ライフサイエンスコーパス: impediment

1 is simply neglected or calibrated for as an impediment.

2 s passed through the initial segment without impediment.

3 s as well as previously thought due to mucus impediment.

4 are produced to provide instruction without impediment.

5 well as repriming replication downstream of impediments.

6 e genome duplication in the presence of such impediments.

7 mpered by both computational and statistical impediments.

8 m of, but closely coupled to, G4 replication impediments.

9 ased catalysts has been limited by technical impediments.

10 g on the future strategies to surmount these impediments.

11 cargo-associated motor behaviour to react to impediments.

12 based metabolomics data by reducing existing impediments.

13 Stat5 overexpression is able to bypass these impediments.

14 nanoparticles has been limited by technical impediments.

15 e Carnivorans may harbor comparatively fewer impediments.

16 operties and are perceived as insurmountable impediments.

17 l as future research needed to resolve these impediments.

18 stance, and hyponatremia represent treatment impediments.

19 To overcome the first impediment, a fusion protein of recombinant NAGLU and a

20 Thus, downmodulation of CTCF-bound scanning-impediment activity promotes cohesin-driven RAG scanning

21 It is essential to understand how impediments alter ecological dynamics via their influenc

22 on analyses with bare electrodes, associated impediments and inspected possible strategies and then c

23 d on carbon-free energy sources, but a major impediment are the costs.

24 Replication forks encounter impediments as they move through the genome, including n

25 ucing end of the substrate imposed by steric impediments at the aglycone-binding site.

26 as at primary clinics or the bedside, faces impediments because they may require highly trained pers

27 ys, we found that CD47(-/-) PMN exhibited no impediment, but slightly enhanced response to and transm

28 Nevertheless, this impediment can be overcome through an E-->K adaptive mut

29 Here, we show this impediment does not extend to Rubisco from Rhodobacter s

30 extension step that presents a considerable impediment due to displacement of the 5' template base,

31 The emissions reduction impediment due to infrastructural inertia is significant

32 mes requires replisomes to overcome numerous impediments during passage through open (eu) and condens

33 taking a few steps backward, can bypass the impediments encountered along the translocation path.

34 ts exemplify how protein design can overcome impediments encountered when expressing synthetic protei

35 Multiple impediments exist to achieving value, including misalign

36 Each scanning impediment focally increases RAG activity on potential s

37 rpentinite ores represent the most important impediment for a large scale implementation of sequester

38 nal costs and high latency that is a serious impediment for applications, such as telecommunications.

39 Saccharomyces cerevisiae, we show that a key impediment for binding of V(1) to V(o) is the conformati

40 d, asymptomatic carrier state is a political impediment for control and potential eradication of foot

41 give rise to resistive switching is a major impediment for engineering reliable and reproducible dev

42 generation from microalgae is a significant impediment for functional employment of these cells.

43 of restoring the "leaky gut," which poses an impediment for HIV cure efforts.

44 consequence of an ASYNAPTIC1 (Hop1)-mediated impediment for intersister repair.

45 The blood-brain barrier (BBB) is the major impediment for penetration of antiretroviral drugs, caus

46 generated by hot spot turnover may create an impediment for recombination in hybrids, potentially lea

47 and shape of molecular orbitals presents no impediment for retrieving molecular structure with adequ

48 The blood-brain barrier is a major impediment for targeted central nervous system (CNS) the

49 ater microbial communities, which is a major impediment for the design of sustainable peptide-based a

50 d computational skill to analyze the data-an impediment for the general public.

51 tified as the most significant thermodynamic impediment for the reduction of CO.

52 hase is optically active, this represents an impediment for the use of CsPbI(3) in optoelectronic dev

53 nd evolution is by far the single unresolved impediment for their practical applications.

54 They therefore represent major impediments for anticancer therapies, particularly for i

55 verlapping in microscopic digital images are impediments for developing fully automated identificatio

56 of most CPPs, has emerged as one of the main impediments for efficient intercellular transport.

57 of beta3 subunits are some of the molecular impediments for functional expression of malpha6mbeta2be

58 her surveillance radar data, we examined two impediments for nocturnally migrating songbirds in easte

59 One of the main impediments for obtaining DNA sequences from ancient hum

60 le highlighting important knowledge gaps and impediments for randomized controlled trials.

