ライフサイエンスコーパス: immunologically

1 Four children were evaluated clinically and immunologically.

2 t tumors paradoxically are better controlled immunologically.

3 and has never to our knowledge been studied immunologically.

4 jugates were characterized biochemically and immunologically.

5 settings (RLSs) is monitored clinically and immunologically, according to World Health Organization

6 ammatory mediator secretion were measured in immunologically activated cultured mast cells derived fr

7 evident with endogenous cysLTs produced from immunologically activated mast cells because inhibition

8 The low quantities of immunologically active allergens transferred through bre

9 gen inoculation directly into the dermis, an immunologically active area containing abundant dendriti

10 mal number of recombinant enzymes to produce immunologically active CPSA, we cloned the genes csaA, c

11 In addition, increasing knowledge on the immunologically active factors in breast milk have also

12 ransmission may be caused by the presence of immunologically active factors, including human milk oli

13 of age, 475 participants received 100 mg of immunologically active gluten daily, and 469 received pl

14 PreventCD protocol, infants received 100 mg immunologically active gluten/d or placebo from 4 to 6 m

15 carriage, including how GBS persists in this immunologically active host niche long term, are not wel

16 , providing a noninvasive method to identify immunologically active microenvironments in secondary br

17 osts and facilitate the determination of the immunologically active molecular components.

18 terial vesicles are a delivery mechanism for immunologically active molecules that contribute to myco

19 in an all-or-nothing manner, existing in an immunologically active or inactive state.

20 o a minor extent in O-4) position results in immunologically active polymer.

21 aling facilitated conversion of tumors to an immunologically active tumor microenvironment with incre

22 Adipocytes have been suggested to be immunologically active, but their role in host defense i

23 It is now appreciated that the brain is immunologically active.

24 0.1 mL) single-visit ID PEP schedule was as immunologically adequate and safe as a 4-dose (4 x 0.1 m

25 te and that antiretroviral therapy (ART) for immunologically advanced disease is associated with subs

26 rmine the effects on transmission or in less immunologically advanced disease.

27 to reduce allergic responses clinically and immunologically after an environmental allergen challeng

28 ated with apoBLG versus holoBLG and analyzed immunologically after systemic challenge.

29 g Treg depletion with anti-Gr-1 antibody was immunologically and clinically more efficacious than ant

30 s and influence the ability of Abeta to form immunologically and morphologically distinct amyloid str

31 were recombinantly produced in insect cells, immunologically and structurally characterized, and thei

32 oteins were characterized physicochemically, immunologically, and in in vivo models with or without a

33 s in the colon and that the balance of these immunologically antagonistic cell types is dictated by m

34 Immunologically, anti-CD40 treatment disrupted multiple

35 Current detection assays are immunologically based and require cumbersome antibody im

36 measurement with traditional methods such as immunologically based assays.

37 f mucin in CF sputum is low when measured by immunologically based techniques, and mass spectrometric

38 Patients were evaluated clinically and immunologically before and after 4, 8, and 24 weeks of t

39 tion and subsequent sepsis may be controlled immunologically by the intervention of M2bM present in M

40 c proteins assembled into VLPs were verified immunologically by their reactivities with a conformatio

41 aracterized biochemically, structurally, and immunologically by using sera from patients with CD and

42 the presence of an invasive placenta and an immunologically challenging pregnancy - an idea we term

43 The goal of this study was to develop and immunologically characterize 3 murine models of ASIT to

44 We sought to identify and immunologically characterize the allergenic components o

45 The aim of this study was to clinically and immunologically characterize these patients with EoE-lik

46 Here, we immunologically characterized 3 patients with de novo ac

47 le Tumour Cell-Line Database, a cell bank of immunologically characterized melanoma cell lines.

