ライフサイエンスコーパス: immunoregulation

1 re of the gut microbiome that disrupt normal immunoregulation.

2 processes, as well as tissue remodeling and immunoregulation.

3 ng that Vitamin D has a nonclassical role in immunoregulation.

4 n programs relevant to tissue remodeling and immunoregulation.

5 rrier function, innate bacterial killing, or immunoregulation.

6 m, and sex-specific epigenetic mechanisms of immunoregulation.

7 roduction and their emerging role in mucosal immunoregulation.

8 erties and are essential to ensure effective immunoregulation.

9 and play important roles in host defense and immunoregulation.

10 nts with MS, demonstrating a defect in TIM-3 immunoregulation.

11 ed secretory proteins that are implicated in immunoregulation.

12 porting our previous reports of ex vivo DBMC immunoregulation.

13 our understanding of glucocorticoid-mediated immunoregulation.

14 n that has functional relevance for cellular immunoregulation.

15 hanism involving apoptotic cell-deletion and immunoregulation.

16 upport an important role of this molecule in immunoregulation.

17 active immunization by regulating Ag-induced immunoregulation.

18 y an important role in both host defense and immunoregulation.

19 development and may be secondary to aberrant immunoregulation.

20 functions in inflammation, host defense, and immunoregulation.

21 the urea cycle as an endogenous mechanism of immunoregulation.

22 atory molecule for T cells that functions in immunoregulation.

23 their biosynthetic pathways center stage in immunoregulation.

24 al T cell tolerance induction and peripheral immunoregulation.

25 ural killer T cells (iNKTs) are important in immunoregulation.

26 al work in adult animal species dealing with immunoregulation.

27 Fox) transcription factors play key roles in immunoregulation.

28 gammadelta T cells play an important role in immunoregulation.

29 luated whether SPr expression was subject to immunoregulation.

30 critical elements in cytokine signaling and immunoregulation.

31 icated in cell adhesion, cell signaling, and immunoregulation.

32 nd identified pathways of intestine-specific immunoregulation.

33 ses the role and importance of PPAR gamma in immunoregulation.

34 that control cytokine production can affect immunoregulation.

35 NF-alpha, and could be important for mucosal immunoregulation.

36 eproduction, lactogenesis, tumorigenesis and immunoregulation.

37 GH has been shown to influence immunoregulation.

38 , especially myonuclei, suggesting disturbed immunoregulation.

39 y in view of its recently described roles in immunoregulation.

40 ce of lung lymphocyte apoptosis in pulmonary immunoregulation.

41 unleashed in the context of local defects in immunoregulation.

42 genes related to antimicrobial response and immunoregulation.

43 OE) has multiple functions in metabolism and immunoregulation.

44 host immunity and chronic parasitism due to immunoregulation.

45 ions in pathogen protection, vaccination and immunoregulation.

46 involved in myogenesis, cell migration, and immunoregulation.

47 y including the induction of ketogenesis and immunoregulation.

48 iated with malignancy, lipid metabolism, and immunoregulation.

49 their ability to facilitate angiogenesis and immunoregulation.

50 -1 in the trained group, indicating stronger immunoregulation.

51 owever, shared among them is a disruption of immunoregulation.

52 X2) plays a key role in pathogen killing and immunoregulation.

53 iled novel mechanisms underlying ES-mediated immunoregulation.

54 ite of MIF-2 and its allosteric coupling for immunoregulation.

55 ned to couple direct antiviral activity with immunoregulation.

56 e spleen after infection, which is vital for immunoregulation.

57 lar genetic mechanisms of vitamin D-mediated immunoregulation.

58 that bind human STING, a protein involved in immunoregulation.

59 n the fields of stem cells, biomaterials and immunoregulation.

60 rventions that target viral infection and/or immunoregulation.

61 s important for both protective immunity and immunoregulation.

62 is DC subset may play a role in farm-related immunoregulation.

63 us functionality of MSCs in inflammation and immunoregulation.

64 nceptualizing mechanisms of host defense and immunoregulation.

65 a framework for appreciating microbe-induced immunoregulation.

66 innate immune cell-mediated host defense and immunoregulation.

67 in promoting some aspects of MSC-associated immunoregulation.