61 lecular elements in alpha6 could be specific impediments for the expression of functional alpha6beta4

62 geous antimicrobial peptides that lack these impediments from parent peptides that have at least some

63 A central impediment has been the challenge of visualizing invasiv

64 A major impediment has been the lack of simple and robust techni

65 om the hydrogel, so far diffusion and steric impediment have been identified as the only mechanisms f

66 s necessary alternative solutions to a major impediment imposed by substitution of the conserved P-lo

67 An impediment in assessing the effectiveness of the treatme

68 This delta2 "activated" state overcomes its impediment in ATP hydrolysis, with the subsequent releas

69 Drug resistance is a major impediment in medical oncology.

70 The impediment in OC differentiation culminated in a high tr

71 Fib(AEK) mice exhibited a profound impediment in Staphylococcus aureus clearance following

72 ertion of a CTCF-binding element (CBE)-based impediment in the extrusion path.

73 ted mutagenesis in obligates remains a major impediment in understanding microbial pathogenesis.

74 n vitro model of metastasis has been a major impediment in understanding the molecular regulation of

75 The primary impediments in developing large antibodies as drugs agai

76 der (ASD), and may potentially contribute to impediments in normal social development, a hallmark of

77 ed As Safe (GRAS) status and should have few impediments in obtaining regulatory approval for commerc

78 One of the largest impediments in the development of microfluidic-based sma

79 The results highlight important impediments in the development of these formulations and

80 actions from neighboring plants and physical impediments in the rhizosphere.

81 nts when replication is disrupted by certain impediments in vivo.

82 reased activities resulted in serious growth impediments in yeast and bacterial cells instead of impr

83 ent with increasing age due to immunological impediments, including defects in T follicular helper (T

84 The taxonomic impediment is characterized by dwindling classical taxon

85 However, the fundamental impediment is that the previously explored materials and

86 The main impediment is the lack of tools to perform specific gene

87 An approach to overcoming this impediment is to reduce the space of possible models to

88 Fork stabilization at DNA impediments is key to maintaining replication fork integ

89 gh cost of synthetic polymers has been a key impediment limiting the widespread adoption of polymer d

90 lack of animal models capable of identifying impediments limiting bnAb induction and ranking vaccine

91 by payment systems and policies that create impediments, misunderstanding, and sometimes misinformat

92 been incorporated into biomolecules without impediment of biological activity.

93 nce and which (2) can explain the associated impediment of conscious perception for additional stimul

94 The impediment of detection of food contaminants has been ov

95 Impediment of DNA replication can lead to DNA damage and

96 However, the impediments of animal models are also apparent and stem

97 ibility of a MOF may constitute an intrinsic impediment on its experimental realization.

98 l inspection of images will impose a serious impediment on the pace of biological discovery.

99 Furthermore, size has been an impediment owing to the importance of achieving nanoscal

100 ogical models for this purpose faces several impediments, particularly the existence of strong, non-a

101 g immunotherapy has been hampered by various impediments related to the stability and isolation proce

102 Depending on impediment severity, this action results in either trans

103 The replicative machinery encounters many impediments, some of which can be overcome by lesion byp

104 veral steps of data processing, resulting in impediments such as missing particle orientations.

105 circumvent significant inherent quantitative impediments, such as of computational complexity.

106 h repeat, (GAA)(10), to become a replication impediment that engages the repriming activity of the pr

107 In part, this is due to impediments that often limit their applications in vivo.

108 replication machinery frequently encounters impediments that slow replication fork progression and t

109 I propose that one impediment to a better understanding of the brain is tha

110 chain facilities appears to be a significant impediment to access to renal transplants.

111 has been increasingly recognized as a major impediment to achieving effective immunosuppression.

112 larization, which is recognized as the major impediment to achieving high FO water flux.

113 Significant liver fibrosis remains an impediment to achieving SVR with short-duration DAA ther

114 An impediment to achieving this is that the current researc

115 he dorsal root ganglion (DRG) is a potential impediment to action potential (AP) propagation towards

116 olonged prevention of ignition and continual impediment to active flaming fronts.

117 id cell infiltrate has emerged as a critical impediment to adaptive antitumor immune responses.

118 compared with that of the anode have been an impediment to advance the lithium-ion battery technology

119 s-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transpl

120 ct DNA from degradation may pose a potential impediment to application of DNA barcoding and metagenom

121 ar matrix in a spinal lesion site is a major impediment to axonal regeneration in mammals.

