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1  an antigen-specific nonresponsiveness (i.e. immunological tolerance).
2 tor Foxp3 have a pivotal role in maintaining immunological tolerance.
3 ant role in the induction and maintenance of immunological tolerance.
4  cells play an essential role in maintaining immunological tolerance.
5  controls B cell development, signaling, and immunological tolerance.
6 mbrane protein involved in the regulation of immunological tolerance.
7 c medullary epithelial cells, which promotes immunological tolerance.
8 ould be exploited to induce antigen-specific immunological tolerance.
9  response and is instrumental in maintaining immunological tolerance.
10 y T cells (Tregs) in the dominant control of immunological tolerance.
11 beta cells as well as the reestablishment of immunological tolerance.
12 e secretion in DCs and macrophages to induce immunological tolerance.
13 erentially contributes to the maintenance of immunological tolerance.
14 tory DCs and TGF-beta+ macrophages to induce immunological tolerance.
15 ing alone without exogenous insult can break immunological tolerance.
16 play an important role in the maintenance of immunological tolerance.
17 sponses and to facilitate the development of immunological tolerance.
18 Treg) are instrumental in the maintenance of immunological tolerance.
19  and suggests a role for plasmacytoid DC2 in immunological tolerance.
20 e in peripheral B-cell anergy, one aspect of immunological tolerance.
21 SK can be prevented by establishing specific immunological tolerance.
22  is a disorder of lymphocyte homeostasis and immunological tolerance.
23 s the others can lead to partial or complete immunological tolerance.
24 y, allograft rejection, and the induction of immunological tolerance.
25 apoptosis and may be critical for peripheral immunological tolerance.
26 tical for the development and maintenance of immunological tolerance.
27 +)FOXP3(+) regulatory T (Treg) cells control immunological tolerance.
28  switches from a type 2 inflammation towards immunological tolerance.
29 s conventional T cells and are essential for immunological tolerance.
30  side-effect burdens and potentially restore immunological tolerance.
31 antigens to naive T cells in ways that break immunological tolerance.
32 of germinal center B cells and drive loss of immunological tolerance.
33 A patients, presumably because of persisting immunological tolerance.
34 -27 is pivotal to safeguarding Treg-mediated immunological tolerance.
35 reg) cells) are instrumental in establishing immunological tolerance.
36 t the balance between effective immunity and immunological tolerance.
37 characterise and compare different states of immunological tolerance.
38  and are used by thymic epithelial cells for immunological tolerance.
39  outcomes through the induction of long-term immunological tolerance.
40 ssional antigen presenting cells to maintain immunological tolerance.
41 ional heterogeneity is a critical feature of immunological tolerance.
42 ponse that later subsided suggested acquired immunological tolerance.
43 regnancy is one of the strongest inducers of immunological tolerance.
44 ory T cells (Tregs) are a central element of immunological tolerance.
45 rine retrovirus, under conditions leading to immunological tolerance.
46 onses and, therefore, uniquely necessary for immunological tolerance.
47 lls are immunosuppressive cells that support immunological tolerance.
48 d rapamycin, not the free form, could induce immunological tolerance.
49 ecific for the 2F5 epitope is constrained by immunological tolerance.
50  organs that should be targeted to reinstate immunological tolerance.
51 pressing regulatory T (Treg) cells safeguard immunological tolerance.
52  of B cell activation and the maintenance of immunological tolerance.
53 eported to participate in the maintenance of immunological tolerance.
54 ct roles in the scenario by which it assures immunological tolerance.
55  protein expression and may help to maintain immunological tolerance.
56  and produce IL-10 are required for systemic immunological tolerance.
57 ral role in the induction and maintenance of immunological tolerance.
58 heral tissue Ag expression to prompt central immunological tolerance.
59  responses and allowing the establishment of immunological tolerance.
60 , but also their impact on the regulation of immunological tolerance.
61 proposed to participate in the regulation of immunological tolerance.
62 es against pathogens and tumours, as well as immunological tolerance.
63 has a fundamental role in the achievement of immunological tolerance after transplantation.