48 ichia canis, including three molecularly and immunologically characterized pairs of immunoreactive ta

49 s deficiency, the present work describes and immunologically characterizes the infection for 28 days,

50 small simian model of chronic HBV infection, immunologically close to humans, that should be most val

51 d that secondary-progressive MS patients are immunologically closer to relapsing-remitting patients a

52 hibitors may be most effectively targeted to immunologically cold melanoma to both induce direct cyto

53 that MCMV infection delayed the growth of an immunologically cold tumor by recruiting and modulating

54 ctal adenocarcinomas (PDACs) are classically immunologically cold tumors that have failed to demonstr

55 D-IL-12 may potentiate CPI immunotherapy for immunologically cold tumours.

56 kable clinical success, yet its efficacy in 'immunologically cold' tumours has been modest.

57 tration-resistant prostate cancer (mCRPC) is immunologically "cold" and predominantly resistant to im

58 as immunological priming agents to sensitize immunologically "cold" tumors and subsequently improve o

59 e show that MCMV delayed the growth of these immunologically "cold" tumors by recruiting and modulati

60 Among immunologically "cold" tumors, limited recognition of tu

61 ccumulation of CD8(+) T cells into otherwise immunologically "cold" tumors, sensitizing tumors to PD-

62 standing IDO inhibitors as adjuvants to turn immunologically 'cold' tumors 'hot' can seed new concept

63 e a relatively low mutation load(1,7) and an immunologically 'cold' tumour microenvironment(8).

64 mena often described colloquially as turning immunologically 'cold' tumours 'hot'.

65 Platelets are immunologically competent cells containing cytokines suc

66 combinations of relatively small numbers of immunologically complementary Env trimers may improve nA

67 The liver is both an immunologically complex and a privileged organ.

68 Colorectal cancer originates within immunologically complex microenvironments.

69 These mutants are starvation sensitive, immunologically compromised and short-lived, all phenoty

70 The sarcomas are transplantable to immunologically compromised hosts, showing that they are

71 auses significant morbidity and mortality in immunologically compromised individuals, such as bone ma

72 atin composite, could transiently repopulate immunologically compromised mice skin to regain pigmenta

73 er penicillins or cephalosporins, which were immunologically confirmed, were recruited from allergy c

74 o, and melanoma cells expressing leptin were immunologically controlled in mice.

75 or microenvironment (TME) also represents an immunologically desirable strategy for reversing immunos

76 barrier that regulates the fly's ability to immunologically detect and respond to the presence of th

77 sed concentrations of urinary EVs containing immunologically detectable podocyte-specific proteins by

78 liac disease and pyoderma gangrenosum may be immunologically different.

79 Here, we review how the CNS immunologically discriminates between pathogens and ster

80 rtant minor blood-group antigen that has two immunologically distinct alleles, referred to as Fy(a) o

81 virus type 1 (HTLV-1) is associated with two immunologically distinct diseases: HTLV-1-associated mye

82 ng data show that prior immunization with an immunologically distinct hemagglutinin of the same subty

83 ved from lungs of 2 clinically relevant, but immunologically distinct murine models of IPA on days 2

84 rlapping cytoskeletal activities can utilize immunologically distinct pathways to achieve synonymous

85 by Clostridium botulinum and exist as seven immunologically distinct serotypes designated A through

86 y fabricated sensors were incubated with two immunologically distinct serotypes of Ad, Ad5 and Ad3, w

87 This leads to the rise of immunologically distinct strains of the same genotype on

88 There are two major types of immunologically distinct Stxs: Stx1a and Stx2a.

89 To investigate whether microbiologically and immunologically distinct subsets of patients with HIV an

90 aiCSU is a relatively small but immunologically distinct subtype of CSU that cannot be i

91 Existence of two immunologically distinct types of apoptotic blebs may pr

92 ew properties of RNA therapeutics, which may immunologically distinguish them from their endogenous c

93 us function and reduce inflammation in three immunologically diverse mouse models of inflammatory dis

94 In four immunologically diverse, murine disease models, characte

95 re effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to

96 DENV-1 was immunologically dominant in both monovalent and tetraval

97 ffecting protection with the intertwined and immunologically driven tissue damage.

