ライフサイエンスコーパス: immunomodulatory

1 erm-free mice, revealing that gut microbiota immunomodulatory actions critically regulate physiologic

2 ay epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repa

3 ompared their physicochemical properties and immunomodulatory activities following in situ vaccinatio

4 of medicinal value because of antiviral and immunomodulatory activities linked to its constituent BI

5 n-natural amino acids on the antibiofilm and immunomodulatory activities of synthetic HDPs remains un

6 The antibiofilm and immunomodulatory activities of these derivatives were as

7 luated several subglutinol analogs for their immunomodulatory activities.

8 s (statins) have broad anti-inflammatory and immunomodulatory activities.

9 Human milk has antimicrobial compounds and immunomodulatory activities.

10 structural requirements of subglutinols for immunomodulatory activity and to provide guiding princip

11 We evaluated the immunomodulatory activity of a panel of TLR triagonist a

12 Given the immunomodulatory activity of avadomide and the need for

13 0.1 has a long-lasting anti-inflammatory and immunomodulatory activity which may help explain some of

14 Consistent with their immunomodulatory activity, MV-differentiated cells upreg

15 he surface of different prokaryotes and show immunomodulatory activity.

16 ic functions but are also recognized to have immunomodulatory activity.

17 -limiting enzyme in the conversion of ATP to immunomodulatory adenosine, are entering clinical trials

18 Here, we show that the immunomodulatory agent pomalidomide depletes pancreatic

19 servations suggest that bergenin is a potent immunomodulatory agent that could be further explored as

20 We conclude that B. subtilis EPS is an immunomodulatory agent that induces hybrid macrophages t

21 four previous lines of therapy (including an immunomodulatory agent), and had an Eastern Cooperative

22 ry to at least one proteasome inhibitor, one immunomodulatory agent, and daratumumab (triple-class re

23 y cytokines and for the use of heparin as an immunomodulatory agent.

24 itin ligase complex, and a binding target of immunomodulatory agents (IMiDs).

25 t with modern combination regimens including immunomodulatory agents (lenalidomide and pomalidomide)

26 ravenous immunoglobulin, steroids, and other immunomodulatory agents have been used frequently.

27 rapeutic combinations based on endocrine and immunomodulatory agents in HR(+) breast cancer.

28 Thus, efforts must be made to identify new immunomodulatory agents that are effective through a nov

29 e a mechanistic rationale for using PARPi as immunomodulatory agents to harness the therapeutic effic

30 Systemic steroids and immunomodulatory agents were successfully used to contro

31 l utility to enrich for clinical response to immunomodulatory agents, including avadomide.

32 The introduction of immunomodulatory agents, proteasome inhibitors, and auto

33 for IPF are limited to anti-inflammatory and immunomodulatory agents, which are only partially effect

34 primarily based on corticosteroids and other immunomodulatory agents, which should be prescribed care

35 outcomes in the era of myeloma-targeted and immunomodulatory agents.

36 timicrobial drugs, anticancer therapies, and immunomodulatory agents.

37 improved loading, targeting, and release of immunomodulatory agents.

38 active tumors) are more likely to respond to immunomodulatory agents.

39 FS between the treatment arms, including new immunomodulatory and angiogenesis gene expression signat

40 the development of cyclic derivatives of the immunomodulatory and antibiofilm innate defense regulato

41 conserved among natural peptides with potent immunomodulatory and antimicrobial activities.

42 d highlight the protein as a drug target for immunomodulatory and antioxidant therapies for AMD.

43 several studies have attributed statins with immunomodulatory and bactericidal properties.

44 (CC-122) is a cereblon-modulating agent with immunomodulatory and direct antitumor activities.

45 anslation of novel, mechanistically-targeted immunomodulatory and regenerative therapies that are eme

46 derived peptides that combine antimicrobial, immunomodulatory, and T2D-related anti-amyloid functions

47 investigating the complex anti-inflammatory, immunomodulatory, and tissue-repair properties of MSCs.

48 nergistic effect between PD-1 inhibitors and immunomodulatory antifungal agents.

49 ability to deliver cyclosporine A (CsA) for immunomodulatory applications.