122 which is unique to MACV GP1, is an important impediment to binding of neutralizing antibodies and con

123 One impediment to broad adoption of ecosystem service inform

124 lack of solid clinical evidence is the main impediment to broader use.

125 Poor access to surgical care is a major impediment to cancer care in sub-Saharan Africa.

126 ning antitumor immunity remains a persistent impediment to cancer immunotherapy.

127 Multidrug resistance (MDR) is a major impediment to cancer treatment.

128 ent amounts of high-quality cells remains an impediment to cell-based therapies.

129 Viewing this development as a potential impediment to clear communication and hypothesis testing

130 thogens using WGS and is therefore a serious impediment to clinical and epidemiological sequencing fo

131 r on tumor metastasis, which is the greatest impediment to clinical management of cancers today.

132 onthly AM screening, thus overcoming a major impediment to CMAM effectiveness.

133 of cellulase enzymes remains a key economic impediment to commercialization of biofuels.

134 A major impediment to comparing the loss of EH during past and c

135 is world heritage ecosystem has been a major impediment to conservation efforts.

136 health record was perceived by nurses as an impediment to contextualizing and synthesizing informati

137 T or remain untreated due to an inability or impediment to coronary sinus (CS) lead implantation.

138 f finding the native topology can be a major impediment to correct folding to the biologically active

139 on, which is identified as another potential impediment to CPP-mediated intercellular transport.

140 ble structural heterogeneity and are a major impediment to crystallization studies.

141 sity within the VPH is poorly understood, an impediment to deconstructing the roles of distinct VPH c

142 This is a major impediment to deployment in resource-poor settings.

143 of vaginal dysbiosis has been a significant impediment to developing optimal treatment and preventio

144 lized microtubule network provides a viscous impediment to diastolic stretch, particularly in HF.

145 A structures pose a frequent and significant impediment to DNA replication and must be actively manag

146 the setting of advanced disease, remains an impediment to durable clinical responses.

147 The major impediment to effective cancer therapy has been the deve

148 Inadequate funding levels are a major impediment to effective global biodiversity conservation

149 Drug resistance is a major impediment to effective treatment of breast cancer.

150 A major impediment to effectively utilizing untargeted metabolom

151 A major impediment to expanding PET applications to study the br

152 The degree and nature of the impediment to flux, as well as the potential approaches

153 is after spinal cord injury (SCI) is a major impediment to functional recovery.

154 uantify receptor protein isoforms is a major impediment to functional studies.

155 Significant impediment to improvement has been the requisite use of

156 A major impediment to improving the treatment of concussion is o

157 Furthermore, tsetse's PM is not a physical impediment to infection establishment, but instead serve

158 A major impediment to investigating such processes at the subcel

159 d microstructure of AM parts remains a major impediment to its widespread adoption.

160 inhibition of Tat-transactivation as a major impediment to latency reactivation.

161 The results suggest that one main impediment to learning the optimal strategy in the Monty

162 Chronic allograft rejection is a major impediment to long-term transplant success.

163 data on larval behaviour traits is a serious impediment to modelling deep-sea ecosystem connectivity;

164 Here we show that the critical impediment to observations of such phase transformations

165 BEST PRACTICE ADVICE 5: A major impediment to our ability to accurately define SIBO is o

166 hotomies as scientifically inadequate and an impediment to our ability to integrate the diverse infor

167 that the trabecular meshwork is the primary impediment to outflow and its ablation benefits those ey

168 t the duplicated ACCase in Arabidopsis is an impediment to plastid transformation provides a rational

169 An impediment to potential treatment identification has bee

170 ization of ischemic neural tissue is a major impediment to preservation of function in central nervou

171 A substantial impediment to progress in trials of new therapies in neu

172 aria, need for intravenous treatment, and an impediment to quinidine.

173 Failure of remyelination is a critical impediment to recovery in multiple sclerosis (MS).

174 ilure to undergo remyelination is a critical impediment to recovery in multiple sclerosis.

175 A similar impediment to reendothelialization was observed in rats

176 PCs and oligodendrocytes, and as a prominent impediment to remyelination.

177 present during much of the cell cycle, is an impediment to repair of radiation-induced lesions in thi

178 SUMO from histones is needed to overcome the impediment to S2 phosphorylation.

179 nt threat to public health and a significant impediment to socio-economic development worldwide.

180 Their extreme reactivity presents an impediment to structural characterization, but their bio

181 ardiotoxicity, the most significant clinical impediment to successful anthracycline treatment.

