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1 y, pancreatitis, systemic steroids, or other immunosuppressants).
2 as an increase in the dose of steroid and/or immunosuppressant.
3 in (IL)-2 receptor antibody as a maintenance immunosuppressant.
4 -like antitumor agents; and a rapamycin-like immunosuppressant.
5 s of corticosteroids and maintenance with an immunosuppressant.
6 rapy only, consisting of corticosteroids and immunosuppressants.
7 oids, combined or not with other traditional immunosuppressants.
8 ally leading to resistance to CD28-targeting immunosuppressants.
9 izumab treatment, and with prior exposure to immunosuppressants.
10 nflammatory bowel disease (IBD) treated with immunosuppressants.
11 cific T cell levels might optimize dosing of immunosuppressants.
12 or-specific tolerance, minimizing the use of immunosuppressants.
13 of the patients received corticosteroids or immunosuppressants.
14 nse to conventional therapy with steroids or immunosuppressants.
15 plants from 1984 to 2008 treated with modern immunosuppressants.
16 rrent treatment with oral corticosteroids or immunosuppressants.
17 tivation and proliferation and are effective immunosuppressants.
18 y mice (Mus sp.) without the aid of powerful immunosuppressants.
19 aking into account the mechanistic impact of immunosuppressants.
20 s and related mTOR inhibitors are transplant immunosuppressants.
21 graft-versus-host disease (GvHD) or received immunosuppressants.
22 ds the therapeutic utility of these drugs as immunosuppressants.
23 itive patients who have not previously taken immunosuppressants.
24 trolling for important confounders including immunosuppressants.
25 roids and, for more severe disease, systemic immunosuppressants.
26 e 5-aminosalicylic acid drugs, steroids, and immunosuppressants.
27 recipients due to the use of lower doses of immunosuppressants.
28 13 on hemodynamic and fluid management, 7 on immunosuppressants, 12 on preconditioning, 34 on preserv
30 rganizing protein Drebrin as a target of the immunosuppressant 3,5-bistrifluoromethyl pyrazole, which
31 with HIV; 2) with renal failure or receiving immunosuppressants; 3) using drugs or with hepatitis; 4)
34 d P2Y12, and at P2X4 and P2X7 receptors), an immunosuppressant (acting at P2Y11), and a growth-promot
36 ioned hereafter, among the clinical factors, immunosuppressants (adjusted hazard ratio [aHR] = 0.408
37 he goal of this study was to investigate how immunosuppressants affect gene expression in a manner th
38 rol by means of conventional and/or biologic immunosuppressants after remission-induction with anti-B
41 etween antiretrovirals (ARVs) and transplant immunosuppressant agents (IS) among HIV-infected transpl
42 h corticosteroids in combination with global immunosuppressant agents and/or immunomodulatory monoclo
43 unosuppression with corticosteroids or other immunosuppressant agents such as infliximab; most irAEs
47 topurine have been extensively prescribed as immunosuppressant and anticancer agents for several deca
48 diolipins and show that prior binding of the immunosuppressant and antifungal antibiotic cyclosporin
49 (also called fingolimod) is recognized as an immunosuppressant and has been approved by the Food and
52 rotocols should allow for improved dosing of immunosuppressants and better management of posttranspla
53 BS sampling for the simultaneous analysis of immunosuppressants and creatinine can replace convention
54 hildren in Group A were treated earlier with immunosuppressants and had more frequent endoscopic asse
55 ressure monitoring, spirometry), 13%-23% for immunosuppressants and other medications, and 4% for tob
56 sing encapsulation may circumvent the use of immunosuppressants and prolong the longevity of transpla
58 avenous immunoglobulin, plasma exchange, and immunosuppressants) and ambulatory outcomes were compare
59 es several validated targets for anticancer, immunosuppressant, and anti-inflammatory chemotherapeuti
60 success was achieved in 74% of patients on 1 immunosuppressant, and in an additional 21% of patients
62 drug intolerance compared with other primary immunosuppressants, and discontinuation rates are partic
63 C virus antibodies, prior or no prior use of immunosuppressants, and duration of treatment (1 to 24 m
