ライフサイエンスコーパス: immunoregulatory

1 Cytokines exert a vast array of immunoregulatory actions critical to human biology and d

2 These results indicated the immunoregulatory activities of licorice.

3 ore, our uveitis data suggest that intrinsic immunoregulatory activities of other single chain IL-12

4 investigates the mechanism(s) underlying the immunoregulatory activities of placenta-derived human am

5 ted protein kinase alpha (AMPKalpha) and the immunoregulatory activity of MDSC in tumors.

6 Despite considerable progress regarding the immunoregulatory activity of this lectin, the role of en

7 atory T and Breg cells orchestrate a general immunoregulatory activity, which can be summarized as su

8 C in the injured spinal cord and explain its immunoregulatory activity.

9 Kalpha signaling intrinsically promoted MDSC immunoregulatory activity.

10 Dendritic cells (DCs), the essential immunoregulatory and APCs, are major producers of the ce

11 with tumourigenesis, we found enrichment of immunoregulatory and cytoskeletal remodelling pathways,

12 LNs following oxidative stress, exhibits an immunoregulatory and hypostimulatory phenotype that is m

13 studies have shown that these compounds are immunoregulatory and immunosuppressive and thus may incr

14 nchymal stem cells (AMCs) demonstrate unique immunoregulatory and precardiac properties.

15 rth and involves epigenetic modifications in immunoregulatory and proinflammatory pathways.

16 ature associated with HCC that includes both immunoregulatory and proliferative genes and that can al

17 IM-4hiCD169+ tissue-resident macrophages are immunoregulatory and promote engraftment of cardiac allo

18 tive products, interesting cardioprotective, immunoregulatory, and cardioregenerative properties have

19 Mesenchymal stem cells (MSCs) possess immunoregulatory, anti-inflammatory, and proangiogenic p

20 Targeted interventions of this immunoregulatory axis may ameliorate tissue pathology in

21 of IL-10 overexpression on the phenotype and immunoregulatory capacity of B cells.

22 miR-125a stabilizes both the commitment and immunoregulatory capacity of Treg cells.

23 t here that CNIs compromise the overall Treg immunoregulatory capacity to a greater extent than would

24 a serovar Typhimurium through liver-resident immunoregulatory CD4(+) helper T cells, alternatively ac

25 can protect against autoimmunity, including immunoregulatory CD4(-)CD8(-) double-negative (DN) T cel

26 Surprisingly, LRBA limits immunoregulatory cell numbers in tissues where GvHD is p

27 be more resistant to suppression mediated by immunoregulatory cell subsets, making them attractive fo

28 adipose tissue (VAT)-localized reduction in immunoregulatory cells and increase in proinflammatory i

29 Administering immunoregulatory cells to patients as medicinal agents i

30 our results demonstrate that recruitment of immunoregulatory cells to the diseased spinal cord in AL

31 ion, and was followed by the accumulation of immunoregulatory cells, including IL-10-producing monocy

32 Foxp3+ regulatory T cells (Tregs) are potent immunoregulatory cells, prompting strong interests in ma

33 -derived suppressor cells (MDSCs) are potent immunoregulatory cells, we tested whether donor-derived

34 ide insight into the design principles of an immunoregulatory checkpoint controlling nutrient absorpt

35 duction of PD-L1, IDO1, CEACAM1, and further immunoregulatory checkpoints in breast cancer cells.

36 h by limited costimulation and triggering of immunoregulatory checkpoints that attenuate T-cell respo

37 nstruct the generation of a highly effective immunoregulatory circuit encompassing tolerogenic DCs an

38 Adaptive immunoregulatory circuits and dynamic homeostasis are at

39 Here, we highlight immunoregulatory circuits engaging epithelial and mesenc

40 These data identify critical immunoregulatory circuits in B cells that may be targete

41 mmunity, whereas stimulation of Gal-1-driven immunoregulatory circuits will help to mitigate exuberan

42 eal cavity microenvironment is skewed toward immunoregulatory conditions promoted by macrophage popul

43 ugh Toll-like receptor 2 (TLR2) binding, the immunoregulatory consequences of VCAN proteolysis remain

44 ted anal cancer risk, largely due to loss of immunoregulatory control of oncogenic human papillomavir

45 n inhibitory factor (MIF), a proinflammatory immunoregulatory cytokine expressed constitutively, were

46 In the present study, we tested whether immunoregulatory cytokine fusion proteins of IL-10/Fc, T

47 alterations that reduce the function of the immunoregulatory cytokine IL-10 contribute to colitis in

48 The immunoregulatory cytokine IL-10 suppresses T-cell immuni

49 nd antimicrobial functions, to producing the immunoregulatory cytokine IL-10 was defined during exten

50 ubsets were also found to be a source of the immunoregulatory cytokine IL-10, raising the potential f

51 ect cell-cell contact and is mediated by the immunoregulatory cytokine IL-10.

