ライフサイエンスコーパス: impaired

1 n cells, and cause neurological disease when impaired.

2 AD mice, SWR-DW and spindle-DW coupling were impaired.

3 smic domain/transport-dependent targeting is impaired.

4 linical scenarios in which AMPK signaling is impaired.

5 th cell types, but spread in fibroblasts was impaired.

6 rly B-cell development in the bone marrow is impaired.

7 Mental switching performance was impaired 7% (IQR = 0-19) after indomethacin (P = 0.04),

8 and degradation of phosphorylated SMAD3 and impaired a SMAD3/beta2SP-dependent tumor-suppressing pat

9 changing soil biogeochemistry that may have impaired a stomatal response.

10 ESCs have a slower self-renewal rate and an impaired ability to differentiate towards cardiac mesode

11 Batf3 (-/-) memory cells had an impaired ability to mount a robust recall response but r

12 c reticular nucleus neurons, burst firing is impaired accompanied by attenuated IT.

13 Its deficiency leads to impaired activation of developmental genes and subsequen

14 but not in B3GLCT (-/-) cells suggested that impaired ADAMTSL2 secretion is not responsible for skele

15 caused by loss of O-fucosylation on TSR3 and impaired ADAMTSL2 secretion.

16 disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2.

17 ent candidates are ganglioside synthesis and impaired addition of O-linked beta-N-acetylglucosamine (

18 e show that persistent antigenic stimulation impaired ADP-coupled oxidative phosphorylation.

19 Two monkeys were impaired after 0.1 mg/kg olanzapine and two were impaire

20 ired after 0.1 mg/kg olanzapine and two were impaired after 0.3 mg/kg deschloroclozapine.

21 roliferation of resident epithelial cells is impaired, alternative regeneration mechanisms can occur.

22 ar-stage hyperoxia injury contributes to the impaired alveolarization and septal thickening observed

23 s involved in lung development along with an impaired alveolarization in female prenatally stressed m

24 disease context, influenza A virus infection impaired AM crawling via the type II interferon signalin

25 re-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling.

26 It is not clear why some brain regions are impaired and others spared by the etiological risks for

27 In the cdkg1-1 mutant, synapsis is impaired and there is a dramatic reduction in the number

28 IFN-mediated JAK-STAT signaling is severely impaired, and activation of MAPKs and PI3K signaling pat

29 gly, NK cell recruitment and activation were impaired, and metastatic burden was increased in E2 (-/-

30 derstanding the processes underlying normal, impaired, and recovered language performance has been a

31 Impaired angiogenesis in the wound tissues results in de

32 d CD86 expression, potentially indicative of impaired antigen presentation.

33 t CD40L-overexpressing CAR T cells elicit an impaired antitumor response in the absence of cDC1s.

34 CD8+ T cell response to vaccination is impaired as a result of cDC1 dysregulation.

35 TBC1D15-NuMA1 association impaired asymmetric division machinery by hijacking NuMA

36 as pursuit eye movements, are significantly impaired at 0.015% BAC, suggesting impaired neural activ

37 impairment at baseline and 2 (22%) remained impaired at week 24.

38 duced expression of Ucp1 and Pgc-1alpha with impaired ATF2 genomic binding.

39 This effect is associated with impaired autoantibody formation, and mitigates experimen

40 Oligodendrocyte signatures suggested impaired axonal myelination and metabolic adaptation to

41 d by more severe intestinal inflammation and impaired bacterial clearance.

42 of structural integrity of the cuticle, and impaired barrier function.

43 livery systems which have potential to cross impaired BBB, target and deliver drugs selectively to ac

44 lipid-raft-associated surface receptors, and impaired BCR signalling and cellular adhesion.

45 CPT2 in the brain did not result in robustly impaired behavior.

46 gainst venous thrombosis results in severely impaired binding to both activated alpha(IIb)beta(3) and

47 lly occurring after CRS and characterized by impaired blood-brain barrier integrity.

48 ant overlap with the patterns of empirically impaired brain regions on later scans, at both group and

49 secretion under control conditions were less impaired by atorvastatin than preparations that were non

50 In contrast, reversal learning was impaired by D2R antagonism, but not D1R antagonism, in t

51 Importantly, connectivity is impaired by insults, which mimic the diabetic milieu, in

52 r is sufficient to recover salivary function impaired by irradiation.