98 e value) and what those tests might indicate immunologically (durability of antibodies and necessity

99 tis with/without asthma were treated with an immunologically enhanced SCIT formulation (AVANZ, ALK, D

100 onvenient updosing schedules, a fast updosed immunologically enhanced SCIT formulation has been devel

101 Fast updosed immunologically enhanced SCIT with an optimized allergen

102 vealed to be a highly stable, monomeric, and immunologically equivalent of its natural counterpart.

103 tuberculosis infection limits expression of immunologically essential transcription factors.

104 We designed, synthesized, and immunologically evaluated a number of fully synthetic ne

105 support a benefit from identifying patients immunologically failing first-line ART at 48 weeks.

106 Finally, the immunologically favorable environment created after ASCT

107 We show that conditions for an immunologically fertile environment are met when TGF-bet

108 nity immune responses of limited duration in immunologically fit individuals and disappointing result

109 g in utero development imprints tolerance to immunologically foreign non-inherited maternal antigens

110 B28-Asp-insulin (which can be distinguished immunologically from endogenous insulin) that raised ins

111 lex role in defending us both physically and immunologically from the outside world, lends itself ide

112 To determine sites of JCV persistence in immunologically healthy individuals.

113 hology at the University of Kentucky from 12 immunologically healthy patients between February 9, 201

114 cated mucosal immune system, which comprises immunologically heterogeneous microenvironments armed wi

115 chistosomes maintain their longevity in this immunologically hostile environment is unknown.

116 hat exhibit high mutation rates and exist in immunologically hostile environments.

117 xhibited reduced PD-L1 expression and became immunologically hot, with increased IFNgamma content and

118 Further work is required to determine immunologically how HLA disparity between mother and fat

119 ent, immunosuppressed, immunocompromised, or immunologically impaired.

120 including Bacteroides fragilis, a common and immunologically important commensal.

121 parasite genotype induced the expression of immunologically important genes, including antimicrobial

122 ocate the recombination breakpoints in these immunologically important proteins and reveal driving fo

123 Investigation of the immunologically important SLA-DQB1 peptide-binding regio

124 Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons

125 we investigated its ability to rescue these immunologically impotent cells.

126 ls engineered to secrete GIFT4 were rejected immunologically in a B-cell-dependent manner.

127 HIV infection is controlled immunologically in a small subset of infected individual

128 concentration cannot be accurately measured immunologically in proteolytically active CF secretions;

129 lid and effective solution for patients with immunologically incompatible donors even in the context

130 transplantation enables many recipients with immunologically incompatible donors to be transplanted w

131 onths (HIV/Immed-ART-24), or when clinically/immunologically indicated (HIV/Def-ART).

132 because the infecting prion source has been immunologically indistinguishable from normal cellular p

133 SCs and their derivatives are not inherently immunologically inert for autologous transplantation and

134 IL-1beta may explain why uromodulin remains immunologically inert inside the luminal compartment of

135 suggest that although melanin as such is an immunologically inert material, it confers virulence by

136 macrophages, revealing that the eggshell is immunologically inert.

137 Melanin as such was immunologically inert; however, deletion mutant conidia

138 thought that synthetic PEGylated lipids were immunologically inert; however, it's been observed that

139 We identify immunologically-inert and -active syngeneic-tumor types

140 ubunit of the pyruvate dehydrogenase complex immunologically intact into apoptotic bodies, forming an

141 e, spontaneously metastatic breast cancer in immunologically intact mice, tumor-derived MIF promotes

142 reviously demonstrated that BECs translocate immunologically intact PDC-E2 to apoptotic bodies and cr

143 utilized to study the absorption kinetics of immunologically intact peanut proteins.

144 d causes among elite controllers to those of immunologically intact persons with medically controlled

145 can replicate and cause AIDS-like disease in immunologically intact rhesus macaques without requiring

146 al enzymes, and four nuclear antigens remain immunologically intact with respect to postapoptotic tra

147 rify the mechanism of HHV-6 reactivation, we immunologically investigated peripheral blood mononuclea

148 ause latently infected cells are long-lived, immunologically invisible, and may undergo homeostatic p

149 Immunologically, lack of CD27 expression was associated

150 also suggest sunburn and NMSC etiologies are immunologically linked.

