ライフサイエンスコーパス: impairment

1 problems, compared to people without vision impairment.

2 cue of amyloid-beta (Abeta) induced synaptic impairment.

3 n in vivo, providing clear evidence of RNF43 impairment.

4 stinct from, and synergistic with, cytotoxic impairment.

5 ultiple system atrophy can develop cognitive impairment.

6 patients to manage cancer-related cognitive impairment.

7 haracterized by tics that cause distress and impairment.

8 at astrocytes stand by in case of microglial impairment.

9 y associated with AD pathology and cognitive impairment.

10 associated with marked quality-of-life (QoL) impairment.

11 fects, endocrine disruption and reproductive impairment.

12 e an essential tool in assessing respiratory impairment.

13 o receive DEX implant for DME-related visual impairment.

14 eric FC was associated with higher levels of impairment.

15 ive neuropsychological testing for cognitive impairment.

16 virus (HCV) coinfection increases cognitive impairment.

17 mained the major cause for presenting visual impairment.

18 cipants met ADNI criteria for mild cognitive impairment.

19 with movement, and relates more to clinical impairment.

20 corneal diseases that lead to severe visual impairment.

21 y two radiologists and correlated with nerve impairment.

22 genetic) risk prediction models of post-BMT impairment.

23 odes, which negatively correlated with motor impairment.

24 isodes, it progresses to scarring and visual impairment.

25 and low estradiol mice, and predicted memory impairment.

26 ay be a means of selectively improving motor impairment.

27 military veterans (mtTBI) without cognitive impairment.

28 ive cytokine or chemokine in this setting of impairment.

29 viduals at high risk of developing cognitive impairment.

30 ion was not found in patients with cognitive impairment.

31 at included participants with mild cognitive impairment.

32 unction for older adults with mild cognitive impairment.

33 ulogram, lipofuscin accumulation, and vision impairment.

34 cular occlusions are common causes of visual impairment.

35 ement of patients with both cancer and renal impairment.

36 had moderate impairment, and 29% had severe impairment.

37 associated with anesthesia-induced learning impairment.

38 g loss, neural reorganisation, and cognitive impairment.

39 spontaneous pain and PNI-mediated cognitive impairment.

40 49 screening instruments to detect cognitive impairment.

41 chanisms underlying stress-induced cognitive impairment.

42 lower risk of incident dementia or cognitive impairment.

43 , endothelial cell density (ECD) and patient impairment.

44 +/- 13) scores were consistent with moderate impairment.

45 the hippocampus, alongside associated memory impairments.

46 time in the prevalence of these acute stroke impairments.

47 esia is due to storage rather than retrieval impairments.

48 ive devices in individuals with severe motor impairments.

49 ility to recover from initial lesion-induced impairments.

50 , cerebral insulin resistance, and cognitive impairments.

51 could potentially exclude people with visual impairments.

52 f survivors experience long-lasting physical impairments.

53 ral deficits, including intestinal and motor impairments.

54 is a brain disorder characterized by social impairments.

55 ) remain at high risk for neurodevelopmental impairments.

56 and those with increased number of limiting impairments 1.54 (1.11-2.14).

57 s four sedated patients) or severe cognitive impairments (16 nonsedated patients vs 17 sedated patien

58 me as: (1) new or worsening multidimensional impairments; (2) physical dysfunction; (3) psychological

59 ntia (or composite of dementia and cognitive impairment [3 trials]) on follow-up and were included in

60 uals and 204 individuals with mild cognitive impairment (320 [53%] were female) were classified into

61 l cognitive function, 17% had mild cognitive impairment, 33% had moderate impairment, and 29% had sev

62 n; (3) psychological disorder; (4) cognitive impairment; (5) failed social reconstruction; and (6) pe

63 tality in flies was accompanied by locomotor impairment, a common phenotype of neurodegenerative diso

64 In addition to cognitive impairment, a range of mental health disorders and suici

65 Concomitant impairment across multiple cognitive domains was common.

66 coordination strategy to identify and manage impairments across the continuum.