53 d in both species, only Z. marina growth was impaired by the accumulative heat stress imposed by the

54 e guide RNA (sgRNA)-guided and catalytically impaired Campylobacter jejuni CRISPR-associated protein

55 ur hypothesis, patients with HFpEF displayed impaired cardiac beta-receptor sensitivity compared with

56 n are vulnerable to vitamin D deficiency and impaired cardiovascular health; vitamin D replenishment

57 Recipients of an HLA-DR1 donor also have an impaired cardiovascular outcome.

58 on of residues involved in metal ion binding impaired catalytic activity and the formation of active

59 nd degradation of phagocytosed materials are impaired, causing lipid droplet (LD) accumulation in aut

60 A2, result in sphingolipid abnormalities and impaired cell growth that are corrected by treatment wit

61 functional exhaustion) is not upregulated on impaired cells but instead is upregulated on highly func

62 reactivity associated with brain metastases impaired cerebrovascular responses to stimuli at both th

63 acid levels (a marker of LXR activation) and impaired chemotactic response toward CXCL8 compared with

64 hils and white blood cells showed a severely impaired chemotactic response.

65 duction of this vasomotion may contribute to impaired clearance of Abeta.

66 stolic and diastolic cardiac dysfunction and impaired clinical outcomes in patients with nonischemic

67 ignatures were associated with predominantly impaired clinical state- and trait-level phenotypes, whi

68 nglia tissue iron levels have been linked to impaired cognition in iron deficient children and adults

69 works in pediatric OCD may contribute to the impaired control over intrusive thoughts early in the il

70 g treadmill running in rats due, in part, to impaired convective and diffusive O(2) delivery, and thu

71 The mutation was linked to modestly impaired CXC chemokine expression and neutrophil recruit

72 ity and enhanced transmission may arise from impaired cyclic nucleotide signalling, resulting from co

73 T cells and NK cells exhibited impaired cytolytic activity, and mice infected with mous

74 An impaired decline in blood pressure at rest is typical in

75 histone trimethylation at meiotic hotspots, impaired DNA double-strand-break repair, and reduced cro

76 Co-depletion of Mdm4 and Mdm2 further impaired DNA replication, and the overexpression of each

77 Visual perception was the most impaired domain, while scholastic progression was age-ap

78 atial function domains were the most serious impaired domains in the major cognitive impairment group

79 Memory and language were the most severe impaired domains in the mild cognitive impairment group,

80 ogenesis and cilia function is significantly impaired during differentiation of CRSwNP epithelium due

81 ular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant accumulation o

82 stenosis undergoing TAVR, even with baseline impaired eGFR, CKD stage is more likely to stay the same

83 e no effects on NOR, however proton exposure impaired egocentric (Cincinnati water maze) and allocent

84 Contractile function was similarly impaired (ejection fraction, day 2: 40.9% +/- 9.7% vs. 5

85 umulate within Sac1(ts) retinal cells due to impaired endo-lysosomal degradation.

86 Impaired endothelium-dependent vasodilation is a hallmar

87 One mechanistic hypothesis involves impaired endothelium-dependent vasodilation through reac

88 promotes IL-1beta/TNF-induced necrosis from impaired energy homeostasis and lysosomal permeabilizati

89 novel therapeutic approaches to restore the impaired epithelial repair mechanisms in COPD, which is

90 naling pathways in MDSs causes anemia due to impaired erythroid maturation.

91 out among the mechanisms contributing to the impaired erythropoiesis in the setting of reduced kidney

92 aptic transmission and plasticity as well as impaired executive functions.

93 The EP group had significantly impaired exercise capacity.

94 Although BLOC-2 depletion impaired exocytosis, exocyst depletion augmented WPB exo

95 we further demonstrate that proximal threats impaired extinction efficacy via persistent multivariate

96 bulo-ocular reflex (VOR) gain adaptation but impaired eyeblink conditioning (EBC), which relies on th

97 estigated if nervonic acid alters markers of impaired fatty acid oxidation in the liver.

98 terized by fear overgeneralization involving impaired fear regulation by safety signals.

99 ticularly around parvalbumin (PV) cells, and impaired fear-induced activity of PV interneurons only i

100 etes can lead to pregnancy complications and impaired fetal development.

101 role of CT-1 in fasting is confirmed by the impaired food restriction-induced adipose tissue lipid m

102 robust interferon responses and was severely impaired for replication in PK1 cells.