50 This immunomodulatory approach could be used to enhance immun

51 Most of these immunomodulatory approaches have focused on enhancing T-

52 We review the immunomodulatory aspects of naive and engineered MSCs, a

53 e pretransplantation increased expression of immunomodulatory-associated genes, and licensed encapsul

54 ile, suppressed FA in mice as did a separate immunomodulatory Bacteroidales consortium.

55 antation of PVPON/TA-encapsulated islets was immunomodulatory because gene expression and flow cytome

56 The immunomodulatory bioconjugate significantly reduced the

57 g antibodies (ADAs) against protein drugs by immunomodulatory bioconjugation is reported.

58 tine at mid-gestation, although strains with immunomodulatory capacity are detected in subsets of spe

59 e and adaptive immune responses and how this immunomodulatory capacity can be both beneficial in the

60 dversely affect the human microbiome and its immunomodulatory capacity.

61 operties, preservation of SCAP viability and immunomodulatory capacity.

62 of death due to infection, has a dynamic and immunomodulatory cell envelope.

63 y bypass were analyzed for the expression of immunomodulatory cell markers by real-time quantitative

64 MSCs have inherent immunomodulatory characteristics, trophic activity, high

65 Immunomodulatory commensal bacteria modify host immunity

66 al evidence that RNA virus IBs are important immunomodulatory complexes within infected cells.IMPORTA

67 in several veterinary vaccines as well as an immunomodulatory component of AS03, an emulsion adjuvant

68 C pathways responsible for the production of immunomodulatory compounds appear to be enriched in mice

69 Many of these immunomodulatory compounds are modified with complex sug

70 pAlign to analyze the impact of 40 different immunomodulatory compounds on a heterogeneous population

71 s within the tumor, allowing for delivery of immunomodulatory compounds to tumor myeloid cells in a v

72 These immunomodulatory consequences are critical, because they

73 ogether, these data confirm that obesity has immunomodulatory consequences in intestinal tissues that

74 ther, these processes create chemotactic and immunomodulatory cues for incoming and resident immune c

75 cant up-regulation of the genes encoding the immunomodulatory cytokine IL-10 and the terminal-differe

76 IL-2 has emerged as a critical immunomodulatory cytokine that both positively and negat

77 crobial response but also serve as important immunomodulatory cytokines in autoimmune and autoinflamm

78 28 and P44 induced upregulated expression of immunomodulatory cytokines.

79 Thalidomide and its immunomodulatory drug (IMiD) analogs, lenalidomide, and

80 us stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance.

81 Lenalidomide is an immunomodulatory drug approved in the United States for

82 ciated gene signatures to identify potential immunomodulatory drug candidates.

83 ole for continuous proteasome inhibitors and immunomodulatory drug combination maintenance therapy fo

84 Fingolimod (FTY720), an FDA-approved immunomodulatory drug for treating multiple sclerosis, i

85 ught to determine the applicability of a new immunomodulatory drug inhibiting the store-operated calc

86 f this approach can monitor the effect of an immunomodulatory drug on brain-infiltrating leukocytes.

87 herapy, including a proteasome inhibitor and immunomodulatory drug, or were double refractory to both

88 rapy, including a proteasome inhibitor or an immunomodulatory drug, or were double refractory.

89 an monitor the response of these cells to an immunomodulatory drug.

90 t that included a proteasome inhibitor or an immunomodulatory drug.

91 efractory to both a proteasome inhibitor and immunomodulatory drug; and had an Eastern Cooperative On

92 understand the molecular mechanisms by which immunomodulatory drugs (IMiDs) induce thrombocytopenia.

93 lines of therapy and who were refractory to immunomodulatory drugs and proteasome inhibitors, and re

94 , epigenetic targeting agents are attractive immunomodulatory drugs and will have major impacts on im

95 ultiple myeloma (NDMM) patients treated with immunomodulatory drugs are at high risk of venous thromb

96 Immunomodulatory drugs may have efficacy for depressive

97 the capacity to co-encapsulate two types of immunomodulatory drugs, a chemokine and an RNAi sequence

98 s that could be augmented when combined with immunomodulatory drugs, a combination therapy the author

99 host immune system can have broad effects on immunomodulatory drugs.

100 ost anti-cancer immunity and the efficacy of immunomodulatory drugs.

