ライフサイエンスコーパス: impede

1 d acts on RNA polymerases when elongation is impeded.

2 replication, entry, and stability were often impeded.

3 ight two key knowledge gaps that continue to impede a comprehensive understanding of non-consumptive

4 lation of PU.1 and GATA2 in the fetal liver, impeding a key step required for commitment to erythroid

5 countervailing effects on people's health by impeding access to dental care.

6 ncludes overlapping spliced units that would impede accurate m(6)A mapping using short-read sequencin

7 of presenilin-1 (PSEN1) function causing AD impedes acidification via defective vacuolar ATPase (vAT

8 uripotent stem cell (iPSC) reprogramming and impedes acquisition of induced pluripotency.

9 sin, which position tropomyosin such that it impedes actomyosin associations.

10 ecapitulate the different molecular subtypes impedes adequate preclinical testing of stratified thera

11 iquitination and the proteasome may together impede aggregate formation.

12 structures and behaviors that accelerate or impede aims; b) developing understanding and agreement o

13 grees of freedom of the multielement systems impede an effective strategy for the design and optimiza

14 rm of cell death triggered when apoptosis is impeded and is dependent on RIPK3 phosphorylation of MLK

15 first-of-its-kind biphasic manner, initially impeded and then facilitated with increasing Zur concent

16 These GSLs sterically impeded antibody and receptor interactions with HLA-I an

17 nd the matrix layer have not been available, impeding antiviral targeting and understanding of the pH

18 tein increases viral transcript stability by impeding ARS2-dependent decay, ARS2 knockdown has only m

19 the CRE lineage can compromise viability and impede auditory analyses.

20 f (N(g))~ 0.84 (per particle) resulting from impeded Auger recombination, along with a large absorpti

21 ion or Cbls ligase activity is sufficient to impede BCR-mediated antigen processing and GC developmen

22 ng of most receptors in close proximity, but impedes beta-arrestin recruitment by all receptors teste

23 via direct interaction with the virion that impeded binding to the plasma membrane.

24 the DNA wrapping around the histone core and impeding binding of DNA-associated proteins, such as tra

25 ative binding and filament severing has been impeded by a lack of structural data describing boundari

26 cytosolic aspartate (Asp) and NAA, which is impeded by aralar deficiency, presumably through citrate

27 n of EGFR, whose signaling activities can be impeded by cetuximab.

28 Their broader adaption, however, has been impeded by cost and lifetime.

29 ernal and neonatal deaths and stillbirths is impeded by data gaps, especially regarding coverage and

30 However, the development has been impeded by difficulties in N(2) adsorption, protonation

31 iral separation that has conventionally been impeded by insufficient yield and low enantiomeric exces

32 orts to construct complex circuits are often impeded by our limited knowledge of the optimal combinat

33 defects behind beta-thalassemia is severely impeded by paucity of material from patients and lack of

34 Cell migration and differentiation were also impeded by SCM.

35 Vesicle motion is in turn impeded by shutting off axonal actin polymerization, med

36 is necessary; however, this has been largely impeded by the cellular diversity of cardiac tissue and

37 diovascular and immune systems, is currently impeded by the dearth of tools to deliver this gaseous m

38 Efforts to quantify behavior at scale are impeded by the fact that our methods for measuring human

39 tomical-functional characterization has been impeded by the inability to selectively label and manipu

40 n of lithium-metal batteries (LMBs) is still impeded by the instability of the interphase between the

41 However, the study of RaF has been impeded by the lack of stable isotopes of radium.

42 hese membrane-bound enzymes has been greatly impeded by the lack of structural information.

43 tal stroke, but translation to the clinic is impeded by the large doses needed.

44 ult-onset neurodegenerative disease has been impeded by the limitations of available animal models in

45 However, uptake of CPL spectroscopy has been impeded by the limitations of conventional scanning mono

46 Care delivery for HHT patients is impeded by the need for laborious, repeated phenotyping

47 tients across multiple institutions is often impeded by the privacy concerns of sharing personal geno

48 iomyopathy and gastrointestinal pathology is impeded by the sequestration and replication of T. cruzi

49 metals shows that their recycling is mainly impeded by their low concentrations.