182 -glycoprotein (Pgp) represents a significant impediment to successful cancer treatment.

183 Resistance to endocrine therapy is a major impediment to successful treatment of breast cancer.

184 to chemotherapeutic drugs, which is a severe impediment to successful treatment.

185 od of extinction or abstinence remains a key impediment to successful treatment.

186 A major impediment to synthesizing compounds from CO2 is the dif

187 f persistence is clearly the single greatest impediment to TB control, and research aimed at understa

188 es, brain pathology and imaging, but a major impediment to testing ASD hypotheses is the lack of huma

189 considerable progress in the field, a major impediment to the clinical translation of hPSCs is the d

190 polymerization should be considered a major impediment to the construction of a self-sustained, RNA-

191 of the sub-Arctic represents a considerable impediment to the construction of roads, thereby greatly

192 undergoing antiretroviral therapy is a major impediment to the cure of HIV/AIDS.

193 Viral diversity is considered a major impediment to the development of an effective HIV-1 vacc

194 complexity of this disease has been a major impediment to the development of appropriate metrics of

195 fic biology of these pathways is an enduring impediment to the development of clinical NR small-molec

196 An impediment to the development of effective therapies for

197 A major impediment to the development of novel treatment strateg

198 vices and circuits, and can be a significant impediment to the development of practical applications

199 enovirus myocarditis, which is a significant impediment to the development of treatment or prevention

200 We show that unless there is some physical impediment to the diversity of signals possible, then po

201 herapeutic is currently the most significant impediment to the effective management of hemophilia A.

202 A major impediment to the effective treatment of patients with p

203 a represents a substantial knowledge gap and impediment to the eventual licensing of new antiviral dr

204 enerational genetic changes is a fundamental impediment to the identifiability of mathematical models

205 A major impediment to the implementation of insecticide resistan

206 onal (2D) superconductors, which presents an impediment to the pursuit of numerous long-standing pred

207 The lack of authentic standards has been an impediment to the rapid identification of such metabolit

208 y in this rearrangement relies on the steric impediment to the rotation around the C-N bond in the ch

209 ediated by preexisting antibodies is a major impediment to the success of transplants across allogene

210 pothesize that the proline codons present an impediment to the translation of mgtL, which can be alle

211 pid clearance by renal filtration is a major impediment to the translation of small bioactive biologi

212 the brain parenchyma, which is a recognized impediment to the treatment of neurodegenerative disorde

213 A major impediment to the use of adeno-associated virus (AAV)-me

214 The most serious impediment to the worldwide spread of heavy ion therapy

215 d human-like sialylated receptors is a major impediment to their efficient transmission in humans and

216 xacerbation of neurodegeneration, is a major impediment to therapeutic development.

217 One impediment to these applications is fluctuations of sing

218 tinum(IV) complexes in vivo is a significant impediment to these complexes being successfully employe

219 rrying 2 APOL1 risk alleles should not be an impediment to transplantation.

220 stretches, where harsh terrain is seen as an impediment to travel.

221 A major impediment to tuberculosis control in Africa is the diff

222 One impediment to understanding how HSV gE/gI and US9 functi

223 A fundamental impediment to understanding the brain is the availabilit

224 in the hantavirus community is a significant impediment to understanding the ecology and evolutionary

225 This is the major impediment to understanding the fundamental contribution

226 ductivity and the pseudogap state remains an impediment to understanding the high transition temperat

227 A major impediment to understanding the impact of environmental

228 ose) (PAR) in a homogeneous form has been an impediment to understanding the interactions of PAR with

229 A major impediment to understanding the mechanistic basis of the

230 e interphalangeal joints) presented a slight impediment to visualization.

231 and show that background photons are a chief impediment to voltage sensing.

232 conditional expression strategy bypassed the impediment to VRC26UCA B cell development, enabling the

233 , livestock, and fisheries sectors act as an impediment to, or an opportunity for, enhanced resilienc

234 There are many impediments to acceptable and accurate administration of

235 Respondents noted a variety of impediments to advancing the science, including inadequa

236 Impediments to animal movement are ubiquitous and vary w

237 In this article, we review the historical impediments to automation in the microbiology laboratory

238 he host spinal cord, which contains numerous impediments to axon growth.

