ライフサイエンスコーパス: impaired insulin secretion

1 an autoimmune disease resulting in severely impaired insulin secretion.

2 tivity display decreased insulin content and impaired insulin secretion.

3 n is associated with beta cell apoptosis and impaired insulin secretion.

4 are reduced in CFRD, thereby contributing to impaired insulin secretion.

5 hich results in reduced ADCY5 expression and impaired insulin secretion.

6 sregulated cytosolic zinc homeostasis led to impaired insulin secretion.

7 permanent reduction in islet vascularity and impaired insulin secretion.

8 s ubiquitination and degradation and thus in impaired insulin secretion.

9 from Isl-1(L/L); Pdx1-CreER(Tm) mice showed impaired insulin secretion.

10 imal glucose intolerance, hyperglycemia, and impaired insulin secretion.

11 tance, indicating a plausible effect through impaired insulin secretion.

12 cassette (ABC) transporter ABCA1 results in impaired insulin secretion.

13 (Glp1r-/-) mice become hyperglycaemic due to impaired insulin secretion.

14 and apoptosis, decreased proliferation, and impaired insulin secretion.

15 ulated to be one of the main contributors to impaired insulin secretion.

16 ochondrial proteins, reduced respiration and impaired insulin secretion.

17 e strains developed glucose intolerance with impaired insulin secretion.

18 age 39 years and in two adult offspring with impaired insulin secretion.

19 xpression as well as reduced cAMP levels and impaired insulin secretion.

20 xpression and pancreatic insulin content and impaired insulin secretion.

21 Mitochondrial dysfunction resulted in impaired insulin secretion.

22 tes, are glucose intolerant, possibly due to impaired insulin secretion.

23 ell mass, increased beta-cell apoptosis, and impaired insulin secretion.

24 resentation of the specific peptide, or have impaired insulin secretion.

25 slet amyloid and leads to beta-cell loss and impaired insulin secretion.

26 levels leads to both insulin resistance and impaired insulin secretion.

27 s of the young [MODY]-3) is characterized by impaired insulin secretion.

28 Type 2 diabetes is characterized by impaired insulin secretion.

29 ssociated with selective beta-cell death and impaired insulin secretion.

30 ed protein tau as a key component underlying impaired insulin secretion.

31 sociated changes for OPRD1, PAX5, and SLC2A2 impaired insulin secretion.

32 Moreover, B cells from diabetic humans with impaired insulin secretion also had reduced SIX2 transcr

33 es is characterized by hyperglycaemia due to impaired insulin secretion and aberrant glucagon secreti

34 R-7a in beta cells developed diabetes due to impaired insulin secretion and beta cell dedifferentiati

35 e, early-onset hyperglycemia associated with impaired insulin secretion and beta-cell death.

36 zygous mutations of PAX6 are associated with impaired insulin secretion and early-onset diabetes mell

37 ucible ablation of LDB1 in mature beta cells impaired insulin secretion and glucose homeostasis.

38 renergic receptor (beta(2)AR) in age-related impaired insulin secretion and glucose homeostasis.

39 ing one or both HNF-3alpha alleles also show impaired insulin secretion and glucose intolerance after

40 t had increased body weight and fat mass and impaired insulin secretion and glucose regulation compar

41 -type (beta(2)AR(+/+)) littermates developed impaired insulin secretion and glucose tolerance.

42 tire Nnt gene in C57BL/6J mice rescues their impaired insulin secretion and glucose-intolerant phenot

43 locus for fasting insulin levels, acting via impaired insulin secretion and increased islet disruptio

44 At presentation, they have markedly impaired insulin secretion and insulin action, but inten

45 n receptor provides a potential link between impaired insulin secretion and insulin resistance.

46 t mice exhibited abnormal glucose tolerance, impaired insulin secretion, and changes in islet gene ex

47 ession of human IAPP causes beta-cell death, impaired insulin secretion, and diabetes mellitus.

48 mass, decreased pancreatic insulin content, impaired insulin secretion, and exacerbated glucose into

49 Asna1(beta-/-) mice develop hypoinsulinemia, impaired insulin secretion, and glucose intolerance that

50 s (T2D) is hallmarked by insulin resistance, impaired insulin secretion, and increased hepatic glucos

51 HtR were associated with a decreased risk of impaired insulin secretion, and NWCO by WC was additiona

52 Chronic exposure to stress causes impaired insulin secretion, apoptosis, and loss of cell

53 Impaired insulin secretion assessed by this index predic

54 0(-/-) mice exhibited increased weight gain, impaired insulin secretion, augmented accumulation of in