52 ile limiting CD4(+) T-cell production of the immunoregulatory cytokine IL-10.

53 S was found to be partially dependent on the immunoregulatory cytokine IL-10.

54 ion and whose expression correlates with the immunoregulatory cytokine IL-10.

55 A novel role for the macrophage-derived immunoregulatory cytokine IL-27 was identified in modula

56 Here, we show that the immunoregulatory cytokine interleukin-27 is upregulated

57 The immunoregulatory cytokine macrophage migration inhibitor

58 um of pregnant women are associated with the immunoregulatory cytokine TGF-beta1 and activated latent

59 Interleukin-10 (IL-10) is a key immunoregulatory cytokine that functions to prevent infl

60 IL-10 is an immunoregulatory cytokine that has broad effects across

61 ur findings present the first evidence of an immunoregulatory cytokine, IL233, which could be a poten

62 IL-10 is an immunoregulatory cytokine, which in other infections can

63 ings demonstrate the differential effects of immunoregulatory cytokines IL-10 and TGF-beta on activat

64 activated in the presence or absence of the immunoregulatory cytokines IL-10 and TGF-beta.

65 asis of immune system, which is regulated by immunoregulatory cytokines such as TGFbeta.

66 inate target cells but they can also produce immunoregulatory cytokines to alert the immune system.

67 daptive response by their ability to produce immunoregulatory cytokines.

68 sformed cells and are important producers of immunoregulatory cytokines.

69 oxp3 expression and subsequent production of immunoregulatory cytokines.

70 le gene variants, environmental factors, and immunoregulatory dysfunction.

71 opulation while also being able to impart an immunoregulatory effect when cultured in tandem with an

72 The exact role of IL-10 with its multiple immunoregulatory effects during CMV infection is not cle

73 defense by desensitizing macrophages to the immunoregulatory effects of adenosine.

74 Here, we discuss the tumorigenic and immunoregulatory effects of ER stress in cancer, and we

75 prisingly, few studies have investigated the immunoregulatory effects of exposure to EE, especially i

76 We suggest that these immunoregulatory effects of PAD inhibition in CIA are co

77 In this study, we investigated immunoregulatory effects of the antimicrobial peptide RN

78 used to delineate the commensal microbiota's immunoregulatory effects on osteoblastogenesis, osteocla

79 We found that solTNF-alpha mediates these immunoregulatory effects primarily through TNFR1, becaus

80 unotherapy, but tools to broadly limit their immunoregulatory effects remain lacking.

81 In conclusion, hAEC exert different in vitro immunoregulatory effects, per se, as a result of interac

82 ptor and, consequently, antiinflammatory and immunoregulatory effects.

83 into ornithine and urea, exerts pleiotropic immunoregulatory effects.

84 nutritive value, fatty acids have important immunoregulatory effects.

85 hanistic framework for how PSGs modulate the immunoregulatory environment at the maternal-fetal inter

86 l responsiveness through the promotion of an immunoregulatory environment.

87 lled preparation of Mycobacterium vaccae, an immunoregulatory environmental microorganism, reduced su

88 ounds identified one potential target as the immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO

89 Indoleamine 2, 3-dioxygenase (IDO) is an immunoregulatory enzyme that breaks down tryptophan (Trp

90 Synthetic peptide immunoregulatory epitopes are a new class of immunothera

91 omical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the

92 eurons that likely contribute to assembly of immunoregulatory factors prior to infection, a more rapi

93 m1(+) effector regulatory T cells expressing immunoregulatory factors, such as Il10, Areg, Fgl2, and

94 Although immunoregulatory factors, such as Prostaglandin E2 (PGE2

95 on mTOR blockade, hMSCs also enhanced their immunoregulatory features.