101 We show that the immunomodulatory effect could be reversed through GSL sy

102 rstanding and to validate the extent of this immunomodulatory effect in human subjects in order to as

103 oth CD4 and CD8 T cells and suggest that the immunomodulatory effect of fumaric acid esters in multip

104 We compared the immunomodulatory effect of MSCs, CIMVs and EVs.

105 cognition by C-type lectin receptors and the immunomodulatory effect of the L. kefiri SLPs on antigen

106 of SiNPs on healthy mouse skin, there is an immunomodulatory effect of these NPs in a model of aller

107 filtrating T lymphocytes, supporting a local immunomodulatory effect of treatment.

108 Finally, an immunomodulatory effect was demonstrated in vivo in an I

109 wnregulation of IRF8 protein, followed by an immunomodulatory effect, as represented by a decrease in

110 Vasopressin exerted no immunomodulatory effects across these experimental setup

111 cting the venom molecules with antitumor and immunomodulatory effects and trying to better understand

112 o suppressing viremia, bNAbs may have T cell immunomodulatory effects as seen for other forms of immu

113 biotic microflora, MOS impart anticancer and immunomodulatory effects by inducing different gene mark

114 xic for PBMC in vitro up to 500 ug/ml, while immunomodulatory effects depended on their chemical comp

115 r nutraceuticals with potentially beneficial immunomodulatory effects in allergies.

116 at the gastrointestinal microbiome may exert immunomodulatory effects in allo-HCT patients at least i

117 ) 9 agonist, are known to possess beneficial immunomodulatory effects in patients with T cell-mediate

118 baseline hyperresponsiveness, and exhibited immunomodulatory effects in the airways of allergic indi

119 The immunomodulatory effects of AIT are attributed mainly to

120 The immunomodulatory effects of bone marrow derived mesenchy

121 The capacity of (18)F-AraG to detect immunomodulatory effects of chemotherapy was determined

122 umor response, CD8+ cells, and evaluates the immunomodulatory effects of chemotherapy.

123 We evaluated the immunomodulatory effects of CpG A in IL-33-induced airwa

124 Interestingly, immunomodulatory effects of HO-1 and/or carbon monoxide

125 Here, we critically assess the potential immunomodulatory effects of Hz, its role in malarial com

126 The immunomodulatory effects of L-AZM were associated with a

127 Previous studies have confirmed that the immunomodulatory effects of MSCs are mainly communicated

128 Taken together, our findings uncovered immunomodulatory effects of niraparib that may sensitize

129 bacteria-killing activities of PG-1, and the immunomodulatory effects of PG-1 via stimulating interle

130 pathways in the cancer cell and the profound immunomodulatory effects of sustained ER stress response

131 Here, we discuss the main immunomodulatory effects of targeted anticancer agents a

132 In addition, the known and potent immunomodulatory effects of these agents which support t

133 do not exclude the possibility of beneficial immunomodulatory effects of thymosin alpha-1, they do no

134 ibition of CTL activity, suggesting that the immunomodulatory effects of TMPs in response to radiothe

135 immune system, in this study we analyzed the immunomodulatory effects of UTMD and miRNAs in HCC.

136 Although immunomodulatory effects of volatile anesthetics have be

137 nal microbiota also has numerous significant immunomodulatory effects that can shape the host alloimm

138 We investigated the immunomodulatory effects using peripheral blood mononucl

139 Bacteria with reported immunomodulatory effects were incubated with ATIs and an

140 ne were found to be noninflammatory, whereas immunomodulatory effects were noted in the presence of L

141 Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms

142 ivery of such low-dose IFN-alpha resulted in immunomodulatory effects, consisting of proinflammatory

143 Azithromycin, a macrolide antibiotic with immunomodulatory effects, is used to treat M. abscessus

144 Knowing that anesthetic drugs can pose immunomodulatory effects, it would be critical to unders

145 stimulates release of epinephrine, which has immunomodulatory effects, we questioned whether epinephr

146 gnaling molecule that has cytoprotective and immunomodulatory effects.

147 luoxetine (FLX) have both been shown to have immunomodulatory effects.

148 Collectively our data demonstrates immunomodulatory efficacy of CIMVs and supports their fu

149 hologically disrupts the lipidome, including immunomodulatory eicosanoid and docosanoid lipid mediato

150 sal Lactobacillus reuteri 6475 gives rise to immunomodulatory ethionine, a source for histone ethylat

151 In particular, regenerative and immunomodulatory EVs hold potential as innate biotherape

152 he glucose-dependent secretion of protective immunomodulatory factor interleukin-10.