50 geted therapies in cancer treatment has been impeded by various mechanisms of resistance.

51 acid and N-acetylglucosamine utilizers that impedes C. difficile's access to these mucosal sugars an

52 iciently suppresses repeat expansion without impeding canonical mismatch repair activity.

53 al depressions in water potential, which may impede carbon export from leaves during the day because

54 ap, which increases the carrier mobility and impedes carrier recombination.

55 133 to 136 (CC4), retained the potential to impede CD58 surface presentation.

56 Consistently, the transfection of each miRNA impeded cell migration.

57 The Q8 deficiency impeded cellular O(2) uptake and also inhibited the acti

58 Mutation of this hydroxyl to a methyl group impedes clamp binding and opening, DNA binding, and ATP

59 river discharge are poorly understood, which impedes climate-change adaptation.

60 apid testing of the patient immune response, impeding clinicians from providing appropriate sepsis tr

61 ions obscured dechlorination by D. mccartyi, impeded ClO(4)(-) reduction, and enhanced SO(4)(2-) redu

62 sistent with their anchors being pause sites impeding cohesin-dependent loop extrusion.

63 ant measurements of the ascending aorta that impede, complicate, and impair appropriate clinical asse

64 structure and supporting primary literature, impeding consensus when evaluating variants and their re

65 t that bursty interaction patterns generally impede cooperation.

66 Intrafamily homology has impeded correlation of expression of individual PE_PGRS

67 that the flagship species approach does not impede cost-effective conservation.

68 s (Avialae) and their closest relatives have impeded deeper understanding of early theropod flight.

69 Anastomosis may be favored or impeded depending on the mechanical configuration of str

70 n and augmenting cell-cell adhesion does not impede detachment.

71 y (Fisher grade <= 3 vs. 4; P = .33) did not impede detection sensitivity or segmentation performance

72 our understanding of CM pathogenesis that is impeding development of therapeutics.METHODSUsing multip

73 tures help overcome activation barriers that impede diffusion and reactions.

74 e, but not negative, net charges drastically impedes diffusion, and that the rate is determined by th

75 faults (SFs) contribute to strengthening by impeding dislocation motion, the contribution of SF stre

76 S (p)-nBu-PTEs at XT sites did not strongly impede DNA replication, and other nBu-PTEs displayed mod

77 machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic i

78 Mechanistically, 6-4PPs, but not CPDs, impeded DNA replication across the genome as revealed by

79 GDC or siKRAS monotherapy each impede downstream signaling, leading to some delay in ce

80 hmC profiles in different human tissue types impedes drawing generalized conclusions about how 5hmC i

81 that glutamatergic AON projections to the OB impede early olfactory signaling by inhibiting OB output

82 are time-consuming and take days to result, impeding early diagnosis.

83 wever, the barrier function of the epidermis impedes effective permeation of siRNA into the skin.

84 ons of the ANS and SAN to HRV are not clear, impeding effective treatment.

85 ation are costly, lengthy, conservative, and impede efficient drug development.

86 ivation, and the structural diversity of OPs impedes efficient reactivation.

87 omplexity caused by electrodes in the system impedes efficient screening of reaction conditions.

88 c transcription errors, and technical noise, impeding efforts to elucidate the mechanisms linking TEE

89 viral glycoproteins are highly diversified, impeding efforts to isolate cross-neutralizing antibodie

90 Similarly, insect eggs trigger defenses that impede egg development or attract predators, but informa

91 Puzzlingly, this form is predicted to impede electrical conduction to an extent that appears i

92 Moreover, this heterojunction impedes electrons transferring from BiCuSeO to Cu(2) Se,

93 (AKAP8) as a splicing regulatory factor that impedes EMT and breast cancer metastasis.

94 s EVs from metabolically active trophozoites impeded encystation.

95 Notably, PSEN1 loss of function impedes Endoplasmic Reticulum (ER)-to-lysosome delivery

96 g, and that manipulation of this pathway can impede endothelial disruption and lung dissemination in

97 , ApoC3 activated human monocytes in vivo to impede endothelial regeneration and promote kidney injur

98 and hydrogen-bond with anionic chain ends to impede epoxide ring opening.