68 eration of T cells and provides insight into immunoregulation.

69 testinal microbiota and promotion of mucosal immunoregulation.

70 ular interactions, which result in divergent immunoregulation.

71 veral pathways involved in cell division and immunoregulation.

72 ntibodies and mucosal immunity as well as to immunoregulation.

73 ll subsets are critical for host defense and immunoregulation.

74 gamma receptors (FcgammaR) provide important immunoregulation.

75 eal a close link between protein folding and immunoregulation.

76 hanism is unknown but is believed to involve immunoregulation.

77 t recipients to test for enhanced markers of immunoregulation: (1) flow-cytometry immunophenotyping o

78 cent discoveries in both host protection and immunoregulation against gastrointestinal nematodes, pla

79 Immune suppression is a crucial component of immunoregulation and a subgroup of nucleotide-binding do

80 by which thymoglobulin may generate durable immunoregulation and allograft survival.

81 due to H. pylori is associated with loss of immunoregulation and alteration of several cytokines and

82 n to have various other functions, including immunoregulation and antiviral activity.

83 n leukocyte antigen (HLA) genes, critical in immunoregulation and associated with susceptibility to n

84 t may have important implications for T cell immunoregulation and autoimmunity.

85 NKL is involved in multifaceted processes of immunoregulation and bone resorption such as they occur

86 cells would have important implications for immunoregulation and cellular therapy.

87 HD1 mutation indicate its important roles in immunoregulation and cerebral vascular hemeostasis.

88 g data demonstrated genes in our clusters of immunoregulation and complement activation were highly e

89 ing evidence suggests that a balance between immunoregulation and deletion of donor alloantigen react

90 s of IL-11 are achieved via a combination of immunoregulation and direct neuroprotection.

91 ion to address their actual contributions to immunoregulation and disease.

92 gene is important for T lymphocyte-mediated immunoregulation and has been associated with several au

93 sight into the mechanisms behind ECP-induced immunoregulation and holds significant promise in the pr

94 inct T-helper subsets is critical for normal immunoregulation and host defense.

95 topes may contribute to the understanding of immunoregulation and immunodiagnosis.

96 ls in the gastrointestinal mucosa to support immunoregulation and immunological tolerance in IBD.

97 s are likely to play broad-spectrum roles in immunoregulation and immunopathology by influencing MIF

98 ges were associated with early modulation of immunoregulation and immunoresponse pathways that may co

99 des proteins which play an important role in immunoregulation and in disease susceptibility.

100 shown to be an active participant in mucosal immunoregulation and inflammation.

101 ish a mechanistic link between PGI2-mediated immunoregulation and metabolic reprogramming, reinforcin

102 sent a molecule of significant importance in immunoregulation and might be a therapeutic target in pa

103 ry demyelination via a unique combination of immunoregulation and neuroprotection.

104 est that progesterone signaling is vital for immunoregulation and normal preimplantation development,

105 ing a paradigm shift in our understanding of immunoregulation and organismal physiology.

106 as also provided the basis for defining host immunoregulation and parasite-evasion strategies, helpin

107 income countries are associated with failing immunoregulation and poorly regulated inflammatory respo

108 ults suggest a novel aspect of CD24-mediated immunoregulation and represent, to our knowledge, the fi

109 A link between immunoregulation and self-nonself discrimination has eme

110 lated strain M. vaccae ATCC 15483(T) promote immunoregulation and stress protection.

111 trate a novel pathway for IFN-gamma-mediated immunoregulation and suggest that IFN-gamma-dependent su

112 likely to perform distinct functions in both immunoregulation and the recognition and removal of ACs.

113 riate animal model is required to understand immunoregulation and to address the role of immunogeneti

114 memory T cells, may condition the imbalanced immunoregulation and tolerance in NOD T cells.

115 The thymus medulla is a key site for immunoregulation and tolerance, and its functional speci

116 d, and we identified three major networks of immunoregulation and tolerance.

117 nd produce IL-4 and IFN-gamma play a role in immunoregulation and tumor rejection.

118 fferentially expressed genes associated with immunoregulation and were the major cellular source of I

119 ctive intestinal peptide (VIP) has a role in immunoregulation, and has been identified as a molecule

120 important role in the normal morphogenesis, immunoregulation, and homeostatic mechanisms in both nor

121 interactions, IgG receptor-triggered events, immunoregulation, and IL-10 signaling.