64 t pests of agricultural crops have establish immunological tolerance against fungal infection caused
65  central role of T cells in the induction of immunological tolerance against i.v. Ags has been well d
66       Hepatic induction of tissue-protective immunological tolerance against particulate antigens is
67 ur findings suggest that a trade-off between immunological tolerance and embryo rejection accompanied
68       Additionally, we address the enigma of immunological tolerance and explore the role tolerance p
69 efore to design interventions that can break immunological tolerance and halt cancer progression, whe
70 vide an effective means of inducing longterm immunological tolerance and has been documented in a mon
71           This crosstalk is likely to affect immunological tolerance and homeostasis within the gut a
72             Thymus is necessary for lifelong immunological tolerance and immunity.
73 th mild symptoms may harm the development of immunological tolerance and impose a burden on families
74 l drugs and therapeutic vaccines to overcome immunological tolerance and induce the recovery phenotyp
75 mensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.
76 this feat is managed is key to understanding immunological tolerance and intervention in treating dis
77 as a central role in the dominant control of immunological tolerance and maintenance of immune homeos
78 elper cells and gut microbiota enforce local immunological tolerance and modulate extra-intestinal im
79           T regulatory (Treg) cells maintain immunological tolerance and organ homeostasis.
80 esponse, occupying a key role in maintaining immunological tolerance and present an attractive therap
81 rotective immune responses while maintaining immunological tolerance and preventing autoimmunity.
82 RE) gene is crucial for establishing central immunological tolerance and preventing autoimmunity.
83 die perinatally, the roles of Bax and Bak in immunological tolerance and prevention of autoimmune dis
84 nd an ancillary role for Bax in safeguarding immunological tolerance and prevention of autoimmune dis
85  discuss how metabolic workload can modulate immunological tolerance and review the molecular mechani
86 sing the crucial contributions of RA to both immunological tolerance and the elicitation of adaptive
87 is not known whether these serpins influence immunological tolerance and the risk for autoimmune dise
88                                Tim-3 induces immunological tolerance, and engagement of the Tim-3 imm
89 ective and safe treatment in LAR, increasing immunological tolerance, and reducing the clinical sympt
90 ) regulatory T cells (T(reg) cells) maintain immunological tolerance, and their deficiency results in
91 aches based on induction of antigen-specific immunological tolerance are being explored for treatment
92 t may also be important for the induction of immunological tolerance, as well as for the regulation o
93  likely depend, in part, on the induction of immunological tolerance, because the high levels of immu
94  that a reovirus strain associated with oral immunological tolerance blockade infects macrophages by
95                                     However, immunological tolerance break by comorbidities or dysbio
96                                         When immunological tolerance breaks down, autoimmune destruct
97 ells) are critically involved in maintaining immunological tolerance, but this potent suppression mus
98 opoietic chimerism results in donor-specific immunological tolerance by apoptosis-mediated deletion o
99 cting (Bcl2-interacting) mediator, maintains immunological tolerance by deleting autoreactive lymphoc
100                              Mammals achieve immunological tolerance by down-regulating both major hi
101                                Aire controls immunological tolerance by driving promiscuous expressio
102       The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic e
103                                 Induction of immunological tolerance by MBP(89-101) therefore inactiv
104 ive regulator of mucosal immunity, promoting immunological tolerance by preventing excessive T cell r
105                                 Aire impacts immunological tolerance by regulating the expression of
106 ognized as a spontaneously acquired state of immunological tolerance by the mother to her semi-alloge
107 tocols constitute important tools to achieve immunological tolerance by Treg vaccination.
108 vity, independent of their predicted role in immunological tolerance, by regulating tissue remodeling
109                                        Thus, immunological tolerance can be achieved by direct modula
110  our results suggest that neonatal and fetal immunological tolerance can be leveraged to improve post
111                                              Immunological tolerance can be mediated by anergy, in wh
112 ates and HIV-1 provides direct evidence that immunological tolerance can impair humoral responses to
113  paucity of T(R) cells and a fatal breach in immunological tolerance, causing highly aggressive multi
114 eg cells develop and how they participate in immunological tolerance, contrasting, when possible, iTr
115 he role of hepatitis B e-antigen in creating immunological tolerance during hepatitis B virus infecti
116  which argues against a failure to establish immunological tolerance during implantation.
117         The establishment and maintenance of immunological tolerance entails both central and periphe
118    To analyze efficacy and better understand immunological tolerance, escape mechanisms, and side eff
119 on of Tregs and a host response outcome with immunological tolerance features.
120 resents an important mechanism of peripheral immunological tolerance for mature autoreactive B cells
121  and these "forbidden" B cells are culled by immunological tolerance from mature B-cell populations.