99 physical and net biological processes which impede equilibrium with the atmosphere.

100 t low sample sizes and subject heterogeneity impede establishment of statistically significant differ

101 toxicity data on electronic cigarette (ECIG) impede evidence-based policy recommendations.

102 Moreover, 8-oxo-guanine impedes EXO1 but enhances resection by BLM-DNA2, and an

103 ever, the best methods for efficient capture impede facile release.

104 is blocked, sheath contraction is inhibited, impeding follicle regression and niche relocation.

105 und challenges supporting clinical workflow, impeding frontline clinicians' ability to deliver safe,

106 limitation of plasticity in the adult brain impedes functional recovery later in life from brain inj

107 t among different model sources and versions impedes further progress.

108 ia unexpectedly hindered parasite control by impeding germinal center responses.

109 ersities that undermine healthy development, impeding growth in the social-emotional and language ski

110 g of embryonic/fetal globin gene expression, impeding hemoglobin switching during erythroid different

111 uces the degradation of a factor, REAF, that impedes HIV infection in macrophages.IMPORTANCE For at l

112 overly similar to that of the host severely impeded host translation.

113 iers, the blood-brain barrier (BBB) strongly impede hurdle for drug transport to brain.

114 e GC engagement of the coronary ostium might impede hyperemic flow, and therefore impact FFR measurem

115 overage of CNV on SS-OCTA en face images may impede identification of CNV.

116 dicating a possible autoinhibitory loop that impedes IFN production by pDCs.

117 cyte glycolysis, while glycolysis inhibition impeded IFNbeta-driven intra-adipocyte inflammation.

118 paper, both polymer and elemental impurities impede in many cases closed-loop recycling and require a

119 oietic stem and progenitor cells (HSPCs) are impeded in AML-infiltrated bone marrow (BM).

120 Genetic adaptation was impeded in highly variable regimes by nongenetic modific

121 However, these cells, when starved, were impeded in the epimastigote to trypomastigote transition

122 id (BIA) family of THIQs, low product titers impede industrial viability and limit access to the full

123 Loss of Mst1 alone or together with Mst2 impedes iNKT cell development, associated with defective

124 SPRR3 deletion did not impede integrin-associated functions including cell adhe

125 e in HBV transcription regulation, via their impeded interaction with cccDNA and altered recruitment

126 red LPP localization to adhesions (mLIM1) or impeded interactions with the actin cytoskeleton via alp

127 host glycosylation of the vaccine target can impede its antigenicity and immunogenicity.

128 ntrol measures are likely to be necessary to impede its progress in these countries.

129 sterically activated by H3K27me3 at CGIs and impede its spreading.

130 ssical arsonium-ylide that have historically impeded its wider study.

131 and years old(5-7)-its unsystematic recovery impedes its accurate dating and placement in human evolu

132 sive fragmentation to these compounds, which impedes its effectiveness.

133 utcompete a large fast-growing population by impeding its migration into the patch, while a small fas

134 odal transcranial direct current stimulation impedes learning mediated by this mechanism, thus potent

135 Moreover, in Xenopus, loss of Strap leads to impeded lineage differentiation in embryos, delayed neur

136 MA1 inhibits the endocytosis of AIS NF186 by impeding Lis1's interaction with doublecortin, a potent

137 f OCA and SUMOylation inhibitors drastically impedes liver fibrosis induced by CCl(4), bile duct liga

138 s for comedications in this aging population impeded lower rates of PDDIs.

139 fabrication process limits on-target design, impeding material diversity and available applications.

140 We found that A-to-I editing impedes MDA5 sensing and sequestration of dsRNAs encodin

141 This gap currently impedes mechanistic models from accurately predicting me

142 The absence of FIGLA significantly impedes meiotic progression, causes DNA damage and resul

143 rically effect its cleavage and subsequently impede metastasis of breast cancer to lung in a mouse mo

144 matin landscape of mesenchymal stem cells by impeding methylation at lysine 36 on histone H3 (H3K36)

145 extent to which these interactions drive or impede microbiome diversity is not well understood.

146 ion is enriched in G-quadruplex regions that impede mitochondrial DNA replication.

147 subtle modifications, and large sizes often impede molecular characterization.

