ライフサイエンスコーパス: impaired @1 function

1 were used to determine the ability to detect impaired LV function.

2 by overexpression of dominant negative Rab11 impaired NET function.

3 europsychiatric-related disease symptoms via impaired PFC function.

4 er nor unit cell of hemozoin are affected by impaired PV5 function.

5 ory phenotype, which could contribute to the impaired TFH function.

6 essive sIgE production and directly affected impaired lung function.

7 death in these mice was not associated with impaired lung function.

8 and develop interventions for children with impaired lung function.

9 pleural thickening, increased stiffness and impaired lung function.

10 epi LXA4, increased IL-8 concentrations, and impaired lung function.

11 CTSS expression in the lungs and results in impaired lung function.

12 n of the "unedited" PsbF protein resulted in impaired PSII function.

13 ory of childhood violence victimization have impaired brain function.

14 -) largely decreased serum klotho levels and impaired heart function.

15 and produces signatures of brain injury and impaired motor function.

16 ated by enhanced inflammation, fibrosis, and impaired renal function.

17 tatus; however, concentrations increase with impaired renal function.

18 eas serum MMA showed notable, increases with impaired renal function.

19 xaban-treated patients with normal or mildly impaired renal function.

20 na, hospital admission for heart failure, or impaired renal function.

21 described as a sensitive marker in detecting impaired renal function.

22 development of diabetes, and development of impaired renal function.

23 inflammation, apoptosis, cyst formation, and impaired renal function.

24 ion, dyslipidemia, the metabolic syndrome or impaired renal function.

25 have an increased incidence of cancer due to impaired immune function.

26 le to infections, likely because of severely impaired immune function.

27 of GA regarding risk of NSF in patients with impaired kidney function.

28 pamine (DA) release in the striatum and thus impaired motor functions.

29 of structural integrity of the cuticle, and impaired barrier function.

30 to changes in left ventricular geometry and impaired cardiac function.

31 ypertension, and myocardial hypertrophy with impaired cardiac function.

32 surgery resulted in cardiac hypertrophy and impaired cardiac function.

33 at E17.5 in Hsd11b2(-/-) fetuses, suggesting impaired cardiac function.

34 +/- 2.7%; p < 0.01), and was associated with impaired cardiac function.

35 where drug toxicity can be aggravated due to impaired hepatic function.

36 phrenia (SZ) and contribute significantly to impaired overall function.

37 all change in synapses numbers, but strongly impaired synapse function.

38 rom those established during differentiation impaired effector function.

39 identified in human peripheral blood and had impaired effector function.

40 ing per se without the confounding impact of impaired physical function.

41 ng per se without the confounding effects of impaired physical function.

42 ted with reduced ceramide levels in skin and impaired platelet function.

43 tricular-arterial coupling ratio, reflecting impaired systolic function.

44 intestine leads to abnormal Paneth cells and impaired autophagy function.

45 ymptoms, such as memory loss, confusion, and impaired cognitive function.

46 ased expression of CD16, perforin, CD57, and impaired cytolytic function.

47 etion of CD56 on the NK92 cell line leads to impaired cytotoxic function.

48 fic CD8(+) T cells from Nlrc5(-/-) mice have impaired effector functions.

49 showed vacuolar abnormalities suggestive of impaired lysosomal function.

50 present altered mitochondrial morphology and impaired metabolic function.

51 identification of children at high risk for impaired executive functions.

52 aptic transmission and plasticity as well as impaired executive functions.

53 l link between GH, which wanes with age, and impaired macrophage function.

54 also had delayed progesterone withdrawal and impaired myometrial function.

55 ed from healthy volunteers and patients with impaired neutrophil function.

56 pacity was significantly reduced, indicating impaired osteolytic function.

57 isk by promoting a proinflammatory state and impaired endothelial function.

58 ing coronary bypass surgical procedures have impaired endothelial function.

59 therapeutic strategy in disorders involving impaired hippocampal function.

60 sregulation of the mitochondrial network and impaired mitochondrial function.