96 ve can originate from an unanticipated RANKL immunoregulatory feedback, involving the induction of Tr

97 This NK's immunoregulatory function depends on the production of i

98 Thus, these findings suggest an immunoregulatory function for intrinsic HB-EGF expressed

99 geneic mesenchymal stem cells (MSCs) exhibit immunoregulatory function in human autoimmune diseases s

100 This previously unrecognized immunoregulatory function of D-mannose may have clinical

101 However, the immunoregulatory function of ILC2s in the inflamed liver

102 Furthermore, given the immunoregulatory function of viral IL-10, targeting this

103 ure, surface markers, IL-5 independence, and immunoregulatory function that is capable of polarizing

104 hat CB contains an abundance of B cells with immunoregulatory function.

105 demonstrate diminished Foxp3 expression and immunoregulatory function.

106 lls, a group of innate T cells with critical immunoregulatory function.

107 hesized by mononuclear phagocytes and exerts immunoregulatory functional activities on lymphocytic an

108 superfamily (TNFRSF) members have important immunoregulatory functions and are of clear interest for

109 echanisms by which TFR cells exert their key immunoregulatory functions are largely unknown.

110 lergens and autoantigens, and exert critical immunoregulatory functions before GC formation.

111 highly expressed in the lung where it exerts immunoregulatory functions dependent on being loaded wit

112 ains have revealed an expanded repertoire of immunoregulatory functions for this cell.

113 we review the most important features of the immunoregulatory functions for this enzyme.

114 In addition to their antimicrobial activity, immunoregulatory functions have been published for sever

115 Here we show that the IL-12p35 subunit has immunoregulatory functions hitherto attributed to IL-35.

116 gammadelta T cells have been shown to have immunoregulatory functions in several experimental autoi

117 he main target cells of IL-27, mediating its immunoregulatory functions in vivo.

118 and in vitro, suggesting that IDO may induce immunoregulatory functions of B cells in atherosclerosis

119 In this review we discuss the immunoregulatory functions of coinhibitory pathways and

120 The immunoregulatory functions of lncRNAs have been revealed

121 The immunoregulatory functions of vitamin D have been well d

122 us system (CNS), which lies beyond its known immunoregulatory functions on microglia/macrophages or p

123 2RA) and new candidate loci with established immunoregulatory functions such as ADGRL2, TENM3, ANKRD3

124 lammation and cancer, associated with innate immunoregulatory functions that critically depend on lig

125 is important in delivering antimicrobial and immunoregulatory functions, and granzyme B, a critical c

126 ed a distinct population of macrophages with immunoregulatory functions, collectively termed regulato

127 ownstream of multiple receptor families with immunoregulatory functions, including members of the TNF

128 including antiviral, antiproliferative, and immunoregulatory functions.

129 ting evidence that the microbiome has potent immunoregulatory functions.

130 eases is closely related to inflammatory and immunoregulatory functions.

131 sized that B cells have antibody-independent immunoregulatory functions.

132 Few studies implicate immunoregulatory gene expression in tumor cells in arbit

133 eration generally associated positively, and immunoregulatory gene sets negatively, with variant burd

134 s' (mregDCs), owing to their coexpression of immunoregulatory genes (Cd274, Pdcd1lg2 and Cd200) and m

135 ed that Hh signaling increased expression of immunoregulatory genes and reduced expression of inflamm

136 revealed several rare, damaging variants in immunoregulatory genes as novel candidate mutations.

137 m genomic changes, gene networks, and master immunoregulatory genes, and this development can lead to

138 cyte injury/morphology and downregulation of immunoregulatory genes.

139 on platform has enabled the discovery of new immunoregulatory genes.

140 ent significant changes in the expression of immunoregulatory genes.

141 ough altering immune responses by binding to immunoregulatory glycan-binding receptors on immune cell

142 The immunoregulatory human leukocyte antigen (HLA) complex h

143 LR4 signaling was required for production of immunoregulatory IL-10 associated with prolonged allogra

144 ss chemokines that recruit a combined type 2/immunoregulatory immune response, which produces these e

145 Mitochondrial target shifting may have immunoregulatory implications.

146 In this review, we discuss the immunoregulatory influence of histamine on a number of g

147 ustrates how genomics yields new fundamental immunoregulatory insights as well as how research genomi

148 PDCs can thus orchestrate the beneficial immunoregulatory interaction of commensal microbial mole

149 nal data correlated N-acetylneuraminate with immunoregulatory interactions between lymphoid and non-l

150 Immunoregulatory interventions that act prophylactically

151 ate (immunostimulatory, IS-SNA) or regulate (immunoregulatory, IR-SNA) immunity by engaging TLRs have

152 togenic Prevotellaceae strains and decreased immunoregulatory Lachnospiraceae strains.