103 nes in patients with HLHS, which may portend impaired functional reserve of the single-ventricle circ

104 developmental disorders are characterized by impaired functional synaptic plasticity and abnormal den

105 Impaired gamma-secretase function is associated with the

106 Exposure to PM2.5 impaired glucose and insulin tolerance and reduced energ

107 and ileum, leading to insulin resistance and impaired glucose and lipid metabolism.

108 essential for the development of obesity or impaired glucose handling due to HFD, and advance unders

109 lpha protein instability was associated with impaired glucose metabolism and lower glycolytic enzyme

110 nism as to how TIH, prevalent in people with impaired glucose metabolism, contributes to cardiovascul

111 Mice lacking TrkB.T1 show impaired glucose tolerance and insulin secretion.

112 oping gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic.

113 inhibition via an anti-alpha-klotho antibody impaired glucose tolerance.

114 rodent schizophrenia model characterized by impaired glutathione synthesis, the Gclm knockout mouse,

115 Human studies have implicated impaired glymphatic function in both AD and iNPH.

116 ty in the causation of addiction, related to impaired goal-directed actions, as well as countervailin

117 ross-chain disulfide bonds, which results in impaired GPC processing into G1 and G2.

118 ureus biofilm infection in wounds results in impaired granulation tissue collagen leading to compromi

119 In the cognitively impaired group, younger age (P = 0.02), higher baseline

120 e show that mutant strains lacking gigC have impaired growth in the absence of the amino acid cystein

121 viability, and immunoblotting revealed that impaired growth is due to perturbation of cell cycle pro

122 ransporters, all of which are precursors for impaired gut integrity and performance.

123 nderlie mechanosensory hyperresponsivity and impaired habituation learning.

124 ocked plaque remodeling and contraction, and impaired hallmarks of inflammation resolution, including

125 y, defined as any atrial dysfunction causing impaired heart performance, symptoms, and worsening qual

126 en storage disease type-Ia (GSD-Ia) leads to impaired hepatic autophagy, a recycling process importan

127 shortening, progressive telomere dysfunction impaired hepatic endoderm formation.

128 sociated with metabolic consequences such as impaired hepatic lipid metabolism and development of non

129 l hypercalcemia-associated missense variants impaired heterologous expression, plasma membrane target

130 ory performance in a scene recognition task, impaired hippocampal connectivity to multiple prefrontal

131 The discovery of impaired hippocampal synaptic plasticity in the heterozy

132 AS in an estrous cycle-dependent manner: MAS impaired hippocampus-dependent spatial memory in early-p

133 Patients with PTLDS reported impaired HRQoL compared to the general US population.

134 mplications are associated with considerably impaired HRQOL up to 10 years after esophageal cancer su

135 uch paradoxical findings may be explained by impaired hypoxic pulmonary vasoconstriction in infected

136 d fewer risk factors, but these cells showed impaired IFN-gamma production.

137 Impaired IL-17A and IL-22 production correlated with red

138 LRG1 deletion causes impaired immune cell infiltration, reepithelialization,

139 those receiving combination therapy, have an impaired immune response compared to controls.

140 deletion of Dot1L in T cells resulted in an impaired immune response.

141 immune checkpoint inhibitors, an immature or impaired immune system and inhibitory tumor microenviron

142 ociated with neuropathology in patients with impaired immunity and/or inflammatory diseases.

143 sponses during allergic inflammation, but is impaired in asthma.

144 ction of the Ep group were detected slightly impaired in comparison with the control group (P >0.05);

145 tory T cells (Tregs), which are functionally impaired in DED, remains unclear.

146 or cells (HSPC) from the bone marrow (BM) is impaired in diabetes.

147 have isolated mutant UAF1 variants that are impaired in DNA binding and tested them together with RA

148 uals, the resolution phase was substantially impaired in elderly individuals.

149 sts that newborn monocytes are intrinsically impaired in extravasation through quiescent endothelia,

150 n and fatty acid and glucose metabolism were impaired in HF-patients compared with HC (P<0.05).

151 pattern separation, complex functions often impaired in individuals with brain disorders characteriz

152 The GLP-1 system is known to be impaired in insulin-resistant conditions, and we sought

153 lX DeltapgnE double mutant was substantially impaired in its ability to form Pel-dependent biofilms.