148 lly requires intensive training and thus can impede molecular studies that often require large number

149 of water to centralized laboratories, which impedes monitoring of trace-level pollutants in many res

150 d bias Tpm to an azimuthal location where it impedes myosin attachment.

151 of juvenile oysters that reduces fitness and impedes natural and artificial repopulation of the oyste

152 We establish that missense KIF21B variants impede neuronal migration through attenuation of kinesin

153 Nono deletion impedes neuronal lineage commitment largely due to a fai

154 dicating these structurally diverse proteins impede Nhp6A mobility on DNA.

155 rotein inhibits biofilm formation by Nm, and impedes Nm adhesion and invasion of human airway cells.

156 which structurally links these two pathways, impede normal conformational cycling and metal transport

157 g hematite more negatively charged and hence impeding NTO adsorption.

158 Loss of WASp impedes nuclear translocation of GOLPH3 and its colocali

159 quitin ligase which dephosphorylates IkB and impedes nuclear translocation of RelA (p65), thus repres

160 However, details of the mechanism that impedes nucleation are broadly considered irrelevant.

161 This large discrepancy impedes OCE's clinical adoption.

162 disease periods, which are also expected to impede onward transmission.

163 he postacute phase of traumatic brain injury impede optimal recovery and contribute substantially to

164 tation of prevention policies has often been impeded or delayed due to the lack of randomized control

165 us-specific cellular response but also might impede other NR pathways involving RXRalpha.

166 and interactions with co-occurring stressors impede our ability to predict their ecological impacts.

167 This has impeded our ability to accurately track the spread of SA

168 enges posed by these properties have greatly impeded our understanding of sHSP structure and mechanis

169 table physiological model of shigellosis has impeded our understanding of this important human diseas

170 processes remains largely unexplored, which impedes our understanding and limits rational improvemen

171 ropod groups remain disputed(1,2,4,7), which impedes our understanding of the evolutionary gap betwee

172 t correlations exist between feature spaces, impeding our ability to determine their relative contrib

173 of the autophagy cargo receptor p62/SQSTM1, impeding p62 autophagy flux.

174 rect contact with cells than from physically impeded particles, suggesting the possibility for altern

175 sugars in situ as well as their potential to impede pathogen colonization.

176 en together, pan-EGFR inhibition by afatinib impedes PCSCs growth and metastasis via the EGFR/ERK/FOX

177 ted environments stabilizing empty MHC I and impeding peptide rebinding.

178 is at the 30% level, inter-study variability impedes performance of universal thresholds at the 70% l

179 However, impeding PERK-phosphorylation through the administration

180 gests that such alterations could promote or impede plant immunity, depending on the nature of the al

181 tion responsible for Duffy negativity, which impedes Plasmodium vivax infection, has reached high fre

182 the causes and consequences of size declines impedes prediction, prevention, and mitigation.

183 ecific anatomic sites for this age group has impeded prevention and early detection programs in the U

184 However, clinical translation is impeded primarily due to limited drug penetration from t

185 e action of one hemisphere in suppressing or impeding processing in its counterpart.

186 tructure of moire superlattices has thus far impeded progress in the field.

187 ell-characterized tool compounds has however impeded progress.

188 However, a major obstacle impeding progress in this area is the lack of tools to r

189 ctiveness of immunization strategies and are impeding progress to control these infections throughout

190 rolled in engineering approaches is limited, impeding progress toward the construction of large, stru

191 vessels with a reduced inflammatory response impeding progression of tissue damage.

192 IACS-13909 potently impeded proliferation of tumors harboring a broad spectr

193 elements (CBEs) within IGCR1 upstream of Ds impede RAG scanning(3-5); however, their inactivation al

194 Here, we demonstrate that ClpS impedes recognition of ssrA-tagged substrates by a non-c

195 ten heal through a fibrotic mechanism, which impedes regeneration and functional recovery.

196 ncreasing interleukin 6 (IL6) expression and impede reparative response by decreasing Arginase-I (Arg

197 ons cause helicase-polymerase uncoupling and impede replication fork progression, but the details of

198 ndardized methods to quantify new neurons is impeding research reproducibility across laboratories.