64 cancer treatment, as antiviral drugs and as immunosuppressants, and have also displayed antibiotic a
65 ct to anti-JC virus antibodies, prior use of immunosuppressants, and increased duration of natalizuma
66 ct to anti-JC virus antibodies, prior use of immunosuppressants, and increasing duration of natalizum
68 uenced positively or negatively by different immunosuppressants, and the impact of exhaustion on graf
69 5-aminosalicylate (5-ASA), corticosteroids, immunosuppressants, anti-tumor necrosis factor (TNF) the
71 class of red-pigmented natural products with immunosuppressant, anticancer, and antimalarial activiti
75 plantation, treatment with steroids or other immunosuppressants, ARF (25.5% vs. 16.3%; P = 0.004), an
80 cineurin inhibitor with sirolimus as primary immunosuppressant attenuates long-term cardiac allograft
84 ls inaugurates the arrival of a new class of immunosuppressants based on costimulatory blockade, an i
85 tors have received considerable attention as immunosuppressants because they are associated with a mo
86 tive for anti-JC virus antibodies, had taken immunosuppressants before the initiation of natalizumab
90 by S. aureus and moonlights as a macrophage immunosuppressant by reducing Toll-like receptor 1/2 (TL
92 himaera were more likely to be prescribed an immunosuppressant compared with all other patients (AOR,
95 duscin's aglycone, and bacterial cell-coated immunosuppressants could be a general strategy to combat
97 ransplant survival associated with extending immunosuppressant coverage was reduced to 50% of that ob
101 contrast, treating activated rCD4s with the immunosuppressant cyclosporin, a calcineurin inhibitor,
104 imals receiving intestinal grafts without an immunosuppressant developed antidonor IgG in 14 days and
105 d transplant recipients who receive lifelong immunosuppressant drug coverage compared with a cohort o
106 ze associations between NR1I2 polymorphisms, immunosuppressant drug exposure, and clinical outcomes i
114 tential to be developed as a new category of immunosuppressant drugs acting via autophagy induction o
115 pendent phosphatase that is inhibited by the immunosuppressant drugs cyclosporine and tacrolimus.
121 can be rapidly adopted for the detection of immunosuppressant drugs, alpha-amylase protein, or prote
124 -76 mg/L]; P=0.006) and a trend toward fewer immunosuppressants drugs used before biologics (P=0.054)
125 le to clearly define the role of concomitant immunosuppressants during initiation therapy with a biol
126 although combinations of glucocorticoids and immunosuppressants (e.g., cyclophosphamide, azathioprine
128 n and often requires treatment with systemic immunosuppressants, extracorporeal photopheresis, or pho
129 to the tumor antigen, and treatment with the immunosuppressant FK506 (tacrolimus) decreases CSF white
130 sruption of the Hom3:Fpr1 interaction by the immunosuppressant FK506, illustrating the assay's capaci
135 A (CsA) and tacrolimus (FK506) are valuable immunosuppressants for a range of clinical settings, inc
136 ssants, antipsychotics, anticonvulsants, and immunosuppressants for transplant patients) that would l
137 ansplant patients, FK778 (an investigational immunosuppressant from the malononitrilamides class) was
142 prognosis is poor but treatments, typically immunosuppressants, have improved survival, albeit with
143 ustment for confounders including the use of immunosuppressants, having NASH was independently associ
145 potentially linked to side effects of their immunosuppressants.Immunosenescence is a physiological p
148 Sirolimus is being used increasingly as an immunosuppressant in allogeneic hematopoietic stem cell
149 ing into question the use of rapamycin as an immunosuppressant in islet transplantation and as a seco
151 yzed the potential of sirolimus as a primary immunosuppressant in the long-term attenuation of cardia
152 S1P analogue FTY720 has been developed as an immunosuppressant in transplantation and tested as a tre
154 antigen (HLA) antibodies after withdrawal of immunosuppressants in 35 type 1 diabetic recipients of i
155 m for the off-label prescription of systemic immunosuppressants in AD, discusses the apparent dilemma
159 nd cyclosporine, are widely used as standard immunosuppressants in organ transplantation recipients.