61 pertrophy and fibrosis, pulmonary edema, and impaired mitochondrial function.

62 e population of processing intermediates and impaired mitochondrial function.

63 dict a poor outcome, probably as a result of impaired mitochondrial function.

64 uses developmental cardiac abnormalities and impaired cardiovascular function.

65 sive-compulsive disorder (OCD) are caused by impaired frontostriatal function.

66 d host proteome in CD patients indicative of impaired mitochondrial functions.

67 type 2 diabetes, cardiovascular disease, and impaired neurocognitive function.

68 Ad-GsKO mice had impaired BAT function, absent browning of WAT, and reduc

69 ide (NO) bioavailability, is associated with impaired cerebrovascular function, accelerated cognitive

70 se reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and

71 ADAP-deficient TRM cells exhibited impaired effector function after Ag rechallenge, correla

72 Type 2 diabetes is the leading cause of impaired kidney function, albuminuria, and renal replace

73 An impaired renal function also leads to 1,25-vitamin D3 de

74 ropensity for asthma; hay fever; eczema; and impaired lung function, also in children without an esta

75 ression in endothelial cell lines results in impaired barrier function and a synthetic repertoire sug

76 ng in brown adipose tissue (BAT), leading to impaired BAT function and thermoregulation.

77 asma triglyceride levels was associated with impaired cardiac function and maintenance of body temper

78 crophages using a Cx3cr1-based system led to impaired cardiac function and promoted adverse remodelin

79 tude would have a higher rate of haemolysis, impaired cardiac function and reduced exercise tolerance

80 patients with CMS (CMS+) is associated with impaired cerebrovascular function and adverse neurologic

81 many Parkinson's disease patients including impaired cognitive function and increased anxiety-like b

82 These symptoms are related to impaired dopamine function and sometimes remedied by lev

83 Chronic exposure to PPIs impaired endothelial function and accelerated human endo

84 Impaired executive function and mental health, in turn,

85 ysglycaemia leading to brain injury, further impaired executive function and mental health, which res

86 ontal cortical dopaminergic abnormalities in impaired executive function and relapse in cocaine depen

87 Substitutions at the dimer interface impaired IreB function and stability in vivo, indicating

88 including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2R

89 um metabolite concentrations may result from impaired kidney function and can be used to estimate fil

90 Impaired kidney function and earlier menopause were asso

91 TMA in humans, these mice exhibited severely impaired kidney function and hypertension.

92 safety of GA administration in patients with impaired kidney function and the incidence of nephrogeni

93 ased levels of blood analytes associate with impaired liver function and muscle damage.

94 th lymphangioleiomyomatosis correlating with impaired lung function and angiomyolipoma presence.

95 low grade systemic inflammation is linked to impaired lung function and cardiovascular outcomes.

96 Impaired lung function and impaired hearing are both cri

97 med that dAKAP1 depletion is associated with impaired mitochondrial function and dynamics, as well as

98 leus in ischemic myofibers to compensate for impaired mitochondrial function and high turnover rate.

99 Loss of FXN causes impaired mitochondrial function and iron homeostasis.

100 that accelerated aging in WS is mediated by impaired mitochondrial function and mitophagy, and that

101 s cellular iron deficiency, which results in impaired mitochondrial function and non-apoptotic cell d

102 es, and immunometabolic phenotyping revealed impaired mitochondrial function and oxidative metabolism

103 is characterized by progressive muscle loss, impaired mitochondrial function and reductions in the sl

104 in critically ill patients is accompanied by impaired mitochondrial function and structure, and by in

105 Adult Dock3 KO mice have impaired muscle function and Dock3 KO myoblasts are defe

106 udies implicate PV+ cell NMDAR disruption in impaired network function and circuit pathologies.

107 d anesthetics causes neurotoxicity including impaired neurocognitive function and abnormal behavior.

108 ive diseases (NDDs) comprise conditions with impaired neuronal function and loss and may be associate

109 cific granule deficiency leading to severely impaired neutrophil function and early mortality.