239 uristic 3000 bar as well as reviews the main impediments to be expected when trying to realize such s

240 ese blood-brain barrier (BBB) properties are impediments to brain drug delivery, and brain vascular d

241 However, impediments to clinical translation of AuNPs have been p

242 mic implantation environment are significant impediments to developing and deploying peripheral inter

243 pical older patient with MDS have been major impediments to development of effective novel therapies.

244 Major impediments to development of vaccines and drugs for Pla

245 Impediments to DNA replication are known to induce gross

246 howed that the cross-link constituted strong impediments to DNA replication in HEK293T cells, with th

247 es is needed to successfully negotiate these impediments to drug delivery.

248 One of the several impediments to effective oncolytic virus therapy of canc

249 of established cellular effectors overcomes impediments to enhance reparative activity.

250 Impediments to enzyme replacement therapy are the absenc

251 Anticipated impediments to estimating heterogeneity for each paramet

252 There are major impediments to finding improved DEET alternatives becaus

253 Here we report a method that overcomes major impediments to highly multiplex tissue imaging.

254 The impediments to integration were many, but they are gradu

255 However, the parasite faces no apparent impediments to invading the entire archipelago, with unk

256 One of the main impediments to ISC proliferation and lineage specificati

257 ity in those disorders, as well as potential impediments to its application.

258 In this study, we identify multiple impediments to MHV-ExoN-AA reversion.

259 As practice reduces the impediments to more complex computation, the chunking st

260 Rather than simply acting as impediments to movement, interactions of trafficking car

261 e barriers and 10% cited a single barrier as impediments to optimal adherence.

262 Data to healthcare, but there are still some impediments to overcome, such as fragmentation, high cos

263 recent efforts attempting to mitigate common impediments to practical commercialization but is also p

264 es potential approaches to address remaining impediments to program success.

265 Major impediments to progress in understanding, early diagnosi

266 in alterations in the disorder, highlighting impediments to progress, recent developments, and promis

267 Although we identify multiple impediments to progress, we conclude that the current st

268 However, currently, one of the main impediments to providing answers to these questions is t

269 t often cited the following factors as major impediments to pursuing basic investigation: pressure to

270 axon regrowth and extrinsic, scar-associated impediments to regeneration results in significant regen

271 ing intrinsic and scar-associated, extrinsic impediments to regeneration results in significant regro

272 The precise impediments to replication fork progression at telomeric

273 ural alterations in DNA can serve as natural impediments to replication fork stability and progressio

274 ensure that this process is not disrupted by impediments to replication.

275 records represent one of the most insidious impediments to seafood traceability, and suggest that wi

276 wever, NF-kappaB dimers encounter additional impediments to selective DNA binding in vivo.

277 rctic Peninsula for environmental or trophic impediments to shoreward expansion.

278 ation shown by our approach removes previous impediments to studies aimed at quantitative differentia

279 Impediments to sustainable SEE include lack of an eviden

280 erant state, which may explain many of these impediments to TB treatment.

281 , this work largely removes any instrumental impediments to the adoption of QDs as routine tools for

282 PRn-mediated toxicity may result from broad impediments to the dynamics of cell structure and inform

283 into functional groups that help explain the impediments to the emergence of maraviroc-associated R5

284 G targeting is associated with corresponding impediments to the loop extrusion process that drives ch

285 The lack of impediments to the replication of the VSV core in eukary

286 HD) and relapse after allo-HSCT remain major impediments to the success of allo-HSCT.

287 n a potential outbreak scenario and identify impediments to these efforts, we studied 84 invasive ser

288 are unable to unwind quadruplexes, which are impediments to transcription, translation, or replicatio

289 Major impediments to understand the transport mechanism are th

290 One of the major impediments to using electroorganic synthesis is the nee

291 We suggest that such impediments to variation in signal form will be uncommon

292 y (ART) is important, but there are multiple impediments to VL testing in resource-constrained settin

293 This self-pairing presents an impediment toward binding of the RNA by nucleic acid-bas

294 A major impediment toward understanding its nontemplating roles

295 with schizophrenia and represent significant impediments toward successful psychosocial functioning w

296 To overcome this impediment, we have developed a robust NMR restraint gui

297 To overcome this impediment, we tested organic solvents as denaturants du

298 To overcome this impediment, we used an eight-channel microphone array sy

299 We overcome these impediments with high-resolution measurements on the str

300 replisome to continue DNA synthesis without impediment, with leading strand re-priming by DnaG.