67 s emotional memory, and persistent REM sleep impairment after cocaine withdrawal negatively impacts r

68 seizures per se, are associated with memory impairment after temporal lobe seizures.

69 ical patients who reported subjective memory impairment (age range: 50-83 years).

70 e (AS) are characterized by severe cognitive impairments alongside an enhanced drive for social engag

71 al interventions for amnestic mild cognitive impairment (aMCI) patients.

72 Prevalence of visual impairment among adults was found to be a significant pu

73 ed the prevalence and consequences of visual impairment among aging long-term survivors of HIV.

74 estradiol experienced stress-induced memory impairment and a loss of underlying synapses.

75 D); however, it is unclear how mitochondrial impairment and alpha-synuclein pathology are coupled.

76 and one pure ADNC) donors had mild cognitive impairment and another two donors with LATE-NC did not h

77 initial surgical success, to prevent visual impairment and blindness.

78 n comparison to patients with mild cognitive impairment and control subjects.

79 eneration, which prolongs epithelial barrier impairment and creates an environment in which disease r

80 ctor for vascular contributions to cognitive impairment and dementia (VCID), particularly in women.

81 sociated to CSF biomarkers in mild cognitive impairment and dementia patients.

82 Cognitive Impairment and Imaging Correlates in End Stage Renal Dis

83 hylococcus aureus sepsis induces CD4+ T-cell impairment and increases susceptibility to secondary pne

84 s underlying alcohol-related cognitive/motor impairment and inform interventions for addiction.

85 tic connectivity is linked to working memory impairment and is specific to repeated exposure to multi

86 Functional impairment and loss of dental enamel, caused by developm

87 Neuronal impairment and neurodegeneration caused by ATP6V1A defic

88 rtially rescued beta-amyloid-mediated memory impairment and neuropathology.

89 ned the association (P < .05) between vision impairment and oral health outcomes by age group, sociod

90 There is a strong association between vision impairment and poorer oral health of adults; adults aged

91 f Wnt6 to the amygdala ameliorates locomotor impairment and social behavioral deficits in these anima

92 The dopaminergic system impairment and the affection of the rod pathway through

93 emporal lobe epilepsy, and rescued cognitive impairment and transcriptomic alterations associated wit

94 er's disease (AD) suffer from spatial memory impairment and wandering behavior, but the brain circuit

95 fore, abnormal glucose metabolism, cognitive impairment and widespread disruption of WM structure occ

96 posterior vermis improved social preference impairments and repetitive/inflexible behaviors, respect

97 n = 14 with amyloid-positive mild cognitive impairment) and 29 healthy control subjects underwent ba

98 factors (for example, pre-existing cognitive impairment) and precipitating factors (for example, urin

99 gn tumor (nonmalignant tumor with functional impairment), and those with a history of malignancy (exc

100 mild cognitive impairment, 33% had moderate impairment, and 29% had severe impairment.

101 espiratory symptoms and severe lung function impairment, and an increased risk of acute respiratory h

102 osis, hypotonic stature, seizures, cognitive impairment, and developmental delay.

103 Seizures, memory impairment, and increased protein content in cerebrospin

104 nosis during the present illness, neurologic impairment, and presence of an enteral feeding tube.

105 (Felis catus) are known to develop cognitive impairment, and several small series have demonstrated b

106 with numerous symptoms, including cognitive impairment, and shortened lifespan.