160 The multimorbid burden and use of systemic immunosuppressants in people with psoriasis may confer g
161 the way to study the differential effects of immunosuppressants in posttransplantation malignancy.
163 esting approach for narrow therapeutic index immunosuppressants in transplant recipients have been la
165 d plasma exchange for acute attacks and with immunosuppressants (in particular, B cell-depleting agen
167 rst study to show that metformin can improve immunosuppressant-induced hyperglycemia, when administer
169 to selectively inactivate immune cells with immunosuppressants is a much sought-after modality for t
170 n multivariate analysis, treatment with both immunosuppressant (IS) and anti-TNF before colectomy was
171 addition, rapamycin, a clinically important immunosuppressant, is a specific and potent inhibitor of
175 RQoL, suggesting that use of non-nephrotoxic immunosuppressants may affect the patient's side effect
177 adherers perceived that their transplant and immunosuppressant medication caused more symptoms and we
180 ey transplantation including nonadherence to immunosuppressant medication, graft failure, and all-cau
181 f transplant survival using current costs of immunosuppressant medications in the era of generic equi
195 actice of anti-JCV antibody index testing of immunosuppressant-naive patients with MS, either current
196 investigated the effect of morphine, a known immunosuppressant, on leukocyte migration and recruitmen
197 ontrol group with trough-level monitoring of immunosuppressants or to an intervention group with addi
198 CD and inadequate response or intolerance to immunosuppressants or tumor necrosis factor antagonists.
199 tion of penicillins (OR, 6.12; P = .03), and immunosuppressants (OR, 7.00; P = .002); (2) day 7, base
200 olved either by holding the drug, initiating immunosuppressants, or both, and rates of recurrent toxi
201 agectomy with neoadjuvant therapy is also in immunosuppressant patients feasible without increased ri
202 hen confirm genetic variants associated with immunosuppressant pharmacokinetics and adverse outcomes.
204 lmodulin-regulated phosphatase and target of immunosuppressants, plays important roles in the circula
205 duscin is one such isocyanide-functionalized immunosuppressant produced in Xenorhabdus and Photorhabd
207 rated via FNP that were dual loaded with the immunosuppressant rapamycin and a fluorescent dye to lin
209 to derive a binding site hotspot map for the immunosuppressant rapamycin, a complex macrocyclic natur
211 meters were gender, age, transplanted organ, immunosuppressant regimen, time between transplantation
212 replication under therapy and the impact of immunosuppressant regimens on viral replication are unkn
213 is lost through multiple factors, including immunosuppressant-related toxicity, often requiring more
214 ween myositis (and other immune-mediated and immunosuppressant-responsive disorders) and its many cli
215 suppressants (RR = 5.6, PPV23 = 68%), and no immunosuppressants (RR = 1 [reference], PPV23 = 74%).