153 adaptive immune responses, we expressed the immunomodulatory factors PD-L1, HLA-G, and the macrophag

154 llows precisely timed expression of numerous immunomodulatory factors will serve as a paradigm for ot

155 study demonstrates the unique and unexpected immunomodulatory features of SA-4-1BBL that bridge innat

156 ctional programs of ascites cells, including immunomodulatory fibroblast sub-populations and dichotom

157 tors with therapeutic molecules that enhance immunomodulatory function for anticancer therapies.

158 s likely resulted from the engagement of the immunomodulatory function of CD31 signaling.

159 d insoluble tau formation independent of its immunomodulatory function was also identified.

160 Because of its immunomodulatory function, CD40L has been used to enhanc

161 Additionally, the BLP increases intestinal immunomodulatory functions by recruiting FOXP3(+)T cells

162 It is not known whether HVEM immunomodulatory functions contribute to latency and rea

163 Wnt signaling regulates immunomodulatory functions during infection and inflamma

164 F1 in regulating cAMP-mediated signaling and immunomodulatory functions in airway smooth muscle (ASM)

165 hrombotic lesions and that the physiological immunomodulatory functions of CD31 are lost at the surfa

166 isease, thus suggesting that the loss of the immunomodulatory functions of NOD2 could contribute to t

167 t is being increasingly appreciated that the immunomodulatory functions of PARP1 inhibitors (PARPi) u

168 PARP1 trapping as a major contributor of the immunomodulatory functions of PARPi.

169 Thus, the immunomodulatory functions of VDR in macrophages are cri

170 s necroptosis rather than apoptosis, induces immunomodulatory functions, and poises HSCs for myeloid

171 ota-derived metabolite able to exert several immunomodulatory functions.

172 receptor (AHR), a transcription factor with immunomodulatory functions.

173 d can be readily engineered to enhance their immunomodulatory functions.

174 a multitude of antimicrobial activities and immunomodulatory functions.

175 We engineered immunomodulatory fusion proteins (IFPs) to enhance ACT e

176 ed monocyte-like AML cells expressed diverse immunomodulatory genes and suppressed T cell activity in

177 ic variants controlling the expression of 41 immunomodulatory genes modulate the risk of MPM compared

178 evidence that DNA repair pathway defects and immunomodulatory genes together lead to specific immunop

179 US) region of HCMV, a region expressing many immunomodulatory genes.

180 trol protein (CCP) domains, similarly to the immunomodulatory HpARI and Hp-TGM proteins.

181 CD14(+)HLA-DR(low) phenotype, expressed the immunomodulatory indoleamine-2,3-dioxygenase, and upregu

182 ultiple myeloma and a suboptimal response to immunomodulatory induction therapy compared with no inte

183 identify opportunities for subgroup-specific immunomodulatory intervention.

184 Herein, we approach SARS-CoV-2 through an immunomodulatory lens, discussing possible mechanisms of

185 re termed immunoevasive due to expression of immunomodulatory ligands.

186 ysophosphatidylinositol (lyso-PI) classes of immunomodulatory lipids.

187 In this study we investigated the immunomodulatory mechanism of azithromycin through its a

188 Conclusion: We report an immunomodulatory mechanism of sorafenib involving MPhi p

189 The immunomodulatory mechanisms constitutively present in su

190 el observations may help explain the complex immunomodulatory mechanisms of GA and adverse injection

191 corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor a

192 promote dysfunction via release of preformed immunomodulatory mediators.

193 t it might not be necessary to stop systemic immunomodulatory medication for ocular inflammation.

194 nd has been refractory to treatment with the immunomodulatory medications that effectively control re

195 of bacterial genera in relation to those of immunomodulatory medications, revealing a considerable i

196 at reversing the inflammatory response using immunomodulatory medications.

197 with moderate COVID-19 who had not received immunomodulatory medications.