107 s may not have excluded clinically important impairment, and the doses tested may not represent commo

108 1 in regulating sensitivity to Abeta-induced impairments, and suggest that inhibition of PME-1 may co

109 1, increase per 10x9 decrease), severe renal impairment (aOR 5.14, 95%CI 2.65-9.97), and low albumin

110 become abnormal long before severe cognitive impairments appear, increasing evidence suggests that su

111 This impairment appeared to critically involve inhibitory neu

112 Cognitive impairments are a particularly disabling feature of majo

113 symptoms of MAS, including neuropsychiatric impairments, are associated with increased PDE4 activity

114 Cognitive impairment as detected by the ECAS is a valid predictor

115 Motor impairment, assessed by ad hoc clinical scales, was corr

116 The likelihood of visual impairment associated with DR is two-fold higher in the

117 idence of death or severe neurodevelopmental impairment at 2 years of age (97 children [26%] vs. 94 c

118 improve survival without neurodevelopmental impairment at 22 to 26 months of age, corrected for prem

119 ients with frailty, disability, or cognitive impairment at 3-month follow-up.

120 Three participants (33%) had NC impairment at baseline and 2 (22%) remained impaired at

121 g Center on participants with mild cognitive impairment at baseline and either no neuritic plaques (i

122 KD, and regardless of the severity of kidney impairment at baseline.

123 n, but it is hard to correlate the degree of impairment at molecular level with the severity of sympt

124 The prevalence of visual impairment based on presenting visual acuity value was 2

125 Finally, mtFAS impairment blocks the differentiation of skeletal myobla

126 iers and more severe in those with cognitive impairment, but is not related to amyloid-beta or tau pa

127 D) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a bro

128 dent ER protein disulfide formation and such impairment can be caused by reductive stress in the ER,

129 Visual impairment can be estimated with corneal densitometry.

130 Visuomotor impairments characterize numerous neurological disorders

131 re-II (LVP-FVQ-II), and the Impact of Vision Impairment-Children (IVI-C) questionnaire.

132 s a composite of death or neurodevelopmental impairment (cognitive delay, cerebral palsy, or hearing

133 She presented with mild intellectual impairment, convergent strabismus, horizontal gaze palsy

134 type, the prevalence of 3 out of the 8 acute impairments declined during the 18-year period, includin

135 disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson's disease, supportin

136 Importantly, these impairments do not seem to be accompanied by biomarker e

137 and empirical data that both enhancement and impairment effects are robust phenomena but predominate

138 G are at moderate risk of neuropsychological impairment, especially for visual perception and cogniti

139 evere CRSwNP and substantial quality of life impairment evidenced by a mean NPS higher than 6 and SNO

140 resent study is to characterize neurological impairment following TBI in rats with an unrepaired cran

141 evere impaired domains in the mild cognitive impairment group, attention and visuospatial function do

142 ious impaired domains in the major cognitive impairment group.

143 le with isolated substantial relative memory impairment had >=1 APOE epsilon4 allele than any other s

144 All patients with cognitive impairment had TDP-43 pathology in extramotor brain regi

145 End-organ impairment has received relatively little research atten

146 ological consequence of circadian governance impairment (ie, the bad); and (3) whether persistence/au

147 us autofluorescence (qAF), indicated chronic impairment in 11-cis-retinal availability and provided i

148 least 15 d in rats who display a significant impairment in acquisition of place learning in the Morri

149 ulative incidence of glaucoma-induced visual impairment in at least 1 eye increased from 0.00 after 5

150 trations in serum associated with a stronger impairment in cognition and a higher permeability of the

151 rders, but are also a contributing factor to impairment in cognitive domains such as memory and perce

152 Children cohort showed significant cognitive impairment in combination antiretroviral therapy (cART)-

153 atdro1 primary and lateral roots showed impairment in establishing an auxin gradient upon gravis

154 in healthy ageing, and thus the age-related impairment in functional sympatholysis probably results

155 ated in auditory processing deficits such as impairment in gap detection.

156 ther, these data show that hepatic autophagy impairment in GSD-Ia is mediated by downregulation of SI

157 y its dysfunction is implicated in cognitive impairment in humans.

158 arrier (CEB) function in mice with a genetic impairment in intestinal epithelial barrier function, ju

159 The prevalence of visual impairment in Kenya is associated with age.

160 etween education in early life and cognitive impairment in later life in Colombia.