199 ation with glutamate or dopamine antagonists impeded responses to the incentive but not to the instru

200 t viral infections by mutating viral DNA and impeding reverse transcription.

201 SVC112 preferentially impeded ribosomal processing of mRNAs critical for stres

202 rtain mRNA stem-loop structures are known to impede ribosome movement along mRNA and stimulate progra

203 We show that G3BP condensates impede RNA entanglement and recruit additional client pr

204 temporal cues governing their generation has impeded robust production from human induced pluripotent

205 ic bacterial colonization through xylem that impedes sap flow.

206 tic punctum imaging data, several issues are impeding satisfactory quantification of these structures

207 e additional CBEs activate rearrangement and impede scanning any further upstream(5).

208 eating a coaxially base-paired obstacle that impedes scanning from a monophosphorylated 5' end to tho

209 Impeding Sh1 growth by RNAi to cofilin and Arp2/3 pertur

210 e viral replicative fitness but, strikingly, impede silencing, whereas low virion pp71 levels reduce

211 kin injuries, complicating clinical care and impeding skin-to-skin contact between parent and child.

212 understanding of root growth in mechanically impeding soil conditions and provides insights relevant

213 causes SPINK1 transcriptional-repression and impedes SPINK1-mediated oncogenesis.

214 , the substitution or hybridization of which impedes splicing.

215 stabilization during the editing process and impedes spontaneous translational activation of partiall

216 the hepatitis C virus (HCV) are nonexistent, impeding studies of host-virus interactions and vaccine

217 HOIP processing impeded substrate ubiquitination in the NF-kappaB pathwa

218 on a flavor preference, while its inhibition impedes sucrose-driven flavor preference conditioning.

219 ifferent way from insulin, promoting DNL and impeding TAG synthesis.

220 views of the genetic architecture of MDD and impede the ability to identify pathways specific to MDD.

221 On land, human activities impede the capacity of terrestrial species to track isot

222 amino acid insertion into mouse Bco2 did not impede the chimeric enzyme's catalytic proficiency.

223 nce of ribo- and arabinonucleotides does not impede the copying of RNA templates.

224 ccess to antibody epitopes in a way that may impede the development of NAb responses.

225 n populations with African ancestry can both impede the dissemination of eQTL mapping results that wo

226 onneutralizing determinants (nND) on Env may impede the elicitation of bNAbs and their precursors by

227 gether, our data show that PS1 FAD mutations impede the EphB4/ephrinB2-mediated angiogenic functions

228 t threaten the viability of the bacteria and impede the establishment of infection.

229 ial network properties that are predicted to impede the evolution of cooperation.

230 o-cephalosporin rather than penicillin would impede the evolution of resistance.

231 These changes impede the gathering of protein bodies and prevent them

232 inistrative demands of modern medicine often impede the human connection that is central to clinical

233 e determined that the R21Q mutation does not impede the interaction between NS1 and TRIM25 or NS1(RBD

234 resent a very potent therapeutic strategy to impede the metastatic dissemination of malignant cells.

235 ilms and devices leads to a steric effect to impede the migration pathways of ions to increase the ac

236 Accurate and timely diagnosis is crucial to impede the progression of a disease and break the chain

237 ts, tissue cracks and shrinkage together may impede the reliability of the PAD method.

238 ylation which promote relocation to NPCs but impede the resumption of DNA synthesis by homologous rec

239 s in the recipient population contributes to impede the spread of sustained measles epidemics, rather

240 arge transfer and rapid charge recombination impede the sunlight-driven photocatalytic performance.

241 her study demonstrated that this interaction impeded the dimerization of P protein and thus suppresse

242 s hampered direct tests of gene function and impeded the establishment of choanoflagellates as a mode

243 ary breadth and range size, which might have impeded the identification of meaningful links between n

244 Mechanistically, the mutation impeded the interaction of PROM1 with ADP-ribosylation f

245 Further studies revealed that eEF1D impeded the nuclear import of NP and PA-PB1 heterodimer

246 he interaction between PB1 and RanBP5, which impeded the nuclear import of vRNP.

247 ectrochemical kinetics of sulfur species has impeded the wide adoption of lithium-sulfur battery, whi

248 in a mouse brainstem-spinal cord preparation impedes the amplitude augmentation of the central autono

249 ses safety risks and short lifetime and thus impedes the commercialization of Li metal batteries.

