological synapse on colonic memory CD4+ T cells and

256 -MHC in the uropod, consistent with a motile immunological synapse or "kinapse." However, in the pres

257 We conclude that the immunological synapse orchestrates TCR sorting and relea

258 Ezrin-/- T cells exhibited normal immunological synapse organization based upon localizati

259 toxic lymphocytes showed specific defects in immunological synapse organization with these targets, r

260 MHC complexes relative to the highly dynamic immunological synapse periphery.

261 e, we have gained an appreciation of how the immunological synapse provides directionality and contex

262 cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation

263 e (PIP2) and that alterations in PIP2 at the immunological synapse regulate cortical actin in CTLs, p

264 ic activation and antigen recognition in the immunological synapse remains limited.

265 ll receptor (TCR) signal transduction at the immunological synapse remains poorly understood.

266 that CD28 recruitment and persistence at the immunological synapse requires TCR signals and CD80 enga

267 Although cytotoxic immunological synapses restrict killing to antigenic tar

268 ligands, B cell Siglecs are recruited to the immunological synapse, resulting in suppression of BCR s

269 during T-cell immune surveillance and at the immunological synapse results in dynamic TCR quaternary

270 We propose that this reorganization of the immunological synapse sequesters the T cell antigen rece

271 ulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with t

272 The immunological synapse stops T-cell migration to allow a

273 hat the cell-to-cell contacts observed in an immunological synapse that involve the CD4(+) T cell and

274 ribe some of the many characteristics of the immunological synapse that make it a vital part of inter

275 pointing toward defective cross-talk at the immunological synapse that may limit immune responses in

276 ivated in vivo at steady state, forming true immunological synapses that polarized and anchored T cel

277 i.e., increased probability to form immature immunological synapses that then provide an entry into d

278 nd preformed CD40 ligand mobilization to the immunological synapse, thus diminishing the help deliver

279 eptide Ag, changing from accumulation at the immunological synapse to retrograde movement toward the

280 V envelope is recruited to the center of the immunological synapse together with the T cell receptor

281 ules themselves, so that TPCs migrate to the immunological synapse upon CTL activation.

282 ecular activation complex (cSMAC) within the immunological synapse upon T cell receptor (TCR) activat

283 ion of polarization of lytic granules to the immunological synapse upon target cell recognition.

284 d the distal pole complex (DPC) opposite the immunological synapse via association with the ezrin-rad

285 indispensable for THEMIS recruitment to the immunological synapse via the transmembrane adapter link

286 We found that the high aspect ratio of the immunological synapse was insufficient in this regard, a

287 Because activated ERK is localized at the immunological synapse, we investigated its role by showi

288 Building on previous studies at the T cell immunological synapse, we quantitatively assess the stru

289 induces the recruitment of PIP5Kbeta to the immunological synapse, where it regulates filamin A and

290 etric, stable intercellular junctions termed immunological synapses which facilitate exchange of cruc

291 uitment of both LFA-1 and lipid rafts to the immunological synapse, which correlates with reduced tum

292 CD2 was identified biochemically and at the immunological synapse, which elicited CD16 signaling aft

293 recapitulates the domain organization of the immunological synapse, which is characterized by central

294 ction between T cells and APCs, known as the immunological synapse, which mediates efficient delivery

295 c F-actin architecture in the context of the immunological synapse, which then amplifies the downstre

296 of the fibrous actin meshwork at the T cell immunological synapse, whose structure has been shown to

297 CTLs achieve this by forming an immunological synapse with their targets and secreting a

298 h immobilized TCR ligands and formed smaller immunological synapses with APCs, likely due to defectiv

299 g, we found that anergic T cells make mature immunological synapses with characteristic central and p

300 D2 localized to the outer edge of the mature immunological synapse, with cellular or artificial APC,