161 Stroked animals developed impairment in long-term memory at 4-weeks post-stroke de

162 ipheral immune stimulation is accompanied by impairment in long-term potentiation (LTP) and spatial l

163 findings support a causal role of pulmonary impairment in lung cancer etiology.

164 rders predicted cognitive and/or behavioural impairment in motor neuron disease (MND).

165 314 mediates synaptic dysfunction and memory impairment in mouse and cellular models of neurodegenera

166 rus replication in the thymus, indicating an impairment in negative selection.

167 Our aim was to assess EPM impairment in OA dogs compared to controls using CPM.

168 We investigated the dose dependence of the impairment in oculomotor and ocular behaviours caused by

169 Cognitive impairment in participants with Down syndrome was classi

170 level variants are associated with cognitive impairment in patients with hematologic malignancies tre

171 Data on bone health and renal impairment in people with human immunodeficiency virus (

172 lations, but their contribution to cognitive impairment in schizophrenia has not been investigated.

173 ysis or with a kidney transplant): (1) Renal Impairment in Secondary Care (RIISC, Queen Elizabeth Hos

174 This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and p

175 t the case in wild-type animals, and worsens impairment in spatial learning following chronic hippoca

176 nce of frailty with disability and cognitive impairment in survivors of critical illness.

177 ced the brain Abeta deposition and cognitive impairment in Tg-SwDI mice.

178 interact with its host result in significant impairment in the ability of S. aureus to cause infectio

179 vered that the S1pr2 absence is linked to an impairment in the skin barrier function.

180 ular degeneration is a major cause of vision impairment in the Western world among people of 55 years

181 80% decrease, the mice displayed only subtle impairment in their motor functions.

182 tion (LTP) in transplant recipients, and LTP impairment in TRANSWT mice was IL-1 dependent.

183 therapeutic target for attenuating cognitive impairment in VaD.

184 at can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) s

185 esents a good marker of cognitive inhibition impairments in C9+ and of proximity to clinical conversi

186 k promotes sleep, in many cases resulting in impairments in cognitive performance and brain functioni

187 Though several studies suggest impairments in depressed individuals in single tasks, th

188 by which Tip60 protects against neurological impairments in different NDs via similar modes of action

189 of NK cells, human STAT5b mutation leads to impairments in early activation events in NK cell lytic

190 nt of invasive aspergillosis correlates with impairments in innate immunity.

191 d metabolic syndrome (MetSyn) rats exhibited impairments in its intrinsic phasic contractile activity

192 ans, early-life adversity is associated with impairments in learning and memory that may emerge later

193 ring simultaneously result in spatial memory impairments in males, but effects on females are unknown

194 The reviewed literature suggests that impairments in medial and lateral VPFC regions and their

195 o describe new or worsening multidimensional impairments in physical, psychological cognitive and soc

196 s with svPPA manifest marked lexico-semantic impairments including difficulties in reading words with

197 ogz deficient mice show microcephaly, growth impairment, increased sociability, learning and motor de

198 these relationships to develop an integrated impairment index of Hg risk to aquatic ecosytems and fou

199 etes mellitus (T2DM) show cognitive and mood impairment, indicating potential for brain injury in reg

200 nderstanding mechanism(s) that underpin this impairment is a critical gap.

201 These are the first data showing that EPM impairment is associated with canine OA pain.

202 Long-term cognitive impairment is common among ICU survivors, but its natura

203 Social impairment is frequently associated with mitochondrial d

204 Despite this, the etiology of the cognitive impairment is poorly understood, and no satisfactory cog

205 0, the burden of global blindness and vision impairment is set to reach historic levels in the coming

206 and reading domains of the Impact of Visual Impairment (IVI) questionnaire.

207 Visual impairment, low vision, and blindness were defined accor

208 ntions are safe for cancer-related cognitive impairment management.