250 gh reactivity of this metal in solution that impedes the controlled assembly of titanium molecular cl

251 s defects by tuning protein synthesis rates, impedes the formation of long-term memory.

252 iments, whereby the binding of external K(+) impedes the forward translocation of the blocker, provid

253 t insufficient knowledge on its binding mode impedes the hunt for superior analogues.

254 d enhances the adsorption of hydrogen, which impedes the hydrogen evolution reaction.

255 ans on Env shields peptidic B cell epitopes, impedes the presentation of T helper cell epitopes, and

256 ereochemical transfer in these processes and impedes the rational development of new stereospecific c

257 e uncontrollable growth of lithium dendrites impedes the service of Li anodes in high energy and safe

258 ain barrier (BBB) to most conventional drugs impedes the treatment of central nervous system (CNS) di

259 ng on the utilized measuring technique, thus impeding the calculation of the appropriate water amount

260 measuring the protein's mass without MS/MS, impeding the confident proteoform identification in comp

261 on of their explicit role in AD progression, impeding the development of tools targeting soluble Abet

262 similarity to known bacteriophage sequences, impeding the identification and characterization of dist

263 an prostate epithelial cells remain unclear, impeding the implementation of new treatment strategies

264 ylated or oligomannose-type glycans slightly impeding the interaction.

265 ning the developmental processes is limited, impeding the quality of differentiation protocols.

266 ds have supported the recovery of murine RV, impeding the study of RV replication and pathogenesis in

267 in even the best studied vdW semiconductors, impeding the understanding and utilization of these mate

268 of gene expression facilitates, rather than impedes, the concomitant maintenance of transcriptional

269 equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces

270 on and screening, several major barriers may impede their effectiveness.

271 oteins handled by the secretory pathway that impede their folding.

272 l difficulties and tough challenges that can impede their large-scale commercial applications are sum

273 and unusual nucleic acid structures that can impede their progress.

274 developed to isolate these rare cells, have impeded their transition into the clinical practice.

275 ciated with suboptimal delivery systems have impeded their use in translational regenerative medicine

276 guest molecule(s) relative to the host often impedes their accurate modelling in crystal structures.

277 eptides are inactivated by the capsule as it impedes their penetration to the bacterial membrane.

278 ey are intolerant to mechanical deformation, impeding their application in flexible electronic device

279 of coastal processes and related feedbacks, impeding their predictions of coastal and global respons

280 ing strategic therapeutic interventions that impede these steps in viral replication requires a detai

281 unction, but that also have the potential to impede timely DNA replication.

282 Persistent and impaired inflammation impedes tissue healing and is a characteristic of chroni

283 ynamics and steps of the association process impedes to link the functional domain swapping to human-

284 intrinsic hallmarks of seizure invasion that impede traditional spike sorting and could be used as de

285 positioning of RNA Polymerase 2 at promoters impeding transcription initiation.

286 Unfortunately, this problem impedes translation of scientific discoveries on miRNA b

287 antibody blockade of these interactions will impede treponemal virulence and thus be of therapeutic v

288 Irinotecan with BBB disruption did not impede tumor growth or increase survival.

289 lts demonstrate a novel role for Beclin 1 in impeding tumor growth by coordinating the regulation of

290 ical inhibition of glycolysis preferentially impedes tumorigenicity of human lung cancer cells bearin

291 re exists a discontinuity in the energy that impedes two beads from fusing.

292 The impeded unbinding component likely results from Zur olig

293 the nonequilibrium nature of the transition impedes understanding.

294 isoforms which remain poorly characterized, impeding understanding of how disease-associated mutatio

295 pants' views on features that facilitated or impeded uptake of the intervention.

296 tigate how muscular changes after stroke may impede variable gearing and adversely impact muscle perf

297 locus resolution and high genetic complexity impede variant discovery.

298 Our team has observed impeded ventilation in intubated patients who are severa

299 Robust, gas-impeding water-conduction nanochannels that can sieve wa

300 absent when social information exchange was impeded, when mutual reward outcomes were disadvantageou