122 s both required for lymphocyte selection and immunoregulation, and is a prominent outcome of immune a

123 host defense, tissue maintenance/remodeling, immunoregulation, and many other biologic responses.

124 which participates in cholesterol transport, immunoregulation, and modulation of cell growth and diff

125 roles of apoE in atherosclerosis regression, immunoregulation, and neurodegeneration.

126 ociated with JAK/STAT signaling, chemotaxis, immunoregulation, and NLRP3 inflammasome activation in L

127 nce that these sensory neurons contribute to immunoregulation, and we hypothesized that IL-10 signali

128 revealed when endogenous mechanisms of DPP4 immunoregulation are inhibited.

129 blood, marrow, and allograft) signatures of immunoregulation are promoted by conversion from tacroli

130 alysis of other NK-cell functions, including immunoregulation, are non-proliferative and require an i

131 tion in depression and anxiety, highlighting immunoregulation as an important mechanism whereby dysfu

132 f Crete became host to lively discussions on immunoregulation as experts from around the world gather

133 ine model may be useful for studying mucosal immunoregulation as it relates to the pathogenesis and t

134 of great interest for their potential use in immunoregulation, as well as for other biological proper

135 s across cancer types reveals that the tumor immunoregulation associated with response to anti-PD1 wo

136 h node DC subsets revealed a predominance of immunoregulation-associated CD11c+ B220+ plasmacytoid DC

137 ld appear to have important implications for immunoregulation at homeostasis and in immune-mediated d

138 genetically susceptible hosts with defective immunoregulation, bacterial clearance, or mucosal barrie

139 ly regulated genes enriched in inflammation, immunoregulation, bacterial sensing, angiogenesis, migra

140 e a framework for developing microbiome- and immunoregulation-based strategies for prevention of stre

141 in the expression of markers associated with immunoregulation between CD11b(+)Gr-1(+) cells of both t

142 ines are critical for normal cell growth and immunoregulation but also contribute to growth of malign

143 ular ion fluxes emerge as critical actors of immunoregulation but still remain poorly explored.

144 nd its synthetic compound AM80 play roles in immunoregulation but their effect on mucosal autoimmunit

145 Tris DBA improved ASLN in mice through immunoregulation by blunting the MAPK (ERK, JNK)-mediate

146 Loss of immunoregulation by CD1d-restricted NKT cells could expl

147 IL-12 family perform essential functions in immunoregulation by connecting innate and adaptive immun

148 We propose widening the view on immunoregulation by considering the participation of CD8

149 tors, we examined how apoptotic cells induce immunoregulation by dendritic cells (DC).

150 Immunoregulation by engineering localized skin neuroimmu

151 cell differentiation and novel mechanisms of immunoregulation by IL-18 and PGE2.

152 istic insights into HDAC inhibition-mediated immunoregulation by induction of IDO.

153 al a novel function of adhesion molecules in immunoregulation by MSCs and provide new insights for th

154 urons to downregulate CCL2 and contribute to immunoregulation by reducing the attraction of immune ce

155 Significance of IL-10 in host immunoregulation by skin stage schistosomula of S. manso

156 It also modulates immunoregulation, cell growth and differentiation and th

157 ing Alzheimer's disease, cognitive function, immunoregulation, cell signaling, and infectious disease

158 ortant role for LFA-1/ICAM-1 interactions in immunoregulation concurrent with lymphocyte migration th

159 Compromised immunoregulation contributes to obesity and complication

160 This form of immunoregulation could explain the "exhaustion" of T cel

161 ion of mucosal barrier function, or altering immunoregulation (decreasing proinflammatory and promoti

162 factors, mucosal permeability and defective immunoregulation drive overactive immunity to a subset o

163 of chronic IFN-I signaling and mechanism of immunoregulation during an established persistent virus

164 ve profound effects on the microbiota and on immunoregulation during early life that persist into adu

165 hat GDF-15 is not essential for survival and immunoregulation during T. gondii infection.

166 ctional link between beneficial microbes and immunoregulation during the first months of life.

167 es involved in trafficking (e.g., CXCR4) and immunoregulation (e.g., programmed death ligand 1).