151 1 targets multiple genes associated with the immunologically localized disease form, providing an eff

152 odel genetic blood diseases, and manufacture immunologically matched cells for transfusion and cancer

153 Immunologically-matched, induced pluripotent stem cell (

154 a profoundly dangerous, potentially lethal, immunologically mediated adverse drug reaction to unfrac

155 ow that mitochondrial STAT3 is essential for immunologically mediated degranulation of human and mous

156 PDH is essential for immunologically mediated degranulation of mast cells.

157 llergic in nature, with drug allergies being immunologically mediated DHRs.

158 with chronic ulcerative stomatitis, an oral immunologically mediated disease.

159 y revolutionary approach to the treatment of immunologically mediated diseases.

160 nsitivity are diverse, ranging from primary, immunologically mediated disorders of photosensitivity t

161 iated allergy; the most common and important immunologically mediated hypersensitivity disease.

162 d provide a rational basis for an effective, immunologically mediated inhibition of the formation of

163 y indicate that a common TLR3 allele confers immunologically mediated protection from HIV-1 and sugge

164 Immunologically mediated type B ADRs, such as drug hyper

165 tter predict patient populations at risk for immunologically mediated type B ADRs.

166 tral nervous system and one indirect, likely immunologically mediated.

167 rtality from early ART in the COAT trial was immunologically mediated.

168 a viremia is resolving and are thought to be immunologically mediated.

169 e of coallergy among these foods and Is this immunologically mediated?

170 ell transplantation where early rejection of immunologically mismatched grafts is driven by the recip

171 indings suggest approaches for transplanting immunologically mismatched HSCs and solid organs with li

172 to drug-free long-term survival in maximally immunologically mismatched swine.

173 allogeneic CDC transplantation in rats from immunologically-mismatched inbred strains.

174 lish a correlation between pH sensitivity of immunologically modified nano-scaled field-effect transi

175 The potential of effector CD4 T cells to immunologically modulate SIV/HIV infection likely is lim

176 on of cockroach allergen by means of SCIT is immunologically more active than SLIT, especially with r

177 I, suggesting that recently acquired LTBI is immunologically more similar to tuberculosis than remote

178 The disease clinically and immunologically most similar to smallpox is monkeypox, a

179 HCMV causes disease in immunologically naive and immunosuppressed patients.

180 al animal studies test influenza vaccines in immunologically naive animal models, even though the res

181 evaluate new influenza vaccine candidates in immunologically naive animals.

182 rogated in 40 transplant recipients who were immunologically naive before their failed transplantatio

183 s likely to develop respiratory disease than immunologically naive dogs (P < 0.001).

184 odulatory properties of progestins protected immunologically naive female mice from the severe outcom

185 After influenza A infection of immunologically naive ferrets with various H1N1 or H3N2

186 ifficulty in producing a vaccine in a young, immunologically naive host.

187 sly been associated with severe infection in immunologically naive hosts, are rarely activated, howev

188 All other age groups (except immunologically naive infants) were likely partially pro

189 Influxes of immunologically naive juvenile fish through recruitment

190 ed the T-cell response to ECTV in previously immunologically naive mice that were chronically infecte

191 The absence of prior infections may put an immunologically naive population at risk for disease out

192 irus into humans can lead to pandemics in an immunologically naive population.

193 o rural populations, spread widely in young, immunologically naive populations (leading to outbreaks

194 ance with high potential to spread into new, immunologically naive populations.

195 nd Chikungunya viruses can spread rapidly in immunologically naive populations.

196 vo fitness on viruses in the newly infected, immunologically naive recipient.

197 Since then, the population that is immunologically naive to orthopoxviruses has increased s

198 obal concern because the human population is immunologically naive to them.

199 virus was compared with that of Dengue virus immunologically naive vaccinees.