209 impair visual working memory, and that this impairment may be related to both increased mind wanderi

210 It is currently unclear whether hearing impairment may impair the ability to use selective atten

211 Memory disruption in mild cognitive impairment (MCI) and Alzheimer's disease (AD) is poorly

212 of sleep characteristics with mild cognitive impairment (MCI) have been examined in cross-sectional,

213 = 22), preclinical AD (pAD) + mild cognitive impairment (MCI) without SCeVD (pAD/MCI without SCeVD, n

214 mpal subfield analysis of AD, mild cognitive impairment (MCI), and healthy subjects.

215 th dementia and its prodrome, mild cognitive impairment (MCI), which are characterized by deficits in

216 ized prevalence of moderate-to-severe vision impairment (MSVI) across all world regions since 1990.

217 uded CD diagnosis during adolescence, growth impairment, NOD2/CARD15 polymorphisms, disease behavior,

218 dividual level were validated with empirical impairment observed at later time points of white matter

219 n are thought to contribute to the cognitive impairments observed in Alzheimer's disease patients.

220 This suggests that functional impairment of A1/C1 CA neurons resulting from antecedent

221 lipid anabolism and, more specifically, the impairment of anabolic flux from glucose to cholesterol

222 Thus, broad impairment of antigenic responses, including autoantigen

223 eased translation of IgG mRNA, but rather to impairment of autophagy.

224 The impairment of catalysis by Tyr68Ala can be understood in

225 ssociation between IL-6 serum levels and the impairment of cytotoxic activity suggests the possibilit

226 ich may explain the mechanism underlying the impairment of DCs in RLN induced by FTY720.

227 peutic target to attenuate manganese-induced impairment of dopamine transmission.SIGNIFICANCE STATEME

228 he causal pathway between macular damage and impairment of facial recognition.

229 e pathomechanisms leading to CSSs, including impairment of granule-mediated cytotoxicity, specific vi

230 sible LDs, glucose-responsive lipolysis, and impairment of GSIS after ATGL silencing.

231 and ventilation/perfusion matching, without impairment of hemodynamics or right heart function.

232 ausative link between serum HBsAg levels and impairment of intrahepatic CD8+ T cells has not been est

233 ed the Delta(9)-tetrahydrocannabinol-induced impairment of motor coordination in mice.

234 Impairment of muscle biogenesis contributes to the progr

235 of PV(+) neurons, and that inhibition of the impairment of NR2B/PSD-95/MAP1A pathway, may be a novel

236 Impairment of PRC1 enzymatic activity does not directly

237 (3.0%) had GERD associated with significant impairment of quality of life.

238 Besides, IS contributes to the impairment of spatial memory and motor coordination.

239 privation may account, at least in part, for impairment of specific CRRs critical for restoration of

240 tance potassium channel, SK2, contributes to impairment of synaptic plasticity and learning in AS mic

241 lantation mammalian embryo and indicate that impairment of the Hippo signaling pathway could be a mol

242 n of different efflux pumps is linked to the impairment of the quorum sensing (QS) response.

243 on of early stage DCTs into mature DCTs, and impairment of their terminal differentiation owing to la

244 Our results depict the temporal impairment of vascular function over the lifespan in mic

245 lesion location and the specific functional impairments of each subject since these variables can ma

246 ic neurons was sufficient to reestablish the impairments of social interaction and working memory aft

247 th the 1q25 risk allele in HUVECs, including impairments of the gamma-glutamyl cycle and methylglyoxa

248 tients in the SLSR had a complexity of acute impairments, of which limb motor deficit, dysphagia, and

249 the last blast) also prevented sensorimotor impairment on a rotarod task 30 days later, long after L

250 xus cell cultures restored the Abeta-induced impairments on autophagy flux and apoptosis in a calcium

251 educed levels of HDL cholesterol and glucose impairment) on the phenotype of LRRK2 and GBA Parkinson'

252 e the estimated median age at mild cognitive impairment onset of 44 years), although the ability of p

253 Dysregulation, impairment or inadvertent activation of complement compo

254 CO, or DLCO percentage predicted), cognitive impairment, or depression.

255 lived with disability (YLDs) of 25 diseases, impairments, or bespoke aggregations of sequelae that we

256 Prevalence ratios comparing impairments over time were also calculated, stratified b

257 ed p-tau217 compared to other mild cognitive impairment patients (beta = 0.79, P < 0.001).