168 nce of immune deviation or other evidence of immunoregulation, elicited by endogenous Escherichia col

169 In this study we demonstrate a new form of immunoregulation: engagement on CD4(+) T cells of the co

170 drive Th1 differentiation and interfere with immunoregulation established by alloreactive natural CD4

171 onsistent with the hypothesis that increased immunoregulation following immunization with M. vaccae N

172 activation responses, and the development of immunoregulation following solid organ transplantation.

173 findings demonstrate that perforin-mediated immunoregulation functions in trans and are consistent w

174 al systems under stress and neuroplasticity, immunoregulation, gut microbiome composition, and integr

175 crosstalk and the mechanism underlying this immunoregulation has been poorly understood.

176 A role for gammadelta T cells in immunoregulation has been shown in a number of studies,

177 mucosal homeostasis; however, their role in immunoregulation has been unknown.

178 This immunoregulation has potential importance for the treatm

179 Conditions consistent with tolerance or immunoregulation have been observed in experimental Cand

180 nal, mechanistic data for dysregulated TIM-3 immunoregulation in a human autoimmune disease and sugge

181 y to Mycobacterium leprae and is a model for immunoregulation in a human disease.

182 and of Gal9 in T-regs contribute to impaired immunoregulation in AIH by rendering effector cells less

183 mmatory challenge, suggesting that defective immunoregulation in AIH might result not only from reduc

184 We investigated whether impaired immunoregulation in AIH results from reduced expression

185 vations provide new mechanistic insight into immunoregulation in allograft recipients relative to obe

186 the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages and inna

187 ore, we suggest that loss of miR-29-mediated immunoregulation in CD DCs might contribute to elevated

188 into the characterization of B cell-mediated immunoregulation in clinical tolerance and show a potent

189 esponse in leprosy has provided insight into immunoregulation in human infectious disease.

190 d reflected amnion is a unique mechanism for immunoregulation in human pregnancy akin to that establi

191 L-23 or gut inflammation and correlated with immunoregulation in inflammatory bowel disease.

192 e results suggest an intrinsic alteration in immunoregulation in RA and have implications for potenti

193 s a critical gap in our understanding of the immunoregulation in response to repeated exposure to A.

194 eting PERK may provide a means for selective immunoregulation in the context of ER stress without dis

195 is able to exploit an endogenous pathway of immunoregulation in the host.

196 definitive evidence for a basic mechanism of immunoregulation in the oral mucosa.

197 that functions in CD4(+) T cells to augment immunoregulation in vitro and in vivo.

198 atric disorders have been found to have poor immunoregulation, increased proinflammatory markers, and

199 is increasingly being appreciated to affect immunoregulation, inflammation and pathology.

200 echanistically was characterized by enhanced immunoregulation involving alterations in CD4+ T cells,

201 t LLR patients have important alterations in immunoregulation involving CD4(+)CD25(hi)FoxP3(+) Tregs.

202 Negative immunoregulation is a major barrier to successful cancer

203 icrobial input from the environment to drive immunoregulation is a major component of the beneficial

204 These results suggest dysregulated immunoregulation is associated with poor prognosis, wher

205 It is likely that this selective immunoregulation is dependent on the nature of the APC a

206 A fundamental problem in immunoregulation is how CD4(+) T cells react to immunoge

207 We revealed that in mMSCs IFN-gamma-induced immunoregulation is mediated by early phosphorylation of

208 This failure of immunoregulation is partly attributable to a lack of exp

209 t the relationship of their action to T cell immunoregulation is unknown.

210 role in the cytokine network responsible for immunoregulation, is also known to contribute to endothe

211 f antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes

212 Thus, the net effect of immunoregulation may be either neuroprotective or neurod

213 Immunoregulation may provide more insight into this phen

214 ng that transplantation tolerance and normal immunoregulation may represent a unique form of Th2-like

215 oire and the mechanisms of antibody-mediated immunoregulation observed in allergy models will lead to

216 rting evidence for NK cell-mediated negative immunoregulation of activated T cells during daclizumab

217 portant physiological role that GrK plays in immunoregulation of adaptive immunity in humans and indi

218 otes both the generation of autoimmunity and immunoregulation of adaptive immunity.