198 mammals, is the precursor of a wide array of immunomodulatory metabolites produced by the kynurenine

199 A distinct poor-outcome immunomodulatory microenvironment, hitherto poorly chara

200 fficacy in vitro and in vivo in oncology and immunomodulatory models, and a number of them are curren

201 CD69 is an immunomodulatory molecule induced during lymphocyte acti

202 mine spermidine (SPD) as another significant immunomodulatory molecule produced by B. dendrobatidis S

203 and PIMs enhance survival and expression of immunomodulatory molecules.

204 sed by high expression of growth factors and immunomodulatory molecules.

205 sent a strong therapeutic candidate for TBI, immunomodulatory nanoparticles (IMPs), which ablate a sp

206 Glutamine has been implicated as an immunomodulatory nutrient, but its role in the response

207 profile of these cells, but also induced an immunomodulatory one, as shown by increased IL-10 produc

208 The addition of immunomodulatory or immunosuppressive agents often allow

209 identify CXCR-1/2 signaling as an important immunomodulatory pathway during the initiation of regene

210 ovide evidence that the genetic variation in immunomodulatory pathways may contribute to the developm

211 d with systemic therapy by concentrating the immunomodulatory payload at the site of disease.

212 ls can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) mi

213 matory bowel disease (IBD)(2,5), the diverse immunomodulatory phenotypes remain largely unknown at th

214 Here, we show that the antimicrobial and immunomodulatory polypeptide human cathelicidin LL-37 bi

215 he IL-10 receptor complex contributes to the immunomodulatory potency of IL-10.

216 SCs have more recently been shown to possess immunomodulatory potential, in which regulatory T cells

217 e secretion pattern demonstrating a specific immunomodulatory profile of these cells.

218 The screening data provide a resource of immunomodulatory properties of cancer drugs and genetic

219 a that identifies and catalogues fundamental immunomodulatory properties of CMCs, which have broad im

220 imited pool of immune cells, and from unique immunomodulatory properties of IFN-lambda.

221 This is the first study to establish the immunomodulatory properties of liposomal AZM formulation

222 Cabozantinib has innate and adaptive immunomodulatory properties providing a rationale for co

223 Progenitor Cells (MAPC((R)) ) possess potent immunomodulatory properties that could minimize ischemia

224 This study suggests that linezolid has immunomodulatory properties that protect human neutrophi

225 that harnessing mast cells' host defense and immunomodulatory properties via the activation of MRGPRX

226 suggest that the endocannabinoid system has immunomodulatory properties, there remains a paucity of

227 dation pathway in the parasite and possesses immunomodulatory properties.

228 robial effect, suggesting the possibility of immunomodulatory properties.

229 strong response to interferon and heightened immunomodulatory properties.

230 ible dietary fibers by gut bacteria and have immunomodulatory properties.

231 Platelets are known to have immunomodulatory properties.

232 To harness the immunomodulatory property of CD200 for surface modificat

233 revealed upregulated galectin-1, which is an immunomodulatory protein linked to the ECM, in AMR glome

234 he robust mechanism employed by single viral immunomodulatory protein targeting a broad spectrum of c

235 d Ly-6/uPAR Related Protein-1 (SLURP1) is an immunomodulatory protein that promotes corneal immune- a

236 Helminth parasites secrete a wide variety of immunomodulatory proteins and lipids to dampen host immu

237 ely expressed proinflammatory chemokines and immunomodulatory proteins in a cell-autonomous manner.

238 nthesis and remodeling, redox regulation and immunomodulatory proteins typify a proteotype associated

239 host immune response by expressing scores of immunomodulatory proteins.

240 breast cancer cells and execute therapeutic immunomodulatory responses.

241 The mechanisms underlying the secretion of immunomodulatory RNA and DNA by pathogens such as Staphy

242 Altogether, we report a immunomodulatory role for ataxin-1 and provide a functio

243 These findings introduce a new immunomodulatory role for LECs in directly generating a

244 abundant presence of viral RNAs may play an immunomodulatory role in the development of allergic rea

245 Here, we investigated the immunomodulatory role of a liposomal AZM formulation (L-

246 In this review, we summarize the immunomodulatory role of IFNs in skin, with a focus on t

247 However, little is known about the immunomodulatory role of the neuroglial cells in cancer

248 Here, we investigate the immunomodulatory role of tumor-derived microparticles (T

249 n from yeast to hyphal morphotype, it has an immunomodulatory role on human dendritic cells (DC) thro

250 tis, the local microbiome appears to play an immunomodulatory role through complex interactions, thou

251 Although the immunomodulatory roles of Hz have been widely investigat

252 ctivity in amoeboid cancer cells controls an immunomodulatory secretome, enabling the recruitment of

253 d and uncover a Hedgehog-regulated choroidal immunomodulatory signaling circuit.