154 By contrast, glucose tolerance was mildly impaired in mice lacking PAK2 specifically in muscle, bu

155 They were also modestly impaired in one simpler spatial task, finding a visible

156 contrast, automatic inhibition was abnormal/impaired in patients with tic disorders.

157 In summary, proNGF maturation is impaired in preclinical and clinical AD while mature NGF

158 Wound-healing was also impaired in PSW compared to controls at baseline and fol

159 on errors benefits learning in health and is impaired in psychosis.

160 receiving cue illumination were specifically impaired in rapid uncertainty-safety discrimination.

161 Modulation of activity duration is impaired in rLG, confirming the role of reflex feedback

162 Alanine transport was impaired in the cycA mutant, and this correlated with in

163 Moreover, interoceptive performance was impaired in the HHD group.

164 s of spontaneous pain and were significantly impaired in the rule-shifting task while genetic and pha

165 However, N-glycan branching was not impaired in these cells.

166 ynaptic plasticity, learning, and memory are impaired in these mutant mice.

167 ion of AP factors, or AH50 less than median, impaired in vitro serum control of KP that was restored

168 technical-reasoning hypothesis, cognitively-impaired individuals will lack the cognitive ability to

169 from healthy volunteers, demonstrating that impaired innate immune mechanisms following DEP exposure

170 (95% CI, 1.4-4.8), and 3.2 times the odds of impaired instrumental activities of daily living (95% CI

171 nstrated improved glucose tolerance, despite impaired insulin sensitivity and enhanced pyruvate-media

172 Conclusion: These findings suggest that impaired integrity of dopaminergic nigrostriatal nerve t

173 pronounced in the hippocampus, manifested by impaired interactions with neurons, coupled with diminut

174 Here, we found that ROS impaired interferon response during murine herpesvirus i

175 n addition, the loss of TMIGD1 significantly impaired intestinal epithelium brush border membrane, ju

176 These defects were a consequence of impaired IP3R function in combination with defective STI

177 Patients with diabetes had impaired LA reservoir (19.8% vs. 21.2%, P < 0.01) and co

178 0) = 1.972, p = 0.049), it was outweighed by impaired landmark-based navigation (t(980) = 6.374, p <

179 rmalities such as psychomotor hyperactivity, impaired learning and memory in the recipient animals.

180 siological features, and its contribution to impaired linear and ponderal growth has been hampered by

181 ses with high accuracy in both older hearing-impaired listeners and age-matched normal-hearing contro

182 FOSL1 silencing impaired LPS-induced in vitro HPMEC angiogenesis.

183 Kir6.1 or SUR2 subunits results in severely impaired lymphatic contractile responses to pinacidil.

184 t a model of mTORC1-ATF4 hyperactivation and impaired lysosomal acidification in beta-cells lacking F

185 een reduced transport of synaptic cargos and impaired maintenance of synaptic transmission and plasti

186 add45gamma in the hippocampus of cognitively impaired male mice.

187 Thus, we hypothesized that impaired memory consolidation mechanisms in hippocampal-

188 without affecting existing oligodendrocytes impaired memory consolidation of water maze, as well as

189 tion markedly improved hepatic inflammation, impaired microcirculation, and fibrosis.

190 of storage bodies in AF(+) cells and led to impaired microglia physiology and cell death, suggestive

191 Impaired microvascular perfusion is central to the devel

192 microcirculation and suggest that restoring impaired microvascular supply, regardless of disease co-

193 Our work raises the hypothesis that impaired mitochondrial calcium transport contributes to

194 betes and heart failure, which are caused by impaired mitochondrial function due to the loss of frata

195 aintenance of ATP levels under conditions of impaired mitochondrial respiration.

196 Parkinson's disease (PD) are associated with impaired motor performance.

197 e 10 mg dose of the GABA(B) agonist baclofen impaired motor sequence learning and visuomotor learning

198 This increased contractility also impaired movement of basal progenitors during hair placo

199 h exogenous mtDNA is lost from metabolically impaired, mtDNA-intact (rho+) cells.

200 C (Villin-Cre(ERT2); Dsc2 (fl/fl)) exhibited impaired mucosal repair after biopsy-induced colonic wou

201 ed social reconstruction; and (6) persistent impaired multidimensional symptoms extending beyond inte

202 le fiber atrophy, sarcolemmal fragility, and impaired muscle regeneration.