110 csq-1 deletion impaired pharynx function and caused missed pumps during

111 , obtained by a knockdown approach, leads to impaired photoreceptor function and abnormally shaped ph

112 ng by full-field electroretinogram and found impaired photoreceptor function and retina-based alterat

113 ematopoietic TFs implicated in patients with impaired platelet function and number include runt-relat

114 ut integral part of the cellular response to impaired proteasome function and altered proteostasis.

115 riant together with its normal version) have impaired receptor function and showed sleep disturbances

116 70 and with medical co-morbidities, such as impaired renal function and diabetes.

117 ients than before are receiving diagnoses of impaired renal function and nephrosclerosis-age-associat

118 sure-volume catheterization studies revealed impaired systolic function and prolonged diastolic relax

119 ory T (Treg) cells (ie, FOXP3), resulting in impaired Treg function and autoimmunity.

120 agmentation results in enhanced, rather than impaired, mitochondrial function and is mediated, in par

121 structures are one of the main indicators of impaired biological function, and hence, the ability to

122 ning uremic toxins, arterial stiffening, and impaired cardiac function, and the therapeutic options t

123 pathies, such as cancer, marked hyperphagia, impaired immune function, and inflammation.

124 independently associated with more dyspnea, impaired kidney function, and lower cardiac output ( P<0

125 gatroban is contraindicated in patients with impaired liver function, and activated partial thrombopl

126 significantly inhibited nuclear maturation, impaired mitochondria function, and damaged the spindle

127 to increased aortic Parkin and IL-6 levels, impaired mitochondrial function, and enhanced atherogene

128 itochondrial genes, fragmented mitochondria, impaired mitochondrial function, and increased oxidative

129 , accompanied by altered cardiac energetics, impaired mitochondrial function, and oxidative stress.

130 y day of life five abcd1 mutants demonstrate impaired motor function, and overall survival to adultho

131 leading to increased inflammatory cytokines, impaired osteoblast function, and bone loss in SCD mice.

132 l physical and psychological symptom burden, impaired physical function, and inferior survival compar

133 Impaired magnocellular functioning appeared to be an imp

134 ated by unbiased transcriptome analyses, and impaired mitochondrial function, arborization, synapse f

135 Depressive symptoms and impaired physical functioning are prevalent among older

136 HF myocardium exhibited impaired contractile function as evidenced by reduced ma

137 s involved in the loss of DSG2, resulting in impaired IEB function as seen in IBD.

138 Impaired kidney function, as measured by reduced estimat

139 ) had stable graft function and 16 (36%) had impaired graft function at the time of dnDSA detection.

140 nt profile of empagliflozin in patients with impaired kidney function at baseline was similar to that

141 en urinary cadmium(UCd) and hypertension and impaired kidney function at low exposure levels (UCd: GM

142 er whose neurodevelopmental symptoms include impaired executive function, attention, and spatial lear

143 Reduced aggression was not a consequence of impaired motor function, because optogenetic stimulation

144 A composite of death, dialysis, or sustained impaired renal function by day 30 after surgery did not

145 s compromised the restoration of irradiation-impaired salivary function by transient Hedgehog activat

146 are essential for the rescue of irradiation-impaired salivary function by transient Hedgehog activat

147 outcomes, including respiratory infections, impaired lung function, cardiac infarctions, and cancers

148 diac remodeling post-MI leads to progressive impaired cardiac function caused by a disarray of severa

149 In humans, impaired axoneme function causes a range of ciliopathies

150 ment induced autophagy (AMPK activation) and impaired lysosomal function (CDK4 inhibition), resulting

151 o the accumulation of extracellular ATP that impaired mitochondrial function, cell migration, IL-2 pr

152 in intact flies also produced a phenotype of impaired mitochondrial function, characterized by respir

153 ior research demonstrating that smokers have impaired inflammatory functioning compared with non-smok

154 Children on antihypertensive medication had impaired physical functioning compared with other LT pat

155 ophysiology of neurologic disorders in which impaired paranodal function contributes to clinical disa