122 , described to be involved in both Tregs and immunological tolerance generation.
123                                              Immunological tolerance guards against spurious immune r
124  critically important for the maintenance of immunological tolerance, immune homeostasis, and prevent
125 ow 60 years since the first demonstration of immunological tolerance in animal models of transplantat
126 mplications for therapies seeking to restore immunological tolerance in autoimmune disorders.
127  both natural and therapeutic acquisition of immunological tolerance in childhood will provide insigh
128 tinal mucosa to support immunoregulation and immunological tolerance in IBD.
129  of autoantigen genes in the thymus, driving immunological tolerance in maturing T cells.
130 lling and is required for the maintenance of immunological tolerance in mice.
131 igand 1 (PD-L1) is crucial in regulating the immunological tolerance in non-small cell lung cancer (N
132 have been used in vivo to induce Ag-specific immunological tolerance in Th1 responses, including tiss
133 f inhibitory signaling in the maintenance of immunological tolerance in the B lineage.
134 vation, thus tuning Treg cell generation and immunological tolerance in the gut.
135                                 Induction of immunological tolerance in utero has potential applicati
136        Importantly, experimentally breaching immunological tolerance in wild-type mice also leads to
137 onditioning regimen (NMCR) aimed at inducing immunological tolerance, including splenectomy, whole bo
138 eral lymphocytes-a new approach to translate immunological tolerance into clinically applicable proto
139                                We assess how immunological tolerance is achieved by reconstruction of
140                               The concept of immunological tolerance is central to our understanding
141                                              Immunological tolerance is constantly being maintained i
142                                              Immunological tolerance is crucial to avoid autoimmune a
143 ft is stably accepted, rejected, or achieves immunological tolerance is dependent on the frequency an
144                                              Immunological tolerance is established and maintained by
145 tion apply as to non-tolerant hosts and that immunological tolerance is permanently lost.
146 o far described that achieves organ-specific immunological tolerance is that which controls periphera
147                               Achievement of immunological tolerance (long-term antigen unresponsiven
148              CeD is caused by a loss of oral immunological tolerance (LOT) to dietary gluten and lead
149 46a in Treg cells resulted in a breakdown of immunological tolerance manifested in fatal IFNgamma-dep
150 are potentially useful in immunotherapy, but immunological tolerance may block their function.
151 s for self-antigens and it has been proposed immunological tolerance may present a barrier to their p
152  an LPA-LPA(5) axis to serve as a peripheral immunological tolerance mechanism that restrains adaptiv
153 hough common genetic pathways affect general immunological tolerance mechanisms in autoimmunity, the
154 t that intranasal exposure to Ags results in immunological tolerance mediated by functionally impaire
155                                Consequently, immunological tolerance, necessary for averting autoimmu
156                           The maintenance of immunological tolerance of B lymphocytes is a complex an
157                                     Maternal immunological tolerance of the semiallogeneic fetus invo
158  results have implications for mechanisms of immunological tolerance operating in chronic HBV infecti
159            Aire is an important regulator of immunological tolerance, operating in a minute subset of
160 sponse may open the way for the induction of immunological tolerance (or unresponsiveness in the abse
161 recipient strains), resulting in "classical" immunological tolerance, or by bone marrow infusion to s
162 abetes involves a number of steps: defective immunological tolerance, priming of anti-islet autoimmun
163 The liver is known to favor the induction of immunological tolerance rather than immunity.
164                         Autoantigen-specific immunological tolerance represents a central objective f
165                           The maintenance of immunological tolerance requires the deletion of self-re
166 e a better therapeutic strategy for inducing immunological tolerance than blocking the ligands for bo
167    New approaches to induce antigen-specific immunological tolerance that control both cellular and h
168                            It is the loss of immunological tolerance that leads to autoimmunity.
169 ied a new B-cell subset that is critical for immunological tolerance through interactions with Treg.
170 ogy of these cells, including maintenance of immunological tolerance to "self" and regulation of immu
171 y approaches may facilitate the induction of immunological tolerance to a donor organ or protect it l
172 the lungs for many weeks, does not result in immunological tolerance to a yeast challenge in adult mi
173                                     Systemic immunological tolerance to Ag encountered in the eye res
174 ions that the microbiota plays in regulating immunological tolerance to allergen exposure outside the
175 review is focused on approaches for inducing immunological tolerance to circumvent the immunogenicity
176 e rapamycin, are capable of inducing durable immunological tolerance to co-administered proteins that
177 nditioned) recipients can produce a state of immunological tolerance to donor and host.