203 unimpaired elderly (n = 89), and cognitively impaired (n = 65)] who underwent amyloid-beta PET with (

204 In myoblasts, we find that impaired NADH oxidation upon electron transport chain (E

205 ance, and inhibiting eye movements in humans impaired navigation precision.

206 ificantly impaired at 0.015% BAC, suggesting impaired neural activity within brain regions associated

207 type 2 diabetes, cardiovascular disease, and impaired neurocognitive function.

208 ive diseases (NDDs) comprise conditions with impaired neuronal function and loss and may be associate

209 CLCb had a reduced synaptic vesicle pool and impaired neurotransmission compared to WT mice, while nC

210 eolae in aECs, but not in neighbouring SMCs, impaired neurovascular coupling.

211 Studies have shown impaired neurovascular function in several mouse models

212 mutations of individual genes that result in impaired neutrophil number or function, and provide insi

213 l maintenance complex member 10 (MCM10) that impaired NK cell maturation in a child with fatal suscep

214 We observed low NK cell numbers and impaired NK cell maturation, suggesting that STAT5b is i

215 activation, perineural net degradation, and impaired NMDA receptor function.

216 ectivity in cultured neurons or in vivo, but impaired NMDA-receptor-mediated responses.

217 PO(2) during twitch contractions reflecting impaired O(2) delivery-to-utilization matching.

218 rtex (lateral occipital complex) selectively impaired object recognition, while TMS over scene-select

219 HDAC1 deficiency causes impaired OGG1 activity, 8-oxoG accumulation at the promo

220 ts implicated in the selection of movements, impaired operation of GABA signaling within the striatum

221 Ser/Thr kinase (BRAF), that result in kinase-impaired or kinase-dead BRAF have the highest mutation f

222 impact these cascades, in particular through impaired organellar interfacing, to propose 'subcellular

223 Impaired oxygen and cellular metabolism is a hallmark of

224 age abilities map to the brain in normal and impaired participants, including the diverse, graded var

225 ITGAV expression is correlated with an impaired patient outcome in the group of patients withou

226 lighted by the pathological consequences and impaired performance resulting from aberrant network exc

227 medicated patients with schizophrenia showed impaired performance.

228 Furthermore, attenuated cGMP signals led to impaired phosphodiesterase two dependent negative cGMP-t

229 nide has antiarrhythmic effects on AF due to impaired Pitx2 by preventing spontaneous calcium release

230 s) in patients in the presence or absence of impaired Pitx2 expression remain unclear.

231 estingly, PEL-negative individuals showed an impaired platelet aggregation, confirming a role for ABC

232 ble microarray data suggested a mechanism of impaired PLGA degradation and intestinal acidification c

233 of pol beta with r8-oxo-GTP, we demonstrate impaired pol beta closure that correlates with a reduced

234 a and liver kinase B1 but fails to normalize impaired PPAR-alpha expression or metabolic abnormalitie

235 osphorylated tau expression, correlated with impaired preoperative executive function.

236 ondrial redox potential and/or ATP synthesis impaired proline biosynthesis.

237 Among the hallmarks of melanoma are impaired proteostasis and rapid development of resistanc

238 reduction in cellular levels of GCC2 or M6PR impaired PS-ASO release from endosomes and decreased PS-

239 of overexpressing efflux pumps are similar (impaired QS response), the underlying mechanisms are dif

240 eading to significant health care burden and impaired quality of life.

241 y had a functional defect in HR, assessed by impaired RAD51 foci formation on end of treatment biopsy

242 a global change in immunological profile and impaired recruitment and activation of T cells.

243 Moreover, c3a.1(-/-) zebrafish larvae have impaired recruitment to localized bacterial infections a

244 s of Notch1 intracellular domain (N1ICD) and impaired regenerative response to injury in comparison t

245 ch enhanced cardiomyocyte contractility, but impaired relaxation and evoked hypertrophic remodeling w

246 Impaired relaxation is a hallmark of hypertrophic and re

247 We propose that this actin-based impaired relaxation is central to NEM6 pathology.

248 Patients with ALD and impaired renal function have a higher risk of graft loss

249 ion, dyslipidemia, the metabolic syndrome or impaired renal function.

250 to learn sensory statistics, resulting in an impaired representation of the world.

251 to assess its performance in the presence of impaired respiratory and renal functions.