156 Impaired physical functioning correlated with decreased

157 ng of the mouse EAE spinal cord reveals that impaired neurological function correlates with the depol

158 Impaired executive functioning creates a potential feedb

159 cise-induced cardiac myocyte hypertrophy and impaired cardiac function, demonstrating a role for ATF6

160 Class 2 represented severe asthma with impaired lung function despite high doses of steroids.

161 It is generally accepted that impaired immune function due to immunosuppression is a p

162 betes and heart failure, which are caused by impaired mitochondrial function due to the loss of frata

163 c inflammatory skin disease characterized by impaired barrier function, eczematous dermatitis, and ch

164 r 1.73 m(2); n=722) to 57%-61% with severely impaired renal function (eGFR<30 ml/min per 1.73 m(2); n

165 Impaired microglial function, either through aberrant ac

166 l pathways for stillbirth frequently involve impaired placental function, either with fetal growth re

167 better understand the mechanisms underlying impaired contractile function, electrophysiological stud

168 an oversupply can trigger lipotoxicity with impaired membrane function, endoplasmic reticulum stress

169 : +44%) shortly after exposure (30 min), and impaired motor functions (falls: +83%; time top: -43%; t

170 Impaired VAT function-for example, in obesity-is associa

171 esearch Council dyspnea scale score >1), and impaired lung function (forced vital capacity <=75% pred

172 Specificity decreased with impaired renal function from 93%-95% with normal functio

173 110 and 75 mg BID in patients with normal or impaired renal function (glomerular filtration rate >80

174 Conversely, Par4(-/-) mice showed impaired cardiac function, greater rates of myocardial r

175 on (group 1) or at least one examination and impaired renal function (group 2).

176 Control groups with normal and impaired renal function (groups 3 and 4) without history

177 Those with impaired graft function had more graft failures; however

178 Eighty-eight percent of patients with impaired graft function had rejection.

179 Those patients with impaired graft function had significantly lower estimate

180 siological causes remain uncertain, although impaired myometrial function has been implicated.

181 About 30% of patients with impaired cardiac function have ventricular dyssynchrony

182 Patients with ALD and impaired renal function have a higher risk of graft loss

183 ascular beds affected with atherosclerosis), impaired renal function, heart failure, and/or diabetes

184 bject fibroblasts and muscle biopsies showed impaired mitochondrial function, higher sensitivity to m

185 centration was significantly associated with impaired ventricular function, highlighting the importan

186 th CA during virion maturation, resulting in impaired capsid functions.IMPORTANCE To become infectiou

187 CN maturational profiles can reliably detect impaired attention functioning in youth.

188 es (DNMTs) in embryonic heart and results in impaired cardiac function in adulthood.

189 This study deepens our understanding of impaired cardiac function in diabetes, identifies GCH1 a

190 TNC deficiency further impaired cardiac function in response to pressure overlo

191 d altered cardiac metabolism at baseline and impaired cardiac function in response to stress.

192 ted the potential mechanisms responsible for impaired cognitive function in a mouse collagenase model

193 scent marijuana use is often associated with impaired cognitive function in adulthood.

194 Various components of impaired community functioning in schizophrenia followed

195 diet was efficient in triggering obesity and impaired contractile function in vitro; however, no card

196 R phosphorylation profile and stability, and impaired dPER function in the circadian negative feedbac

197 led to increased oxidative stress as well as impaired endothelial function in ApoE-deficient mice.

198 l mechanism of late up-regulation of EP4 and impaired gliding function in EP4cKO(S100a4) tendon repai

199 Human studies have implicated impaired glymphatic function in both AD and iNPH.

200 These defects were a consequence of impaired IP3R function in combination with defective STI

201 h in the immediate posttransplant period and impaired islet function in the longer term.

202 erebellum appear to be the most sensitive to impaired ITPR1 function in humans.