254 cription factor STAT3 to drive expression of immunomodulatory STAT3-targets.

255 Immunomodulatory strategies targeting this disease in sm

256 ct, focusing on mechanisms of relapse and on immunomodulatory strategies that are being developed to

257 Immunomodulatory strategies that limit virus-induced inf

258 ilure setting, such as anti-inflammatory and immunomodulatory strategies.

259 ndings suggest that PA can serve as a potent immunomodulatory supplement to MS drugs.

260 To garner an insight into tumor-specific immunomodulatory targets, we analyzed 94 patients repres

261 resence of the PI3K inhibitor may render the immunomodulatory therapeutic ineffective in these combin

262 mary driver of poor outcomes and submit that immunomodulatory therapeutic strategies may offer a bene

263 but also opportunities to develop biomimetic immunomodulatory therapeutics that mitigate cardiovascul

264 autoantibodies would help justify the use of immunomodulatory therapies and provide insight into the

265 Immunomodulatory therapies are limited by unavoidable si

266 clinical trials provide hope that available immunomodulatory therapies could have therapeutic potent

267 hose at risk for VUE and the use of specific immunomodulatory therapies during gestation to improve o

268 and mycophenolate mofetil are commonly used immunomodulatory therapies for achieving corticosteroid-

269 ial FTD, warranting further consideration of immunomodulatory therapies for disease modification and

270 isms underlying this phenomenon could inform immunomodulatory therapies for HBV cure.

271 The introduction of sophisticated immunomodulatory therapies has given renewed hope to man

272 iduals infected with HIV or taking prolonged immunomodulatory therapies have a heightened risk for de

273 knowledge gaps still to be addressed before immunomodulatory therapies might be applied to at least

274 n evaluating T-cell pathogenesis, developing immunomodulatory therapies or vaccines for HIV, and when

275 those of transfusion recipients or providing immunomodulatory therapies prior to blood product exposu

276 Whilst immunomodulatory therapies reduce disease activity, the

277 Thus, immunomodulatory therapies that improve CD8(+) T cell im

278 Expanding the use of immunomodulatory therapies to include HIV treatment depe

279 Despite widespread use of immunomodulatory therapies, patients may still face prog

280 ating brain disease in individuals receiving immunomodulatory therapies.

281 Concurrent classic immunomodulatory therapy (IMT) was given to 251 patients

282 ungal infection, specifically in patients on immunomodulatory therapy for autoimmune disease.

283 There is no proven antiviral or immunomodulatory therapy for coronavirus disease 2019 (C

284 therapeutic potential of IRF8 inhibition as immunomodulatory therapy for inflammatory bowel disease

285 st that RASSF1A may be a promising target in immunomodulatory therapy for the management of acute hea

286 Immunomodulatory therapy given to patients with MIS-C in

287 ld be aware that patients receiving systemic immunomodulatory therapy have a higher risk of developin

288 Specific subtypes of FM may respond to immunomodulatory therapy in addition to guideline-direct

289 tudy provides further evidence that targeted immunomodulatory therapy may be beneficial in specific p

290 These data implicate the DLN as a target for immunomodulatory therapy of transplant rejection.

291 ly recalcitrant cases, inability to wean off immunomodulatory therapy, and long-term complications le

292 agent, adjunctive treatment for thrombosis, immunomodulatory therapy, complement inhibition, vascula

293 ases, including 6 cases that did not require immunomodulatory therapy.

294 identify patients who may be candidates for immunomodulatory therapy.

295 imal effects of S100A9 blockade as potential immunomodulatory treatment in acute myocardial infarctio

296 knowledge of immune mechanisms and targeted immunomodulatory treatment options for the current coron

297 ic neuritis, 4-AP potentiated the effects of immunomodulatory treatment with fingolimod.

298 ch could potentially generate more effective immunomodulatory treatments to induce disease regression

299 mmatory arthritis, all of whom were naive to immunomodulatory treatments, were obtained.

300 repress the expression of more than a dozen immunomodulatory virulence factors.