153 article, we show that galectin-1 (Gal-1), an immunoregulatory lectin widely expressed in mucosal tiss

154 regulated MZB cell surface expression of the immunoregulatory ligand PDL1 in an ATF3-dependent manner

155 linc1992 THRIL (TNFalpha and hnRNPL related immunoregulatory LincRNA).

156 Here, we identify an immunoregulatory lincRNA, lincRNA-EPS, that is precisely

157 Macrophages can be converted in vitro into immunoregulatory M2b macrophages in the presence of immu

158 by means of PLD-MNA preferentially attracted immunoregulatory macrophages and stimulated the cells to

159 ino acids such as arginine and tryptophan by immunoregulatory macrophages is one pathway that suppres

160 amma effects and promotes the development of immunoregulatory macrophages.

161 ses B. cinerea-induced activation of the key immunoregulatory MAPKs MPK3/MPK6 and reduces MPK3 protei

162 n, as shown by upregulated expression of the immunoregulatory markers IL-10, forkhead box P3, and cyt

163 icroscopic parasitemia and expression of the immunoregulatory markers Tim-3 and CD57 were associated

164 aining lymph nodes and bearing migratory and immunoregulatory markers, including increased CCR7 and b

165 Collectively, our study unravels a novel immunoregulatory mechanism of NAD(+) that regulates Treg

166 te B-cell help and are involved in an innate immunoregulatory mechanism through induction of itBreg c

167 unctions, increasingly provides insight into immunoregulatory mechanisms and thereby provides opportu

168 Cancer cells have evolved to evade these immunoregulatory mechanisms by upregulating PD-1 ligands

169 We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically pe

170 Amino acid catabolism has been implicated in immunoregulatory mechanisms present in several diseases,

171 olerogenic responses via STING by activating immunoregulatory mechanisms such as indoleamine 2,3 diox

172 the need for novel approaches to circumvent immunoregulatory mechanisms that limit the induction of

173 Remarkably, although immunoregulatory mechanisms were activated, they only pa

174 are robust new players involved in human MSC immunoregulatory mechanisms, and the higher suppressive

175 cacy is often inhibited through a variety of immunoregulatory mechanisms, including the PD1/PDL1 T-ce

176 Finally, we review immunoregulatory mechanisms, such as inhibitory receptor

177 tiple specific molecules, mobilizing various immunoregulatory mechanisms.

178 ase severity may be the outcome of lapses in immunoregulatory mechanisms; because as much, if not mor

179 Histamine is a key immunoregulatory mediator and can dampen proinflammatory

180 IL-17, but decreased the levels of systemic immunoregulatory mediators TGF-beta, myeloid-derived sup

181 ine pathway is a paramount source of several immunoregulatory metabolites, including l-kynurenine (Ky

182 ding viral re-engineering, modulation of the immunoregulatory microenvironment and combinatorial ther

183 Further research on distorted immunoregulatory molecules expression in BM-MSCs could p

184 nly act as pro-inflammatory mediators but as immunoregulatory molecules that control the activation s

185 s (DCs) that we name 'mature DCs enriched in immunoregulatory molecules' (mregDCs), owing to their co

186 in C57BL/6 and BALB/c mice abundant negative immunoregulatory molecules, associated with T-cell exhau

187 regates in the peritoneum where they produce immunoregulatory molecules, including TSG6, that reduce

188 immune crosstalk acts via a diverse array of immunoregulatory molecules.

189 he immune response through the production of immunoregulatory molecules.

190 Patients with ACLF have increased numbers of immunoregulatory monocytes and macrophages that express

191 tion of T cell proliferation and function by immunoregulatory myeloid cells are an essential means of

192 central role for IFN-Is in orchestrating an immunoregulatory network leading to the dampening of pro

193 The complex immunoregulatory network of the epithelial barrier surve

194 entified IFN-lambda regulation of a DC IL-10 immunoregulatory network.

195 populations and, in particular, the role of immunoregulatory networks in influencing antimalarial im

196 ns, but also highlight the broader impact of immunoregulatory networks on vaccine efficacy.