203 isk of HF and demonstrate a possible role of impaired kidney function in HF development in asymptomat

204 exacerbated cystic and fibrotic lesions and impaired kidney function in these mice, consequently lea

205 To investigate a mechanism underlying impaired lymphatic function in TBI, we examined how incr

206 alanced by an opposite effect resulting from impaired lymphatic function in ubiquitous Panx1-deficien

207 changes correlate with oxidative stress and impaired mitochondrial function in both PVI and pyramida

208 Furthermore, we found impaired mitochondrial function in hepatocytes of Zdhhc1

209 Furthermore, this led to impaired mitochondrial function in mouse muscle-an obser

210 te activation, enhanced M2 polarization, and impaired monocyte function in helminth-LTBI coinfection.

211 Metabolic syndrome also associates with impaired nerve function in people without polyneuropathy

212 in vitro and in vivo and has been linked to impaired neurocognitive function in humans.

213 These data indicate that impaired neurocognitive function in some children with C

214 Studies have shown impaired neurovascular function in several mouse models

215 BACE1-deficient T cells showed impaired pathogenic function in experimental autoimmune

216 growth and pathology, we generated mice with impaired RC function in cartilage.

217 I is associated with increased mortality and impaired renal function in the first postoperative year.

218 on of Hedgehog signaling rescues irradiation-impaired salivary function in animal models, but the und

219 homeostatic response gone awry and underlie impaired synaptic function in HAND.

220 e will also discuss potential mechanisms for impaired vascular function in BL women, as well as possi

221 ock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differ

222 let aggregation and secretion, indicative of impaired platelet function (increased bleeding tendency)

223 on or CRISPR/Cas9 genome editing resulted in impaired mitochondrial function, increased superoxide pr

224 ating gluten-specific CD4(+) T cells but had impaired suppressive function, indicating that Treg cell

225 structural states may be able to rescue the impaired motor function induced by disease mutations.

226 Thus, we propose that impaired AURKA function induces premature senescence by

227 Impaired conduit function is associated with impaired ea

228 he JAK1-deficient cells demonstrate that the impaired JAK1 function is mainly attributable to the eff

229 Impaired lung function is often caused by cigarette smok

230 work corroborates the emerging evidence that impaired mitochondrial function is a characteristic of a

231 Our results emphasize that impaired monocyte function is, at least in part, related

232 disease, in isolation of co-morbidities, to impaired muscle function is unknown.

233 nitive dysfunction is solely attributable to impaired renal function is unclear.

234 Impaired ALIX function leads to altered endosomal locali

235 kinesia (PCD) is a genetic disorder in which impaired ciliary function leads to chronic airway diseas

236 organism Drosophila melanogaster resulted in impaired locomotor function, learning, and short-term me

237 Altered protein turnover due to impaired COP1 function led to accumulation and enhanced

238 We propose that impaired mitochondrial function marks the progression fr

239 Potential safety concerns relative to impaired cognitive function may exist when high folic ac

240 Increased inflammation and impaired endothelial function may be pathways by which c

241 Furthermore, Ces3 inhibition led to impaired mitochondrial function measured by Seahorse.

242 Main Results: PDDE plus allergen coexposure impaired lung function more than DE plus allergen, parti

243 ith the potential to reverse and enhance the impaired mitochondrial function observed with aging and

244 ith excessive manganese accumulation was the impaired motor function observed in the Zip14 KO mice.

245 Impaired mitochondrial function occurred before intracel

246 Here we report that impaired channel function of TRPM7 in MKs causes macroth

247 An impaired mitochondrial function of atherosclerotic-MSCs

248 revented autoimmune disease and reversed the impaired suppressive function of Tregs in TregDelta142 a

249 In the soma, Smed-TTBK-d RNAi impaired the function of multiciliated epidermal cells i

250 Both HDACi also impaired the function of primary CD8(+) T cells in viral

251 rations on kidney function and the effect of impaired kidney function on dose-normalised deferasirox

252 ms of RCT, and highlight conditions in which impaired HDL function or RCT contributes to vascular dis

253 Objectives: To test the hypothesis that impaired lung function or lung disease in midlife is ass

254 nfants are predisposed to illness because of impaired lung function or whether respiratory illness re

255 nd epigenetic errors that eventually lead to impaired organ function or catastrophic transformation s

256 interval (CI): 1.104, 1.953; P = 0.008) and impaired kidney function (OR = 1.902, 95% CI: 1.054, 3.4

257 est a strong tracking of asthma activity and impaired lung function over time.