178 epatitis (AIH) is characterized by a loss of immunological tolerance to hepatocytes.
179 nt mice, lung-derived CD301b(+) cDC2s confer immunological tolerance to inhaled allergens.
180 show that anti-TNF-alpha-treated mice showed immunological tolerance to islet cell proteins.
181 utoimmune hepatitis and attempted to restore immunological tolerance to liver autoantigens.
182 transforming rat proto-oncogene, demonstrate immunological tolerance to neu that is similar to what i
183 e response to reovirus infection that blocks immunological tolerance to new food antigens.IMPORTANCEM
184 tion is associated with the blockade of oral immunological tolerance to newly introduced dietary anti
185                          Attempts to achieve immunological tolerance to porcine tissues in nonhuman p
186 t and microbiota has required development of immunological tolerance to prevent ongoing inflammatory
187                                     Although immunological tolerance to self Ags represents an import
188 dentifies T(reg) cells as vital mediators of immunological tolerance to self and Foxp3 as the mediato
189 ity against pathogens as well as maintaining immunological tolerance to self antigens.
190  B cells, is important in the maintenance of immunological tolerance to self-Ags.
191 utoreactive anergic B cell as an enforcer of immunological tolerance to self-Ags.
192 ated disease that is associated with loss of immunological tolerance to self-antigens.
193 f T cells that are essential for maintaining immunological tolerance to self.
194                                              Immunological tolerance to semiallogeneic fetuses is nec
195     To understand the mechanisms involved in immunological tolerance to skin-associated antigens, we
196              Even when successfully induced, immunological tolerance to solid organs remains vulnerab
197 roclimate is critical for maternal and fetal immunological tolerance to sustain viable pregnancy, but
198 mbats autoimmunity or allergy by reinstating immunological tolerance to target antigens without compr
199 We examined, therefore, whether induction of immunological tolerance to the adhesion molecule that is
200 on their normal tissues do, in fact, exhibit immunological tolerance to the Ag, recapitulating the co
201 any adverse side effects, and fail to induce immunological tolerance to the graft.
202 t tumors can be hindered by the induction of immunological tolerance to the target Ag as a result of
203 ed research in high school, experimenting on immunological tolerance to transplantation antigens.
204  to investigate the mechanisms that regulate immunological tolerance to tumor antigens and will facil
205                   In an attempt to establish immunological tolerance toward GAD65 in NOD mice, and th
206          The liver is essential for inducing immunological tolerance toward harmless antigens to main
207                       Similarly, breakage of immunological tolerance toward self-antigens results in
208                                              Immunological tolerance toward the semiallogeneic fetus
209 gp41-specific BnAb, 2F5, to demonstrate that immunological tolerance triggered by self-reactivity of
210          Lastly, peripheral signs of altered immunological tolerance unfold in mutant mice and in imm
211                           The achievement of immunological tolerance using helminth-derived products
212                               Donor-specific immunological tolerance using high doses of bone marrow
213 ation is also critical to the development of immunological tolerance via both deletional and regulato
214  cells play an essential role in maintaining immunological tolerance via their suppressive function o
215 atitis B surface antigen, indicating that no immunological tolerance was induced by prior fetal immun
216                                              Immunological tolerance was studied by measuring Cyp c 1
217 s important for induction and maintenance of immunological tolerance, we engineered two retroviral co
218 stablished the role of regulatory T cells in immunological tolerance were recognized by this year's N
219 minated with Medawar's discovery of acquired immunological tolerance, which helped to explain the tra
220 rough BDCA2 is an effective method to induce immunological tolerance, which may be useful for treatin
221 ro with Ag/CTB conjugate induced Ag-specific immunological tolerance, which was further enhanced by a
222  early young adulthood, while an increase in immunological tolerance with aging suppresses disease on
223 rom a resistant strain coexist in a state of immunological tolerance with cells from a susceptible st
224 pressive macrophages as crucial mediators of immunological tolerance with the concomitant therapeutic
225 tory (Treg) cells have a fundamental role in immunological tolerance, with transcriptional and functi
226 ti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protectio

 
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