252 dramatically increased PDH activity, and an impaired response to mitochondrial stress in affected ce

253 However, diabetic females displayed impaired responsiveness to superovulation.

254 cutaneous Staphylococcus aureus application, impaired S1pr2(-/-) mouse epidermal barrier function all

255 mitotic slippage due to defective AURKB and impaired SAC activity, downstream of condensin complex d

256 on of Hedgehog signaling rescues irradiation-impaired salivary function in animal models, but the und

257 ve cortex (occipital place area) selectively impaired scene recognition.

258 d skewing, reduced reconstitution potential, impaired self-renewal, and a proinflammatory phenotype.

259 ddressed this question either by focusing on impaired sensory processing in patients or using local a

260 ed with the decreased SERCA2a expression and impaired SERCA2 activity in lymphatic muscle.

261 tified single amino acid mutations result in impaired shRNA-mediated silencing.

262 precursor protein knockin (APP-KI) mice with impaired spatial memory.

263 cells show chromatid cohesion defects and an impaired spindle assembly checkpoint (SAC), thus undergo

264 f gene expression; whereas, mutant OGG1 with impaired substrate recognition/binding was not.

265 d heteromeric receptors that contain binding-impaired subunits, as we show for both kainate and GluA2

266 d, a critical key event relationship linking impaired swim bladder inflation to TH disruption.

267 Deletion of C1ql3 in the dorsolateral AON impaired synaptic AON->OB connections and abolished acqu

268 nd changes in protein synthesis that trigger impaired synaptic maturation and autistic behaviors.

269 p2(+/R552H) mice) display motor deficits and impaired synaptic plasticity in the striatum.

270 strocyte lactate supply alone rescued stress-impaired synaptic plasticity, which was blocked by inhib

271 4 in mice results in cardiac hypertrophy and impaired systolic function, which could severely limit t

272 tricular-arterial coupling ratio, reflecting impaired systolic function.

273 H3K79me2 led to low expression of STAT5 and impaired T cell immunity.

274 Chemogenetic silencing of GC impaired task performance.

275 king TAGAP mount defective immune responses, impaired Th17 cell differentiation, and higher fungal bu

276 th murine and human tumor cells, HOTAIR-sbid impaired the ability of HOTAIR to bind Snail and, in tur

277 lated modulation of CDh neurons and strongly impaired the classification of task-epochs based on CDh

278 fter the extinction session dose-dependently impaired the consolidation of fear extinction memory of

279 While this impaired the correction of erroneous KT-MT attachments,

280 lesser degree, deletion of just the B boxes impaired the de novo establishment of the heterochromati

281 iption factors PPARgamma and C/EBPalpha, and impaired the differentiation of 3T3-L1 murine fibroblast

282 Importantly, eEF1D impaired the interaction between NP and importin alpha5

283 This mutation, however, impaired the maturation of NLGN4 protein by inhibiting N

284 the proximal Valpha genes, and its deletion impaired the Tcra rearrangement.

285 ogenetic inhibition of iSPNs, but not dSPNs, impaired the updating of this learning and attenuated re

286 Impaired thermoregulation and lowered average daily gain

287 e emergence of EC neuronal hyperactivity and impaired theta rhythmicity.

288 Rather than impaired threat learning, pathological anxiety involves

289 Impaired thrombopoiesis leads to increased plasma thromb

290 due to prolonged intestinal inflammation and impaired tissue repair.

291 caspase-8/gasdermin-D (GSDM-D) renders mice impaired to produce both TNFalpha and IL-1beta and highl

292 ory T (Treg) cells (ie, FOXP3), resulting in impaired Treg function and autoimmunity.

293 Impaired Treg suppression in the absence of ERbeta was a

294 oclast metabolic quiescence, associated with impaired tricarboxylic acid (TCA) cycle function and met

295 R7 were identified that were associated with impaired type I and II IFN responses.

296 d alphaKlotho-hypomorphic mouse (kl/kl) with impaired urinary Pi excretion, low autophagy, and premat

297 aracterized by dysregulated angiogenesis and impaired vascular and alveolar development.

298 ration of thymic NKT cells was significantly impaired when CD28 engagement was blocked, but unaffecte

299 This response was impaired when the minimum EBE was fused with a thymidine

300 onstrate that hippocampal memory updating is impaired with aging and establish that the OUL paradigm