258 llation (P < .001), diabetes (P < .001), and impaired renal function (P < .001); and had higher N-ter

259 m testosterone level less than 275 ng/mL and impaired sexual function, physical function, or vitality

260 On longer-term follow-up, impaired microvascular function predicts adverse cardiov

261 For most PTCs, impaired secretion/function produced by readthrough-medi

262 e atrio-ventricular valves corresponded with impaired cardiovascular function (reduced ventricular be

263 Impaired physical functioning reduces the quality of lif

264 olecular and cellular mechanisms involved in impaired neutrophil function remain incompletely defined

265 olescence is a promising method of enhancing impaired hippocampal function resulting from early life

266 Impaired MCUC function, resulting from down-regulation o

267 iated with focal or global brain overgrowth, impaired TBCK function results in progressive loss of br

268 We used mice of both sexes to show that impaired Tcf4 function results in consistent microcephal

269 Impaired RV function (RV ejection fraction </=50%) was p

270 rmities, reduced larval growth and survival, impaired immune function, skewed sex ratios, ovarian atr

271 he entorhinal cortex (EC) is associated with impaired cognitive function such as in the case of Alzhe

272 Has2 KO ( Has2 deficient) mice showed impaired hemodynamic function suggesting a protective ro

273 ilencing Rev7 in primary hematopoietic cells impaired progenitor function, suggesting that the DNA re

274 physema classifications were associated with impaired pulmonary function tests, 6-minute walk distanc

275 AP-HSV showed impaired vasomotor function that was associated with inc

276 ult mice resulted in venous hypertension and impaired VV function that was associated with loss of EC

277 In subjects with normal to mildly impaired lung function, the mammalian target of rapamyci

278 s with opportunistic infections demonstrated impaired mitochondrial function, the mitochondrial quali

279 cates beta-lactam therapy, particularly with impaired renal function, though no studies have reported

280 Several studies have linked impaired AMPK function to peripheral metabolic diseases

281 The role of hyper-phosphorylation in impaired ETBR-function was supported by results in human

282 Impaired executive function was defined as a score >/=2

283 sociation between 4-hydroxyphenylacetate and impaired executive function was replicated in the second

284 Laboratory-evaluated impaired gonadal function was found in 24.3% of female a

285 Mechanistically, impaired Rab5 function was caused by reduced synaptic re

286 Impaired renal function was determined via urinary album

287 a gradient of increasing severity, all-cause impaired visual function was associated with adverse soc

288 Using mice with impaired cDC2 function, we ruled out a role for cDC2s in

289 ients with normal renal function, those with impaired renal function were older, were more often wome

290 Shorter fasting times and impaired renal function were significantly associated wi

291 UpperB exposure impaired mitochondrial function, whereas LowerB exposure

292 e.Conclusions: Coexposure to DE and allergen impaired lung function, which was worse after particle d

293 r people face a high risk of muscle loss and impaired physical function, which may contribute to sarc

294 4 in mice results in cardiac hypertrophy and impaired systolic function, which could severely limit t

295 cellular TFV-DP concentrations, both equally impaired barrier function, while wound closure was more

296 The LQT mutant K526E revealed a severely impaired channel function with a right shift in the volt

297 hear stress further deteriorates the already impaired endothelial function with attendant endothelial

298 (DSS-induced) colitis in C57Bl/6 mice led to impaired IEB function with reduced DSG2 mediated by p38

299 tion in HEK293 Tet-on G1 and G2 cells led to impaired mitochondrial function, with markedly reduced m

300 is revealed that the transgenic mice exhibit impaired diastolic function, without changes in systolic