197 Induction of immunoregulatory networks requires prolonged desensitiza

198 emergence, establishment, and maintenance of immunoregulatory networks that shape the immune response

199 NK cells are more long-lived than canonical, immunoregulatory NK cells.

200 the long-sought foreign ligand for this key immunoregulatory NKR family and reveal how it controls t

201 Adenosine is a potent immunoregulatory nucleoside produced during inflammatory

202 k of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may prot

203 The liver is an immunoregulatory organ in which a tolerogenic microenvir

204 estern environment deprive the infant of the immunoregulatory organisms with which humans co-evolved,

205 o-evolved, while encouraging exposure to non-immunoregulatory organisms, associated with more recentl

206 nitor lung inflammation through targeting of immunoregulatory pathways contributing to ALI pathogenes

207 e whereby both amino acid auxotrophy and the immunoregulatory pathways controlled by amino acids can

208 rders, due to their unique ability to induce immunoregulatory pathways in their hosts.

209 adult brain, differences in bioenergetic and immunoregulatory pathways were the major sources of hete

210 x stress response, metabolism, inflammation, immunoregulatory pathways, and tissue repair, providing

211 ocytes and tumor samples identified critical immunoregulatory pathways, including CTLA-4 and PD-1.

212 r suppressive function, p53 controls several immunoregulatory pathways.

213 arkers, and strategies to bolster endogenous immunoregulatory pathways.

214 verlapping and unique functions of these key immunoregulatory pathways.

215 ulates inflammation by enzymatic cleavage of immunoregulatory peptides and through its soluble form (

216 eads to the induction of macrophages with an immunoregulatory phenotype and the downregulation of inf

217 e an essential role for IL-10 in inducing an immunoregulatory phenotype in B cells that exerts substa

218 Indeed, this treatment induced an immunoregulatory phenotype in Th17 cells, which was mark

219 gamma(low), interleukin-4(high) and FoxP3(+) immunoregulatory phenotype.

220 ons, respectively, represent the extremes of immunoregulatory plasticity in the macrophage population

221 Here we review the current findings on the immunoregulatory plasticity of MSCs in disease pathogene

222 The primary mechanisms supporting immunoregulatory polarization of myeloid cells upon infi

223 cells have recently been characterized as an immunoregulatory population highly enriched in the colon

224 exposure resulted in decreased abundance of immunoregulatory populations (regulatory B cells, myeloi

225 Given the importance of DN T cells in immunoregulatory processes and their potential as target

226 tory state also was temporally supplanted by immunoregulatory processes, suggesting a mechanism under

227 -overexpressing B cells acquired a prominent immunoregulatory profile comprising upregulation of supp

228 nhibitor (mTOR-I), has been shown to enhance immunoregulatory profiles in liver transplant (LT) recip

229 nhibitor (mTOR-I), has been shown to enhance immunoregulatory profiles in liver transplant recipients

230 que splenic CD19(+) B cell with a functional immunoregulatory program is generated that promotes the

231 s function in T cells to coordinate distinct immunoregulatory programs within the lung that are permi

232 of tobacco alkaloids, compounds that possess immunoregulatory properties and have been linked to the

233 H2S antiviral and immunoregulatory properties could represent a novel trea

234 ent activation possesses proinflammatory and immunoregulatory properties critical for the development

235 ct human IL-10-producing B-cell subsets with immunoregulatory properties have been described.

236 enuate the effector potential while boosting immunoregulatory properties in Teff.

237 Serotonin is a bioactive factor with immunoregulatory properties naturally produced by the ca

238 Here, we will discuss non-classical immunoregulatory properties of C3 and C5 cleavage fragme

239 In an effort to highlight the varied immunoregulatory properties of fibroblastic reticular ce

240 upports cell priming as a way to enhance the immunoregulatory properties of IFP-MSC, which selectivel

241 The combined data provide evidence for immunoregulatory properties of this versatile DC populat

242 , we have shown that the cytokine IL-34, the immunoregulatory properties of which have not been previ

243 Helminths have strong immunoregulatory properties that may be exploited in tre

244 ed efficient cytokine producers endowed with immunoregulatory properties, but they can also become cy

245 ns, as well as the characterization of their immunoregulatory properties, is an emerging topic under

246 ithin ECM hydrogels did not impact upon SCAP immunoregulatory properties, with significant downregula

247 ary polyunsaturated fatty acids (PUFAs) have immunoregulatory properties.

248 differential CD10 expression, exert opposite immunoregulatory properties.

249 of cells prior to apoptosis abolishes their immunoregulatory properties.