258 Mild cognitive impairment patients who later converted to Alzheimer's d

259 after ECT can track patients' verbal memory impairments (r = 0.613, p = 0.008).

260 are at a particularly high risk for serious impairment relative to others with these disorders.

261 adults; adults aged 40-64 years with vision impairment reported 90%-150% greater odds of oral health

262 -toxic dose of MPTP resulted in severe motor impairment, selective loss of dopamine neurons and incre

263 ely contributing to stress-induced cognitive impairment.SIGNIFICANCE STATEMENT Repeated exposure to s

264 the treatment of disorders involving memory impairments.SIGNIFICANCE STATEMENT The dentate gyrus (DG

265 a few individuals with potential age-related impairments significantly affected the general age traje

266 ber of patients with mild/moderate cognitive impairments (six nonsedated patients vs four sedated pat

267 age extracellular Abeta burden and cognitive impairment, suggesting that preclinical/prodromal YAP-de

268 pathy, cerebral gray matter atrophy), visual impairment, testicular dysgenesis in males and sudden de

269 exhibiting greater metabolic stress-induced impairments than females.

270 explanation is that p represents an index of impairment that has the potential to inform the duration

271 he functional, morphological, and structural impairments that characterize the diabetic heart are con

272 ficient mice exhibited olfactory sensitivity impairments that correlated with an age-dependent reduct

273 Early impairments to neurovascular coupling have been proposed

274 We confirmed that stroke results in impairments to specific motor domains linked to the dama

275 Impairments to the pathways that transform all-trans-ret

276 Visual impairment (VI) can have a detrimental impact on vision-

277 e of falls and their association with visual impairment (VI) in elderly residents in 'homes for the a

278 havioral and medical risk factors for visual impairment (VI).

279 at myopia is a high-priority cause of visual impairment, warranting a timely evaluation and synthesis

280 , 279 (52%) were employed, and mean activity impairment was 24.5%.

281 re-tumor and tumor stages, hepatic autophagy impairment was attributed to downregulation of SIRT1 sig

282 SPPB impairment was defined as a score of <=10.

283 Cognitive impairment was defined as the lowest tertile in the main

284 The mean prevalence of cognitive impairment was higher with objective rather than subject

285 SPPB impairment was highly prevalent in KT candidates.

286 scores, the hazard of substantive cognitive impairment was reduced by 14% in those assigned dulaglut

287 ients with widely distributed focal cortical impairments, we derive lesion-deficit maps of a broad ra

288 ere congestive heart failure or severe renal impairment were excluded.

289 gnosis of neurological disorder or cognitive impairment were exclusion criteria.

290 Cortical perfusion and CA impairment were heterogeneously distributed across the e

291 Functional impairments were assessed during hospitalization via dir

292 These impairments were prevented in MCSFA-HFD, accompanied by

293 per deciliter) or level 3 (severe cognitive impairment) were low (icodec group, 0.53 events per pati

294 roQol-5D, and Work Productivity and Activity Impairment) were prospectively collected.

295 Who should be screened for long-term impairments, what tools to use, and when remain unclear.

296 ompanied by hemorrhagic lesions and neuronal impairment, which are largely described processes in psy

297 icipants, or in patients with mild cognitive impairment who did not convert to Alzheimer's disease de

298 zes around oocyte-derived centrioles, kinase impairment with BI-2536 does not protect centrioles from

299 ies have suggested higher rates of cognitive impairment with restrictive transfusion thresholds.

300 fections comprise a leading cause of newborn impairments worldwide and are pervasive concerns among t