200 Immunologically, natural killer cells had an immature ph

201 t have been irradiated and transplanted with immunologically normal bone marrow from either MIA or co

202 Avidity to an immunologically novel GII.4 strain VLP correlated with p

203 Because these viruses are immunologically novel to humans, they could spark a pand

204 s study, we employed DNA vaccination with an immunologically optimized mouse melanoma-shared Ag, Trp1

205 ecific immunoregulatory mechanisms create an immunologically permissive environment for tumor coloniz

206 radiotherapy can help create and maintain an immunologically permissive environment.

207 Here, we argue that targeting IL-17 is immunologically plausible as a strategy to prevent acute

208 Immunologically, PLGA-KAg vaccine irrespective of not si

209 Brain death (BD) can immunologically prime the donor organ and is thought to

210 t oropharyngeal delivery of low-dose LPS can immunologically prime the lung to augment alveolar macro

211 The eye is an immunologically privileged and profoundly immunosuppress

212 disease to occur, these cells must enter the immunologically privileged CNS through a breach in the r

213 Invasion of immunologically privileged erythrocytes provides a relat

214 active factors in tick saliva that create an immunologically privileged micro-environment in the host

215 The immunologically privileged nature of the cornea results

216 the host immune system by the expression of immunologically privileged neuronal-site NE genes, and N

217 LA-4:CD86 interactions as a component of the immunologically privileged niche surrounding HRS cells a

218 to create an important viral reservoir in an immunologically privileged site in vivo, whether immunol

219 to the traditional view that the brain is an immunologically privileged site shielded behind the bloo

220 advantage, as the expression of proteins at immunologically privileged sites such as neurons on endo

221 is the main EAV tissue reservoir rather than immunologically privileged tissues (i.e., testes).

222 scAbs may be restricted from entry into the "immunologically privileged" CNS.

223 remaining proliferating parasites located in immunologically protected sites such as the fetal brain.

224 le of tolerating CNI withdrawal by targeting immunologically quiescent kidney transplant recipients.

225 ession, including those who are deemed to be immunologically quiescent on the basis of current clinic

226 Fungi (the mycobiota) represent a highly immunologically reactive component of the gut microbiota

227 5(-/-) dnTGFbetaRII mice, histologically and immunologically, reflect key features of PBC, providing

228 nct clinical trajectories, some of which are immunologically related and others which follow patholog

229 ajor role of these loci in the regulation of immunologically related mechanisms.

230 antibodies promotes the degradation of both immunologically relevant and irrelevant MHC-II molecules

231 vival and function was evaluated in vitro in immunologically relevant assays and in vivo in allogenic

232 Polysaccharides are essential and immunologically relevant components of bacterial cell wa

233 We aimed to combine immunologically relevant epitopes of Bet v 1 and the 2 c

234 ed tumor-infiltrating lymphocytes (TILs) and immunologically relevant genes in the neoadjuvant GeparS

235 The L. loa genome encodes many immunologically relevant genes, as well as protein kinas

236 older individuals that were homozygous at an immunologically relevant genetic locus.

237 These findings mechanistically link an immunologically relevant genetic risk factor with a func

238 ng disease cohorts, we established that this immunologically relevant genetic variation in the promot

239 lass II and CD28-B7 interactions, we defined immunologically relevant interactions as those >/=500 s.

240 AFM, using tips functionalized with immunologically relevant molecules, can map epitopes of

241 PE-PilA is a fusion protein composed of immunologically relevant parts of protein E (PE) and the

242 and by increasing the surface expression of immunologically relevant receptors, including class II M

243 GM3 trisaccharide was then conjugated to the immunologically relevant zwitterionic polysaccharide PS

244 We consider the immunologically relevant, yet epidemiologically largely

245 e granulomas serve to physically contain and immunologically restrain bacteria growth, some granuloma

246 Granulomas physically contain and immunologically restrain bacteria that cannot be cleared

247 y for sexually transmitted infections, is an immunologically restrictive tissue that prevents entry o

248 However, the mechanisms that drive the immunologically restrictive tumor microenvironment remai

249 mes ((D)VAP-liposomes) were identified as an immunologically safe carrier and therefore utilized for

250 king cessation, but a reliably effective and immunologically safe vaccine remains to be identified.