216 rticosteroids (RR = 6.2, PPV23 = 64%), other immunosuppressants (RR = 5.6, PPV23 = 68%), and no immun
217 ydroxyphenylalanyl-(3S)-piperazate common to immunosuppressant sanglifehrins was synthesized from the
219 also loaded with cyclophosphamide (CYC), an immunosuppressant shown to reduce the cerebrovascular in
221 BMI, race, diabetes, COPD, OR time>2 hours, immunosuppressants, smoking, active infection, ASA class
223 s, 96 patients) and find that antivirals and immunosuppressants strongly affect the structure of the
226 e, including antibiotics such as penicillin, immunosuppressants such as cyclosporine, and cytostatics
228 approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant re
229 ytotoxicity of the calcineurin inhibitor and immunosuppressant tacrolimus (FK-506) was prevented by N
233 In conclusion, this study discovers that immunosuppressant TAM kinases are promoters of pro-infla
235 ponse was detected in vitro and conventional immunosuppressants targeting T cell activation had limit
236 ycophenolic acid (MPA) is a highly effective immunosuppressant that has broad antiviral activity agai
239 1/3 inhibitor R507 is a very well-tolerated immunosuppressant that similarly diminished obliterative
240 urrently treated using mainly broad-spectrum immunosuppressants that can lead to adverse side effects
241 res treatment with nonspecific pharmacologic immunosuppressants that carry both systemic and nephrolo
242 nses can be limited with the use of systemic immunosuppressants, the induction of regulatory cell pop
243 6 may represent an optimal target for future immunosuppressant therapeutics with a particular role in
245 n the conventional management group required immunosuppressant therapy (61%; median time to first pre
247 ing for CRMP5 IgG to expedite vision-sparing immunosuppressant therapy and a targeted search for a sy
248 ents achieved response with a combination of immunosuppressant therapy and thrombopoietin-receptor ag
255 ent cohort included 76 patients who received immunosuppressant therapy; the remaining 82 patients did
256 ects of standard treatment (glucocorticoids, immunosuppressants), there is an unmet need for safe and
257 erlying illnesses and the use of concomitant immunosuppressants; therefore, a clear causal relationsh
258 ought to establish the ability of a systemic immunosuppressant to modulate immune and epidermal alter
259 ence supports therapeutic monitoring of this immunosuppressant to optimize its efficacy and reduce to
264 eated with corticosteroids (83%), 11 with an immunosuppressant treatment (27%) and 5 with biological
265 ntibodies are being identified and receiving immunosuppressant treatment earlier and more aggressivel
266 Patients were divided into 2 subgroups: an immunosuppressant treatment group and a nonimmunosuppres
267 story of hepatic encephalopathy (P = 0.033), immunosuppressant treatment protocol (P = 0.041), donor
268 nd understand the putative new bile acid and immunosuppressant treatment strategies under development
271 % (95% CI 1.8-4.0) in patients with previous immunosuppressant use and 1.7% (1.4-2.1) in those withou
273 cumulative PML risk with or without previous immunosuppressant use was estimated using Kaplan-Meier a
274 am virus (JCV) antibodies in serum, previous immunosuppressant use, and treatment duration, which wer
277 regardless of natalizumab exposure or prior immunosuppressant use, p = 0.9709 and p = 0.6632, respec
278 antibody-positive patients without previous immunosuppressant use, risk estimates were further strat
281 rin inhibitor (CNI) cyclosporine A (CsA), an immunosuppressant used to prevent allograft rejection, c
282 ine and tacrolimus are calcineurin inhibitor immunosuppressants used to prevent organ rejection after
283 FICANCE STATEMENT Calcineurin inhibitors are immunosuppressants used to prevent rejection of transpla
284 n equation approach revealed that the use of immunosuppressants was an independent predictor for slow
288 filtration rates, and concentrations of the immunosuppressants were measured along with (1)H-magneti
290 er drugs (eg, penicillins, fluoroquinolones, immunosuppressants) were the strongest predictors of ren
292 alcineurin inhibitors (CNIs) are 2 effective immunosuppressants which are essential to prevent allogr
293 ELPs) fused with FKBP12, to deliver a potent immunosuppressant with dose-limiting toxicity, rapamycin
294 onist effect of tacrolimus, a potent natural immunosuppressant with multiple clinical applications, o
295 al target of tacrolimus (FK506), a macrolide immunosuppressant with several clinical uses, including
296 thermore, immunosuppression therapy based on immunosuppressants with antitumoral effects should be pr
299 erogenic therapies, and to allow intelligent immunosuppressant withdrawal in patients whose autoimmun