55 Loss of ABCG1 expression impaired insulin secretion both in vivo and in vitro, bu

56 2, the blockade of GLP-1 action resulted in impaired insulin secretion but limited deterioration of

57 played a pathological glucose tolerance with impaired insulin secretion but normal peripheral insulin

58 Impaired insulin secretion, but not insulin resistance,

59 ) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlyin

60 ells, resulting in elevated inflammation and impaired insulin secretion by triggering cGAS/STING acti

61 tive of this work was to investigate whether impaired insulin secretion can be restored by lifestyle

62 with NIDDM and 2) did not contribute to the impaired insulin secretion characteristic of NIDDM in Ca

63 -cell mass, decreased glucose tolerance, and impaired insulin secretion compared with WT mice 28 days

64 This resulted in impaired insulin secretion, decreased beta-cell mass, an

65 macroencapsulated islets have significantly impaired insulin secretion despite achieving normal fed

66 Tcf7(-/-) mice show impaired insulin secretion, deterioration of glucose tol

67 on might, as in the mouse model, result from impaired insulin secretion due a failure of insulin cont

68 lopment of peripheral insulin resistance and impaired insulin secretion due to pancreatic beta-cell f

69 of C2CD4A-linked polymorphisms, resulting in impaired insulin secretion during glucose tolerance test

70 Notably, impaired insulin secretion during T2D might be reversibl

71 ovides novel insights for the development of impaired insulin secretion during T2D progression.

72 Impaired insulin secretion from the pancreatic beta-cell

73 w chronic tissue inflammation results in IR, impaired insulin secretion, glucose intolerance, and T2D

74 ther demonstrate that SLC19A2 deficit causes impaired insulin secretion in conjunction with mitochond

75 ral role for the channel might contribute to impaired insulin secretion in diabetes.

76 Increased dietary fat was associated with impaired insulin secretion in hIAPP transgenic (P = 0.05

77 Both doses of BPA significantly impaired insulin secretion in male but not female F1 and

78 mber of risk alleles and type 2 diabetes and impaired insulin secretion in normoglycemic subjects (P

79 n in clonal MIN6 and INS1(832/13) beta-cells impaired insulin secretion in response to glucose plus f

80 This form of diabetes is characterized by impaired insulin secretion in response to glucose, but w

81 stingly, hepatic GK knock-out mice also have impaired insulin secretion in response to glucose.

82 murine Zranb3 in MIN6 beta-cells results in impaired insulin secretion in response to high glucose,

83 Type 2 diabetes is characterized by impaired insulin secretion in response to increased meta

84 levated glucose levels may contribute to the impaired insulin secretion in severe type II diabetes me

85 h increased mortality, but the mechanisms of impaired insulin secretion in this disease remain unclea

86 affirmed, leading to a novel hypothesis for impaired insulin secretion in type 2 diabetes and follow

87 The 1339A mice have markedly impaired insulin secretion in vivo and disrupted islet m

88 oth models exhibited glucose intolerance and impaired insulin secretion in vivo.

89 ion of beta-cell cholesterol homeostasis and impaired insulin secretion increase adiposity, reduce sk

90 Glucolipotoxicity impaired insulin secretion, increased apoptosis, and sig

91 Impaired insulin secretion is a characteristic of non-in

92 ough the physiological explanation as to why impaired insulin secretion is not accompanied by elevate

93 annels by oleoyl-CoA might contribute to the impaired insulin secretion observed in non-insulin-depen

94 Notably, pyruvate fully rescues the impaired insulin secretion of fission-deficient beta-cel

95 ns in this gene that might contribute to the impaired insulin secretion of NIDDM.

96 Hyperglycemia and/or insulin resistance impaired insulin secretion only from human islets in viv

97 of its overexpression elsewhere, results in impaired insulin secretion, reduced beta cell number and

98 l model, EndoC-betaH1, PAX4 knockdown led to impaired insulin secretion, reduced total insulin conten

99 similar crossover to glucose intolerance and impaired insulin secretion seen in Sur1 KO animals.

100 iabetes, but also the insulin resistance and impaired insulin secretion seen in type 2 diabetes.

101 This resulted in impaired insulin secretion, thereby connecting different

102 eveloped glucose intolerance attributable to impaired insulin secretion, together with reduced alpha-

103 y the biochemical mechanisms responsible for impaired insulin secretion, we used (31)P NMR measured m

104 n elderly men than elderly women, indicating impaired insulin secretion, whereas disposition indexes

105 Islets from donors with T2D exhibited impaired insulin secretion, which was more pronounced in

106 e beta cell-intrinsic NIK activation present impaired insulin secretion with DIO.

107 FAK-deficient beta-cells exhibited impaired insulin secretion with normal glucose sensing a