251 third and final phase of the process, where immunologically sculpted tumours begin to grow progressi

252 t nonetheless dramatically depletes multiple immunologically significant commensal bacteria.

253 Early colonization by immunologically silencing microbiota may thus preclude a

254 As compared to Lpn, Llo is immunologically silent and fails to trigger the producti

255 the ability of commensal bacteria to remain immunologically silent and in turn provide pathogen prot

256 nt outcomes, yet most pancreatic cancers are immunologically silent and resistant to currently availa

257 sis-driven rational design of highly potent, immunologically silent and stable siRNAs suitable for th

258 n, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in theory, more li

259 vert inflammatory pyroptotic cell death into immunologically silent apoptotic cell death.

260 iminate a pool of long-lived cells harboring immunologically silent but replication-competent proviru

261 phages share characteristics compatible with immunologically silent clearance of ACs; such characteri

262 The immunologically silent clearance of apoptotic cells is c

263 e signals and how these relate to prompt and immunologically silent clearance of apoptotic cells.

264 generation depends on reliable production of immunologically silent functional iPSC derivatives.

265 clearance of NETs and that this occurs in an immunologically silent manner.

266 These experiments suggest that the immunologically silent nature of the natural glycans is

267 determines whether mitochondria initiate an immunologically silent or a proinflammatory type of cell

268 developmental switch to a more invasive and immunologically silent phenotype.

269 the growth of desmoplastic, angiogenic, and immunologically silent tumors through derepression of Mm

270 rapid form of phagocytosis that produces an "immunologically silent" clearance of the apoptotic cells

271 Llo is immunologically silent, highly virulent, and lethal.

272 lls trigger inflammatory responses or remain immunologically silent.

273 functions to render mitochondrial apoptosis immunologically silent.

274 ort indicates that even the cloak can become immunologically silent.

275 totic cell death and may serve to provide an immunologically-silent window by generating specific "fi

276 and an IgG control antibody, gave potent and immunologically specific activities in vitro and in vivo

277 Here we show that gLNs are immunologically specific to the functional gut segment t

278 Among immunologically stable patients who underwent transplant

279 iduals in this study being virologically and immunologically stable.

280 Although NA is immunologically subdominant to HA, and clinical studies

281 d that during infection, the stem domain was immunologically subdominant to the head in terms of seru

282 These findings may explain why the LAIV is immunologically superior and offers immediate protection

283 random potential environmental insults in an immunologically susceptible individual.

284 hildren will result in a large population of immunologically susceptible persons who will be at risk

285 unity was contingent on two nonredundant but immunologically synergistic p53-dependent processes: rev

286 We provide proof of principle for immunologically targeting AML-initiating fusions and dem

287 Immunologically, there is a trade-off between transmissi

288 ntified significantly more zebras responding immunologically to anthrax than have previous studies us

289 y and on beta function, mass, and insulin in immunologically tolerant anti-CD3 monoclonal antibody (m

290 The liver maintains an immunologically tolerant environment as a result of cont

291 est the hypothesis that nonresponders may be immunologically tolerant.

292 ile tolerated well during development and in immunologically unchallenged animals, impairs the expans

293 Brain metastasis (br-met) develops in an immunologically unique br-met niche.

294 that the N-terminal two-thirds of BoNT/H is immunologically unique.

295 Immunologically, we noted hypogammaglobulinemia with ter

296 Immunologically, we observed significant increases in th

297 The 3 phenotypes were immunologically well discriminated by means of microarra

298 by pulmonary immune effector cells and were immunologically well tolerated by lung tissues.

299 CLB present in bovine hair samples competes immunologically with alkaline phosphatase (AP) enzyme-la

300 omatography-mass spectrometry (LC-MS/MS) and immunologically with monoclonal antibody E06.