250 r isolation, to better define their specific immunoregulatory properties.

251 (NKT) cells are innate-like lymphocytes with immunoregulatory properties.

252 he trafficking receptor CCR6 and have potent immunoregulatory properties.

253 tency III-transformed B cells exhibit strong immunoregulatory properties.

254 e actions of CMCs may be attributed to their immunoregulatory properties.

255 as defined a molecular pathway driven by the immunoregulatory protein coronin 1 that regulates the ph

256 as defined a molecular pathway driven by the immunoregulatory protein coronin 1 that regulates the ph

257 Human eosinophils contain stores of the immunoregulatory protein galectin-10.

258 Among the repertoire of immunoregulatory proteins encoded by myxoma virus, M013

259 Expression levels of 19 immunoregulatory proteins in MTEX, non-MTEX and HDs exos

260 Expression of certain immunoregulatory proteins is modulated by prosurvival tr

261 ical Hodgkin lymphoma (cHL) express multiple immunoregulatory proteins that shape the cHL microenviro

262 rotein, DNA, mucin content, sialic acid, and immunoregulatory proteins), as well as structural and tr

263 We investigated the contribution of the immunoregulatory receptor CD33 to a uniquely human postr

264 FCRL4 is an immunoregulatory receptor expressed by a subpopulation o

265 Fc receptor-like (FCRL) 4 is an immunoregulatory receptor expressed on a subpopulation o

266 ber of the human gastric microbiota, elicits immunoregulatory responses implicated in protective vers

267 r interplay controlling immunopathogenic and immunoregulatory responses is critical for understanding

268 ntly colonizes the human stomach by inducing immunoregulatory responses.

269 o generate adequate protective and balancing immunoregulatory responses.

270 osed beekeepers suggest a similar functional immunoregulatory role for B cells in allergen tolerance

271 APCs, has been detected in B cells, yet its immunoregulatory role has only been explored on T cells.

272 The immunoregulatory role of Lyst on TLR signaling pathways

273 39 expressed by Tregs may participate in the immunoregulatory role of Tregs.

274 ted antithrombotic activity, Efb can play an immunoregulatory role via inhibition of P-selectin-PSGL-

275 In addition to their immunoregulatory role, a growing body of evidence highli

276 To examine their immunoregulatory role, we profiled miRNA expression in t

277 Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan metabo

278 otent bioactivities, and they have important immunoregulatory roles in both health and disease.

279 e revealed that Mac-1 also plays significant immunoregulatory roles, and genetic variants in ITGAM, t

280 ells were originally named 'Treg' to reflect immunoregulatory roles, this also captures emerging, reg

281 ltures to assess their anti-inflammatory and immunoregulatory roles.

282 pool of MMs, including loss of bacterial and immunoregulatory sensors.

283 of apoptotic cells (ACs) is usually a potent immunoregulatory signal but can also promote inflammatio

284 ared with B6.Sle1b mice, indicating that Mer immunoregulatory signaling in APCs regulates B cell sele

285 IL-27R is an immunoregulatory signaling nod in autoimmune and infecti

286 es are exposed to metabolic, homeostatic and immunoregulatory signals of local or systemic origin tha

287 clearing apoptotic cells (ACs) and inducing immunoregulatory signals.

288 akes it an excellent model to identify novel immunoregulatory strategies that account for its niche a

289 viral perturbation, suggesting unrecognized immunoregulatory strategies.

290 ay represent a coinhibitory pathway for this immunoregulatory T cell population.

291 lls and an increase in CD4(+)CD25(+)Foxp3(+) immunoregulatory T cells (Treg) in the periphery.

292 renal disease and increased the frequency of immunoregulatory T cells (Tregs) compared with leptin-su

293 Invariant NKT cells (iNKT) are potent immunoregulatory T cells that recognize CD1d via a semi-

294 s, and drive development of Foxp3-expressing immunoregulatory T cells.

295 eprogram intraepithelial CD4(+) T cells into immunoregulatory T cells.

296 t natural killer T (iNKT) cells are a potent immunoregulatory T-cell subset in both humans and mice.

297 ning 2 (Plxdc2) was selected as the top lead immunoregulatory target.

298 al implications for designing more selective immunoregulatory therapies.

299 d how this knowledge could be used to direct immunoregulatory therapy with antigen-specific regulator

300 F4-expressing DCs is linked to a DC-specific immunoregulatory transcriptional program.