219 de the appropriate conditions to enhance the immunoregulation of alloimmune responses in clinical tra

220 LC2s, have improved our understanding of the immunoregulation of asthma and opened new avenues for dr

221 environmental changes and participate in the immunoregulation of autoimmune, neurologic, cardiovascul

222 )CD25(+) T reg) cells play a key role in the immunoregulation of autoimmunity.

223 f these src-family kinases in FCRL4-mediated immunoregulation of B cells in the context of previously

224 prominent cytoskeletal protein, LEK1, in the immunoregulation of DC functions; specifically cytokine

225 e for novel roles for c-Src and STAT3 in the immunoregulation of DCs.

226 abetes of NOD mice, insulin-based preventive immunoregulation of diabetes in man is not yet possible.

227 acious immune response and the potential for immunoregulation of effector cells at the local site of

228 Both the loss of immunoregulation of Epstein-Barr virus (EBV) infected ce

229 e to lymphomagenesis by inducing (1) loss of immunoregulation of Epstein-Barr virus-infected B cells

230 nable neuroprotective strategy is to harness immunoregulation of glial and retinal ganglion cell fate

231 stic and prognostic data regarding effective immunoregulation of HIV-1.

232 Immunoregulation of lymphocytes and macrophages in the p

233 e detrimental effects of hyperinsulinemia on immunoregulation of metabolic syndrome.

234 cells appear to play a critical role in the immunoregulation of stress states, renal cell therapy du

235 f MS may function in part by restoring TIM-3 immunoregulation of T cell function.

236 on by human T cells might play a role in the immunoregulation of T cell responses.

237 selected individuals likely involves failed immunoregulation of the T-cell-RGC axis and is thus a di

238 are not associated with antagonistic type 2 immunoregulation of type 1 responses in liver.

239 owever, it remains unknown whether MSCs have immunoregulation on Tfh cells.

240 bility alleles at loci expected to influence immunoregulation (PTPN22, CTLA4, and IL2RA) did not diff

241 These findings indicate that an induction of immunoregulation, rather than simple lymphocyte depletio

242 ivotal processes, such as liver development, immunoregulation, regeneration, and also fibrogenesis.

243 Additionally, immunoregulation-related markers were differentially exp

244 are beginning to be appreciated as agents of immunoregulation that can modulate antigen presentation,

245 that potentially contribute to the impaired immunoregulation that is characteristic of AIH.

246 This is postulated to be due to immunoregulation that prohibits a more profound Candida-

247 autoimmunity rather than the risk of failed immunoregulation that results in islet destruction.

248 understand the mechanism of this failure of immunoregulation, these results suggest that similar pro

249 offer new insights about mucosal-derived DC immunoregulation through SIgA opening new therapeutic ap

250 nations acting at multiple sites of aberrant immunoregulation to achieve disease quiescence and immun

251 This form of immunoregulation was absent after sensitization of Fas l

252 Ameliorating autoimmunity through immunoregulation was assessed by adoptive transfer.

253 Immunoregulation was associated with localization of B c

254 Mechanistically, DPSC-induced immunoregulation was associated with the expression of F

255 in vitro, and omega-6 PUFAs conferred potent immunoregulation when bound to tumor-derived AFP.

256 findings establish a new paradigm for innate immunoregulation, whereby magnesium plays a critical reg

257 llular allograft acceptance show evidence of immunoregulation which is not due to immune deletion or

258 sms, including clonal depletion, anergy, and immunoregulation, which act in a synergistic fashion to

259 tinal mucosa represents a novel mechanism of immunoregulation, which contributes to the generation of

260 ancer-related biological pathways, including immunoregulation, which may influence susceptibility to

261 UF1-induced immunoregulation, which safeguard against proinflammator

262 iology, such as stem cell niche, homing, and immunoregulation, will also be discussed.

263 es in pathways involved in proliferation and immunoregulation, with an overall pattern that bears hal

264 adelta T cell-dependent cardiac inflammatory immunoregulation, with increased numbers of CD3(+)CD4(+)

265 a critical role in tumor surveillance and in immunoregulation within the tumor microenvironment.

266 ated by low doses of IL-2 (ld-IL-2) inducing immunoregulation without immunosuppression and establish